Published in Proc Natl Acad Sci U S A on July 18, 2016
Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. J Biol Chem (2002) 5.61
The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. Prog Retin Eye Res (2009) 3.40
Sorting GPI-anchored proteins. Nat Rev Mol Cell Biol (2004) 2.77
Membrane proximal lysosomes are the major vesicles responsible for calcium-dependent exocytosis in nonsecretory cells. J Cell Biol (2002) 2.65
Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature (2011) 2.64
Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium. Proc Natl Acad Sci U S A (2006) 2.45
Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning. J Cell Biol (2009) 2.45
Histone deacetylase inhibitors prevent exocytosis of interleukin-1beta-containing secretory lysosomes: role of microtubules. Blood (2006) 1.48
Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury. J Biol Chem (2009) 1.45
The lipofuscin fluorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells. Proc Natl Acad Sci U S A (2007) 1.45
The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation. J Cell Sci (2013) 1.33
Complement system dysregulation and inflammation in the retinal pigment epithelium of a mouse model for Stargardt macular degeneration. J Biol Chem (2011) 1.28
Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age-related macular degeneration. J Pathol (2013) 1.24
Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging. Invest Ophthalmol Vis Sci (2013) 1.17
Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy. Prog Retin Eye Res (2014) 1.17
Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids. Proc Natl Acad Sci U S A (2012) 1.16
Immune regulation in the retina. Immunol Res (2010) 1.12
Damage control: cellular mechanisms of plasma membrane repair. Trends Cell Biol (2014) 1.10
Age-related macular degeneration and the role of the complement system. Mol Immunol (2015) 1.07
Complement dysregulation in AMD: RPE-Bruch's membrane-choroid. Mol Aspects Med (2012) 1.03
Recent developments in the treatment of age-related macular degeneration. J Clin Invest (2014) 0.99
Sublytic membrane-attack-complex (MAC) activation alters regulated rather than constitutive vascular endothelial growth factor (VEGF) secretion in retinal pigment epithelium monolayers. J Biol Chem (2011) 0.99
Role of AP1 and Gadkin in the traffic of secretory endo-lysosomes. Mol Biol Cell (2011) 0.98
Axonal and dendritic synaptotagmin isoforms revealed by a pHluorin-syt functional screen. Mol Biol Cell (2012) 0.94
Fundus autofluorescence in the Abca4(-/-) mouse model of Stargardt disease--correlation with accumulation of A2E, retinal function, and histology. Invest Ophthalmol Vis Sci (2013) 0.94
Immune mechanisms in inflammatory and degenerative eye disease. Trends Immunol (2015) 0.90
Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium. Mol Biol Cell (2014) 0.88
Mechanism of polarized lysosome exocytosis in epithelial cells. J Cell Sci (2012) 0.88
Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide. Mol Biol Cell (2014) 0.87
Rescue of the Stargardt phenotype in Abca4 knockout mice through inhibition of vitamin A dimerization. Proc Natl Acad Sci U S A (2015) 0.85
The making of a macromolecular machine: assembly of the membrane attack complex. Biochemistry (2014) 0.83
The complement inhibitor CD59 regulates insulin secretion by modulating exocytotic events. Cell Metab (2014) 0.82
A detailed three-step protocol for live imaging of intracellular traffic in polarized primary porcine RPE monolayers. Exp Eye Res (2014) 0.82
Should I stay or should I go? Trafficking of sub-lytic MAC in the retinal pigment epithelium. Adv Exp Med Biol (2014) 0.80
Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis. J Cell Biol (2015) 0.78
Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury. Sci Transl Med (2015) 0.78
Activation of endogenously expressed ion channels by active complement in the retinal pigment epithelium. Pflugers Arch (2014) 0.78
Retinal Pigment Epithelial Cells Mitigate the Effects of Complement Attack by Endocytosis of C5b-9. J Immunol (2015) 0.78