Autophagy and Mitochondrial Dysfunction in Tenon Fibroblasts from Exfoliation Glaucoma Patients.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27391778)

Published in PLoS One on July 08, 2016

Authors

Andrew Want1, Stephanie R Gillespie1,2, Zheng Wang1, Ronald Gordon3, Carlo Iomini1, Robert Ritch4, J Mario Wolosin1, Audrey M Bernstein1,2

Author Affiliations

1: Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States of America.
2: Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States of America.
3: Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States of America.
4: Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, 10003, United States of America.

Articles cited by this

How to interpret LC3 immunoblotting. Autophagy (2007) 12.30

Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy (2007) 11.74

Rab11 regulates recycling through the pericentriolar recycling endosome. J Cell Biol (1996) 9.27

Protein turnover via autophagy: implications for metabolism. Annu Rev Nutr (2007) 5.75

Super-resolution fluorescence microscopy. Annu Rev Biochem (2009) 5.47

Lysosomal positioning coordinates cellular nutrient responses. Nat Cell Biol (2011) 4.96

Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nat Genet (2004) 3.83

Exfoliation syndrome. Surv Ophthalmol (2001) 3.55

JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis. FEBS Lett (1997) 3.41

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J (2012) 3.37

Autophagy and aging: keeping that old broom working. Trends Genet (2008) 3.09

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo. Proc Natl Acad Sci U S A (2009) 2.95

Pseudoexfoliation syndrome. Ocular manifestation of a systemic disorder? Arch Ophthalmol (1992) 2.36

Role of microtubules in the organisation of the Golgi apparatus. Cell Motil Cytoskeleton (1990) 2.21

Autophagy induction favours the generation and maturation of the Coxiella-replicative vacuoles. Cell Microbiol (2005) 2.03

PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation. EMBO Rep (2009) 1.89

Pseudoexfoliative fibrillopathy in visceral organs of a patient with pseudoexfoliation syndrome. Arch Ophthalmol (1992) 1.81

Morphologic characterization of organized extracellular matrix deposition by ascorbic acid-stimulated human corneal fibroblasts. Invest Ophthalmol Vis Sci (2007) 1.56

Autophagy, mitochondria and cell death in lysosomal storage diseases. Autophagy (2007) 1.55

Proteomic analysis of exfoliation deposits. Invest Ophthalmol Vis Sci (2007) 1.47

Consideration about negative controls for LC3 and expression vectors for four colored fluorescent protein-LC3 negative controls. Autophagy (2007) 1.45

Role of transforming growth factor-beta1 and its latent form binding protein in pseudoexfoliation syndrome. Exp Eye Res (2001) 1.39

Serum starvation: caveat emptor. Am J Physiol Cell Physiol (2011) 1.37

Pseudoexfoliation syndrome, a systemic disorder with ocular manifestations. Hum Genomics (2012) 1.22

Autophagy and microtubules - new story, old players. J Cell Sci (2013) 1.19

Expression and significance of lysyl oxidase-like 1 and fibulin-5 in the cardinal ligament tissue of patients with pelvic floor dysfunction. J Biomed Res (2012) 1.14

A histopathologic study of zonular instability in pseudoexfoliation syndrome. Am J Ophthalmol (1994) 1.11

Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to Zidovudine. Environ Mol Mutagen (2007) 1.02

Exfoliation syndrome. Curr Opin Ophthalmol (2001) 1.02

Differential expression of the lysosome-associated membrane proteins in normal human tissues. Arch Biochem Biophys (1999) 1.01

Lyst mutation in mice recapitulates iris defects of human exfoliation syndrome. Invest Ophthalmol Vis Sci (2008) 1.00

Pseudoexfoliation syndrome and asymptomatic myocardial dysfunction. Graefes Arch Clin Exp Ophthalmol (2004) 0.98

The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease. Biochim Biophys Acta (2013) 0.97

Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris. J Neurochem (2012) 0.96

Ocular and systemic manifestations of exfoliation syndrome. J Glaucoma (2014) 0.96

Dysregulation of protein trafficking in neurodegeneration. Mol Neurodegener (2014) 0.95

Analysis of dermal elastic fibers in the absence of fibulin-5 reveals potential roles for fibulin-5 in elastic fiber assembly. Matrix Biol (2009) 0.95

The interplay between autophagy and mitochondrial dysfunction in oxidative stress-induced cardiac aging and pathology. J Mol Cell Cardiol (2014) 0.93

Elevated oxidative membrane damage associated with genetic modifiers of Lyst-mutant phenotypes. PLoS Genet (2010) 0.92

The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy. Drug Discov Today (2014) 0.92

Super-Resolution Microscopy: From Single Molecules to Supramolecular Assemblies. Trends Cell Biol (2015) 0.90

Lysosomal fusion dysfunction as a unifying hypothesis for Alzheimer's disease pathology. Int J Alzheimers Dis (2012) 0.88

Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration. J Clin Invest (2016) 0.87

Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry system. J Biomol Screen (2009) 0.87

Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death. Front Neuroanat (2014) 0.86

Rescue of compromised lysosomes enhances degradation of photoreceptor outer segments and reduces lipofuscin-like autofluorescence in retinal pigmented epithelial cells. Adv Exp Med Biol (2014) 0.85

Mechanisms of protein aggregation in the retinal pigment epithelial cells. Front Biosci (Elite Ed) (2010) 0.85

Mitochondrial responsibility in ageing process: innocent, suspect or guilty. Biogerontology (2015) 0.83

Exfoliative glaucoma: new evidence in the pathogenesis and treatment. Prog Brain Res (2015) 0.82

Review: The role of LOXL1 in exfoliation syndrome/glaucoma. Saudi J Ophthalmol (2011) 0.80

Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease. Neurotherapeutics (2015) 0.80

Lithium Modulates Autophagy in Esophageal and Colorectal Cancer Cells and Enhances the Efficacy of Therapeutic Agents In Vitro and In Vivo. PLoS One (2015) 0.78

Subcellular injuries in Alzheimer's disease. CNS Neurol Disord Drug Targets (2014) 0.77

Rab and Arf G proteins in endosomal trafficking. Methods Cell Biol (2015) 0.76