Published in Sci Rep on July 22, 2016
How to Train a Cell-Cutting-Edge Molecular Tools. Front Chem (2017) 0.75
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31
Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega. Mol Syst Biol (2011) 28.61
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol (2013) 11.58
Synthetic gene networks that count. Science (2009) 4.54
Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells. Proc Natl Acad Sci U S A (2001) 4.51
Structure of Cre recombinase complexed with DNA in a site-specific recombination synapse. Nature (1997) 4.39
Amplifying genetic logic gates. Science (2013) 3.33
Ocean plankton. Structure and function of the global ocean microbiome. Science (2015) 3.08
Boltzmann's principle, knowledge-based mean fields and protein folding. An approach to the computational determination of protein structures. J Comput Aided Mol Des (1993) 3.06
HIV-1 proviral DNA excision using an evolved recombinase. Science (2007) 2.81
Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids. Proc Natl Acad Sci U S A (2000) 2.71
Synthetic circuits integrating logic and memory in living cells. Nat Biotechnol (2013) 2.62
Current issues in mouse genome engineering. Nat Genet (2005) 2.25
Metagenomic analyses: past and future trends. Appl Environ Microbiol (2010) 2.21
Detection of native-like models for amino acid sequences of unknown three-dimensional structure in a data base of known protein conformations. Proteins (1992) 2.11
ACLAME: a CLAssification of Mobile genetic Elements, update 2010. Nucleic Acids Res (2009) 2.07
Alteration of Cre recombinase site specificity by substrate-linked protein evolution. Nat Biotechnol (2001) 1.92
Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy. Curr Gene Ther (2011) 1.76
The molecular genetics of bacteriophage P1. Annu Rev Genet (1983) 1.75
DNA recombination with a heterospecific Cre homolog identified from comparison of the pac-c1 regions of P1-related phages. Nucleic Acids Res (2004) 1.63
Supporting conditional mouse mutagenesis with a comprehensive cre characterization resource. Nat Commun (2012) 1.51
Technical approaches for mouse models of human disease. Dis Model Mech (2011) 1.36
Metagenomic exploration of viruses throughout the Indian Ocean. PLoS One (2012) 1.23
Release of initiation control by a mutational alteration in the R6K pi protein required for plasmid DNA replication. Proc Natl Acad Sci U S A (1983) 1.20
Metagenomics and the protein universe. Curr Opin Struct Biol (2011) 1.18
Highly significant antiviral activity of HIV-1 LTR-specific tre-recombinase in humanized mice. PLoS Pathog (2013) 1.08
VCre/VloxP and SCre/SloxP: new site-specific recombination systems for genome engineering. Nucleic Acids Res (2011) 1.08
Comparative genomics in ecological physiology: toward a more nuanced understanding of acclimation and adaptation. J Exp Biol (2012) 1.04
Crystal structure of a wild-type Cre recombinase-loxP synapse reveals a novel spacer conformation suggesting an alternative mechanism for DNA cleavage activation. Nucleic Acids Res (2003) 1.04
SeLOX--a locus of recombination site search tool for the detection and directed evolution of site-specific recombination systems. Nucleic Acids Res (2010) 1.02
Site-specific recombinases: from tag-and-target- to tag-and-exchange-based genomic modifications. FASEB J (2011) 0.95
Vika/vox, a novel efficient and specific Cre/loxP-like site-specific recombination system. Nucleic Acids Res (2012) 0.92
Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity. Nat Biotechnol (2016) 0.90
Engineering DNA processing enzymes for the postgenomic era. Curr Opin Biotechnol (2009) 0.90
A novel group of diverse Polinton-like viruses discovered by metagenome analysis. BMC Biol (2015) 0.87
Prolonged Cre expression driven by the α-myosin heavy chain promoter can be cardiotoxic. J Mol Cell Cardiol (2015) 0.86
Recombinant DNA technology. Lancet (1982) 0.85
Conditional gene manipulation: Cre-ating a new biological era. J Zhejiang Univ Sci B (2012) 0.85
Towards a more accurate annotation of tyrosine-based site-specific recombinases in bacterial genomes. Mob DNA (2012) 0.83
Engineering of a target site-specific recombinase by a combined evolution- and structure-guided approach. Nucleic Acids Res (2012) 0.82
Dual fluorescent reporter pig for Cre recombination: transgene placement at the ROSA26 locus. PLoS One (2014) 0.82
Cre Recombinase. Microbiol Spectr (2015) 0.82
Excision of a selectable marker gene in transgenic banana using a Cre/lox system controlled by an embryo specific promoter. Plant Mol Biol (2013) 0.81
Visual marker and Agrobacterium-delivered recombinase enable the manipulation of the plastid genome in greenhouse-grown tobacco plants. Plant J (2012) 0.80
Mining environmental high-throughput sequence data sets to identify divergent amplicon clusters for phylogenetic reconstruction and morphotype visualization. Environ Microbiol Rep (2015) 0.79
Synthetic biology: A circuit to remember. Nat Rev Genet (2013) 0.76