Published in J Clin Invest on July 11, 2016
Heart disease and stroke statistics--2011 update: a report from the American Heart Association. Circulation (2010) 30.07
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J (1998) 7.15
A critical role for IL-21 in regulating immunoglobulin production. Science (2002) 7.09
Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci (2003) 6.53
The science of stroke: mechanisms in search of treatments. Neuron (2010) 6.14
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature (2000) 5.86
Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol (1997) 5.38
Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu Rev Immunol (2008) 4.90
What does Stat3 do? J Clin Invest (2002) 4.83
Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function. J Exp Med (2005) 4.60
Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction. Blood (2010) 3.82
Ischemic tolerance and endogenous neuroprotection. Trends Neurosci (2003) 3.44
The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J Clin Invest (2006) 3.33
A quantitative trait locus (LSq-1) on mouse chromosome 7 is linked to the absence of tissue loss after surgical hindlimb ischemia. Circulation (2008) 2.77
Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury. Circ Res (2004) 2.45
Pathophysiology and therapy of experimental stroke. Cell Mol Neurobiol (2006) 2.21
Regulation of STAT-dependent pathways by growth factors and cytokines. FASEB J (1996) 1.85
Wide genetic variation in the native pial collateral circulation is a major determinant of variation in severity of stroke. J Cereb Blood Flow Metab (2010) 1.80
Vascular endothelial growth factor-A specifies formation of native collaterals and regulates collateral growth in ischemia. Circ Res (2008) 1.77
Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations. Stroke (2012) 1.68
Interleukin 21: a cytokine/cytokine receptor system that has come of age. J Leukoc Biol (2008) 1.48
The two pathophysiologies of focal brain ischemia: implications for translational stroke research. J Cereb Blood Flow Metab (2012) 1.46
Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome. J Exp Med (2013) 1.39
Saturation mutagenesis of the WSXWS motif of the erythropoietin receptor. J Biol Chem (1996) 1.32
Cardiac glycosides provide neuroprotection against ischemic stroke: discovery by a brain slice-based compound screening platform. Proc Natl Acad Sci U S A (2006) 1.29
A locus mapping to mouse chromosome 7 determines infarct volume in a mouse model of ischemic stroke. Circ Cardiovasc Genet (2009) 1.19
A quantitative study of microglial-macrophage synthesis of tumor necrosis factor during acute and late focal cerebral ischemia in mice. J Cereb Blood Flow Metab (2005) 1.18
Sensitivity to cerebral ischaemic insult in a rat model of stroke is determined by a single genetic locus. Nat Genet (1997) 1.18
Genetic architecture underlying variation in extent and remodeling of the collateral circulation. Circ Res (2010) 1.14
IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain. Am J Pathol (2011) 1.11
Cytokine-induced nuclear factor kappa B activation promotes the survival of developing neurons. J Cell Biol (2000) 1.10
An objective procedure for ischemic area evaluation of the stroke intraluminal thread model in the mouse and rat. J Neurosci Methods (2002) 1.01
In vitro and in vivo neuroprotective activity of the cardiac glycoside oleandrin from Nerium oleander in brain slice-based stroke models. J Neurochem (2011) 0.99
Differential regulation of proliferation and differentiation in neural precursor cells by the Jak pathway. Stem Cells (2010) 0.97
Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R. J Biol Chem (2012) 0.94
T cell-derived interleukin (IL)-21 promotes brain injury following stroke in mice. J Exp Med (2014) 0.93
Mutations in the WSAWSE and cytosolic domains of the erythropoietin receptor affect signal transduction and ligand binding and internalization. Mol Cell Biol (1992) 0.92
Molecular cloning of the cDNA coding sequence of IL-2 receptor-gamma (gammac) from human and murine forebrain: expression in the hippocampus in situ and by brain cells in vitro. Brain Res Mol Brain Res (1998) 0.91
Loss of interleukin-21 receptor activation in hypoxic endothelial cells impairs perfusion recovery after hindlimb ischemia. Arterioscler Thromb Vasc Biol (2015) 0.89
Multi-functional roles of Stat3 revealed by conditional gene targeting. Arch Immunol Ther Exp (Warsz) (2001) 0.88
STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function. J Exp Med (2015) 0.86
Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice. J Cereb Blood Flow Metab (1998) 0.85
Congenic removal of a QTL for blood pressure attenuates infarct size produced by middle cerebral artery occlusion in hypertensive rats. Physiol Genomics (2007) 0.85
