Published in J Clin Invest on May 23, 2016
Rdh10 loss-of-function and perturbed retinoid signaling underlies the etiology of choanal atresia. Hum Mol Genet (2017) 0.82
Enzymatic Metabolism of Vitamin A in Developing Vertebrate Embryos. Nutrients (2016) 0.75
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A (2005) 167.46
Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet (1999) 55.63
GenePattern 2.0. Nat Genet (2006) 29.07
AP-1: a double-edged sword in tumorigenesis. Nat Rev Cancer (2003) 8.88
Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity (2006) 7.22
Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell (2007) 6.02
A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell (1994) 4.55
Retinoic acid synthesis and signaling during early organogenesis. Cell (2008) 4.52
Retinoid signaling determines germ cell fate in mice. Science (2006) 4.17
Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis. Genes Dev (1991) 3.79
Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. Mol Cell Biol (1997) 3.77
Retinoic acid in development: towards an integrated view. Nat Rev Genet (2008) 3.24
Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J Exp Med (2004) 2.91
Stromal cell contributions to the homeostasis and functionality of the immune system. Nat Rev Immunol (2009) 2.82
Retinoic acid signalling during development. Development (2012) 2.47
Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity. Nature (2014) 2.26
Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse. Development (2001) 2.25
Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity. Endocrinology (2002) 2.19
RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. Genes Dev (2007) 2.10
The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse. Genes Dev (1997) 2.09
Regulation of retinoic acid distribution is required for proximodistal patterning and outgrowth of the developing mouse limb. Dev Cell (2004) 2.07
Risk of infection and death among post-splenectomy patients. J Infect (2001) 2.06
The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo. Genes Dev (2001) 2.04
The TLX1 oncogene drives aneuploidy in T cell transformation. Nat Med (2010) 1.93
Hox11 controls the genesis of the spleen. Nature (1994) 1.81
Promoter specificity and biological activity of tethered AP-1 dimers. Mol Cell Biol (2002) 1.75
Infections of people with complement deficiencies and patients who have undergone splenectomy. Clin Microbiol Rev (2010) 1.70
Retinoic acid controls the bilateral symmetry of somite formation in the mouse embryo. Science (2005) 1.66
Regional differences in retinoid release from embryonic neural tissue detected by an in vitro reporter assay. Development (1992) 1.65
Nkx2-5(+)islet1(+) mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity. Immunity (2013) 1.62
Ribosomal protein SA haploinsufficiency in humans with isolated congenital asplenia. Science (2013) 1.57
Development of endothelial cell lines from embryonic stem cells: A tool for studying genetically manipulated endothelial cells in vitro. Arterioscler Thromb Vasc Biol (2000) 1.57
HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint. Nature (1997) 1.50
The Hox11 gene is essential for cell survival during spleen development. Development (1995) 1.45
TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression. Cancer Cell (2012) 1.36
Differential expression of the retinoic acid-metabolizing enzymes CYP26A1 and CYP26B1 during murine organogenesis. Mech Dev (2002) 1.31
Mechanisms of retinoic acid signalling and its roles in organ and limb development. Nat Rev Mol Cell Biol (2015) 1.29
SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro. J Biol Chem (2003) 1.28
Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2. Nat Struct Mol Biol (2006) 1.27
A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny. Development (2005) 1.25
Retinoic acid regulates endothelial cell proliferation during vasculogenesis. Development (2003) 1.24
Development and function of the mammalian spleen. Bioessays (2007) 1.23
Sex differences in brain developing in the presence or absence of gonads. Dev Neurobiol (2008) 1.20
JDP2, a repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells. Mol Cell Biol (2002) 1.18
A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium. J Clin Invest (2010) 1.18
Isolated congenital asplenia: a French nationwide retrospective survey of 20 cases. J Pediatr (2010) 1.17
Risk and patterns of bacteraemia after splenectomy: a population-based study. Scand J Infect Dis (2000) 1.14
Long-term risks after splenectomy among 8,149 cancer-free American veterans: a cohort study with up to 27 years follow-up. Haematologica (2013) 1.14
Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid. Am J Hum Genet (2011) 1.12
RDH10 oxidation of Vitamin A is a critical control step in synthesis of retinoic acid during mouse embryogenesis. PLoS One (2012) 1.10
A paradoxical teratogenic mechanism for retinoic acid. Proc Natl Acad Sci U S A (2012) 1.08
Gene expression profiling elucidates a specific role for RARgamma in the retinoic acid-induced differentiation of F9 teratocarcinoma stem cells. Biochem Pharmacol (2007) 1.06
Retinoic acid is required in the mouse embryo for left-right asymmetry determination and heart morphogenesis. Development (1999) 1.05
Tamoxifen-dependent, inducible Hoxb6CreERT recombinase function in lateral plate and limb mesoderm, CNS isthmic organizer, posterior trunk neural crest, hindgut, and tailbud. Dev Dyn (2009) 1.05
Risk for hospital contact with infection in patients with splenectomy: a population-based cohort study. Ann Intern Med (2009) 1.04
Cyp26b1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor-β. PLoS One (2011) 0.99
Development expression of Hox11 and specification of splenic cell fate. Am J Pathol (1995) 0.99
Structural and functional abnormalities in the spleen of an mFtz-F1 gene-disrupted mouse. Blood (1999) 0.98
G1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemia. Oncogene (2005) 0.98
TLX1/HOX11-mediated disruption of primary thymocyte differentiation prior to the CD4+CD8+ double-positive stage. Br J Haematol (2006) 0.96
Suppression of cell-cycle progression by Jun dimerization protein-2 (JDP2) involves downregulation of cyclin-A2. Oncogene (2010) 0.95
Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module. Dev Cell (2012) 0.94
The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH 3T3 cells but represses its expression in mouse spleen development. Mol Cell Biol (1998) 0.94
Removal of maternal retinoic acid by embryonic CYP26 is required for correct Nodal expression during early embryonic patterning. Genes Dev (2009) 0.93
TLX1/HOX11-induced hematopoietic differentiation blockade. Oncogene (2007) 0.91
Antagonistic regulation of Cyp26b1 by transcription factors SOX9/SF1 and FOXL2 during gonadal development in mice. FASEB J (2011) 0.89
Inhibition of all-TRANS-retinoic acid metabolism by R116010 induces antitumour activity. Br J Cancer (2002) 0.88
Role of TLX1 in T-cell acute lymphoblastic leukaemia pathogenesis. Br J Haematol (2009) 0.88
Vitamin A: a multifunctional tool for development. Semin Cell Dev Biol (2011) 0.87
Rargb regulates organ laterality in a zebrafish model of right atrial isomerism. Dev Biol (2012) 0.86
The dynamics of spleen morphogenesis. Dev Biol (2008) 0.86
Retinoic acid affects left-right patterning. Dev Biol (1999) 0.85
Hox11 acts cell autonomously in spleen development and its absence results in altered cell fate of mesenchymal spleen precursors. Dev Biol (2001) 0.85
Transposition of great arteries: new insights into the pathogenesis. Front Pediatr (2013) 0.83
Retinoic acid induces CDK inhibitors and growth arrest specific (Gas) genes in neural crest cells. Dev Growth Differ (2005) 0.82
Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo. Dev Biol (2013) 0.80
Testicular differentiation factor SF-1 is required for human spleen development. J Clin Invest (2014) 0.77
Exposure of cynomolgus monkey embryos to retinoic acid causes thymic defects: effects on peripheral lymphoid organ development. J Med Primatol (2002) 0.76
Transcriptional regulation of the c-jun gene by AP-1 repressor protein JDP2 during the differentiation of F9 cells. Nucleic Acids Res Suppl (2002) 0.76
In situ hybridization of mouse embryo and tissue sections with radiolabeled RNA probes. CSH Protoc (2007) 0.76
Somatic mutations affect key pathways in lung adenocarcinoma. Nature (2008) 30.02
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev (2006) 14.36
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet (2009) 10.21
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J (2003) 9.55
Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med (2002) 8.33
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature (2007) 8.32
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev (2007) 6.77
Telomere dysfunction induces metabolic and mitochondrial compromise. Nature (2011) 6.36
Pancreatic cancers require autophagy for tumor growth. Genes Dev (2011) 6.17
Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat Rev Cancer (2007) 5.57
A model for transmission of the H3K27me3 epigenetic mark. Nat Cell Biol (2008) 5.55
The effect of telithromycin in acute exacerbations of asthma. N Engl J Med (2006) 5.35
A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. Am J Hum Genet (2003) 5.34
