Published in PLoS One on June 09, 2016
mTOR signaling in growth control and disease. Cell (2012) 29.21
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science (2008) 14.08
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell (2010) 12.24
Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc Natl Acad Sci U S A (1988) 10.77
Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol (2008) 8.92
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science (2011) 7.55
Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome. Cancer Cell (2002) 5.10
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science (2013) 3.96
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell (2012) 3.77
A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast. Nat Cell Biol (2006) 3.57
Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc Natl Acad Sci U S A (2006) 3.51
Amino acid signalling upstream of mTOR. Nat Rev Mol Cell Biol (2013) 3.36
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science (2015) 2.80
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell (2013) 2.79
Birt-Hogg-Dubé syndrome, a genodermatosis associated with spontaneous pneumothorax and kidney neoplasia, maps to chromosome 17p11.2. Am J Hum Genet (2001) 2.68
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell (2014) 2.68
The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFs. Bioinformatics (2013) 2.31
Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys. J Natl Cancer Inst (2008) 2.25
Metabolism. Differential regulation of mTORC1 by leucine and glutamine. Science (2015) 2.14
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. Nature (2015) 2.01
Where is mTOR and what is it doing there? J Cell Biol (2013) 1.91
Identification and characterization of a lysosomal transporter for small neutral amino acids. Proc Natl Acad Sci U S A (2001) 1.88
Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8. Genetics (1997) 1.74
Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases. J Cell Biol (2013) 1.43
A germ-line insertion in the Birt-Hogg-Dubé (BHD) gene gives rise to the Nihon rat model of inherited renal cancer. Proc Natl Acad Sci U S A (2004) 1.40
Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation. Oncogene (2010) 1.37
The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe. J Biol Chem (2007) 1.34
mTOR signaling in cellular and organismal energetics. Curr Opin Cell Biol (2014) 1.32
Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes. PLoS One (2012) 1.30
Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling. Mol Cancer (2010) 1.30
Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer. Open Biol (2012) 1.29
The Drosophila homolog of the human tumor suppressor gene BHD interacts with the JAK-STAT and Dpp signaling pathways in regulating male germline stem cell maintenance. Oncogene (2006) 1.26
Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2. J Physiol (2003) 1.23
Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription. Oncogene (2011) 1.23
LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis. Science (2012) 1.18
Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN. J Natl Cancer Inst (2012) 1.16
The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport. Br J Pharmacol (2011) 1.13
Birt-Hogg-Dubé syndrome: from gene discovery to molecularly targeted therapies. Fam Cancer (2013) 1.12
The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons. J Neurosci (2003) 1.07
Birt-Hogg-Dube syndrome is a novel ciliopathy. Hum Mol Genet (2013) 1.04
Folliculin regulates ampk-dependent autophagy and metabolic stress survival. PLoS Genet (2014) 1.00
Folliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK. Cell Rep (2014) 0.94
Genetic analysis of TOR signaling in Drosophila. Curr Top Microbiol Immunol (2004) 0.93
FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. Autophagy (2014) 0.87
Genetic characterization of the Drosophila birt-hogg-dubé syndrome gene. PLoS One (2013) 0.87
Birt-Hogg-Dubé: tumour suppressor function and signalling dynamics central to folliculin. Fam Cancer (2013) 0.85
Folliculin regulates cell-cell adhesion, AMPK, and mTORC1 in a cell-type-specific manner in lung-derived cells. Physiol Rep (2014) 0.82
Leucine transport by the larval midgut of the parasitoid Aphidius ervi (Hymenoptera). J Insect Physiol (2009) 0.76