Published in Curr Neurovasc Res on January 01, 2016
Harnessing the Power of SIRT1 and Non-coding RNAs in Vascular Disease. Curr Neurovasc Res (2016) 0.75
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (2005) 38.99
mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol (2010) 21.16
TSC2 mediates cellular energy response to control cell growth and survival. Cell (2003) 20.21
Early detection of undiagnosed diabetes mellitus: a US perspective. Diabetes Metab Res Rev (2000) 7.81
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem J (2008) 7.18
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016) 7.05
Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin. N Engl J Med (2002) 7.00
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr Biol (2006) 5.06
PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations. J Clin Oncol (2012) 4.77
Erythropoietin. Blood (1991) 4.37
Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial. JAMA (2011) 4.09
Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a randomized clinical trial. JAMA (2014) 3.86
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol (2008) 3.50
New avenues of exploration for erythropoietin. JAMA (2005) 3.23
mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res (2011) 3.12
Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice. Diabetes (2011) 2.72
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex. J Biol Chem (2007) 2.50
Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease. Prog Neurobiol (2005) 2.44
Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases. Circulation (2002) 2.37
Resveratrol and cardiovascular health--promising therapeutic or hopeless illusion? Pharmacol Res (2014) 1.77
Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein. J Biol Chem (2009) 1.67
Palmitate activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic islets. PLoS One (2012) 1.66
Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial. Lancet (2015) 1.60
mTOR: on target for novel therapeutic strategies in the nervous system. Trends Mol Med (2012) 1.59
Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase-mediated pathways. Br J Pharmacol (2003) 1.54
The Wnt signaling pathway: aging gracefully as a protectionist? Pharmacol Ther (2008) 1.38
The vitamin nicotinamide: translating nutrition into clinical care. Molecules (2009) 1.36
Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney. Biochem J (2011) 1.34
Erythropoietin involves the phosphatidylinositol 3-kinase pathway, 14-3-3 protein and FOXO3a nuclear trafficking to preserve endothelial cell integrity. Br J Pharmacol (2007) 1.33
Erythropoietin concentrations and neurodevelopmental outcome in preterm infants. Pediatrics (2006) 1.32
Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injury. PLoS One (2012) 1.30
Erythropoietin in the brain: can the promise to protect be fulfilled? Trends Pharmacol Sci (2004) 1.30
Apaf-1, Bcl-xL, cytochrome c, and caspase-9 form the critical elements for cerebral vascular protection by erythropoietin. J Cereb Blood Flow Metab (2003) 1.28
Mechanistic insights into diabetes mellitus and oxidative stress. Curr Med Chem (2007) 1.25
The inhibitor of phagocytosis, O-phospho-L-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina. Exp Eye Res (2010) 1.25
Life span extension and neuronal cell protection by Drosophila nicotinamidase. J Biol Chem (2008) 1.23
Vascular injury during elevated glucose can be mitigated by erythropoietin and Wnt signaling. Curr Neurovasc Res (2007) 1.21
Angiogenesis and plasticity: role of erythropoietin in vascular systems. J Hematother Stem Cell Res (2002) 1.21
Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease. FASEB J (2014) 1.20
Hematopoietic factor erythropoietin fosters neuroprotection through novel signal transduction cascades. J Cereb Blood Flow Metab (2002) 1.19
SIRT1 positively regulates autophagy and mitochondria function in embryonic stem cells under oxidative stress. Stem Cells (2014) 1.19
An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E⁻/⁻ mice. Sci Rep (2014) 1.18
Erythropoietin prevents early and late neuronal demise through modulation of Akt1 and induction of caspase 1, 3, and 8. J Neurosci Res (2003) 1.17
Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling. J Neurosci Res (2011) 1.16
From oxygen to erythropoietin: relevance of hypoxia for retinal development, health and disease. Prog Retin Eye Res (2011) 1.16
SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model. FEBS Lett (2010) 1.15
Targeting disease through novel pathways of apoptosis and autophagy. Expert Opin Ther Targets (2012) 1.14
SIRT1: new avenues of discovery for disorders of oxidative stress. Expert Opin Ther Targets (2012) 1.14
Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin. Prog Neurobiol (2012) 1.13
Erythropoietin on a tightrope: balancing neuronal and vascular protection between intrinsic and extrinsic pathways. Neurosignals (2005) 1.13
Erythropoietin: elucidating new cellular targets that broaden therapeutic strategies. Prog Neurobiol (2008) 1.13
PPARα and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders. Diabetes (2013) 1.12
Erythropoietin mediated bone formation is regulated by mTOR signaling. J Cell Biochem (2012) 1.11
Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance. J Neurosci (2013) 1.10
