Surgical and molecular pathology of pancreatic neoplasms.

PubWeight™: 0.77‹?›

🔗 View Article (PMID 27267993)

Published in Diagn Pathol on June 07, 2016

Authors

Wenzel M Hackeng1, Ralph H Hruban2, G Johan A Offerhaus1, Lodewijk A A Brosens3

Author Affiliations

1: Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
2: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
3: Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. l.a.a.brosens@umcutrecht.nl.

Articles cited by this

(truncated to the top 100)

Cancer statistics, 2015. CA Cancer J Clin (2015) 57.51

A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A (2006) 40.09

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (2008) 36.02

Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature (2010) 17.38

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N Engl J Med (2015) 13.08

Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med (2011) 11.93

Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med (2011) 11.55

DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science (2011) 10.26

Pancreatic cancer. Lancet (2011) 8.54

Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med (2014) 8.36

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature (2012) 8.31

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science (2009) 7.39

Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res (2014) 7.15

MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior. J Clin Oncol (2006) 5.40

Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell (2014) 5.38

Altered telomeres in tumors with ATRX and DAXX mutations. Science (2011) 4.60

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nat Med (2011) 4.10

Whole genomes redefine the mutational landscape of pancreatic cancer. Nature (2015) 4.01

Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clin Cancer Res (2006) 3.81

Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21. Cancer Cell (2010) 3.72

ATM mutations in patients with hereditary pancreatic cancer. Cancer Discov (2011) 3.27

Adoptive cell transfer as personalized immunotherapy for human cancer. Science (2015) 3.19

International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer. Gut (2012) 3.09

A compendium of potential biomarkers of pancreatic cancer. PLoS Med (2009) 3.00

Pancreatic neuroendocrine tumors (PNETs): incidence, prognosis and recent trend toward improved survival. Ann Oncol (2008) 2.97

Beckwith-Wiedemann syndrome. Eur J Hum Genet (2010) 2.85

miR-21 as a key regulator of oncogenic processes. Biochem Soc Trans (2009) 2.78

Beckwith-Wiedemann syndrome: imprinting in clusters revisited. J Clin Invest (2000) 2.77

Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4. Virchows Arch (2001) 2.73

Acinar cell carcinoma of the pancreas. A clinicopathologic study of 28 cases. Am J Surg Pathol (1992) 2.52

Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays. Cancer Res (2003) 2.49

SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res (2009) 2.44

Hypermethylation of multiple genes in pancreatic adenocarcinoma. Cancer Res (2000) 2.40

Genome-wide profiling of methylated promoters in pancreatic adenocarcinoma. Cancer Biol Ther (2008) 2.38

Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations. Am J Pathol (2002) 2.35

Risk of pancreatic cancer in families with Lynch syndrome. JAMA (2009) 2.32

DNA methylation alterations in the pancreatic juice of patients with suspected pancreatic disease. Cancer Res (2006) 2.29

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma. Nat Genet (2015) 2.27

Frequent beta-catenin mutation and cytoplasmic/nuclear accumulation in pancreatic solid-pseudopapillary neoplasm. Cancer Res (2001) 2.22

MicroRNA miR-155 is a biomarker of early pancreatic neoplasia. Cancer Biol Ther (2009) 2.01

Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway. Am J Pathol (2002) 1.96

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets. Nat Commun (2015) 1.94

Candidate microRNA biomarkers of pancreatic ductal adenocarcinoma: meta-analysis, experimental validation and clinical significance. J Exp Clin Cancer Res (2013) 1.82

Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer. Mol Cancer (2015) 1.75

Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors. Am J Surg Pathol (2012) 1.71

672 patients with acinar cell carcinoma of the pancreas: a population-based comparison to pancreatic adenocarcinoma. Surgery (2008) 1.67

TNM staging of neoplasms of the endocrine pancreas: results from a large international cohort study. J Natl Cancer Inst (2012) 1.65

E-cadherin/catenin complex status in solid pseudopapillary tumor of the pancreas. Am J Surg Pathol (2008) 1.60

Time to progression of pancreatic ductal adenocarcinoma from low-to-high tumour stages. Gut (2015) 1.59

Paranuclear dot-like immunostaining for CD99: a unique staining pattern for diagnosing solid-pseudopapillary neoplasm of the pancreas. Am J Surg Pathol (2011) 1.58

Mutant proteins as cancer-specific biomarkers. Proc Natl Acad Sci U S A (2011) 1.56

Multiple endocrine neoplasia type 1 (MEN1): loss of one MEN1 allele in tumors and monohormonal endocrine cell clusters but not in islet hyperplasia of the pancreas. J Clin Endocrinol Metab (2006) 1.55

Solid-pseudopapillary tumor of the pancreas: immunohistochemical localization of neuroendocrine markers and CD10. Am J Surg Pathol (2000) 1.53

Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma. Am J Pathol (2002) 1.53

Genome-wide analysis of promoter methylation associated with gene expression profile in pancreatic adenocarcinoma. Clin Cancer Res (2011) 1.52

Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas : frequent alterations in the APC/beta-catenin pathway and chromosome 11p. Am J Pathol (2001) 1.46

