Published in Mol Syst Biol on July 29, 2016
High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet (2000) 11.80
ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks. Bioinformatics (2009) 8.60
Analysis of protein complexes using mass spectrometry. Nat Rev Mol Cell Biol (2007) 4.70
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature (2000) 4.08
Cbl-b regulates the CD28 dependence of T-cell activation. Nature (2000) 3.89
The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites. Development (1997) 3.78
Targeted disruption of the MHC class II Aa gene in C57BL/6 mice. Int Immunol (1993) 3.73
Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nat Methods (2009) 3.68
The Cbl interactome and its functions. Nat Rev Mol Cell Biol (2005) 3.27
Directed evolution of a monomeric, bright and photostable version of Clavularia cyan fluorescent protein: structural characterization and applications in fluorescence imaging. Biochem J (2006) 3.20
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances. Cell (2015) 3.12
A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science (1995) 2.84
c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation. Nat Immunol (2002) 2.64
Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Nature (2013) 2.33
Tailoring T-cell receptor signals by proximal negative feedback mechanisms. Nat Rev Immunol (2008) 2.06
In vivo discovery of immunotherapy targets in the tumour microenvironment. Nature (2014) 2.05
Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells. Nat Immunol (2001) 2.02
Fine tuning of TCR signaling by CD5. J Immunol (2001) 2.02
TCR affinity and negative regulation limit autoimmunity. Nat Med (2004) 1.94
Transmembrane adaptor proteins: organizers of immunoreceptor signalling. Nat Rev Immunol (2004) 1.92
Bayesian network analysis of signaling networks: a primer. Sci STKE (2005) 1.85
The role of ubiquitylation in receptor endocytosis and endosomal sorting. J Cell Sci (2012) 1.73
Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster. Immunity (2010) 1.56
Quantifying protein interaction dynamics by SWATH mass spectrometry: application to the 14-3-3 system. Nat Methods (2013) 1.56
Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data. BMC Syst Biol (2011) 1.52
Single-step Strep-tag purification for the isolation and identification of protein complexes from mammalian cells. Proteomics (2005) 1.45
Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor. Mol Cell Biol (2003) 1.44
The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis. J Exp Med (2001) 1.40
Insights into the initiation of TCR signaling. Nat Immunol (2014) 1.37
TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin. Oncogene (2004) 1.30
Ablation of Cbl-b provides protection against transplanted and spontaneous tumors. J Clin Invest (2007) 1.29
Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b. Oncogene (2004) 1.24
Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase. J Biol Chem (1999) 1.23
Negative regulation of CD4 lineage development and responses by CD5. J Immunol (1999) 1.20
Interactions of Cbl with two adapter proteins, Grb2 and Crk, upon T cell activation. J Biol Chem (1996) 1.18
Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions. J Immunol (2011) 1.18
The ubiquitously expressed Csk adaptor protein Cbp is dispensable for embryogenesis and T-cell development and function. Mol Cell Biol (2005) 1.11
PI 3-K and T-cell activation: limitations of T-leukemic cell lines as signaling models. Trends Immunol (2001) 1.11
Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell development. EMBO J (2010) 1.11
The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport. J Biol Chem (2003) 1.08
Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub. Nat Immunol (2014) 1.07
CD5 inhibits signaling at the immunological synapse without impairing its formation. J Immunol (2003) 1.06
Negative regulation of lymphocyte development and function by the Cbl family of proteins. Immunol Rev (2008) 1.05
Cbp deficiency alters Csk localization in lipid rafts but does not affect T-cell development. Mol Cell Biol (2005) 1.02
The cytotoxic T cell proteome and its shaping by the kinase mTOR. Nat Immunol (2015) 1.00
Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 and T cell receptor signaling pathways. J Biol Chem (2011) 1.00
Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation. Proc Natl Acad Sci U S A (2011) 0.99
Cbl-b regulates antigen-induced TCR down-regulation and IFN-gamma production by effector CD8 T cells without affecting functional avidity. J Immunol (2007) 0.95
Rho GTPases, phosphoinositides, and actin: a tripartite framework for efficient vesicular trafficking. Small GTPases (2014) 0.93
CD5 signal transduction: positive or negative modulation of antigen receptor signaling. Crit Rev Immunol (2000) 0.93
Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation. Mol Syst Biol (2015) 0.92
K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8(+) T cell activation. Nat Immunol (2015) 0.88
T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency. Proc Natl Acad Sci U S A (2010) 0.88
The role of the E3 ligase Not4 in cotranslational quality control. Front Genet (2014) 0.87
Adoptive transfer of siRNA Cblb-silenced CD8+ T lymphocytes augments tumor vaccine efficacy in a B16 melanoma model. PLoS One (2012) 0.87
The cytoskeletal adaptor protein IQGAP1 regulates TCR-mediated signaling and filamentous actin dynamics. J Immunol (2012) 0.86
Sequence and structure evolved separately in a ribosomal ubiquitin variant. EMBO J (2007) 0.86
Differential ubiquitin binding of the UBA domains from human c-Cbl and Cbl-b: NMR structural and biochemical insights. Protein Sci (2008) 0.86
Protein kinase C activation inhibits tyrosine phosphorylation of Cbl and its recruitment of Src homology 2 domain-containing proteins. J Immunol (1999) 0.85
The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane. Mol Biol Cell (2012) 0.85
T cell activation induces direct binding of the Crk adapter protein to the regulatory subunit of phosphatidylinositol 3-kinase (p85) via a complex mechanism involving the Cbl protein. J Biol Chem (2001) 0.84
A new pathway of CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of Fyn kinase. J Biol Chem (2011) 0.84
Thymocyte activation induces the association of the proto-oncoprotein c-cbl and ras GTPase-activating protein with CD5. Eur J Immunol (1998) 0.83
The carboxy-terminal region of CD5 is required for c-CBL mediated TCR signaling downmodulation in thymocytes. Biochem Biophys Res Commun (2013) 0.81
Early T cell activation: integrating biochemical, structural, and biophysical cues. Annu Rev Immunol (2015) 0.80
c-Cbl mediated ubiquitylation and regulation of cell surface exposure of CD5. Biochem Biophys Res Commun (2010) 0.79
Cbl-family proteins as regulators of cytoskeleton-dependent phenomena. J Cell Physiol (2013) 0.77
Revisiting the Timing of Action of the PAG Adaptor Using Quantitative Proteomics Analysis of Primary T Cells. J Immunol (2015) 0.77
The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor β (PDGFRβ) Internalization and Signaling. J Biol Chem (2016) 0.76
CD6 modulates thymocyte selection and peripheral T cell homeostasis. J Exp Med (2016) 0.92
Dynamics and Transcriptomics of Skin Dendritic Cells and Macrophages in an Imiquimod-Induced, Biphasic Mouse Model of Psoriasis. J Immunol (2015) 0.79
Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations. J Exp Med (2016) 0.78
Revisiting the Timing of Action of the PAG Adaptor Using Quantitative Proteomics Analysis of Primary T Cells. J Immunol (2015) 0.77
The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells. J Exp Med (2016) 0.75
TGFβR signalling controls CD103(+)CD11b(+) dendritic cell development in the intestine. Nat Commun (2017) 0.75