T cells expressing an anti-B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma.

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Published in Blood on July 13, 2016

Authors

Syed Abbas Ali1, Victoria Shi2, Irina Maric3, Michael Wang4, David F Stroncek5, Jeremy J Rose2, Jennifer N Brudno1, Maryalice Stetler-Stevenson6, Steven A Feldman7, Brenna G Hansen2, Vicki S Fellowes2, Frances T Hakim2, Ronald E Gress2, James N Kochenderfer2

Author Affiliations

1: Center for Cancer Research, and.
2: Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD;
3: Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, MD;
4: University of Texas MD Anderson Cancer Center, Houston, TX;
5: Department of Transfusion Medicine, Clinical Center, NIH, Bethesda, MD;
6: Laboratory of Pathology, and.
7: Surgery Branch, National Cancer Institute, NIH, Bethesda, MD.

Associated clinical trials:

Study of T Cells Targeting B-Cell Maturation Antigen for Previously Treated Multiple Myeloma | NCT02215967

Anti-CD19/BCMA Bispecific CAR-T Cell Therapy for R/R MM | NCT03706547

Carfilzomib, Iberdomide (CC-220) and Dexamethasone (KID) in Transplant Eligible Multiple Myeloma | NCT05199311

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