Published in Methods Enzymol on January 01, 2000
Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics. Biophys J (2006) 4.06
Actin and intermediate filaments stabilize the Chlamydia trachomatis vacuole by forming dynamic structural scaffolds. Cell Host Microbe (2008) 2.72
Reassessing the role and dynamics of nonmuscle myosin II during furrow formation in early Drosophila embryos. Mol Biol Cell (2003) 2.50
Cortical recruitment of nonmuscle myosin II in early syncytial Drosophila embryos: its role in nuclear axial expansion and its regulation by Cdc2 activity. J Cell Biol (2002) 2.35
Effects of cell tension on the small GTPase Rac. J Cell Biol (2002) 2.24
Human keratinocytes are efficiently immortalized by a Rho kinase inhibitor. J Clin Invest (2010) 2.19
The Rho kinases I and II regulate different aspects of myosin II activity. J Cell Biol (2005) 2.16
Tissue elongation requires oscillating contractions of a basal actomyosin network. Nat Cell Biol (2010) 2.15
Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors. J Biol Chem (2007) 1.99
Cortical actomyosin breakage triggers shape oscillations in cells and cell fragments. Biophys J (2005) 1.96
Modulation of fibroblast morphology and adhesion during collagen matrix remodeling. Mol Biol Cell (2002) 1.92
Integrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesions. Curr Biol (2014) 1.75
Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography. Nat Cell Biol (2010) 1.72
The Rho-associated protein kinase p160ROCK is required for centrosome positioning. J Cell Biol (2002) 1.65
Dendritic fibroblasts in three-dimensional collagen matrices. Mol Biol Cell (2003) 1.61
ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells. Circ Res (2009) 1.61
Actomyosin stiffens the vertebrate embryo during crucial stages of elongation and neural tube closure. Development (2009) 1.59
Cytoskeletal rearrangements and cell extensions induced by the US3 kinase of an alphaherpesvirus are associated with enhanced spread. Proc Natl Acad Sci U S A (2005) 1.59
Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells. Proc Natl Acad Sci U S A (2012) 1.46
ROCK inhibition enhances the recovery and growth of cryopreserved human embryonic stem cells and human induced pluripotent stem cells. Mol Reprod Dev (2009) 1.45
Cell wound repair in Drosophila occurs through three distinct phases of membrane and cytoskeletal remodeling. J Cell Biol (2011) 1.34
Contractility modulates cell adhesion strengthening through focal adhesion kinase and assembly of vinculin-containing focal adhesions. J Cell Physiol (2010) 1.29
Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil. J Cardiovasc Pharmacol (2013) 1.24
The actin cytoskeleton participates in the early events of autophagosome formation upon starvation induced autophagy. Autophagy (2012) 1.22
PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells. J Cell Biol (2007) 1.20
Rho kinase as a therapeutic target in cardiovascular disease. Future Cardiol (2011) 1.18
Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases. Chem Biol (2012) 1.13
RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells. Oncogene (2012) 1.13
CASZ1 promotes vascular assembly and morphogenesis through the direct regulation of an EGFL7/RhoA-mediated pathway. Dev Cell (2013) 1.10
Lipoxins induce actin reorganization in monocytes and macrophages but not in neutrophils: differential involvement of rho GTPases. Am J Pathol (2002) 1.05
The ROCK inhibitor Y-27632 improves recovery of human embryonic stem cells after fluorescence-activated cell sorting with multiple cell surface markers. PLoS One (2010) 1.02
Signaling through Rho GTPase pathway as viable drug target. Curr Med Chem (2009) 1.02
Opposite effects of HIV-1 p17 variants on PTEN activation and cell growth in B cells. PLoS One (2011) 1.01
Maturation and the role of PKC-mediated contractility in ovine cerebral arteries. Am J Physiol Heart Circ Physiol (2009) 1.01
Pericyte Rho GTPase mediates both pericyte contractile phenotype and capillary endothelial growth state. Am J Pathol (2007) 1.00
Cytosolic retention of phosphorylated extracellular signal-regulated kinase and a Rho-associated kinase-mediated signal impair expression of p21(Cip1/Waf1) in phorbol 12-myristate-13- acetate-induced apoptotic cells. Mol Cell Biol (2002) 0.98
