Published in BMC Genomics on July 21, 2016
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Pathogen recognition and innate immunity. Cell (2006) 44.14
A map of recent positive selection in the human genome. PLoS Biol (2006) 29.19
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature (2006) 15.48
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet (2007) 14.99
Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? Am J Hum Genet (1962) 13.72
Signals of recent positive selection in a worldwide sample of human populations. Genome Res (2009) 8.38
A genome-scan method to identify selected loci appropriate for both dominant and codominant markers: a Bayesian perspective. Genetics (2008) 6.62
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet (2007) 5.88
STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene. Nucleic Acids Res (2000) 5.68
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet (2009) 5.43
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest (2010) 5.39
Immune signaling by RIG-I-like receptors. Immunity (2011) 5.02
Trends in infectious disease mortality in the United States during the 20th century. JAMA (1999) 4.97
Bacterial invasion: the paradigms of enteroinvasive pathogens. Science (2004) 4.95
The NCBI BioSystems database. Nucleic Acids Res (2009) 4.80
The causes and consequences of HIV evolution. Nat Rev Genet (2004) 4.34
Signatures of positive selection in genes associated with human skin pigmentation as revealed from analyses of single nucleotide polymorphisms. Ann Hum Genet (2007) 4.21
The signature of positive selection on standing genetic variation. Evolution (2005) 4.17
Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans. Nat Genet (2013) 3.89
How culture shaped the human genome: bringing genetics and the human sciences together. Nat Rev Genet (2010) 3.21
Pattern of polymorphism after strong artificial selection in a domestication event. Proc Natl Acad Sci U S A (2004) 3.09
From evolutionary genetics to human immunology: how selection shapes host defence genes. Nat Rev Genet (2009) 2.98
Origins of HIV and the AIDS pandemic. Cold Spring Harb Perspect Med (2011) 2.98
A prospective study of red meat consumption and type 2 diabetes in middle-aged and elderly women: the women's health study. Diabetes Care (2004) 2.57
Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunity. Curr Opin Immunol (2007) 2.48
Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense. PLoS Genet (2009) 2.35
Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature (2009) 2.35
Population differentiation as a test for selective sweeps. Genome Res (2010) 2.08
Positive selection, relaxation, and acceleration in the evolution of the human and chimp genome. PLoS Comput Biol (2006) 1.95
Splanchnic glucose and amino acid metabolism in obesity. J Clin Invest (1974) 1.73
Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection. Am J Hum Genet (2010) 1.71
Chemokines: attractive mediators of the immune response. Semin Immunol (2003) 1.66
Apoptosis in the pathogenesis of systemic lupus erythematosus. Lupus (2008) 1.59
Influence of obesity and type 2 diabetes on gluconeogenesis and glucose output in humans: a quantitative study. Diabetes (2000) 1.57
Natural selection and infectious disease in human populations. Nat Rev Genet (2014) 1.48
Natural selection in a bangladeshi population from the cholera-endemic ganges river delta. Sci Transl Med (2013) 1.39
Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes. Proc Natl Acad Sci U S A (2009) 1.37
Purifying selection maintains highly conserved noncoding sequences in Drosophila. Mol Biol Evol (2007) 1.36
Prevention of overweight and obesity: how effective is the current public health approach. Int J Environ Res Public Health (2010) 1.34
Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice. Genes Cells (2009) 1.28
Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation. Nat Med (2008) 1.27
Genome wide evolutionary analyses reveal serotype specific patterns of positive selection in selected Salmonella serotypes. BMC Evol Biol (2009) 1.26
Comparing gene set analysis methods on single-nucleotide polymorphism data from Genetic Analysis Workshop 16. BMC Proc (2009) 1.26
Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivo. Diabetes (2009) 1.23
Extreme evolutionary disparities seen in positive selection across seven complex diseases. PLoS One (2010) 1.23
Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population. JAMA (2014) 1.22
Signatures of positive selection in Toll-like receptor (TLR) genes in mammals. BMC Evol Biol (2011) 1.17
Evidence for polygenic adaptation to pathogens in the human genome. Mol Biol Evol (2013) 1.16
Mapping sites of positive selection and amino acid diversification in the HIV genome: an alternative approach to vaccine design? Genetics (2004) 1.15
Challenges in human genetic diversity: demographic history and adaptation. Hum Mol Genet (2007) 1.14
Gowinda: unbiased analysis of gene set enrichment for genome-wide association studies. Bioinformatics (2012) 1.11
Genome-wide detection of natural selection in African Americans pre- and post-admixture. Genome Res (2011) 1.09
