Published in Proc Natl Acad Sci U S A on March 01, 2010
Mechanisms of mitophagy. Nat Rev Mol Cell Biol (2011) 10.66
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat Cell Biol (2011) 7.40
Selective autophagy mediated by autophagic adapter proteins. Autophagy (2011) 6.88
Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol (2010) 6.58
Mitochondria: in sickness and in health. Cell (2012) 6.05
Autophagy in mammalian development and differentiation. Nat Cell Biol (2010) 5.99
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell (2011) 5.98
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. J Cell Biol (2010) 5.94
Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. Hum Mol Genet (2011) 4.41
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Hum Mol Genet (2010) 3.77
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Nature (2013) 3.57
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol (2012) 3.42
Ubiquitin is phosphorylated by PINK1 to activate parkin. Nature (2014) 3.36
The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway. PLoS One (2010) 3.16
Mitochondria: the next (neurode)generation. Neuron (2011) 3.06
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy. Hum Mol Genet (2010) 3.00
Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane. J Biol Chem (2011) 2.99
Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control. EMBO J (2014) 2.93
p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. Genes Cells (2010) 2.91
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease. Neuron (2015) 2.82
Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration. Nat Rev Neurosci (2012) 2.68
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy. Sci Rep (2012) 2.60
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria. Nat Commun (2012) 2.55
The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ (2012) 2.45
Structure of the human Parkin ligase domain in an autoinhibited state. EMBO J (2013) 2.38
Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences. EMBO J (2012) 2.36
Recent advances in the genetics of Parkinson's disease. Annu Rev Genomics Hum Genet (2011) 2.29
Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1. PLoS One (2011) 2.21
The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo. Proc Natl Acad Sci U S A (2013) 2.10
Mitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism. Cold Spring Harb Perspect Biol (2012) 2.10
The interplay between mitochondrial dynamics and mitophagy. Antioxid Redox Signal (2011) 2.05
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding. J Cell Biol (2013) 2.04
Mitochondrial dynamics in neurodegeneration. Trends Cell Biol (2012) 1.99
PINK1- and Parkin-mediated mitophagy at a glance. J Cell Sci (2012) 1.89
The role of oxidative stress in Parkinson's disease. J Parkinsons Dis (2013) 1.86
Mitochondrial quality control: a matter of life and death for neurons. EMBO J (2012) 1.83
Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control. Antioxid Redox Signal (2011) 1.82
Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease. J Biol Chem (2011) 1.75
Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation. Proc Natl Acad Sci U S A (2014) 1.73
Protein breakdown in muscle wasting: role of autophagy-lysosome and ubiquitin-proteasome. Int J Biochem Cell Biol (2013) 1.73
VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Neuron (2013) 1.70
The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover. Mol Biol Cell (2010) 1.65
Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts. PLoS One (2011) 1.62
Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation. Curr Opin Cell Biol (2011) 1.62
Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature (2015) 1.62
Parkin and PINK1: much more than mitophagy. Trends Neurosci (2014) 1.60
Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster. Cell Death Differ (2012) 1.60
Role of autophagy in glycogen breakdown and its relevance to chloroquine myopathy. PLoS Biol (2013) 1.59
Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism. Cell Res (2013) 1.59
A molecular explanation for the recessive nature of parkin-linked Parkinson's disease. Nat Commun (2013) 1.51
Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation. J Biol Chem (2013) 1.50
Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis. Mol Cell (2012) 1.46
Parkinson's disease and cancer: two wars, one front. Nat Rev Cancer (2011) 1.45
The role of autophagy in Parkinson's disease. Cold Spring Harb Perspect Med (2012) 1.44
The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons. Hum Mol Genet (2011) 1.44
Mitochondrial trafficking and anchoring in neurons: New insight and implications. J Cell Biol (2014) 1.41
The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila. PLoS Genet (2010) 1.41
Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism. Neurobiol Dis (2012) 1.39
Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast. J Biol Chem (2011) 1.38
Self and nonself: how autophagy targets mitochondria and bacteria. Cell Host Microbe (2014) 1.36
Mitophagy and Parkinson's disease: the PINK1-parkin link. Biochim Biophys Acta (2010) 1.34
Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan. Proc Natl Acad Sci U S A (2013) 1.34
Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy. J Biol Chem (2012) 1.33
Following Ariadne's thread: a new perspective on RBR ubiquitin ligases. BMC Biol (2012) 1.33
Reconstitution of mitochondria derived vesicle formation demonstrates selective enrichment of oxidized cargo. PLoS One (2012) 1.27
Phosphorylated ubiquitin chain is the genuine Parkin receptor. J Cell Biol (2015) 1.24
Probing mechanisms that underlie human neurodegenerative diseases in Drosophila. Annu Rev Genet (2012) 1.21
Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering. PLoS Genet (2014) 1.20
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy. Nat Neurosci (2013) 1.19
Parkin- and PINK1-Dependent Mitophagy in Neurons: Will the Real Pathway Please Stand Up? Front Neurol (2013) 1.17
Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase. J Biol Chem (2014) 1.16
Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant. Hum Mol Genet (2010) 1.15
Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease. Nat Cell Biol (2014) 1.15
Drosophila spermiogenesis: Big things come from little packages. Spermatogenesis (2012) 1.15
Reduction of protein translation and activation of autophagy protect against PINK1 pathogenesis in Drosophila melanogaster. PLoS Genet (2010) 1.14
Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts. PLoS One (2010) 1.14
Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin. Circ Res (2013) 1.13
RBR E3 ubiquitin ligases: new structures, new insights, new questions. Biochem J (2014) 1.13
Mitochondria and the culture of the Borg: understanding the integration of mitochondrial function within the reticulum, the cell, and the organism. Bioessays (2010) 1.12
Cell metabolism affects selective vulnerability in PINK1-associated Parkinson's disease. J Cell Sci (2012) 1.11
Analysis of neural subtypes reveals selective mitochondrial dysfunction in dopaminergic neurons from parkin mutants. Proc Natl Acad Sci U S A (2012) 1.10
Mitochondria autophagy in yeast. Antioxid Redox Signal (2011) 1.10
DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease. Aging Cell (2011) 1.09
Regulation of mitophagy by the Gp78 E3 ubiquitin ligase. Mol Biol Cell (2013) 1.09
A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment. J Biol Chem (2013) 1.08
Mitochondrial dynamics in the adult cardiomyocytes: which roles for a highly specialized cell? Front Physiol (2013) 1.08
Mitochondrial involvement in cell death of non-mammalian eukaryotes. Biochim Biophys Acta (2010) 1.07
Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease. Cell Death Dis (2013) 1.06
The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants. PLoS Genet (2012) 1.06
Mechanisms for countering oxidative stress and damage in retinal pigment epithelium. Int Rev Cell Mol Biol (2012) 1.05
Programmed cell death in Parkinson's disease. Cold Spring Harb Perspect Med (2012) 1.04
Bioenergetic consequences of PINK1 mutations in Parkinson disease. PLoS One (2011) 1.04
Drosophila as a model to study mitochondrial dysfunction in Parkinson's disease. Cold Spring Harb Perspect Med (2012) 1.04
parkin-induced defects in neurophysiology and locomotion are generated by metabolic dysfunction and not oxidative stress. Hum Mol Genet (2012) 1.04
Unravelling mitochondrial pathways to Parkinson's disease. Br J Pharmacol (2014) 1.03
The mitochondrial component of intracrine action. Am J Physiol Heart Circ Physiol (2010) 1.03
Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice. PLoS One (2011) 1.03
Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy? Br J Pharmacol (2014) 1.02
Mechanisms of mitochondria and autophagy crosstalk. Cell Cycle (2011) 1.01
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol (2008) 17.81
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J (2008) 12.89
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol (2010) 12.26
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature (2006) 11.91
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol (2010) 11.85
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature (2006) 11.81
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci U S A (2009) 8.25
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet (2000) 7.83
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc Natl Acad Sci U S A (2003) 7.57
The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci U S A (2008) 7.41
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci U S A (2006) 5.78
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J Neurosci (2007) 5.68