Sponge-associated microorganisms: evolution, ecology, and biotechnological potential. Microbiol Mol Biol Rev (2007) 5.24
High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients. Cancer Cell (2006) 5.01
p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature (2008) 5.00
Amoxicillin for acute lower-respiratory-tract infection in primary care when pneumonia is not suspected: a 12-country, randomised, placebo-controlled trial. Lancet Infect Dis (2012) 4.62
Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study. Am J Respir Crit Care Med (2004) 4.58
RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3. Cell (2007) 4.34
Molecular evidence for a uniform microbial community in sponges from different oceans. Appl Environ Microbiol (2002) 4.24
Deciphering the evolution and metabolism of an anammox bacterium from a community genome. Nature (2006) 4.06
probeBase--an online resource for rRNA-targeted oligonucleotide probes: new features 2007. Nucleic Acids Res (2006) 3.98
Microbial diversity and the genetic nature of microbial species. Nat Rev Microbiol (2008) 3.89
The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis. Cancer Cell (2007) 3.76
A moderately thermophilic ammonia-oxidizing crenarchaeote from a hot spring. Proc Natl Acad Sci U S A (2008) 3.76
Complex Loci in human and mouse genomes. PLoS Genet (2006) 3.74
The microbial community composition of a nitrifying-denitrifying activated sludge from an industrial sewage treatment plant analyzed by the full-cycle rRNA approach. Syst Appl Microbiol (2002) 3.65
Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function. Nat Med (2008) 3.53
Karyotypic complexity of the NCI-60 drug-screening panel. Cancer Res (2003) 3.42
Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint. EMBO J (2002) 3.42
Illuminating the evolutionary history of chlamydiae. Science (2004) 3.39
Oligonucleotide microarray for 16S rRNA gene-based detection of all recognized lineages of sulfate-reducing prokaryotes in the environment. Appl Environ Microbiol (2002) 3.26
Nitrososphaera viennensis, an ammonia oxidizing archaeon from soil. Proc Natl Acad Sci U S A (2011) 3.25
probeBase: an online resource for rRNA-targeted oligonucleotide probes. Nucleic Acids Res (2003) 3.23
Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. Cancer Cell (2007) 3.16
Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans. J Neurosci (2010) 3.12
Selection of genetic markers for association analyses, using linkage disequilibrium and haplotypes. Am J Hum Genet (2003) 2.94
daime, a novel image analysis program for microbial ecology and biofilm research. Environ Microbiol (2006) 2.88
Distinct gene set in two different lineages of ammonia-oxidizing archaea supports the phylum Thaumarchaeota. Trends Microbiol (2010) 2.84
Distinctive neurocognitive effects of repetitive transcranial magnetic stimulation and electroconvulsive therapy in major depression. Br J Psychiatry (2005) 2.84
NSD1 is essential for early post-implantation development and has a catalytically active SET domain. EMBO J (2003) 2.72
p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J Biol Chem (2003) 2.69
Predicting Mycobacterium tuberculosis in patients with community-acquired pneumonia. Eur Respir J (2013) 2.69
Deep sequencing reveals exceptional diversity and modes of transmission for bacterial sponge symbionts. Environ Microbiol (2009) 2.68
Oligonucleotide microarray for identification of Enterococcus species. FEMS Microbiol Lett (2005) 2.67
Heated Humidified High-Flow Nasal Oxygen in Adults: Mechanisms of Action and Clinical Implications. Chest (2015) 2.66
Polycomb complexes act redundantly to repress genomic repeats and genes. Genes Dev (2010) 2.63
Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore. Curr Biol (2011) 2.62
Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity. Mol Cell Biol (2004) 2.61
Amoebae as training grounds for intracellular bacterial pathogens. Appl Environ Microbiol (2005) 2.59
Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor. Mol Cell Biol (2008) 2.57
Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel. Mol Cancer Ther (2006) 2.55
Barcoded primers used in multiplex amplicon pyrosequencing bias amplification. Appl Environ Microbiol (2011) 2.52
Tcof1/Treacle is required for neural crest cell formation and proliferation deficiencies that cause craniofacial abnormalities. Proc Natl Acad Sci U S A (2006) 2.39
In vitro FRAP identifies the minimal requirements for Mad2 kinetochore dynamics. Curr Biol (2006) 2.37
Thrombocytopenia and thrombocytosis at time of hospitalization predict mortality in patients with community-acquired pneumonia. Chest (2009) 2.34
