Published in Acta Pharmacol Sin on May 30, 2016
Bufalin Inhibits Proliferation and Induces Apoptosis in Osteosarcoma Cells by Downregulating MicroRNA-221. Evid Based Complement Alternat Med (2016) 0.75
Structure and functions of the 20S and 26S proteasomes. Annu Rev Biochem (1996) 10.70
Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res (1999) 5.35
The emerging complexity of protein ubiquitination. Biochem Soc Trans (2009) 3.85
Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity. Nature (2011) 3.37
Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1. Cancer Res (2014) 2.54
Assembly, structure, and function of the 26S proteasome. Trends Cell Biol (2010) 1.61
Regulated protein turnover: snapshots of the proteasome in action. Nat Rev Mol Cell Biol (2014) 1.57
Structure of the 26S proteasome with ATP-γS bound provides insights into the mechanism of nucleotide-dependent substrate translocation. Proc Natl Acad Sci U S A (2013) 1.50
Regulation of the 26S proteasome complex during oxidative stress. Sci Signal (2010) 1.48
Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer. Cancer (2009) 1.42
In vivo assembly of the proteasomal complexes, implications for antigen processing. J Biol Chem (1995) 1.42
Regulation of proteolysis by human deubiquitinating enzymes. Biochim Biophys Acta (2013) 1.42
Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans Cantor. Int Immunopharmacol (2010) 1.38
Kinetic characterization of the chymotryptic activity of the 20S proteasome. Biochemistry (1996) 1.36
Na,K-ATPase activity regulates AMPA receptor turnover through proteasome-mediated proteolysis. J Neurosci (2009) 1.30
Dissecting beta-ring assembly pathway of the mammalian 20S proteasome. EMBO J (2008) 1.28
Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network. Mol Cell Proteomics (2007) 1.05
Anti-tumor activity and apoptosis-regulation mechanisms of bufalin in various cancers: new hope for cancer patients. Asian Pac J Cancer Prev (2012) 1.04
Structure, assembly and homeostatic regulation of the 26S proteasome. J Mol Cell Biol (2010) 1.00
Kinetic studies of the branched chain amino acid preferring peptidase activity of the 20S proteasome: development of a continuous assay and inhibition by tripeptide aldehydes and clasto-lactacystin beta-lactone. Biochemistry (1998) 0.95
Structure characterization of the 26S proteasome. Biochim Biophys Acta (2010) 0.95
ER stress-mediated apoptosis induced by celastrol in cancer cells and important role of glycogen synthase kinase-3β in the signal network. Cell Death Dis (2013) 0.91
Bufalin Induces Reactive Oxygen Species Dependent Bax Translocation and Apoptosis in ASTC-a-1 Cells. Evid Based Complement Alternat Med (2011) 0.90
Proteomic profile of KSR1-regulated signalling in response to genotoxic agents in breast cancer. Breast Cancer Res Treat (2015) 0.90
Na+/K+ ATPase inhibitors in cancer. Curr Drug Targets (2014) 0.90
Assembly of the 20S proteasome. Biochim Biophys Acta (2013) 0.88
Bufalin induces cell cycle arrest and apoptosis in gallbladder carcinoma cells. Tumour Biol (2014) 0.88
Microarray and biochemical analysis of bufalin-induced apoptosis of HL-60 Cells. Biotechnol Lett (2008) 0.86
Evaluating the cancer therapeutic potential of cardiac glycosides. Biomed Res Int (2014) 0.85
Pre-clinical evaluation of cinobufotalin as a potential anti-lung cancer agent. Biochem Biophys Res Commun (2014) 0.82
Comparative proteomics analysis reveals role of heat shock protein 60 in digoxin-induced toxicity in human endothelial cells. Biochim Biophys Acta (2008) 0.82
Bufalin alters gene expressions associated DNA damage, cell cycle, and apoptosis in human lung cancer NCI-H460 cells in vitro. Molecules (2014) 0.81
Bufalin inhibits TGF-β-induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF-β receptors. Int J Mol Med (2015) 0.80
Bufalin induces cell death in human lung cancer cells through disruption of DNA damage response pathways. Am J Chin Med (2014) 0.80
Regulation of PSMB5 protein and β subunits of mammalian proteasome by constitutively activated signal transducer and activator of transcription 3 (STAT3): potential role in bortezomib-mediated anticancer therapy. J Biol Chem (2014) 0.79
Using siRNA techniques to dissect proteasome assembly pathways in mammalian cells. Methods Mol Biol (2012) 0.79
Synthesis and biological evaluation of bufalin-3-yl nitrogen-containing-carbamate derivatives as anticancer agents. Steroids (2016) 0.79
Chansu inhibits the expression of cortactin in colon cancer cell lines in vitro and in vivo. BMC Complement Altern Med (2015) 0.77
The Stability of Ribosome Biogenesis Factor WBSCR22 Is Regulated by Interaction with TRMT112 via Ubiquitin-Proteasome Pathway. PLoS One (2015) 0.77
The effects of bufadienolides on HER2 overexpressing breast cancer cells. Tumour Biol (2015) 0.76
Salvianolic acid B functioned as a competitive inhibitor of matrix metalloproteinase-9 and efficiently prevented cardiac remodeling. BMC Pharmacol (2010) 0.97
Salvianolic acid A, a matrix metalloproteinase-9 inhibitor of Salvia miltiorrhiza, attenuates aortic aneurysm formation in apolipoprotein E-deficient mice. Phytomedicine (2014) 0.87
Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation. Nat Commun (2016) 0.81
Salvianolic acid A inhibits endothelial dysfunction and vascular remodeling in spontaneously hypertensive rats. Life Sci (2015) 0.81
Proteomic and bioinformatic analyses of possible target-related proteins of gambogic acid in human breast carcinoma MDA-MB-231 cells. Chin J Nat Med (2015) 0.76
Agglutinin isolated from Arisema heterophyllum Blume induces apoptosis and autophagy in A549 cells through inhibiting PI3K/Akt pathway and inducing ER stress. Chin J Nat Med (2016) 0.76
Protective Effects of Scutellarin on Human Cardiac Microvascular Endothelial Cells against Hypoxia-Reoxygenation Injury and Its Possible Target-Related Proteins. Evid Based Complement Alternat Med (2015) 0.75