Published in Am J Physiol Heart Circ Physiol on May 03, 2016
Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature (1984) 25.71
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase) Science (1996) 15.88
Inositol phospholipids and cell surface receptor function. Biochim Biophys Acta (1975) 11.82
Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev (2003) 9.32
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem (1991) 8.92
A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle. Nature (1987) 5.94
Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol (2000) 4.80
Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation. J Biol Chem (1997) 3.12
Noradrenaline contracts arteries by activating voltage-dependent calcium channels. Nature (1988) 2.94
Ca2+-dependent activation of Rho and Rho kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contraction. Circ Res (2003) 2.85
Stimulus-specific patterns of intracellular calcium levels in smooth muscle of ferret portal vein. J Physiol (1984) 2.72
Epidemiology of varicose veins. Br J Surg (1994) 2.56
TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells. Circ Res (2001) 2.53
Mechanisms of smooth muscle contraction. Physiol Rev (1996) 2.37
Chronic venous disease. N Engl J Med (2006) 2.35
Use and properties of ROCK-specific inhibitor Y-27632. Methods Enzymol (2000) 2.19
The epidemiology of chronic venous insufficiency and varicose veins. Ann Epidemiol (2005) 2.13
Changes in cytosolic calcium level in vascular smooth muscle strip measured simultaneously with contraction using fluorescent calcium indicator fura 2. J Pharmacol Exp Ther (1988) 2.02
Regulation of smooth muscle contractile elements by second messengers. Annu Rev Physiol (1989) 1.98
Myoplasmic [Ca2+] determines myosin phosphorylation in agonist-stimulated swine arterial smooth muscle. Circ Res (1988) 1.79
Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase. Biochem J (2002) 1.60
Role of dysfunctional maternal venous hemodynamics in the pathophysiology of pre-eclampsia: a review. Ultrasound Obstet Gynecol (2011) 1.54
Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertension. Biochem Pharmacol (2005) 1.52
Receptor-operated Ca2(+)-permeable nonselective cation channels in vascular smooth muscle: a physiologic perspective. J Cardiovasc Electrophysiol (2002) 1.49
Calcium-force relationships as detected with aequorin in two different vascular smooth muscles of the ferret. J Physiol (1985) 1.47
Ca(2+)-independent isoforms of protein kinase C differentially translocate in smooth muscle. Am J Physiol (1992) 1.40
KCl evokes contraction of airway smooth muscle via activation of RhoA and Rho-kinase. Am J Physiol Lung Cell Mol Physiol (2004) 1.30
Gender-specific inhibition of Ca2+ entry mechanisms of arterial vasoconstriction by sex hormones. Clin Exp Pharmacol Physiol (1999) 1.30
Different molecular mechanisms for Rho family GTPase-dependent, Ca2+-independent contraction of smooth muscle. J Biol Chem (1998) 1.26
Mechanisms of varicose vein formation: valve dysfunction and wall dilation. Phlebology (2008) 1.26
Identification and characterization of voltage-sensitive calcium channels in neuronal clonal cell lines. J Neurosci (1984) 1.24
Epidemiology of chronic venous disease. Phlebology (2008) 1.23
Determination of oestrous cycle of the rats by direct examination: how reliable? Anat Histol Embryol (2007) 1.16
Enhanced vascular reactivity during inhibition of nitric oxide synthesis in pregnant rats. Hypertension (1998) 1.16
The superficial buffer barrier in venous smooth muscle: sarcoplasmic reticulum refilling and unloading. Br J Pharmacol (1993) 1.13
Matrix metalloproteinase 2-induced venous dilation via hyperpolarization and activation of K+ channels: relevance to varicose vein formation. J Vasc Surg (2007) 1.11
Store-operated calcium entry in vascular smooth muscle. Br J Pharmacol (2007) 1.11
Molecular aspects of arterial smooth muscle contraction: focus on Rho. Exp Biol Med (Maywood) (2005) 1.11
Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric arteries of angiotensin II-induced hypertensive rats. J Hypertens (2007) 1.10
Sustained contraction of vascular smooth muscle: calcium influx or C-kinase activation? J Pharmacol Exp Ther (1988) 1.09
Decreased [Ca(2+)](i) during inhibition of coronary smooth muscle contraction by 17beta-estradiol, progesterone, and testosterone. J Pharmacol Exp Ther (1999) 1.09
Gender-related distinctions in protein kinase C activity in rat vascular smooth muscle. Am J Physiol Cell Physiol (2001) 1.07
Gender-specific reduction in contractility and [Ca(2+)](i) in vascular smooth muscle cells of female rat. Am J Physiol Cell Physiol (2000) 1.05
Prevalence and risk factors of varicose veins in lower extremities: mini-Finland health survey. Eur J Surg (1995) 1.04
Interventions for varicose veins and leg oedema in pregnancy. Cochrane Database Syst Rev (2007) 1.03
Chronic hypoxia during gestation causes epigenetic repression of the estrogen receptor-α gene in ovine uterine arteries via heightened promoter methylation. Hypertension (2012) 1.03
Prolonged increases in vein wall tension increase matrix metalloproteinases and decrease constriction in rat vena cava: Potential implications in varicose veins. J Vasc Surg (2008) 1.02
Increased vascular angiotensin type 2 receptor expression and NOS-mediated mechanisms of vascular relaxation in pregnant rats. Am J Physiol Heart Circ Physiol (2009) 1.00
Signal transduction by protein kinase C in mammalian cells. Clin Exp Pharmacol Physiol (1998) 1.00
Diagnosis of deep vein thrombosis and pulmonary embolism in pregnancy. Thromb Res (2002) 1.00
Uteroplacental insufficiency programs regional vascular dysfunction and alters arterial stiffness in female offspring. J Physiol (2010) 1.00
The specific bisindolylmaleimide PKC-inhibitor GF 109203X efficiently modulates MRP-associated multiple drug resistance. Biochem Biophys Res Commun (1995) 0.98
Pregnancy upregulates large-conductance Ca(2+)-activated K(+) channel activity and attenuates myogenic tone in uterine arteries. Hypertension (2011) 0.98
Chronic hypoxia inhibits sex steroid hormone-mediated attenuation of ovine uterine arterial myogenic tone in pregnancy. Hypertension (2010) 0.98
Pregnancy-associated reduction in vascular protein kinase C activity rebounds during inhibition of NO synthesis. Am J Physiol Regul Integr Comp Physiol (2000) 0.94
Prostaglandin E2-prostanoid EP3 signal induces vascular contraction via nPKC and ROCK activation in rat mesenteric artery. Eur J Pharmacol (2011) 0.94
Intracellular free calcium concentration/force relationship in rabbit inferior vena cava activated by norepinephrine and high K+. Pflugers Arch (1990) 0.92
Subtype-specific estrogen receptor-mediated vasodilator activity in the cephalic, thoracic, and abdominal vasculature of female rat. J Cardiovasc Pharmacol (2013) 0.91
Mechanisms modulating estrogen-induced uterine vasodilation. Vascul Pharmacol (2002) 0.88
Mechanism of calcium activation in vascular smooth muscle. J Hypertens Suppl (1987) 0.88
New tetracarboxylate chelators for fluorescence measurement and photochemical manipulation of cytosolic free calcium concentrations. Soc Gen Physiol Ser (1986) 0.88
MMP-2 induced vein relaxation via inhibition of [Ca2+]e-dependent mechanisms of venous smooth muscle contraction. Role of RGD peptides. J Surg Res (2008) 0.87
Alpha 1-adrenergic activation of brown adipocytes leads to an increased formation of inositol polyphosphates. FEBS Lett (1986) 0.86
Estrogen receptor-mediated enhancement of venous relaxation in female rat: implications in sex-related differences in varicose veins. J Vasc Surg (2010) 0.86
Endogenous modulation of the blunted adrenergic response in resistance-sized mesenteric arteries from the pregnant rat. Am J Obstet Gynecol (1992) 0.86
Plasma vasopressin, oxytocin, estradiol, and progesterone related to water and sodium excretion in normal pregnancy and gestational hypertension. Acta Obstet Gynecol Scand (2009) 0.86