Rho-kinase-mediated Ca2+-independent contraction in rat embryo fibroblasts. Am J Physiol Cell Physiol (2003) 0.96
Neuronal Nogo-A regulates glutamate receptor subunit expression in hippocampal neurons. J Neurochem (2011) 0.93
A spindle-independent cleavage pathway controls germ cell formation in Drosophila. Nat Cell Biol (2013) 0.91
Astrocyte stellation, a process dependent on Rac1 is sustained by the regulated exocytosis of enlargeosomes. Glia (2011) 0.89
The insert region of RhoA is essential for Rho kinase activation and cellular transformation. Mol Cell Biol (2001) 0.89
Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis. Elife (2016) 0.88
Effects of hemagglutinin-neuraminidase protein mutations on cell-cell fusion mediated by human parainfluenza type 2 virus. J Virol (2008) 0.88
Simvastatin stimulates apoptosis in cholangiocarcinoma by inhibition of Rac1 activity. Dig Liver Dis (2011) 0.87
Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity. Int J Cancer (2009) 0.87
Calyculin A, an enhancer of myosin, speeds up anaphase chromosome movement. Cell Chromosome (2007) 0.87
Features of distinct contractions induced with a high and a low concentration of KCl, noradrenaline, and histamine in swine lingual artery. Naunyn Schmiedebergs Arch Pharmacol (2010) 0.86
mDia1 targets v-Src to the cell periphery and facilitates cell transformation, tumorigenesis, and invasion. Mol Cell Biol (2010) 0.86
Maturation and long-term hypoxia-induced acclimatization responses in PKC-mediated signaling pathways in ovine cerebral arterial contractility. Am J Physiol Regul Integr Comp Physiol (2010) 0.86
The effect of Rho kinase inhibitor Y-27632 on endotoxemia-induced intestinal apoptosis in infant rats. J Mol Histol (2011) 0.85
Mutant huntingtin alters cell fate in response to microtubule depolymerization via the GEF-H1-RhoA-ERK pathway. J Biol Chem (2010) 0.84
Slit2 regulates the dispersal of oligodendrocyte precursor cells via Fyn/RhoA signaling. J Biol Chem (2012) 0.84
Actomyosin-dependent cortical dynamics contributes to the prophase force-balance in the early Drosophila embryo. PLoS One (2011) 0.84
Induction of oligodendrocyte differentiation and in vitro myelination by inhibition of rho-associated kinase. ASN Neuro (2014) 0.82
Dual role for RhoA in suppression and induction of cytokines in the human neutrophil. Blood (2006) 0.81
Effects of Substrate Stiffness and Actomyosin Contractility on Coupling between Force Transmission and Vinculin-Paxillin Recruitment at Single Focal Adhesions. Mol Biol Cell (2017) 0.81
Airway Progenitor Clone Formation Is Enhanced by Y-27632-Dependent Changes in the Transcriptome. Am J Respir Cell Mol Biol (2016) 0.80
Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem (2011) 0.80
Rho-ROCK and Rac-PAK signaling pathways have opposing effects on the cell-to-cell spread of Marek's Disease Virus. PLoS One (2012) 0.80
Hyperoxia increases the elastic modulus of alveolar epithelial cells through Rho kinase. FEBS J (2013) 0.80
Enhanced Non-Viral Gene Delivery to Human Embryonic Stem Cells via Small Molecule-Mediated Transient Alteration of Cell Structure. J Mater Chem B Mater Biol Med (2015) 0.79
Enhancement of cell recovery for dissociated human embryonic stem cells after cryopreservation. Biotechnol Prog (2010) 0.79
Metabolic actions of Rho-kinase in periphery and brain. Trends Endocrinol Metab (2013) 0.79
Selective glucocorticoid control of Rho kinase isoforms regulate cell-cell interactions. Biochem Biophys Res Commun (2007) 0.79
The role of uridine adenosine tetraphosphate in the vascular system. Adv Pharmacol Sci (2011) 0.79
Coupling between apical tension and basal adhesion allow epithelia to collectively sense and respond to substrate topography over long distances. Integr Biol (Camb) (2015) 0.78
Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). Medchemcomm (2012) 0.78
Inflammatory Eicosanoids Increase Amyloid Precursor Protein Expression via Activation of Multiple Neuronal Receptors. Sci Rep (2015) 0.77
Improving viability and transfection efficiency with human umbilical cord wharton's jelly cells through use of a ROCK inhibitor. Cell Reprogram (2014) 0.77