Molecular signatures of pancreatic cancer. Arch Pathol Lab Med (2011) 1.46

Frequent loss of heterozygosity at chromosome 3p14.2-3p21 in human pancreatic islet cell tumours. Clin Endocrinol (Oxf) (1999) 1.45

Consistent chromosome abnormalities in adenocarcinoma of the pancreas. Cancer Res (1995) 1.45

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. Nat Genet (2014) 1.41

Loss of DAXX and ATRX are associated with chromosome instability and reduced survival of patients with pancreatic neuroendocrine tumors. Gastroenterology (2013) 1.39

A Combination of Molecular Markers and Clinical Features Improve the Classification of Pancreatic Cysts. Gastroenterology (2015) 1.39

A systematic review of solid-pseudopapillary neoplasms: are these rare lesions? Pancreas (2014) 1.35

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer. Nat Genet (2015) 1.34

Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients. Nat Commun (2015) 1.33

Characterizing DNA methylation patterns in pancreatic cancer genome. Mol Oncol (2009) 1.29

Papillary cystic tumor of the pancreas. An analysis of cellular differentiation by electron microscopy and immunohistochemistry. Am J Surg Pathol (1987) 1.27

The high-grade (WHO G3) pancreatic neuroendocrine tumor category is morphologically and biologically heterogenous and includes both well differentiated and poorly differentiated neoplasms. Am J Surg Pathol (2015) 1.25

Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling. Int J Cancer (2014) 1.24

Mucin expression profile in pancreatic cancer and the precursor lesions. J Hepatobiliary Pancreat Surg (2007) 1.23

Whole-exome sequencing of pancreatic neoplasms with acinar differentiation. J Pathol (2014) 1.22

Acinar cell carcinoma of the pancreas: new genetic and treatment insights into a rare malignancy. Oncologist (2011) 1.20

Global expression analysis of well-differentiated pancreatic endocrine neoplasms using oligonucleotide microarrays. Clin Cancer Res (2003) 1.18

RASSF1C, an isoform of the tumor suppressor RASSF1A, promotes the accumulation of beta-catenin by interacting with betaTrCP. Cancer Res (2007) 1.16

Alpha-fetoprotein production by pancreatic tumors exhibiting acinar cell differentiation: study of five cases, one arising in a mediastinal teratoma. Hum Pathol (2000) 1.14

Chromosomal alterations detected by comparative genomic hybridization in nonfunctioning endocrine pancreatic tumors. Cancer Genet Cytogenet (2005) 1.14

Allelotype of pancreatic acinar cell carcinoma. Int J Cancer (2000) 1.11

Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium. Cancer Epidemiol Biomarkers Prev (2010) 1.11

Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to foregut neoplasms. Am J Pathol (1999) 1.09

A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas. Am J Surg Pathol (2015) 1.09

Diagnosis, treatment and outcome of pancreatoblastoma. Pancreatology (2004) 1.07

Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors. Mod Pathol (2012) 1.06

Fluorescence in situ hybridization to visualize genetic abnormalities in interphase cells of acinar cell carcinoma, ductal adenocarcinoma, and islet cell carcinoma of the pancreas. Mayo Clin Proc (2009) 1.04

Expression of MUC apomucins in normal pancreas and pancreatic tumours. J Pathol (1996) 1.04

Aberrant hypermethylation of tumor suppressor genes in pancreatic endocrine neoplasms. Ann Surg (2003) 1.01

Stromal reengineering to treat pancreas cancer. Carcinogenesis (2014) 1.00

Circulating miR-483-3p and miR-21 is highly expressed in plasma of pancreatic cancer. Int J Oncol (2014) 0.98

BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: a PACGENE study. Genet Med (2014) 0.97

PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors. Proc Natl Acad Sci U S A (2014) 0.97

Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes. Cancer Discov (2014) 0.96

Gene expression profiling provides insights into the pathways involved in solid pseudopapillary neoplasm of the pancreas. J Pathol (2009) 0.96

Multiple allelic deletions and intratumoral genetic heterogeneity in men1 pancreatic tumors. J Clin Endocrinol Metab (2001) 0.95

Methylation-associated down-regulation of RASSF1A and up-regulation of RASSF1C in pancreatic endocrine tumors. BMC Cancer (2011) 0.95

Genetic predisposition to pancreatic cancer. World J Gastroenterol (2014) 0.94

Analysis of LKB1 mutations and other molecular alterations in pancreatic acinar cell carcinoma. Mod Pathol (2011) 0.94

Pancreatic cancer and its stroma: a conspiracy theory. World J Gastroenterol (2014) 0.94

APC alterations are frequently involved in the pathogenesis of acinar cell carcinoma of the pancreas, mainly through gene loss and promoter hypermethylation. Virchows Arch (2014) 0.94

Characterization of gene expression and activated signaling pathways in solid-pseudopapillary neoplasm of pancreas. Mod Pathol (2013) 0.93

Long-term follow-up of patients with familial adenomatous polyposis undergoing pancreaticoduodenal surgery. J Gastrointest Surg (2002) 0.93

Ubiquitous aberrant RASSF1A promoter methylation in childhood neoplasia. Clin Cancer Res (2004) 0.92