Proline-rich Akt substrate of 40kDa (PRAS40): a novel downstream target of PI3k/Akt signaling pathway. Cell Signal (2011) 1.10
A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death. J Neurochem (2009) 1.09
MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells. Biochem Pharmacol (2011) 1.09
The role of carbohydrate in recombinant human erythropoietin. Eur J Biochem (1990) 1.07
Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1. Br J Pharmacol (2014) 1.07
ERK and Akt signaling pathways are involved in advanced glycation end product-induced autophagy in rat vascular smooth muscle cells. Int J Mol Med (2012) 1.07
Erythropoietin and oxidative stress. Curr Neurovasc Res (2008) 1.07
High-Dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial. Pediatrics (2016) 1.07
Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy. Br J Pharmacol (2014) 1.06
Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation. Curr Neurovasc Res (2010) 1.06
Oxidative stress: Biomarkers and novel therapeutic pathways. Exp Gerontol (2010) 1.04
Mammalian target of rapamycin signaling in diabetic cardiovascular disease. Cardiovasc Diabetol (2012) 1.04
Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL. Aging (Albany NY) (2012) 1.04
Pharmacologic agents targeting autophagy. J Clin Invest (2015) 1.04
Erythropoietin employs cell longevity pathways of SIRT1 to foster endothelial vascular integrity during oxidant stress. Curr Neurovasc Res (2011) 1.04
Erythropoietin and Wnt1 govern pathways of mTOR, Apaf-1, and XIAP in inflammatory microglia. Curr Neurovasc Res (2011) 1.04
Association between early administration of high-dose erythropoietin in preterm infants and brain MRI abnormality at term-equivalent age. JAMA (2014) 1.03
Triple play: promoting neurovascular longevity with nicotinamide, WNT, and erythropoietin in diabetes mellitus. Biomed Pharmacother (2008) 1.02
Brain erythropoietin receptor expression in Alzheimer disease and mild cognitive impairment. J Neuropathol Exp Neurol (2007) 1.01
EPO relies upon novel signaling of Wnt1 that requires Akt1, FoxO3a, GSK-3β, and β-catenin to foster vascular integrity during experimental diabetes. Curr Neurovasc Res (2011) 1.01
Overnutrition, mTOR signaling, and cardiovascular diseases. Am J Physiol Regul Integr Comp Physiol (2014) 1.01
Adiponectin stimulates autophagy and reduces oxidative stress to enhance insulin sensitivity during high-fat diet feeding in mice. Diabetes (2014) 1.00
Autophagy in hypoxia-ischemia induced brain injury. J Matern Fetal Neonatal Med (2012) 0.99
Raves and risks for erythropoietin. Cytokine Growth Factor Rev (2008) 0.99
New strategies for Alzheimer's disease and cognitive impairment. Oxid Med Cell Longev (2010) 0.98
Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity. Neurosci Res (2012) 0.98
Rapamycin induces of protective autophagy in vascular endothelial cells exposed to oxygen-glucose deprivation. Brain Res (2014) 0.97
Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders. Br J Clin Pharmacol (2015) 0.97
The human glucagon-like peptide-1 analogue liraglutide regulates pancreatic beta-cell proliferation and apoptosis via an AMPK/mTOR/P70S6K signaling pathway. Peptides (2012) 0.97
Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction. Int J Mol Sci (2015) 0.96
Stabilization of human recombinant erythropoietin through interactions with the highly branched N-glycans. J Biochem (2000) 0.96
Erythropoietin, a novel versatile player regulating energy metabolism beyond the erythroid system. Int J Biol Sci (2014) 0.96
Crosstalk Between Endoplasmic Reticulum Stress, Oxidative Stress, and Autophagy: Potential Therapeutic Targets for Acute CNS Injuries. Mol Neurobiol (2014) 0.95
GLP1-derived nonapeptide GLP1(28-36)amide protects pancreatic β-cells from glucolipotoxicity. J Endocrinol (2012) 0.95
Erythropoietin: new directions for the nervous system. Int J Mol Sci (2012) 0.95
Death in the United States, 2011. NCHS Data Brief (2013) 0.95
WISP1 (CCN4) autoregulates its expression and nuclear trafficking of β-catenin during oxidant stress with limited effects upon neuronal autophagy. Curr Neurovasc Res (2012) 0.95
New Insights for Oxidative Stress and Diabetes Mellitus. Oxid Med Cell Longev (2015) 0.94
Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease. Neural Regen Res (2015) 0.94
Tract-based spatial statistics to assess the neuroprotective effect of early erythropoietin on white matter development in preterm infants. Brain (2014) 0.93
Platelet dysfunction in vascular pathologies and how can it be treated. Thromb Res (2011) 0.93
The mTOR signalling cascade: paving new roads to cure neurological disease. Nat Rev Neurol (2016) 0.93
Translating cell survival and cell longevity into treatment strategies with SIRT1. Rom J Morphol Embryol (2011) 0.93
Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease. Expert Opin Investig Drugs (2014) 0.92
Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes. Nat Commun (2014) 0.92
WISP1: Clinical insights for a proliferative and restorative member of the CCN family. Curr Neurovasc Res (2014) 0.88
Cutting through the complexities of mTOR for the treatment of stroke. Curr Neurovasc Res (2014) 0.86
FoxO Transcription Factors and Regenerative Pathways in Diabetes Mellitus. Curr Neurovasc Res (2015) 0.85