The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts. Cancer Lett (2015) 0.76
The CASZ1/Egfl7 transcriptional pathway is required for RhoA expression in vascular endothelial cells. Small GTPases (2013) 0.76
VE-Cadherin Disassembly and Cell Contractility in the Endothelium are Necessary for Barrier Disruption Induced by Tumor Cells. Sci Rep (2017) 0.75
Pregnancy-associated adaptations in [Ca2+]i-dependent and Ca2+ sensitization mechanisms of venous contraction: implications in pregnancy-related venous disorders. Am J Physiol Heart Circ Physiol (2016) 0.75
Epigenetic repression of ribosomal RNA transcription by ROCK-dependent aberrant cytoskeletal organization. Sci Rep (2016) 0.75
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature (1997) 14.91
Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J Cell Biol (2001) 9.73
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science (1999) 7.12
Cooperation between mDia1 and ROCK in Rho-induced actin reorganization. Nat Cell Biol (1999) 5.84
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J (1997) 5.03
Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol (2000) 4.80
An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nat Med (1999) 3.76
Role of citron kinase as a target of the small GTPase Rho in cytokinesis. Nature (1998) 3.55
ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett (1996) 3.46
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho. Science (1996) 2.99
Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. J Biol Chem (2000) 2.99
Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain. J Biol Chem (1996) 2.92
Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells. J Cell Biol (1998) 2.81
A novel partner for the GTP-bound forms of rho and rac. FEBS Lett (1995) 2.52
Structural and mechanistic insights into the interaction between Rho and mammalian Dia. Nature (2005) 2.52
Transformation mediated by RhoA requires activity of ROCK kinases. Curr Biol (1999) 2.39
Rho effectors and reorganization of actin cytoskeleton. FEBS Lett (1997) 2.19
Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics. Clin Pharmacol Ther (1992) 2.18
Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow. Oncogene (2000) 2.08
Walking speed as a good predictor for the onset of functional dependence in a Japanese rural community population. Age Ageing (2000) 1.99
Studies of prevalence of Japanese cedar pollinosis among the residents in a densely cultivated area. Ann Allergy (1987) 1.92
Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations. Pharmacogenetics (1997) 1.92
Nomenclature for human CYP2D6 alleles. Pharmacogenetics (1996) 1.91
Effects of CYP2C19 genotypic differences in the metabolism of omeprazole and rabeprazole on intragastric pH. Aliment Pharmacol Ther (2001) 1.77
A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons. Neuron (2000) 1.76
Substrate for botulinum ADP-ribosyltransferase, Gb, has an amino acid sequence homologous to a putative rho gene product. J Biol Chem (1988) 1.64
Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase. J Biol Chem (1996) 1.55
Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer. Ann Intern Med (1998) 1.51
Rho-dependent transfer of Citron-kinase to the cleavage furrow of dividing cells. J Cell Sci (2001) 1.50
Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese versus mainland Chinese. Clin Pharmacol Ther (1989) 1.48
Effect of genotypic differences in CYP2C19 on cure rates for Helicobacter pylori infection by triple therapy with a proton pump inhibitor, amoxicillin, and clarithromycin. Clin Pharmacol Ther (2001) 1.45
Genetic analysis of CYP2C9 polymorphism in a Japanese population. Pharmacogenetics (1997) 1.45
p160ROCK mediates RhoA activation of Na-H exchange. EMBO J (1998) 1.45
Genotyping of S-mephenytoin 4'-hydroxylation in an extended Japanese population. Clin Pharmacol Ther (1996) 1.44
Allergenic identity between the common floor mite (Dermatophagoides farinae Hughes, 1961) and house dust as a causative antigen in bronchial asthma. J Allergy (1968) 1.43
CYP2C19 genotype status and effect of omeprazole on intragastric pH in humans. Clin Pharmacol Ther (1999) 1.43
