Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson's disease.

PubWeight™: 0.87‹?›

🔗 View Article (PMID 27336715)

Published in Cell Death Dis on June 23, 2016

Authors

I Celardo1, A C Costa1, S Lehmann1, C Jones1, N Wood2, N E Mencacci2, G R Mallucci1,3, S H Y Loh1, L M Martins1

Author Affiliations

1: MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK.
2: Department of Molecular Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK.
3: Department of Clinical Neurosciences, University of Cambridge, Clifford Allbutt Building, Cambridge Biomedical Campus, Cambridge CB1 0HN, UK.

Articles cited by this

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science (2006) 13.91

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature (2006) 11.81

Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature (2008) 9.66

The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci U S A (2008) 7.41

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc Natl Acad Sci U S A (2008) 5.43

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proc Natl Acad Sci U S A (2010) 5.17

Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice. Sci Transl Med (2013) 4.62

Sustained translational repression by eIF2α-P mediates prion neurodegeneration. Nature (2012) 3.54

Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease. Proc Natl Acad Sci U S A (2005) 3.40

Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell (2013) 2.43

Endoplasmic reticulum-mitochondria contacts: function of the junction. Nat Rev Mol Cell Biol (2012) 2.40

Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). J Med Chem (2012) 2.21

Nuclear translation visualized by ribosome-bound nascent chain puromycylation. J Cell Biol (2012) 1.93

Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models. Nat Genet (2013) 1.63

Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone. J Neurochem (2007) 1.34

Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease. Nat Cell Biol (2014) 1.15

Targeting the unfolded protein response in neurodegeneration: A new approach to therapy. Neuropharmacology (2013) 1.06

The unfolded protein response in neurodegenerative diseases: a neuropathological perspective. Acta Neuropathol (2015) 1.05

Unravelling mitochondrial pathways to Parkinson's disease. Br J Pharmacol (2014) 1.03

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity. Cell Death Dis (2015) 1.02

PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia. Acta Neuropathol (2015) 0.97

Gene expression profiling identifies a role for CHOP during inhibition of the mitochondrial respiratory chain. J Biochem (2009) 0.95

Reduction of endoplasmic reticulum stress attenuates the defects caused by Drosophila mitofusin depletion. J Cell Biol (2014) 0.90