C/EBP homologous protein modulates liraglutide-mediated attenuation of non-alcoholic steatohepatitis.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27239734)

Published in Lab Invest on May 30, 2016

Authors

Khalidur Rahman1,2, Yunshan Liu2, Pradeep Kumar1, Tekla Smith1,2, Natalie E Thorn1, Alton B Farris3, Frank A Anania1,2

Author Affiliations

1: Division of Digestive Diseases, Emory University, Atlanta, GA.
2: Atlanta VA Medical Center, Decatur, GA.
3: Department of Pathology, Emory University Hospital, Atlanta, GA.

Articles cited by this

NIH Image to ImageJ: 25 years of image analysis. Nat Methods (2012) 84.41

Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology (2005) 29.57

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science (2004) 19.08

The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology (2005) 15.74

The unfolded protein response: from stress pathway to homeostatic regulation. Science (2011) 15.71

Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ (2004) 9.96

Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest (2005) 8.45

Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep (2006) 8.16

Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology (2010) 8.05

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest (2002) 6.48

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest (2008) 4.30

UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell (2008) 4.26

Endoplasmic reticulum stress in liver disease. J Hepatol (2010) 3.90

Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. Cell Metab (2009) 3.51

Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings. Hepatology (2011) 3.46

Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab (2008) 3.45

Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response. Biochem J (2002) 3.36

Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites. Hepatology (2010) 3.11

Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin Liver Dis (2008) 2.89

Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology (2005) 2.47

Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent. Am J Physiol Gastrointest Liver Physiol (2008) 2.45

Minireview: the glucagon-like peptides. Endocrinology (2001) 2.15

CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. J Neurochem (2005) 2.08

Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and apoptosis in cholesterol-loaded macrophages. J Biol Chem (2004) 2.06

Endoplasmic reticulum stress, obesity and diabetes. Trends Mol Med (2011) 1.95

Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway. Hepatology (2010) 1.86

Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition. Am J Physiol Gastrointest Liver Physiol (2011) 1.85

From NAFLD to NASH to cirrhosis-new insights into disease mechanisms. Nat Rev Gastroenterol Hepatol (2013) 1.75

The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques. Arterioscler Thromb Vasc Biol (2010) 1.56

Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis. J Hepatol (2015) 1.50

Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding. Alcohol Clin Exp Res (2005) 1.49

Mechanisms of lipotoxicity in NAFLD and clinical implications. J Pediatr Gastroenterol Nutr (2011) 1.35

Positive role of CCAAT/enhancer-binding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis. Am J Pathol (2009) 1.32

GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy. PLoS One (2011) 1.26

The glucagon-like peptide-1 receptor regulates endogenous glucose production and muscle glucose uptake independent of its incretin action. Endocrinology (2008) 1.26

Glp-1 analog, liraglutide, ameliorates hepatic steatosis and cardiac hypertrophy in C57BL/6J mice fed a Western diet. Am J Physiol Gastrointest Liver Physiol (2011) 1.19

Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor. Hepatology (2013) 1.13

Stress signaling in the methionine-choline-deficient model of murine fatty liver disease. Gastroenterology (2010) 1.13

New insights into the roles of CHOP-induced apoptosis in ER stress. Acta Biochim Biophys Sin (Shanghai) (2014) 1.05

Management of nonalcoholic steatohepatitis: an evidence-based approach. Clin Liver Dis (2012) 1.05

C/EBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitis. J Biol Chem (2013) 1.05

Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets. J Hepatol (2011) 1.04

C/EBP homologous protein (CHOP) contributes to suppression of metabolic genes during endoplasmic reticulum stress in the liver. J Biol Chem (2012) 1.04

A rapid two-step method for isolation of functional primary mouse hepatocytes: cell characterization and asialoglycoprotein receptor based assay development. Cytotechnology (2011) 0.99

ER stress and hepatic lipid metabolism. Front Genet (2014) 0.92

Saturated fat and cholesterol are critical to inducing murine metabolic syndrome with robust nonalcoholic steatohepatitis. J Nutr Biochem (2014) 0.88

Adiponectin agonist ADP355 attenuates CCl4-induced liver fibrosis in mice. PLoS One (2014) 0.83

Potential roles of glucagon-like peptide-1-based therapies in treating non-alcoholic fatty liver disease. World J Gastroenterol (2014) 0.79

Glucagon-like peptide-1 preserves non-alcoholic fatty liver disease through inhibition of the endoplasmic reticulum stress-associated pathway. Hepatol Res (2015) 0.78

Protective effect of liraglutide against ER stress in the liver of high-fat diet-induced insulin-resistant rats. Endocrine (2014) 0.77