Phytochemicals Mediate the Expression and Activity of OCTN2 as Activators of the PPARγ/RXRα Pathway.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27445823)

Published in Front Pharmacol on June 29, 2016

Authors

Jian Luo1, Jian Qu2, Rui Yang1, Meng-Xue Ge3, Yin Mei3, Bo-Ting Zhou1, Qiang Qu1

Author Affiliations

1: Department of Pharmacy, Xiangya Hospital, Central South University Changsha, China.
2: Department of Pharmacy, Second Xiangya Hospital and Institute of Clinical Pharmacy, Central South University Changsha, China.
3: Institute of Clinical Pharmacology, Xiangya Hospital, Central South University Changsha, China.

Articles cited by this

Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27

The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature (1998) 13.58

PPARs and the complex journey to obesity. Nat Med (2004) 7.44

Functional variants of OCTN cation transporter genes are associated with Crohn disease. Nat Genet (2004) 5.83

Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res (2001) 5.78

Multiple biological activities of curcumin: a short review. Life Sci (2006) 3.96

Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J Biol Chem (1998) 2.05

Peroxisome proliferator-activated receptor gamma and cancers. Clin Cancer Res (2003) 2.05

A review on the dietary flavonoid kaempferol. Mini Rev Med Chem (2011) 1.96

A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer. Int J Cancer (2007) 1.76

Flavonols and pancreatic cancer risk: the multiethnic cohort study. Am J Epidemiol (2007) 1.69

cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun (1998) 1.59

Peroxisome proliferator-activated receptor structures: ligand specificity, molecular switch and interactions with regulators. Biochim Biophys Acta (2007) 1.50

Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. J Agric Food Chem (2005) 1.40

Thiazolidinediones: effects on insulin resistance and the cardiovascular system. Br J Pharmacol (2007) 1.26

A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention. Food Chem (2012) 1.24

Herbal medicines put into context. BMJ (2003) 1.22

Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance. Cancer Res (2004) 1.20

Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-gamma by flavonoids in mouse macrophages. FEBS Lett (2001) 1.20

Defective urinary carnitine transport in heterozygotes for primary carnitine deficiency. Genet Med (2001) 1.13

Dietary flavonoid intake and lung cancer--a population-based case-control study. Cancer (2008) 1.10

Induction of apoptosis by puerarin in colon cancer HT-29 cells. Cancer Lett (2005) 1.06

Hypoglycemic effects of turmeric (Curcuma longa L. rhizomes) on genetically diabetic KK-Ay mice. Biol Pharm Bull (2005) 1.05

Kaempferol induces apoptosis in glioblastoma cells through oxidative stress. Mol Cancer Ther (2007) 1.05

Peroxisome proliferator-activated receptors as novel targets in lung disease. Chest (2008) 1.04

Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity. Life Sci (2008) 1.04

Oxaliplatin transport mediated by organic cation/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic kidney 293 cells and rat dorsal root ganglion neurons. J Pharmacol Exp Ther (2011) 1.03

Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets. Prostaglandins Leukot Essent Fatty Acids (1995) 0.97

Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting apoptosis caused by down regulation of cMyc. Cancer Cell Int (2010) 0.96

Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats by activation of peroxisome proliferator-activated receptor gamma. Int Immunopharmacol (2006) 0.96

Neuroprotective effects of puerarin against beta-amyloid-induced neurotoxicity in PC12 cells via a PI3K-dependent signaling pathway. Brain Res Bull (2011) 0.96

Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells. J Surg Res (2008) 0.93

Improved blood-brain barrier distribution: effect of borneol on the brain pharmacokinetics of kaempferol in rats by in vivo microdialysis sampling. J Ethnopharmacol (2015) 0.92

Polymorphisms in OCTN1 and OCTN2 transporters genes are associated with prolonged time to progression in unresectable gastrointestinal stromal tumours treated with imatinib therapy. Pharmacol Res (2012) 0.91

Intake of specific carotenoids and flavonoids and the risk of lung cancer in women in Barcelona, Spain. Nutr Cancer (1998) 0.91

Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence. Oncotarget (2016) 0.86

The carnitine transporter SLC22A5 is not a general drug transporter, but it efficiently translocates mildronate. Drug Metab Dispos (2008) 0.86

Curcumin is not a ligand for peroxisome proliferator-activated receptor-γ Gene Ther Mol Biol (2009) 0.85

Carnitine/organic cation transporter OCTN2 (Slc22a5) is responsible for renal secretion of cephaloridine in mice. Drug Metab Dispos (2009) 0.84

Puerarin inhibits growth and induces apoptosis in SMMC-7721 hepatocellular carcinoma cells. Mol Med Rep (2014) 0.84

Peroxisome proliferator-activated receptor gamma (PPARgamma) and colorectal carcinogenesis. J Cancer Res Clin Oncol (2007) 0.84

Anti-inflammatory properties of culinary herbs and spices that ameliorate the effects of metabolic syndrome. Maturitas (2012) 0.83

Puerarin prevents isoprenaline-induced myocardial fibrosis in mice by reduction of myocardial TGF-β1 expression. J Nutr Biochem (2011) 0.83

Curcumin Enhances the Effects of 5-Fluorouracil and Oxaliplatin in Inducing Gastric Cancer Cell Apoptosis Both In Vitro and In Vivo. Oncol Res (2016) 0.82

Colon OCTN2 gene expression is up-regulated by peroxisome proliferator-activated receptor gamma in humans and mice and contributes to local and systemic carnitine homeostasis. J Biol Chem (2010) 0.81

Genetic deficiency of carnitine/organic cation transporter 2 (slc22a5) is associated with altered tissue distribution of its substrate pyrilamine in mice. Biopharm Drug Dispos (2009) 0.81

Dietary modulation of inflammation-induced colorectal cancer through PPARγ. PPAR Res (2009) 0.80

Flavonoids potentiate the efficacy of cytarabine through modulation of drug-induced apoptosis. Neoplasma (2007) 0.80

Curcumin mediates oxaliplatin-acquired resistance reversion in colorectal cancer cell lines through modulation of CXC-Chemokine/NF-κB signalling pathway. Sci Rep (2016) 0.80

Puerarin improve insulin resistance of adipocyte through activating Cb1 binding protein path. Chin J Integr Med (2012) 0.79

Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway. Food Chem Toxicol (2013) 0.79

In silico approach for the discovery of new PPARγ modulators among plant-derived polyphenols. Drug Des Devel Ther (2015) 0.79

Red wine: a source of potent ligands for peroxisome proliferator-activated receptor γ. Food Funct (2010) 0.78

Luteolin potentiates the sensitivity of colorectal cancer cell lines to oxaliplatin through the PPARγ/OCTN2 pathway. Anticancer Drugs (2014) 0.76

Absorptive interactions of concurrent oral administration of (+)-catechin and puerarin in rats and the underlying mechanisms. Acta Pharmacol Sin (2016) 0.76

Production, Characterization and Evaluation of Kaempferol Nanosuspension for Improving Oral Bioavailability. Curr Pharm Biotechnol (2016) 0.76

Kaempferol suppresses lipid accumulation by inhibiting early adipogenesis in 3T3-L1 cells and zebrafish. Food Funct (2015) 0.76