Published in J Biol Inorg Chem on July 01, 2016
In-crystal reaction cycle of a toluene-bound diiron hydroxylase. Nature (2017) 0.79
Celebrating Ed Solomon. J Biol Inorg Chem (2016) 0.75
Structural and Functional Aspects of Metal Sites in Biology. Chem Rev (1996) 8.70
Geometric and electronic structure/function correlations in non-heme iron enzymes. Chem Rev (2000) 5.44
Microbial biosynthesis of alkanes. Science (2010) 4.74
Non-heme Fe(IV)-oxo intermediates. Acc Chem Res (2007) 3.55
An Fe2IVO2 diamond core structure for the key intermediate Q of methane monooxygenase. Science (1997) 3.29
Crystal structure of delta9 stearoyl-acyl carrier protein desaturase from castor seed and its relationship to other di-iron proteins. EMBO J (1996) 2.84
Stearoyl-acyl carrier protein delta 9 desaturase from Ricinus communis is a diiron-oxo protein. Proc Natl Acad Sci U S A (1993) 2.38
Ribonucleotide reductase inhibitors and future drug design. Curr Cancer Drug Targets (2006) 2.30
Peroxodiferric intermediate of stearoyl-acyl carrier protein delta 9 desaturase: oxidase reactivity during single turnover and implications for the mechanism of desaturation. Biochemistry (1998) 2.16
Dioxygen activation in soluble methane monooxygenase. Acc Chem Res (2011) 2.07
A manganese(IV)/iron(III) cofactor in Chlamydia trachomatis ribonucleotide reductase. Science (2007) 1.95
Di-iron-carboxylate proteins. Curr Opin Struct Biol (1995) 1.91
MCD C-Term Signs, Saturation Behavior, and Determination of Band Polarizations in Randomly Oriented Systems with Spin S >/= (1)/(2). Applications to S = (1)/(2) and S = (5)/(2). Inorg Chem (1999) 1.75
Evidence for C-H cleavage by an iron-superoxide complex in the glycol cleavage reaction catalyzed by myo-inositol oxygenase. Proc Natl Acad Sci U S A (2006) 1.65
Oxygen activation catalyzed by methane monooxygenase hydroxylase component: proton delivery during the O-O bond cleavage steps. Biochemistry (1999) 1.64
Crystal structure of the hydroxylase component of methane monooxygenase from Methylosinus trichosporium OB3b. Protein Sci (1997) 1.64
Di-iron-tyrosyl radical ribonucleotide reductases. Curr Opin Chem Biol (2003) 1.63
O2 activation by non-heme diiron proteins: identification of a symmetric mu-1,2-peroxide in a mutant of ribonucleotide reductase. Biochemistry (1998) 1.61
Characterization of the arene-oxidizing intermediate in ToMOH as a diiron(III) species. J Am Chem Soc (2007) 1.60
Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009. Proc Natl Acad Sci U S A (2002) 1.57
Human deoxyhypusine hydroxylase, an enzyme involved in regulating cell growth, activates O2 with a nonheme diiron center. Proc Natl Acad Sci U S A (2009) 1.52
Crystal structures of the soluble methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath) demonstrating geometrical variability at the dinuclear iron active site. J Am Chem Soc (2001) 1.49
Crystal structure of bullfrog M ferritin at 2.8 A resolution: analysis of subunit interactions and the binuclear metal center. J Biol Inorg Chem (1999) 1.47
Nature of the peroxo intermediate of the W48F/D84E ribonucleotide reductase variant: implications for O2 activation by binuclear non-heme iron enzymes. J Am Chem Soc (2004) 1.43
Complex formation between the protein components of methane monooxygenase from Methylosinus trichosporium OB3b. Identification of sites of component interaction. J Biol Chem (1991) 1.39
In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis. Proc Natl Acad Sci U S A (2008) 1.39
Kinetics and activation thermodynamics of methane monooxygenase compound Q formation and reaction with substrates. Biochemistry (2000) 1.37
A long-lived, substrate-hydroxylating peroxodiiron(III/III) intermediate in the amine oxygenase, AurF, from Streptomyces thioluteus. J Am Chem Soc (2009) 1.36
(Mu-1,2-peroxo)diiron(III/III) complex as a precursor to the diiron(III/IV) intermediate X in the assembly of the iron-radical cofactor of ribonucleotide reductase from mouse. Biochemistry (2007) 1.33
Structures of deoxy and oxy hemerythrin at 2.0 A resolution. J Mol Biol (1991) 1.29
Mössbauer studies of the formation and reactivity of a quasi-stable peroxo intermediate of stearoyl-acyl carrier protein Delta 9-desaturase. Biochemistry (1999) 1.29
Structure-function correlations in oxygen activating non-heme iron enzymes. Chem Commun (Camb) (2005) 1.28
Crystal structure of a substrate complex of myo-inositol oxygenase, a di-iron oxygenase with a key role in inositol metabolism. Proc Natl Acad Sci U S A (2006) 1.27
A flavodiiron protein and high molecular weight rubredoxin from Moorella thermoacetica with nitric oxide reductase activity. Biochemistry (2003) 1.27