A novel genetic locus modulates infarct volume independently of the extent of collateral circulation. Physiol Genomics (2013) 0.84
Natural genetic variation of integrin alpha L (Itgal) modulates ischemic brain injury in stroke. PLoS Genet (2013) 0.84
Cutting edge: IL-21 derived from human follicular helper T cells acts as a survival factor for secondary lymphoid organ, but not for bone marrow, plasma cells. J Immunol (2012) 0.82
Heterozygous mutation in the WSXWS equivalaent motif of the growth hormone receptor in a child with poor response to growth hormone therapy. Growth Horm IGF Res (1998) 0.78
Immunohistochemical localization of interleukin-2 and its receptor subunits alpha, beta and gamma in the main olfactory bulb of the rat. Brain Res (2001) 0.78
A conserved sugar bridge connected to the WSXWS motif has an important role for transport of IL-21R to the plasma membrane. Genes Immun (2015) 0.76
Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ. N Engl J Med (2013) 4.26
The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nat Med (2009) 3.05
A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10). Am J Hum Genet (2002) 2.98
A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4). Lancet (2004) 2.97
A quantitative trait locus (LSq-1) on mouse chromosome 7 is linked to the absence of tissue loss after surgical hindlimb ischemia. Circulation (2008) 2.77
Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis. JAMA (2005) 2.59
Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations. Am J Hum Genet (2003) 2.58
CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis. Hum Mol Genet (2005) 2.52
Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1. Nat Neurosci (2006) 2.37
Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations. Development (2004) 2.35
KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis. Hum Mol Genet (2002) 2.28
Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage. Stroke (2003) 2.17
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J Cell Biol (2009) 2.16
Brain oxygenation and energy metabolism: part I-biological function and pathophysiology. Neurosurgery (2002) 2.13
Oxidants, antioxidants and the ischemic brain. J Exp Biol (2004) 2.05
Serotonin-related gene polymorphisms and central nervous system serotonin function. Neuropsychopharmacology (2002) 1.96
Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis. Hum Mol Genet (2008) 1.95
Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. Stroke (2011) 1.91
The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice. Anesthesiology (2003) 1.83
APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response. J Biol Chem (2003) 1.80
Transient global cerebral ischemia induces a massive increase in protein sumoylation. J Cereb Blood Flow Metab (2007) 1.74
Analysis of the brain bioavailability of peripherally administered magnesium sulfate: A study in humans with acute brain injury undergoing prolonged induced hypermagnesemia. Crit Care Med (2005) 1.66
Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins. Nat Chem Biol (2010) 1.62
Intraischemic nitrous oxide alters neither neurologic nor histologic outcome: a comparison with dizocilpine. Anesth Analg (2004) 1.60
Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. Nature (2013) 1.59
Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage. Stroke (2002) 1.57
A retrospective analysis of a remifentanil/propofol general anesthetic for craniotomy before awake functional brain mapping. Anesth Analg (2005) 1.55
Redefining heart failure: the utility of genomics. J Am Coll Cardiol (2006) 1.52
Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma. Genes Chromosomes Cancer (2002) 1.49
Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc (2014) 1.49
Overlapping spectra of SMAD4 mutations in juvenile polyposis (JP) and JP-HHT syndrome. Am J Med Genet A (2010) 1.49
Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation. J Cereb Blood Flow Metab (2008) 1.45
Vascular endothelial growth factor induces abnormal microvasculature in the endoglin heterozygous mouse brain. J Cereb Blood Flow Metab (2004) 1.44
Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial. Stroke (2005) 1.44
Tnni3k modifies disease progression in murine models of cardiomyopathy. PLoS Genet (2009) 1.44
Isoflurane provides long-term protection against focal cerebral ischemia in the rat. Anesthesiology (2007) 1.44
Mouse model of subarachnoid hemorrhage associated cerebral vasospasm: methodological analysis. Neurol Res (2002) 1.43
A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. Hum Mol Genet (2010) 1.39
Altered perceptions after upper and lower extremity blocks: an initial investigation. Reg Anesth Pain Med (2003) 1.39
Polymorphisms in genes involved in inflammatory and angiogenic pathways and the risk of hemorrhagic presentation of brain arteriovenous malformations. Stroke (2004) 1.39
Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression. Arch Gen Psychiatry (2005) 1.39
A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2. Hum Mol Genet (2003) 1.38
A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury. Exp Neurol (2005) 1.34
Downregulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation. Neuron (2009) 1.31
Increased expression of brain-derived neurotrophic factor induces formation of basal dendrites and axonal branching in dentate granule cells in hippocampal explant cultures. J Neurosci (2002) 1.31
Loss of p53 sensitizes mice with a mutation in Ccm1 (KRIT1) to development of cerebral vascular malformations. Am J Pathol (2004) 1.30
Cardiac glycosides provide neuroprotection against ischemic stroke: discovery by a brain slice-based compound screening platform. Proc Natl Acad Sci U S A (2006) 1.29
Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat. Anesthesiology (2004) 1.29
Preclinical models of intracerebral hemorrhage: a translational perspective. Neurocrit Care (2008) 1.29
Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity. J Neurosci (2008) 1.28
Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Exp Neurol (2007) 1.26
Gene microarray analysis of human brain arteriovenous malformations. Neurosurgery (2004) 1.26
Low frequency of PDCD10 mutations in a panel of CCM3 probands: potential for a fourth CCM locus. Hum Mutat (2006) 1.24
Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation. Am J Physiol Heart Circ Physiol (2008) 1.24
Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations. Mamm Genome (2006) 1.23
Isoflurane-induced neuronal degeneration: an evaluation in organotypic hippocampal slice cultures. Anesth Analg (2005) 1.21
Genetic modifier loci affecting survival and cardiac function in murine dilated cardiomyopathy. Circulation (2002) 1.21
Peripheral nerve block techniques for ambulatory surgery. Anesth Analg (2005) 1.19
Deletions in CCM2 are a common cause of cerebral cavernous malformations. Am J Hum Genet (2006) 1.19
Intragenic modifiers of hereditary spastic paraplegia due to spastin gene mutations. Neurogenetics (2004) 1.19
A locus mapping to mouse chromosome 7 determines infarct volume in a mouse model of ischemic stroke. Circ Cardiovasc Genet (2009) 1.19
Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia. Free Radic Biol Med (2002) 1.17
Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses. PLoS Pathog (2010) 1.17
Updates and future horizons on the understanding, diagnosis, and treatment of Sturge-Weber syndrome brain involvement. Dev Med Child Neurol (2011) 1.16
Genetics of cerebral cavernous malformations. Curr Neurol Neurosci Rep (2005) 1.15
Limit on the role of activity in controlling the release-ready supply of synaptic vesicles. J Neurosci (2002) 1.13
TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease. Chem Biol (2012) 1.13
Advanced magnetic resonance imaging of cerebral cavernous malformations: part II. Imaging of lesions in murine models. Neurosurgery (2008) 1.12
Ambulatory discharge after long-acting peripheral nerve blockade: 2382 blocks with ropivacaine. Anesth Analg (2002) 1.12
Multiple quantitative trait loci modify the heart failure phenotype in murine cardiomyopathy. Hum Mol Genet (2003) 1.11
Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat. Free Radic Biol Med (2009) 1.10
Paravertebral somatic nerve block compared with peripheral nerve blocks for outpatient inguinal herniorrhaphy. Reg Anesth Pain Med (2002) 1.10
Skeletal muscle-specific genetic determinants contribute to the differential strain-dependent effects of hindlimb ischemia in mice. Am J Pathol (2012) 1.09
A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage. Neurocrit Care (2006) 1.09
Synaptic activation modifies microtubules underlying transport of postsynaptic cargo. Proc Natl Acad Sci U S A (2009) 1.06
A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity. Free Radic Biol Med (2012) 1.05
Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition. Proc Natl Acad Sci U S A (2014) 1.05
Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema. Ann Neurol (2002) 1.05
Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. J Med Chem (2012) 1.04
Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models. Nat Med (2013) 1.04
Childhood socioeconomic status and serotonin transporter gene polymorphism enhance cardiovascular reactivity to mental stress. Psychosom Med (2007) 1.04
Magnesium neuroprotection is limited in humans with acute brain injury. Neurocrit Care (2005) 1.03
QTL mapping in a mouse model of cardiomyopathy reveals an ancestral modifier allele affecting heart function and survival. Mamm Genome (2005) 1.03
Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models. Chem Biol (2010) 1.02