Thrombosis in pregnancy and maternal outcomes. Birth Defects Res C Embryo Today (2015) 0.85
Venous reactivity and pregnancy abnormalities. Acta Obstet Gynecol Scand (1986) 0.84
A subnormal plasma volume in formerly preeclamptic women is associated with a low venous capacitance. J Soc Gynecol Investig (2005) 0.83
Stimulated mechanisms of Ca2+ entry into vascular smooth muscle during NO synthesis inhibition in pregnant rats. Am J Physiol (1999) 0.83
Pregnancy-related venous thromboembolism: risk and the effect of thromboprophylaxis. Thromb Res (2012) 0.83
Enhanced endothelin receptor type B-mediated vasodilation and underlying [Ca²⁺]i in mesenteric microvessels of pregnant rats. Br J Pharmacol (2013) 0.82
Differential [Ca2+]i signaling of vasoconstriction in mesenteric microvessels of normal and reduced uterine perfusion pregnant rats. Am J Physiol Regul Integr Comp Physiol (2008) 0.82
[Ca(2+)](i) signaling in renal arterial smooth muscle cells of pregnant rat is enhanced during inhibition of NOS. Am J Physiol Regul Integr Comp Physiol (2001) 0.81
The effect of pregnancy on the compliance of large arteries and veins in healthy parous control subjects and women with a history of preeclampsia. Am J Obstet Gynecol (2000) 0.81
Ca(2+)-dependent contraction by the saponoside escin in rat vena cava: implications in venotonic treatment of varicose veins. J Vasc Surg (2011) 0.81
Pan-junctional sarcoplasmic reticulum in vascular smooth muscle: nanospace Ca2+ transport for site- and function-specific Ca2+ signalling. J Physiol (2013) 0.81
Characterization of late-pregnant rat uterine contraction via the contractility ratio in vitro significance of alpha1-adrenoceptors. Life Sci (2001) 0.80
Inhibition of nicotinic receptor-mediated responses in bovine chromaffin cells by diltiazem. Br J Pharmacol (1996) 0.80
The vasorelaxant mechanisms of a Rho kinase inhibitor DL0805 in rat thoracic aorta. Molecules (2012) 0.80
Sex-related decrease in [Ca2+]i signaling and Ca2+-dependent contraction in inferior vena cava of female rat. Am J Physiol Regul Integr Comp Physiol (2009) 0.79
Tonic arterial contraction mediated by L-type Ca2+ channels requires sustained Ca2+ influx, G protein-associated Ca2+ release, and RhoA/ROCK activation. Eur J Pharmacol (2012) 0.79
Repeated pregnancies (multiparity) increases venous tone and reduces compliance. Am J Physiol Regul Integr Comp Physiol (2005) 0.78
Vasodilatory effect of a novel Rho-kinase inhibitor, DL0805-2, on the rat mesenteric artery and its potential mechanisms. Cardiovasc Drugs Ther (2014) 0.78
Adaptive increases in expression and vasodilator activity of estrogen receptor subtypes in a blood vessel-specific pattern during pregnancy. Am J Physiol Heart Circ Physiol (2015) 0.78
Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat. J Pharmacol Exp Ther (2014) 0.77
Inositol lipid breakdown as a step in alpha-adrenergic stimulus-response coupling. Clin Sci (Lond) (1985) 0.77
Interventions for varicosities and leg oedema in pregnancy. Cochrane Database Syst Rev (2000) 0.76
ROCK1 translocates from non-caveolar to caveolar regions upon KCl stimulation in airway smooth muscle. Physiol Res (2014) 0.76
Changes in the size of maternal inferior vena cava during pregnancy. J Perinat Med (2004) 0.76
Rho-kinase inhibition attenuates calcium-induced contraction in β-escin but not Triton X-100 permeabilized rabbit femoral artery. J Muscle Res Cell Motil (2011) 0.76
Pelvic congestion syndrome: the current state of the literature. Arch Gynecol Obstet (2015) 0.76
Pregnancy-related venous thrombosis: comparison between spontaneous and ART conception in an Italian cohort. BMJ Open (2015) 0.76
Matrix Metalloproteinases as Regulators of Vein Structure and Function: Implications in Chronic Venous Disease. J Pharmacol Exp Ther (2015) 0.76
Venous conditions associated with pregnancy. Semin Dermatol (1993) 0.75
Epidemiology of venous thromboembolism (VTE) associated with pregnancy. Birth Defects Res C Embryo Today (2015) 0.75
Pregnancy-associated venous thrombosis. Phlebology (2012) 0.75