Thyroid disorders and diabetes mellitus. J Thyroid Res (2011) 1.09
Evolutionary insights into host-pathogen interactions from mammalian sequence data. Nat Rev Genet (2015) 1.06
Targeting apoptosis pathways for new cancer therapeutics. Annu Rev Med (2013) 1.06
Suppressor of cytokine signaling 1 is required for the differentiation of CD4+ T cells. Nat Immunol (2005) 1.05
How bacterial pathogens colonize their hosts and invade deeper tissues. Microbes Infect (2015) 1.04
Mapping of positive selection sites in the HIV-1 genome in the context of RNA and protein structural constraints. Retrovirology (2011) 1.00
Apoptosis and Alzheimer's disease. J Neural Transm (Vienna) (2000) 0.99
Integrin alpha(IIb)beta(3) signaling in platelet adhesion and aggregation. Curr Opin Cell Biol (1999) 0.99
Population genetic analysis of the uncoupling proteins supports a role for UCP3 in human cold resistance. Mol Biol Evol (2010) 0.99
Type 2 diabetes susceptibility gene TCF7L2 and its role in beta-cell function. Diabetes (2009) 0.98
Evolutionary perspectives on the obesity epidemic: adaptive, maladaptive, and neutral viewpoints. Annu Rev Nutr (2013) 0.98
Invasion and multiplication of Helicobacter pylori in gastric epithelial cells and implications for antibiotic resistance. Infect Immun (2010) 0.98
Detecting lineage-specific adaptive evolution of brain-expressed genes in human using rhesus macaque as outgroup. Genomics (2006) 0.96
Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation. PLoS One (2009) 0.96
Revisiting the thrifty gene hypothesis via 65 loci associated with susceptibility to type 2 diabetes. Am J Hum Genet (2014) 0.96
Evolutionary origins of insulin resistance: a behavioral switch hypothesis. BMC Evol Biol (2007) 0.95
Mammalian NPC1 genes may undergo positive selection and human polymorphisms associate with type 2 diabetes. BMC Med (2012) 0.94
Comparison of two major forms of the Shigella virulence plasmid pINV: positive selection is a major force driving the divergence. Infect Immun (2003) 0.94
Positive selection on apoptosis related genes. FEBS Lett (2009) 0.93
Altered T-cell receptor signaling in the pathogenesis of allergic disease. J Allergy Clin Immunol (2011) 0.92
Network-level and population genetics analysis of the insulin/TOR signal transduction pathway across human populations. Mol Biol Evol (2011) 0.90
Insulin resistance and type 2 diabetes. Diabetes (2012) 0.90
IRS2 takes center stage in the development of type 2 diabetes. J Clin Invest (2004) 0.89
Positive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia. Eur J Hum Genet (2013) 0.89
Evodiamine inhibits insulin-stimulated mTOR-S6K activation and IRS1 serine phosphorylation in adipocytes and improves glucose tolerance in obese/diabetic mice. PLoS One (2013) 0.89
The role of insulin receptor substrate-1 gene (IRS1) in type 2 diabetes in Pima Indians. Diabetes (2003) 0.88
Positive evolutionary selection on the RIG-I-like receptor genes in mammals. PLoS One (2013) 0.88
Pathogen-driven selection in the human genome. Int J Evol Biol (2013) 0.85
Human genome variability, natural selection and infectious diseases. Curr Opin Immunol (2014) 0.85
Genes associated with SLE are targets of recent positive selection. Autoimmune Dis (2014) 0.84
Technical note: linkage disequilibrium and disease-associated CTLA4 gene polymorphisms. J Immunol (2001) 0.82
Colon cancer associated genes exhibit signatures of positive selection at functionally significant positions. BMC Evol Biol (2012) 0.80
In obese and non-obese adults, the cis-regulatory rs361072 promoter variant of PIK3CB is associated with insulin resistance not with type 2 diabetes. Mol Genet Metab (2008) 0.79
Whole-genome scan for signatures of recent selection reveals loci associated with important traits in White Leghorn chickens. Poult Sci (2012) 0.78
The effects of purifying selection on patterns of genetic differentiation between Drosophila melanogaster populations. Heredity (Edinb) (2014) 0.78
Evolutionary determinants of genetic variation in susceptibility to infectious diseases in humans. PLoS One (2012) 0.77
Diacylglycerol metabolism attenuates T-cell receptor signaling and alters thymocyte differentiation. Cell Death Dis (2013) 0.77
Evidence of selection at insulin receptor substrate-1 gene loci. Acta Diabetol (2012) 0.77
Characterization and expression of the CXCR1 and CXCR4 in miiuy croaker and evolutionary analysis shows the strong positive selection pressures imposed in mammal CXCR1. Dev Comp Immunol (2013) 0.77
Culture Method and PCR for the Detection of Helicobacter pylori in Drinking Water in Basrah Governorate Iraq. Gastroenterol Res Pract (2012) 0.77
Constraint and adaptation in newt toll-like receptor genes. Genome Biol Evol (2014) 0.77
Detection of selective sweeps in structured populations: a comparison of recent methods. Mol Ecol (2015) 0.77
Comparison of two culture techniques used to detect environmental contamination with Salmonella enterica in a large-animal hospital. J S Afr Vet Assoc (2015) 0.76
Apoptosis and Its Role in Neutrophil Dysfunction in AIDS. Oncologist (1997) 0.76