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc Natl Acad Sci U S A (2008) 5.43
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci U S A (2008) 4.97
Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem (2009) 4.90
Structural basis of mitochondrial tethering by mitofusin complexes. Science (2004) 4.21
A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling. Nat Cell Biol (2006) 4.05
Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism. Hum Mol Genet (2005) 3.76
The kinase domain of mitochondrial PINK1 faces the cytoplasm. Proc Natl Acad Sci U S A (2008) 3.65
Mitochondrial dynamics in mammalian health and disease. Physiol Rev (2009) 3.59
Quality control of mitochondria: protection against neurodegeneration and ageing. EMBO J (2008) 3.39
Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. J Cell Biol (2007) 3.13
PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem Biophys Res Commun (2008) 3.06
Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem (2009) 2.64
Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP. Proc Natl Acad Sci U S A (2008) 2.64
Diverse effects of pathogenic mutations of Parkin that catalyze multiple monoubiquitylation in vitro. J Biol Chem (2005) 2.60
Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. Biochim Biophys Acta (2008) 2.56
PINK1 protein in normal human brain and Parkinson's disease. Brain (2006) 2.49
Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts. Ann Neurol (2008) 2.34
Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin. Dis Model Mech (2008) 2.29
Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity. Hum Mol Genet (2006) 2.24
Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1. PLoS One (2009) 2.23
Molecular pathogenesis of Parkinson disease: insights from genetic studies. Expert Rev Mol Med (2009) 2.23
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling. Hum Mol Genet (2009) 2.10
Parkin-mediated lysine 63-linked polyubiquitination: a link to protein inclusions formation in Parkinson's and other conformational diseases? Neurobiol Aging (2005) 1.96
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol Med (2009) 1.89
The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process. Biochem Biophys Res Commun (2008) 1.84
The PINK1/Parkin pathway: a mitochondrial quality control system? J Bioenerg Biomembr (2009) 1.72
Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels. Mol Biol Cell (2007) 1.69
Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease. Exp Neurol (2009) 1.68
Positioning mitochondrial plasticity within cellular signaling cascades. Biochim Biophys Acta (2008) 1.48
Parkin mediates the degradation-independent ubiquitination of Hsp70. J Neurochem (2008) 1.42
Visualization and quantification of mitochondrial dynamics in living animal cells. Methods Cell Biol (2007) 1.39
Does impairment of the ubiquitin-proteasome system or the autophagy-lysosome pathway predispose individuals to neurodegenerative disorders such as Parkinson's disease? J Alzheimers Dis (2010) 1.31
Tickled PINK1: mitochondrial homeostasis and autophagy in recessive Parkinsonism. Biochim Biophys Acta (2009) 1.09
RNAi screening in cultured Drosophila cells. Methods Mol Biol (2008) 1.01
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc Natl Acad Sci U S A (2003) 7.57
The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci U S A (2008) 7.41
Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss. Nat Neurosci (2009) 2.35
Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. Curr Biol (2005) 2.35
PINK1 cleavage at position A103 by the mitochondrial protease PARL. Hum Mol Genet (2010) 2.30
Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis. Hum Mol Genet (2005) 1.61
Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations. Open Biol (2011) 1.42
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy. Nat Neurosci (2013) 1.19
How could Parkin-mediated ubiquitination of mitofusin promote mitophagy? Autophagy (2010) 1.11
Welwitindolinone C synthetic studies. Construction of the welwitindolinone carbon skeleton via a transannular nitrone cycloaddition. Tetrahedron (2010) 1.03
Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1. Exp Cell Res (2010) 1.03
TRAP1 rescues PINK1 loss-of-function phenotypes. Hum Mol Genet (2013) 0.93
Molecular mechanisms of PINK1-related neurodegeneration. Curr Neurol Neurosci Rep (2011) 0.87
Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects. PLoS One (2012) 0.86
Exploring binding and effector functions of natural human antibodies using synthetic immunomodulators. ACS Chem Biol (2013) 0.80
The many faces of mitophagy. EMBO Rep (2014) 0.79
Translating translation: regulated protein translation as a biomedical intervention. Fly (Austin) (2009) 0.77
Wharton-fragmentation-based approach to the carbocyclic core of the phomoidrides. Org Lett (2012) 0.75