A standardized boundary element method volume conductor model. Clin Neurophysiol (2002) 2.30
Anxiety and depression in COPD patients: The roles of gender and disease severity. Respir Med (2006) 2.28
Relations and interactions between cranial mesoderm and neural crest populations. J Anat (2005) 2.26
Noncoding RNA synthesis and loss of Polycomb group repression accompanies the colinear activation of the human HOXA cluster. RNA (2006) 2.26
A Nitrospira metagenome illuminates the physiology and evolution of globally important nitrite-oxidizing bacteria. Proc Natl Acad Sci U S A (2010) 2.25
New insights into metabolic properties of marine bacteria encoding proteorhodopsins. PLoS Biol (2005) 2.23
The urokinase plasminogen activator system in cancer: recent advances and implication for prognosis and therapy. Cancer Metastasis Rev (2003) 2.22
Old ideas to innovate tuberculosis control: preventive treatment to achieve elimination. Eur Respir J (2013) 2.20
Impact of age and comorbidity on cause and outcome in community-acquired pneumonia. Chest (2013) 2.19
The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Dev Biol (2011) 2.16
The Thaumarchaeota: an emerging view of their phylogeny and ecophysiology. Curr Opin Microbiol (2011) 2.14
Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice. Dev Biol (2005) 2.13
Discovery of the novel candidate phylum "Poribacteria" in marine sponges. Appl Environ Microbiol (2004) 2.13
RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. Genes Dev (2007) 2.10
Progressive cognitive dysfunction in spinocerebellar ataxia type 3. Mov Disord (2013) 2.09
Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus. PLoS Genet (2008) 2.08
A worldwide perspective of atypical pathogens in community-acquired pneumonia. Am J Respir Crit Care Med (2007) 2.08
Prediction of dementia by subjective memory impairment: effects of severity and temporal association with cognitive impairment. Arch Gen Psychiatry (2010) 2.04
The European Respiratory Society plans its future: the 2013-2018 strategic plan. Eur Respir J (2014) 2.02
amoA-based consensus phylogeny of ammonia-oxidizing archaea and deep sequencing of amoA genes from soils of four different geographic regions. Environ Microbiol (2011) 2.02
Who eats what, where and when? Isotope-labelling experiments are coming of age. ISME J (2007) 1.99
Zero-valent sulphur is a key intermediate in marine methane oxidation. Nature (2012) 1.97
Stratifying risk factors for multidrug-resistant pathogens in hospitalized patients coming from the community with pneumonia. Clin Infect Dis (2011) 1.97
Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment. Neurology (2012) 1.94
Risk factors for community-acquired pneumonia in adults in Europe: a literature review. Thorax (2013) 1.92
Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart. Dev Biol (2003) 1.89
Reduction in the incidence of influenza A but not influenza B associated with use of hand sanitizer and cough hygiene in schools: a randomized controlled trial. Pediatr Infect Dis J (2011) 1.87
probeCheck--a central resource for evaluating oligonucleotide probe coverage and specificity. Environ Microbiol (2008) 1.85
Involvement of the urokinase-type plasminogen activator receptor in hematopoietic stem cell mobilization. Blood (2004) 1.83
Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells. Mol Cell (2013) 1.78
Performance of immunoglobulin G (IgG) and IgM enzyme-linked immunosorbent assays using a West Nile virus recombinant antigen (preM/E) for detection of West Nile virus- and other flavivirus-specific antibodies. J Clin Microbiol (2004) 1.76
16S rRNA and amoA-based phylogeny of 12 novel betaproteobacterial ammonia-oxidizing isolates: extension of the dataset and proposal of a new lineage within the nitrosomonads. Int J Syst Evol Microbiol (2003) 1.72
Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation. Nat Immunol (2009) 1.71
Neural crest stem and progenitor cells. Annu Rev Cell Dev Biol (2006) 1.71
uPA and uPAR in fibrinolysis, immunity and pathology. Trends Immunol (2004) 1.71
Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction. Development (2007) 1.70
Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet (2013) 1.68
Thaumarchaeotes abundant in refinery nitrifying sludges express amoA but are not obligate autotrophic ammonia oxidizers. Proc Natl Acad Sci U S A (2011) 1.68
Retinoic acid controls the bilateral symmetry of somite formation in the mouse embryo. Science (2005) 1.66
Cohn's Crenothrix is a filamentous methane oxidizer with an unusual methane monooxygenase. Proc Natl Acad Sci U S A (2006) 1.65
Antagonism between retinoic acid and fibroblast growth factor signaling during limb development. Cell Rep (2013) 1.65