Published in Eur J Immunol on August 29, 2016
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol (2010) 24.08
IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature (2005) 13.23
Triggering the interferon antiviral response through an IKK-related pathway. Science (2003) 11.62
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science (2012) 10.47
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell (2009) 10.11
IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol (2010) 8.97
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol (2006) 7.98
Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7. EMBO J (1998) 7.20
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science (2012) 7.08
TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature (2011) 6.29
The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat Immunol (2011) 5.34
Newcastle disease virus (NDV)-based assay demonstrates interferon-antagonist activity for the NDV V protein and the Nipah virus V, W, and C proteins. J Virol (2003) 4.45
IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. Nat Immunol (2011) 4.18
Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7. FEBS Lett (1998) 3.80
Intracellular DNA recognition. Nat Rev Immunol (2010) 3.70
The structure and mechanism of protein phosphatases: insights into catalysis and regulation. Annu Rev Biophys Biomol Struct (1998) 3.64
DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells. Immunity (2011) 3.01
The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nat Immunol (2010) 2.95
The extended PP1 toolkit: designed to create specificity. Trends Biochem Sci (2010) 2.51
RIGorous detection: exposing virus through RNA sensing. Science (2010) 2.46
Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. Mol Cell Biol (2001) 2.39
Type I interferons in infectious disease. Nat Rev Immunol (2015) 2.37
Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling. Immunity (2013) 2.33
Emerging roles of nuclear protein phosphatases. Nat Rev Mol Cell Biol (2007) 2.28
Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells. Proc Natl Acad Sci U S A (2010) 2.25
Multiple regulatory domains control IRF-7 activity in response to virus infection. J Biol Chem (2000) 2.20
The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat Immunol (2012) 2.11
Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes. J Biol Chem (1998) 2.08
Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. J Virol (2004) 2.06
Antagonism of the phosphatase PP1 by the measles virus V protein is required for innate immune escape of MDA5. Cell Host Microbe (2014) 1.89
IRF7: activation, regulation, modification and function. Genes Immun (2011) 1.80
Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain. Mol Cell Biol (2000) 1.73
Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit. J Biol Chem (1998) 1.68
Regulation of the transcriptional activity of the IRF7 promoter by a pathway independent of interferon signaling. J Biol Chem (2005) 1.45
Ikaros stability and pericentromeric localization are regulated by protein phosphatase 1. J Biol Chem (2009) 1.43
Interferon regulatory factor 7 regulates expression of Epstein-Barr virus latent membrane protein 1: a regulatory circuit. J Virol (2003) 1.42
DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking. Proc Natl Acad Sci U S A (2013) 1.41
Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processing. J Biol Chem (1995) 1.28
Type I IFN system in the development and manifestations of SLE. Curr Opin Rheumatol (2012) 1.26
Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity. FEBS Lett (1997) 1.25
Nuclear organisation of NIPP1, a regulatory subunit of protein phosphatase 1 that associates with pre-mRNA splicing factors. J Cell Sci (1999) 1.19
Diversity and relatedness among the type I interferons. J Interferon Cytokine Res (2004) 1.01
Inhibition of PP1 phosphatase activity by HBx: a mechanism for the activation of hepatitis B virus transcription. Sci Signal (2012) 1.00
The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors. BMC Cancer (2007) 1.00
Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells. Proc Natl Acad Sci U S A (2012) 0.93
Regulation of HIV-1 transcription by protein phosphatase 1. Curr HIV Res (2007) 0.92
Role of protein phosphatase 1 in dephosphorylation of Ebola virus VP30 protein and its targeting for the inhibition of viral transcription. J Biol Chem (2014) 0.91
Interferon signatures in immune disorders and disease. Immunol Cell Biol (2012) 0.89
Protein phosphatase 1-dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cells. J Cell Biochem (2011) 0.88
Identification and functional characterization of inhibitor-3, a regulatory subunit of protein phosphatase 1 in plants. Plant Physiol (2009) 0.88
Direct interaction between myocyte enhancer factor 2 (MEF2) and protein phosphatase 1alpha represses MEF2-dependent gene expression. Mol Cell Biol (2009) 0.87
Hepatitis C virus-induced reduction in miR-181a impairs CD4(+) T-cell responses through overexpression of DUSP6. Hepatology (2015) 0.85
Phosphatase holoenzyme PP1/GADD34 negatively regulates TLR response by inhibiting TAK1 serine 412 phosphorylation. J Immunol (2014) 0.85
Identification and functional characterization of a PP1-binding site in BRCA1. Biochem Biophys Res Commun (2007) 0.85
Human NLRP3 inflammasome senses multiple types of bacterial RNAs. Proc Natl Acad Sci U S A (2014) 0.83
Protein phosphatase PP1 negatively regulates the Toll-like receptor- and RIG-I-like receptor-triggered production of type I interferon by inhibiting IRF3 phosphorylation at serines 396 and 385 in macrophage. Cell Signal (2014) 0.83
Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ. PLoS One (2014) 0.79
PP1 phosphatase is involved in Bcl-2 dephosphorylation after prolonged mitotic arrest induced by paclitaxel. Biochem Biophys Res Commun (2002) 0.76