First sporadic cases of non-pneumonic legionellosis, Pontiac fever in Japan. Intern Med (1998) 1.40
Acute myeloid leukaemia with t(9;11)(p22;q23) in a patient treated for adult T cell leukaemia. Br J Haematol (1994) 1.40
Human buprenorphine N-dealkylation is catalyzed by cytochrome P450 3A4. Drug Metab Dispos (1998) 1.35
Pharmacogenomics-based tailored versus standard therapeutic regimen for eradication of H. pylori. Clin Pharmacol Ther (2007) 1.35
Localization of a mammalian homolog of diaphanous, mDia1, to the mitotic spindle in HeLa cells. J Cell Sci (2001) 1.33
Dose-dependent pharmacokinetics of benzoic acid following oral administration of sodium benzoate to humans. Eur J Clin Pharmacol (1991) 1.32
Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance. Pharmacogenetics (2000) 1.30
An operon containing the genes for cholesterol oxidase and a cytochrome P-450-like protein from a Streptomyces sp. J Bacteriol (1990) 1.26
31P-nuclear magnetic resonance evidence of abnormal skeletal muscle metabolism in patients with chronic lung disease and congestive heart failure. Eur Respir J (1992) 1.26
The disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria. Br J Clin Pharmacol (2005) 1.25
Growth ability of human immunodeficiency virus type 1 auxiliary gene mutants in primary blood macrophage cultures. J Gen Virol (1994) 1.22
Effects of genotypic differences in CYP2C19 status on cure rates for Helicobacter pylori infection by dual therapy with rabeprazole plus amoxicillin. Pharmacogenetics (2001) 1.21
Double-blind studies of tolerance to praziquantel in Japanese patients with Schistosoma japonicum infections. Bull World Health Organ (1979) 1.21
Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules. J Biol Chem (1998) 1.21
Pharmacokinetics of ketoprofen following single oral, intramuscular and rectal doses and after repeated oral administration. Eur J Clin Pharmacol (1980) 1.21
Effects of clarithromycin on the metabolism of omeprazole in relation to CYP2C19 genotype status in humans. Clin Pharmacol Ther (1999) 1.20
Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. J Cell Sci (2000) 1.19
Pharmacokinetics of haloperidol: an update. Clin Pharmacokinet (1999) 1.19
Dissolution of cholesterol gallstones by ursodeoxycholic acid. Lancet (1977) 1.17
Cross-antigenicity among six species of dust mites and house dust antigens. J Allergy (1969) 1.16
Oxidative metabolism of omeprazole in human liver microsomes: cosegregation with S-mephenytoin 4'-hydroxylation. J Pharmacol Exp Ther (1993) 1.16
Changes in amounts of cytochrome P450 isozymes and levels of catalytic activities in hepatic and renal microsomes of rats with streptozocin-induced diabetes. Biochem Pharmacol (1993) 1.15
Inhibition of Rho is required for cAMP-induced melanoma cell differentiation. Mol Biol Cell (1998) 1.15
Cloning and expression of a Streptomyces cholesterol oxidase gene in Streptomyces lividans with plasmid pIJ702. Appl Environ Microbiol (1986) 1.14
Simultaneous determination of omeprazole and its metabolites in plasma and urine by reversed-phase high-performance liquid chromatography with an alkaline-resistant polymer-coated C18 column. J Chromatogr (1992) 1.13
Citron, a Rho target that affects contractility during cytokinesis. Microsc Res Tech (2000) 1.13
Comparison of the kinetic disposition and metabolism of E3810, a new proton pump inhibitor, and omeprazole in relation to S-mephenytoin 4'-hydroxylation status. Clin Pharmacol Ther (1995) 1.12
Disposition kinetics and metabolism of omeprazole in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation recruited from an Oriental population. J Pharmacol Exp Ther (1992) 1.11
Late bone metastasis from an encapsulated follicular carcinoma of the thyroid without capsular and vascular invasion. Pathol Int (1996) 1.11
High and variable frequencies of CYP2C19 mutations: medical consequences of poor drug metabolism in Vanuatu and other Pacific islands. Pharmacogenetics (1999) 1.09
Diffuse follicular variant of papillary carcinoma of the thyroid. Histopathology (1995) 1.09
Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data. Pharmacol Ther (1997) 1.08
