Impact of intracellular ion channels on cancer development and progression.

PubWeight™: 0.78‹?›

🔗 View Article (PMID 27289382)

Published in Eur Biophys J on June 11, 2016

Authors

Roberta Peruzzo1, Lucia Biasutto2,3, Ildikò Szabò1,2, Luigi Leanza4

Author Affiliations

1: Department of Biology, University of Padua, Padua, Italy.
2: CNR Institute of Neuroscience, Padua, Italy.
3: Department of Biomedical Sciences, University of Padua, Padua, Italy.
4: Department of Biology, University of Padua, Padua, Italy. luigi.leanza@unipd.it.

Articles cited by this

(truncated to the top 100)

Hallmarks of cancer: the next generation. Cell (2011) 140.01

The hallmarks of cancer. Cell (2000) 113.05

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature (2000) 64.32

Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci U S A (2001) 24.34

Regulation of cancer cell metabolism. Nat Rev Cancer (2011) 15.44

Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature (2002) 15.36

Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer (2003) 15.17

A mitochondrial protein compendium elucidates complex I disease biology. Cell (2008) 13.51

Reverse engineering of regulatory networks in human B cells. Nat Genet (2005) 13.16

Stromal gene expression predicts clinical outcome in breast cancer. Nat Med (2008) 10.68

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov (2009) 10.32

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature (2011) 9.70

MAP kinase signalling pathways in cancer. Oncogene (2007) 8.52

The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci (2004) 7.92

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature (2011) 7.44

X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell (2006) 7.17

The mitochondrial permeability transition. Biochim Biophys Acta (1995) 7.14

The mitochondrial calcium uniporter is a highly selective ion channel. Nature (2004) 6.97

Transient receptor potential cation channels in disease. Physiol Rev (2007) 6.91

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature (2011) 6.48

Role of calcium ions in regulation of mammalian intramitochondrial metabolism. Physiol Rev (1990) 5.94

Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer. Proc Natl Acad Sci U S A (2001) 5.57

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet (2000) 5.42

Diagnosing and exploiting cancer's addiction to blocks in apoptosis. Nat Rev Cancer (2008) 5.35

Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med (2001) 4.83

Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov (2013) 4.72

FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell (2009) 4.48

Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the International Microarray Innovations in Leukemia Study Group. J Clin Oncol (2010) 4.09

Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase. Biochem J (1972) 4.05

Ca(2+)-activated K+ currents in neurones: types, physiological roles and modulation. Trends Neurosci (1996) 3.94

Gene expression in the urinary bladder: a common carcinoma in situ gene expression signature exists disregarding histopathological classification. Cancer Res (2004) 3.76

Mitochondria and calcium: from cell signalling to cell death. J Physiol (2000) 3.73

Mitochondria as sensors and regulators of calcium signalling. Nat Rev Mol Cell Biol (2012) 3.59

Gene expression profiling of the tumor microenvironment during breast cancer progression. Breast Cancer Res (2009) 3.52

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev (2005) 3.50

The mitochondrial uncoupling-protein homologues. Nat Rev Mol Cell Biol (2005) 3.42

Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays. Am J Pathol (2003) 3.40

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter. Nat Cell Biol (2013) 3.39

Role of calcium ions in the regulation of intramitochondrial metabolism. Effects of Na+, Mg2+ and ruthenium red on the Ca2+-stimulated oxidation of oxoglutarate and on pyruvate dehydrogenase activity in intact rat heart mitochondria. Biochem J (1980) 3.28

The mitochondrial permeability transition from in vitro artifact to disease target. FEBS J (2006) 3.26

The functional network of ion channels in T lymphocytes. Immunol Rev (2009) 3.21

RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature (2007) 3.21

Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics. Neurochem Res (2006) 3.12

The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis. BMC Med Genomics (2008) 3.11

Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis. EMBO J (2005) 3.11

Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network. Cell (2007) 3.00

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci U S A (2004) 3.00

Dimers of mitochondrial ATP synthase form the permeability transition pore. Proc Natl Acad Sci U S A (2013) 2.96

The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex. Biochem J (1979) 2.95

On the role of the calcium transport cycle in heart and other mammalian mitochondria. FEBS Lett (1980) 2.85

Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival. Nat Rev Cancer (2008) 2.85

Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation. Biochem Soc Trans (2003) 2.81

MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival. Cell (2012) 2.75

Oncogenic potential of EAG K(+) channels. EMBO J (1999) 2.74

Gene signatures of progression and metastasis in renal cell cancer. Clin Cancer Res (2005) 2.67

Potassium channels. FEBS Lett (2003) 2.58

Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. Cancer Cell (2013) 2.55

Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues. Biochem J (1978) 2.38

VDAC, a multi-functional mitochondrial protein regulating cell life and death. Mol Aspects Med (2010) 2.36

TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell (2012) 2.35

Calcium in tumour metastasis: new roles for known actors. Nat Rev Cancer (2011) 2.30

Ca(2+)-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons. Biochem J (1992) 2.27

Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membrane. Science (2002) 2.23

Regulation of mitochondrial dehydrogenases by calcium ions. Biochim Biophys Acta (2009) 2.18

Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling. Nat Genet (2013) 2.11

Role of glycogen synthase kinase-3beta in cardioprotection. Circ Res (2009) 2.10

The transient receptor potential family of ion channels. Genome Biol (2011) 2.08

Mitochondrial permeability transition in Ca(2+)-dependent apoptosis and necrosis. Cell Calcium (2011) 2.06

International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev (2003) 2.05

Gene expression analysis of peripheral T cell lymphoma, unspecified, reveals distinct profiles and new potential therapeutic targets. J Clin Invest (2007) 1.97

Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors. Cancer Res (2006) 1.94

Shikonin circumvents cancer drug resistance by induction of a necroptotic death. Mol Cancer Ther (2007) 1.90

Evidence that TRPM8 is an androgen-dependent Ca2+ channel required for the survival of prostate cancer cells. Cancer Res (2004) 1.88

Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels. PLoS One (2008) 1.87

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore. Proc Natl Acad Sci U S A (2014) 1.85

TRP channels in disease. Biochim Biophys Acta (2007) 1.84

The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy. Mol Aspects Med (2010) 1.84

Molecular mechanisms of BK channel activation. Cell Mol Life Sci (2009) 1.81

New markers for minimal residual disease detection in acute lymphoblastic leukemia. Blood (2011) 1.78

The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A. J Biol Chem (1991) 1.78

Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell (2003) 1.76

Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations. J Biol Chem (1992) 1.71

The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells. Cancer Res (2008) 1.71

Targeting ion channels in cancer: a novel frontier in antineoplastic therapy. Curr Med Chem (2009) 1.70

Mitochondrial ion channels. Annu Rev Physiol (2007) 1.70

The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins. J Cell Sci (2009) 1.65

Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding. J Biol Chem (2008) 1.65

Apoptosis regulation by Bcl-x(L) modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating. Proc Natl Acad Sci U S A (2007) 1.64

The voltage-dependent anion channel-1 modulates apoptotic cell death. Cell Death Differ (2005) 1.63

Electrophysiological study of a novel large pore formed by Bax and the voltage-dependent anion channel that is permeable to cytochrome c. J Biol Chem (2000) 1.61

Hierarchical involvement of Bak, VDAC1 and Bax in cisplatin-induced cell death. Oncogene (2008) 1.60

Identification of novel candidate oncogenes and tumor suppressors in malignant pleural mesothelioma using large-scale transcriptional profiling. Am J Pathol (2005) 1.60

Calcium-activated potassium channels and endothelial dysfunction: therapeutic options? Br J Pharmacol (2009) 1.60

Mitochondrial reactive oxygen species and Ca2+ signaling. Am J Physiol Cell Physiol (2006) 1.59

Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death. Mol Cell (2009) 1.58

Downregulated REST transcription factor is a switch enabling critical potassium channel expression and cell proliferation. Mol Cell (2005) 1.58

Therapeutic potential of KCa3.1 blockers: recent advances and promising trends. Expert Rev Clin Pharmacol (2010) 1.56

Mrs2p is an essential component of the major electrophoretic Mg2+ influx system in mitochondria. EMBO J (2003) 1.56

Emerging roles for two-pore-domain potassium channels and their potential therapeutic impact. Trends Pharmacol Sci (2008) 1.56

High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomas. BMC Cancer (2009) 1.55

Articles by these authors

The Roles of Mitochondrial Cation Channels Under Physiological Conditions and in Cancer. Handb Exp Pharmacol (2017) 0.75