Revisiting the mechanism of dioxygen activation in soluble methane monooxygenase from M. capsulatus (Bath): evidence for a multi-step, proton-dependent reaction pathway. Biochemistry (2009) 1.26
The nature of the di-iron site in the bacterioferritin from Desulfovibrio desulfuricans. Nat Struct Biol (2003) 1.26
Spectroscopic and electronic structure studies of intermediate X in ribonucleotide reductase R2 and two variants: a description of the FeIV-oxo bond in the FeIII-O-FeIV dimer. J Am Chem Soc (2007) 1.26
Spectroscopic definition of the ferroxidase site in M ferritin: comparison of binuclear substrate vs cofactor active sites. J Am Chem Soc (2008) 1.24
The O2-scavenging flavodiiron protein in the human parasite Giardia intestinalis. J Biol Chem (2007) 1.21
Non-heme iron enzymes: contrasts to heme catalysis. Proc Natl Acad Sci U S A (2003) 1.21
Cyanobacterial alkane biosynthesis further expands the catalytic repertoire of the ferritin-like 'di-iron-carboxylate' proteins. Curr Opin Chem Biol (2011) 1.19
A coupled dinuclear iron cluster that is perturbed by substrate binding in myo-inositol oxygenase. Biochemistry (2006) 1.19
Peroxo-type intermediates in class I ribonucleotide reductase and related binuclear non-heme iron enzymes. J Am Chem Soc (2009) 1.19
Structural basis for iron mineralization by bacterioferritin. J Am Chem Soc (2009) 1.18
Identification of protonated oxygenic ligands of ribonucleotide reductase intermediate X. J Am Chem Soc (2009) 1.18
Comparison between the geometric and electronic structures and reactivities of [FeNO]7 and [FeO2]8 complexes: a density functional theory study. J Am Chem Soc (2004) 1.18
myo-Inositol oxygenase: a radical new pathway for O(2) and C-H activation at a nonheme diiron cluster. Dalton Trans (2008) 1.16
New insights from spectroscopy into the structure/function relationships of lipoxygenases. Chem Biol (1997) 1.14
Structure and action of the N-oxygenase AurF from Streptomyces thioluteus. J Mol Biol (2007) 1.14
Oxygen activation by a mixed-valent, diiron(II/III) cluster in the glycol cleavage reaction catalyzed by myo-inositol oxygenase. Biochemistry (2006) 1.13
The ferritin Fe2 site at the diiron catalytic center controls the reaction with O2 in the rapid mineralization pathway. Proc Natl Acad Sci U S A (2008) 1.12
A Mycobacterium tuberculosis ligand-binding Mn/Fe protein reveals a new cofactor in a remodeled R2-protein scaffold. Proc Natl Acad Sci U S A (2009) 1.12
Control of substrate access to the active site in methane monooxygenase. Nature (2013) 1.12
Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins. Nat Chem (2012) 1.11
Structure of the key species in the enzymatic oxidation of methane to methanol. Nature (2015) 1.10
Characterization of a peroxodiiron(III) intermediate in the T201S variant of toluene/o-xylene monooxygenase hydroxylase from Pseudomonas sp. OX1. J Am Chem Soc (2009) 1.09
X-ray crystal structures of manganese(II)-reconstituted and native toluene/o-xylene monooxygenase hydroxylase reveal rotamer shifts in conserved residues and an enhanced view of the protein interior. J Am Chem Soc (2006) 1.09
Four-electron oxidation of p-hydroxylaminobenzoate to p-nitrobenzoate by a peroxodiferric complex in AurF from Streptomyces thioluteus. Proc Natl Acad Sci U S A (2010) 1.08
Use of a chemical trigger for electron transfer to characterize a precursor to cluster X in assembly of the iron-radical cofactor of Escherichia coli ribonucleotide reductase. Biochemistry (2004) 1.08
Protein engineering of toluene 4-monooxygenase of Pseudomonas mendocina KR1 for synthesizing 4-nitrocatechol from nitrobenzene. Biotechnol Bioeng (2004) 1.07
A family of diiron monooxygenases catalyzing amino acid beta-hydroxylation in antibiotic biosynthesis. Proc Natl Acad Sci U S A (2010) 1.07
Rational reprogramming of the R2 subunit of Escherichia coli ribonucleotide reductase into a self-hydroxylating monooxygenase. J Am Chem Soc (2001) 1.05
Electronic and spectroscopic studies of the non-heme reduced binuclear iron sites of two ribonucleotide reductase variants: comparison to reduced methane monooxygenase and contributions to O2 reactivity. J Am Chem Soc (2004) 1.05
Spectroscopic and computational studies of the de novo designed protein DF2t: correlation to the biferrous active site of ribonucleotide reductase and factors that affect O2 reactivity. J Am Chem Soc (2005) 1.03
CD and MCD studies of the effects of component B variant binding on the biferrous active site of methane monooxygenase. Biochemistry (2008) 1.01
