Do studies reporting 'U'-shaped serum 25-hydroxyvitamin D-health outcome relationships reflect adverse effects?

PubWeight™: 0.85‹?›

🔗 View Article (PMID 27489574)

Published in Dermatoendocrinol on May 16, 2016

Authors

William B Grant1, Spyridon N Karras2, Heike A Bischoff-Ferrari3, Cedric Annweiler4, Barbara J Boucher5, Asta Juzeniene6, Cedric F Garland7, Michael F Holick8

Author Affiliations

1: Sunlight, Nutrition, and Health Research Center San Francisco , CA, USA.
2: Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki , Thessaloniki, Greece.
3: Department of Geriatrics, University Hospital Zurich, Switzerland Centre on Aging and Mobility, University of Zurich , Switzerland.
4: Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, University Memory Clinic of Angers, UPRES EA 4638, University of Angers , France.
5: Honorary Professor, Blizard Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London , London UK.
6: Oslo University Hospital, The Norwegian Radium Hospital, Institute for Cancer Research, Department of Radiation Biology , Montebello, Oslo, Norway.
7: Department of Family Medicine and Public Health, University of California San Diego , La Jolla, CA USA.
8: Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University Medical Center , Boston, MA, USA.

Articles cited by this

(truncated to the top 100)

Cancer statistics, 2010. CA Cancer J Clin (2010) 103.28

The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab (2010) 13.29

Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA (2010) 11.59

A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med (2012) 6.85

Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ (2003) 6.43

Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA (2005) 5.95

Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med (2009) 5.63

The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes: a trial sequential meta-analysis. Lancet Diabetes Endocrinol (2014) 5.40

Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries. Int J Cancer (2004) 4.10

Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr (2010) 3.31

Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr (2007) 2.94

Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. Autoimmun Rev (2013) 2.87

Effect of annual intramuscular vitamin D on fracture risk in elderly men and women--a population-based, randomized, double-blind, placebo-controlled trial. Rheumatology (Oxford) (2007) 2.81

Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial. JAMA Intern Med (2016) 2.71

Vitamin D for cancer prevention: global perspective. Ann Epidemiol (2009) 2.61

The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease. Contemp Clin Trials (2011) 2.59

Effect of high-dosage cholecalciferol and extended physiotherapy on complications after hip fracture: a randomized controlled trial. Arch Intern Med (2010) 2.59

A prospective nested case-control study of vitamin D status and pancreatic cancer risk in male smokers. Cancer Res (2006) 2.53

Interventions for preventing falls in older people in nursing care facilities and hospitals. Cochrane Database Syst Rev (2010) 2.50

Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studies. Circ Cardiovasc Qual Outcomes (2012) 2.43

Vitamin D for health: a global perspective. Mayo Clin Proc (2013) 2.41

Vitamin D deficiency, muscle function, and falls in elderly people. Am J Clin Nutr (2002) 2.38

A Reverse J-Shaped Association Between Serum 25-Hydroxyvitamin D and Cardiovascular Disease Mortality: The CopD Study. J Clin Endocrinol Metab (2015) 2.36

Infant vitamin d supplementation and allergic conditions in adulthood: northern Finland birth cohort 1966. Ann N Y Acad Sci (2004) 2.28

A reverse J-shaped association of all-cause mortality with serum 25-hydroxyvitamin D in general practice: the CopD study. J Clin Endocrinol Metab (2012) 2.16

Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies. Am J Clin Nutr (2011) 2.16

Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Lancet Diabetes Endocrinol (2014) 2.10

Vitamin D treatment for the prevention of falls in older adults: systematic review and meta-analysis. J Am Geriatr Soc (2010) 2.10

Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care (2013) 1.95

Serum 25-hydroxy vitamin D and prostate cancer risk in a large nested case-control study. Cancer Epidemiol Biomarkers Prev (2011) 1.94

Circulating 25-hydroxyvitamin D levels and frailty status in older women. J Clin Endocrinol Metab (2010) 1.93

Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res (2004) 1.89

High serum 25-hydroxyvitamin D concentrations are associated with a favorable serum lipid profile. Eur J Clin Nutr (2010) 1.85

Serum 25-hydroxyvitamin D and cognitive decline in the very old: the Newcastle 85+ Study. Eur J Neurol (2014) 1.85

Vitamin D-related genetic variation, plasma vitamin D, and risk of lethal prostate cancer: a prospective nested case-control study. J Natl Cancer Inst (2012) 1.79

Vitamin D and the risk of dementia and Alzheimer disease. Neurology (2014) 1.74

Vitamin D status and the risk of major adverse cardiac and cerebrovascular events in cardiac surgery. Eur Heart J (2013) 1.71

Benefit-risk assessment of vitamin D supplementation. Osteoporos Int (2009) 1.70

Serum vitamin D and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian screening trial. Cancer Res (2009) 1.67

Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial. JAMA (2014) 1.66

Vitamin D deficiency predicts prostate biopsy outcomes. Clin Cancer Res (2014) 1.65

Maternal serum 25-hydroxyvitamin D concentrations are associated with small-for-gestational age births in white women. J Nutr (2010) 1.64

