Published in Nat Immunol on March 02, 2014
Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT. J Exp Med (2016) 1.41
The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells. Proc Natl Acad Sci U S A (2014) 1.01
Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction. Structure (2015) 1.00
Initiation of T cell signaling by CD45 segregation at 'close contacts'. Nat Immunol (2016) 0.99
The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters. J Biol Chem (2015) 0.95
A THEMIS:SHP1 complex promotes T-cell survival. EMBO J (2014) 0.92
CD6 modulates thymocyte selection and peripheral T cell homeostasis. J Exp Med (2016) 0.92
Relevance of CD6-Mediated Interactions in the Regulation of Peripheral T-Cell Responses and Tolerance. Front Immunol (2017) 0.82
Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation. Mol Syst Biol (2016) 0.80
GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells. Cell Signal (2015) 0.79
Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells. J Immunol (2015) 0.77
CD6 regulates intestinal ischemia/reperfusion-induced injury by modulating natural IgM-producing B1a cell self-renewal. J Biol Chem (2016) 0.76
The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells. Mol Cell (2015) 0.76
Micro-adhesion rings surrounding TCR microclusters are essential for T cell activation. J Exp Med (2016) 0.75
Multiplex matrix network analysis of protein complexes in the human TCR signalosome. Sci Signal (2016) 0.75
Ubiquitylation as a Rheostat for TCR Signaling: From Targeted Approaches Toward Global Profiling. Front Immunol (2015) 0.75
Blood and Intestine eQTLs from an Anti-TNF-Resistant Crohn's Disease Cohort Inform IBD Genetic Association Loci. Clin Transl Gastroenterol (2016) 0.75
The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells. J Exp Med (2016) 0.75
CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS One (2016) 0.75
Protein networks and activation of lymphocytes. Curr Opin Immunol (2015) 0.75
Precise Temporal Profiling of Signaling Complexes in Primary Cells Using SWATH Mass Spectrometry. Cell Rep (2017) 0.75
Analysis of Phosphorylation-dependent Protein Interactions of Adhesion and Degranulation Promoting Adaptor Protein (ADAP) Reveals Novel Interaction Partners Required for Chemokine-directed T cell Migration. Mol Cell Proteomics (2015) 0.75
Human CD6 Down-Modulation following T-Cell Activation Compromises Lymphocyte Survival and Proliferative Responses. Front Immunol (2017) 0.75
T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab. PLoS One (2017) 0.75
Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol (2004) 101.91
Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics (2003) 100.88
TANDEM: matching proteins with tandem mass spectra. Bioinformatics (2004) 17.41
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet (2009) 7.16
A guided tour of the Trans-Proteomic Pipeline. Proteomics (2010) 5.09
DNA cloning by homologous recombination in Escherichia coli. Nat Biotechnol (2000) 4.75
Targeted disruption of the MHC class II Aa gene in C57BL/6 mice. Int Immunol (1993) 3.73
Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nat Methods (2009) 3.68
LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. Immunity (1998) 3.36
Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. Proc Natl Acad Sci U S A (2002) 3.28
The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules. Cell (1992) 3.11
An integrated workflow for charting the human interaction proteome: insights into the PP2A system. Mol Syst Biol (2009) 2.92
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal (2009) 2.92
Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene. EMBO J (1995) 2.84
Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. J Biol Chem (2010) 2.67
Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon. Science (1992) 2.67
A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science (2002) 2.35
Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Nature (2013) 2.33
STING and the innate immune response to nucleic acids in the cytosol. Nat Immunol (2013) 2.23
Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain. J Exp Med (1993) 2.17
Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor. Immunity (2009) 2.13
The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes. Nat Immunol (2008) 2.12
Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events. J Biol Chem (1993) 2.02
Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. Mol Cell Biol (1998) 2.01
The LAT story: a tale of cooperativity, coordination, and choreography. Cold Spring Harb Perspect Biol (2010) 1.77
Single-step Strep-tag purification for the isolation and identification of protein complexes from mammalian cells. Proteomics (2005) 1.45
RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation. Mol Cell Biol (2007) 1.41
Identifying differences in protein expression levels by spectral counting and feature selection. Genet Mol Res (2008) 1.39
Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76. EMBO J (2003) 1.38
CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76. Mol Cell Biol (2006) 1.35
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Nat Methods (2013) 1.30
Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells. Blood (2005) 1.30
Relevance of CD6-mediated interactions in T cell activation and proliferation. J Immunol (2004) 1.27
Abacus: a computational tool for extracting and pre-processing spectral count data for label-free quantitative proteomic analysis. Proteomics (2011) 1.24
Frontline: Optimal T cell activation requires the engagement of CD6 and CD166. Eur J Immunol (2004) 1.18
A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76. J Exp Med (2007) 1.17
The integrin LFA-1 signals through ZAP-70 to regulate expression of high-affinity LFA-1 on T lymphocytes. Blood (2011) 1.17
The role of the LAT-PLC-gamma1 interaction in T regulatory cell function. J Immunol (2010) 1.14
PI 3-K and T-cell activation: limitations of T-leukemic cell lines as signaling models. Trends Immunol (2001) 1.11
Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes. PLoS Pathog (2013) 1.09
Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors. J Exp Med (1993) 1.01
The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation. J Immunol (2011) 1.01
Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells. Proc Natl Acad Sci U S A (2012) 1.01
Mitogen-activated protein kinase pathway activation by the CD6 lymphocyte surface receptor. J Immunol (2006) 1.00
Transferrin receptor induces tyrosine phosphorylation in T cells and is physically associated with the TCR zeta-chain. J Immunol (1995) 0.97
CD6 attenuates early and late signaling events, setting thresholds for T-cell activation. Eur J Immunol (2011) 0.93
Deletion of the LIME adaptor protein minimally affects T and B cell development and function. Eur J Immunol (2007) 0.90
Role of LAT in the granule-mediated cytotoxicity of CD8 T cells. Mol Cell Biol (2012) 0.88
Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function. Blood (2013) 0.88
Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains. Eur J Immunol (1997) 0.85
Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation. J Cell Biol (2011) 0.85
LAT signaling pathology: an "autoimmune" condition without T cell self-reactivity. Trends Immunol (2010) 0.85
Reconstitution of CD3 zeta coupling to calcium mobilization via genetic complementation. J Biol Chem (1994) 0.79
OpenMS: a flexible open-source software platform for mass spectrometry data analysis. Nat Methods (2016) 0.91
High-efficiency gene transfer to primary T lymphocytes by recombinant adenovirus vectors. J Immunol Methods (2002) 0.85
TRIC: an automated alignment strategy for reproducible protein quantification in targeted proteomics. Nat Methods (2016) 0.81
Dectin-2 deficiency promotes Th2 response and mucin production in the lungs after pulmonary infection with Cryptococcus neoformans. Infect Immun (2014) 0.81
Statistical control of peptide and protein error rates in large-scale targeted data-independent acquisition analyses. Nat Methods (2017) 0.76
C-type Lectin Mincle Recognizes Glucosyl-diacylglycerol of Streptococcus pneumoniae and Plays a Protective Role in Pneumococcal Pneumonia. PLoS Pathog (2016) 0.75
Quantitative proteomics: challenges and opportunities in basic and applied research. Nat Protoc (2017) 0.75
Inference and quantification of peptidoforms in large sample cohorts by SWATH-MS. Nat Biotechnol (2017) 0.75
Application of SWATH Proteomics to Mouse Biology. Curr Protoc Mouse Biol (2017) 0.75
Integrating highly quantitative proteomics and genome-scale metabolic modeling to study pH adaptation in the human pathogen Enterococcus faecalis. NPJ Syst Biol Appl (2016) 0.75