Rapid-freeze-quench magnetic circular dichroism of intermediate X in ribonucleotide reductase: new structural insight. J Am Chem Soc (2003) 1.00
Insights into the nitric oxide reductase mechanism of flavodiiron proteins from a flavin-free enzyme. Biochemistry (2010) 1.00
Iron-containing urease in a pathogenic bacterium. Proc Natl Acad Sci U S A (2011) 0.99
Structural and spectroscopic properties of the peroxodiferric intermediate of Ricinus communis soluble Δ9 desaturase. Inorg Chem (2012) 0.94
Geometric and electronic structure contributions to function in non-heme iron enzymes. Acc Chem Res (2013) 0.94
Geometric and electronic structure studies of the binuclear nonheme ferrous active site of toluene-4-monooxygenase: parallels with methane monooxygenase and insight into the role of the effector proteins in O2 activation. J Am Chem Soc (2008) 0.94
Structure of coenzyme F420H2 oxidase (FprA), a di-iron flavoprotein from methanogenic Archaea catalyzing the reduction of O2 to H2O. FEBS J (2007) 0.93
Oxidation reactions performed by soluble methane monooxygenase hydroxylase intermediates H(peroxo) and Q proceed by distinct mechanisms. Biochemistry (2010) 0.92
CD and MCD spectroscopic studies of the two Dps miniferritin proteins from Bacillus anthracis: role of O2 and H2O2 substrates in reactivity of the diiron catalytic centers. Biochemistry (2010) 0.90
Crystal structure of CmlI, the arylamine oxygenase from the chloramphenicol biosynthetic pathway. J Biol Inorg Chem (2016) 0.89
An unusual peroxo intermediate of the arylamine oxygenase of the chloramphenicol biosynthetic pathway. J Am Chem Soc (2015) 0.88
Crystal structures and functional studies of T4moD, the toluene 4-monooxygenase catalytic effector protein. Biochemistry (2005) 0.88
A 2.8 Å Fe-Fe separation in the Fe2(III/IV) intermediate, X, from Escherichia coli ribonucleotide reductase. J Am Chem Soc (2013) 0.87
Histidine ligand variants of a flavo-diiron protein: effects on structure and activities. J Biol Inorg Chem (2012) 0.87
Mixed pollutant degradation by Methylosinus trichosporium OB3b expressing either soluble or particulate methane monooxygenase: can the tortoise beat the hare? Appl Environ Microbiol (2006) 0.86
Nuclear resonance vibrational spectroscopy and DFT study of peroxo-bridged biferric complexes: structural insight into peroxo intermediates of binuclear non-heme iron enzymes. Angew Chem Int Ed Engl (2012) 0.83
Structure and mechanism of iron translocation by a Dps protein from Microbacterium arborescens. J Biol Chem (2011) 0.83
Solution structure of T4moC, the Rieske ferredoxin component of the toluene 4-monooxygenase complex. J Biol Inorg Chem (2004) 0.83
Nuclear resonance vibrational spectroscopic and computational study of high-valent diiron complexes relevant to enzyme intermediates. Proc Natl Acad Sci U S A (2013) 0.83
Purification, crystallization and preliminary crystallographic analysis of mouse myo-inositol oxygenase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.82
X-ray absorption spectroscopic characterization of the diferric-peroxo intermediate of human deoxyhypusine hydroxylase in the presence of its substrate eIF5a. J Biol Inorg Chem (2016) 0.81
Mutasynthesis of aureonitrile: an aureothin derivative with significantly improved cytostatic effect. Angew Chem Int Ed Engl (2005) 0.80
Mediation by indole analogues of electron transfer during oxygen activation in variants of Escherichia coli ribonucleotide reductase R2 lacking the electron-shuttling tryptophan 48. Biochemistry (2004) 0.80
Composition and Structure of the Inorganic Core of Relaxed Intermediate X(Y122F) of Escherichia coli Ribonucleotide Reductase. J Am Chem Soc (2015) 0.79
Geometric and electronic structure of the Mn(IV)Fe(III) cofactor in class Ic ribonucleotide reductase: correlation to the class Ia binuclear non-heme iron enzyme. J Am Chem Soc (2013) 0.77
CD/MCD/VTVH-MCD Studies of Escherichia coli Bacterioferritin Support a Binuclear Iron Cofactor Site. Biochemistry (2015) 0.76
Reactivity of the binuclear non-heme iron active site of Δ⁹ desaturase studied by large-scale multireference ab initio calculations. J Am Chem Soc (2014) 0.76
Circular dichroism, magnetic circular dichroism, and variable temperature variable field magnetic circular dichroism studies of biferrous and mixed-valent myo-inositol oxygenase: insights into substrate activation of O2 reactivity. J Am Chem Soc (2013) 0.76
Spectroscopic studies of single and double variants of M ferritin: lack of conversion of a biferrous substrate site into a cofactor site for O2 activation. Biochemistry (2014) 0.75