Metabolic disposition of lansoprazole in relation to the S-mephenytoin 4'-hydroxylation phenotype status. Clin Pharmacol Ther (1997) 1.07
Integrin-dependent translocation of p160ROCK to cytoskeletal complex in thrombin-stimulated human platelets. Biochem J (1997) 1.04
Pharmacodynamic effects and kinetic disposition of rabeprazole in relation to CYP2C19 genotypes. Aliment Pharmacol Ther (2001) 1.02
A calculation of percutaneous drug absorption--I. Theoretical. Comput Biol Med (1986) 1.02
Bronchial hyperresponsiveness in patients with chronic congestive heart failure. Chest (1990) 1.00
Evidence for polymorphic oxidation of sparteine in Japanese subjects. Br J Clin Pharmacol (1987) 0.99
Identification of cytochrome P450 isoforms involved in citalopram N-demethylation by human liver microsomes. J Pharmacol Exp Ther (1997) 0.98
Involvement of human liver cytochrome P4502B6 in the metabolism of propofol. Br J Clin Pharmacol (2001) 0.98
Proguanil disposition and toxicity in malaria patients from Vanuatu with high frequencies of CYP2C19 mutations. Pharmacogenetics (1999) 0.97
Pharmacokinetics of piroxicam, a new nonsteroidal anti-inflammatory agent, under fasting and postprandial states in man. J Pharmacokinet Biopharm (1979) 0.97
A new CYP2D6 allele with a nine base insertion in exon 9 in a Japanese population associated with poor metabolizer phenotype. Pharmacogenetics (1996) 0.97
Effect of high-dose lansoprazole on intragastic pH in subjects who are homozygous extensive metabolizers of cytochrome P4502C19. Clin Pharmacol Ther (2001) 0.96
Activation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-Crk adaptor protein. Mol Cell Biol (1998) 0.96
A kinetic and dynamic study of oral alprazolam with and without erythromycin in humans: in vivo evidence for the involvement of CYP3A4 in alprazolam metabolism. Clin Pharmacol Ther (1996) 0.96
[Association of physical performance and falls among the community elderly in Japan in a five year follow-up study]. Nihon Ronen Igakkai Zasshi (1999) 0.94
Occupational asthma from western red cedar dust (Thuja plicata) in furniture factory workers. J Occup Med (1973) 0.94
Rhophilin, a small GTPase Rho-binding protein, is abundantly expressed in the mouse testis and localized in the principal piece of the sperm tail. FEBS Lett (1999) 0.94
Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450. J Pharmacol Exp Ther (1996) 0.94
Stereoselective pharmacokinetics of pantoprazole, a proton pump inhibitor, in extensive and poor metabolizers of S-mephenytoin. Clin Pharmacol Ther (2001) 0.94
Metabolic disposition of pantoprazole, a proton pump inhibitor, in relation to S-mephenytoin 4'-hydroxylation phenotype and genotype. Clin Pharmacol Ther (1997) 0.93
Effect of MDR1 C3435T polymorphism on cure rates of Helicobacter pylori infection by triple therapy with lansoprazole, amoxicillin and clarithromycin in relation to CYP 2C19 genotypes and 23S rRNA genotypes of H. pylori. Aliment Pharmacol Ther (2007) 0.93
Marchiafava-Bignami's disease. Report of the first case in an Asian. Acta Neuropathol (1970) 0.93
Antigenic relation between house dust and a dust mite, Dermatophagoides farinae Hughes, 1961, by a fractionation method. J Allergy (1969) 0.93
Increased incidence of osteonecrosis of the jaw after tooth extraction in patients treated with bisphosphonates: a cohort study. Int J Oral Maxillofac Surg (2012) 0.93
A drug-induced turbid peritoneal dialysate in five patients treated with continuous ambulatory peritoneal dialysis. Clin Nephrol (1993) 0.92
Cigarette smoking, N-acetyltransferase 2 acetylation status, and bladder cancer risk: a case-series meta-analysis of a gene-environment interaction. Cancer Epidemiol Biomarkers Prev (2000) 0.92
Poor metabolizer genotype status of CYP2C19 is a risk factor for developing gastric cancer in Japanese patients with Helicobacter pylori infection. Aliment Pharmacol Ther (2005) 0.92
A study on the metabolism of etoposide and possible interactions with antitumor or supporting agents by human liver microsomes. J Pharmacol Exp Ther (1998) 0.91
Comparison of the kinetic disposition of and serum gastrin change by lansoprazole versus rabeprazole during an 8-day dosing scheme in relation to CYP2C19 polymorphism. Eur J Clin Pharmacol (2001) 0.91