Plasma vitamin D and mortality in older men: a community-based prospective cohort study. Am J Clin Nutr (2010) 1.64

Vitamin D levels for preventing acute coronary syndrome and mortality: evidence of a nonlinear association. J Clin Endocrinol Metab (2013) 1.60

Cord blood 25-hydroxyvitamin D levels are associated with aeroallergen sensitization in children from Tucson, Arizona. J Allergy Clin Immunol (2011) 1.51

Are serum levels of vitamin D associated with semen quality? Results from a cross-sectional study in young healthy men. Fertil Steril (2010) 1.48

No association between serum 25-hydroxyvitamin D3 level and performance on psychometric tests in NHANES III. Neuroepidemiology (2007) 1.47

Serum 25-hydroxyvitamin D and IgE - a significant but nonlinear relationship. Allergy (2009) 1.45

Neurosteroid hormone vitamin D and its utility in clinical nutrition. Curr Opin Clin Nutr Metab Care (2007) 1.45

Serum 25-hydroxyvitamin D measurement in a large population survey with statistical harmonization of assay variation to an international standard. J Clin Endocrinol Metab (2007) 1.37

Plasma 25-hydroxyvitamin D and risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev (2011) 1.37

Diagnosis and treatment of vitamin D deficiency. Expert Opin Pharmacother (2008) 1.37

25-hydroxyvitamin D: a difficult analyte. Clin Chem (2012) 1.36

Low serum vitamin D concentrations in Alzheimer's disease: a systematic review and meta-analysis. J Alzheimers Dis (2013) 1.36

D-hormone and the immune system. J Rheumatol Suppl (2005) 1.34

Higher serum vitamin D3 levels are associated with better cognitive test performance in patients with Alzheimer's disease. Dement Geriatr Cogn Disord (2008) 1.33

Vitamin D and health: perspectives from mice and man. J Bone Miner Res (2008) 1.30

Effect of interval between serum draw and follow-up period on relative risk of cancer incidence with respect to 25-hydroxyvitamin D level: Implications for meta-analyses and setting vitamin D guidelines. Dermatoendocrinol (2011) 1.29

Vitamin A deficiency decreases and high dietary vitamin A increases disease severity in the mouse model of asthma. J Immunol (2008) 1.28

Vitamin D insufficiency and diabetes risks. Curr Drug Targets (2011) 1.27

Does vitamin D intake during infancy promote the development of atopic allergy? Acta Derm Venereol (2009) 1.25

Addressing the musculoskeletal components of fracture risk with calcium and vitamin D: a review of the evidence. Calcif Tissue Int (2006) 1.24

Serum vitamin D and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). Am J Epidemiol (2009) 1.23

Vitamin D in systemic and organ-specific autoimmune diseases. Clin Rev Allergy Immunol (2013) 1.23

Effect of Vitamin D Supplementation on Blood Pressure: A Systematic Review and Meta-analysis Incorporating Individual Patient Data. JAMA Intern Med (2015) 1.22

Vitamin D and ageing: neurological issues. Neuropsychobiology (2010) 1.20

Relevance of vitamin D in muscle health. Rev Endocr Metab Disord (2012) 1.19

Predicted vitamin D status and pancreatic cancer risk in two prospective cohort studies. Br J Cancer (2010) 1.19

Evidence for a U-shaped relationship between prehospital vitamin D status and mortality: a cohort study. J Clin Endocrinol Metab (2014) 1.12

Vitamin D and dental caries in controlled clinical trials: systematic review and meta-analysis. Nutr Rev (2012) 1.12

Recent trends in prostate cancer mortality show a continuous decrease in several countries. Int J Cancer (2008) 1.11

Molecular link between vitamin D and cancer prevention. Nutrients (2013) 1.10

Vitamin D deficiency, cognitive impairment and dementia: a systematic review and meta-analysis. Dement Geriatr Cogn Disord (2012) 1.10

Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D. Am J Public Health (2014) 1.10

Meta-analysis of memory and executive dysfunctions in relation to vitamin D. J Alzheimers Dis (2013) 1.09

Vitamin D3 supplementation at 4000 international units per day for one year results in a decrease of positive cores at repeat biopsy in subjects with low-risk prostate cancer under active surveillance. J Clin Endocrinol Metab (2012) 1.08

Plasma vitamin D and prostate cancer risk: results from the Selenium and Vitamin E Cancer Prevention Trial. Cancer Epidemiol Biomarkers Prev (2014) 1.07

Circulating 25-hydroxyvitamin D levels and frailty in older men: the osteoporotic fractures in men study. J Am Geriatr Soc (2010) 1.07

Temporal relationship between vitamin D status and parathyroid hormone in the United States. PLoS One (2015) 1.07

Vitamin D: do we get enough? A discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe. Osteoporos Int (2012) 1.05

Multi-step immunofluorescent analysis of vitamin D receptor loci and myosin heavy chain isoforms in human skeletal muscle. J Mol Histol (2010) 1.03

Fish consumption during pregnancy, prenatal mercury exposure, and anthropometric measures at birth in a prospective mother-infant cohort study in Spain. Am J Clin Nutr (2009) 1.02

Transcriptional targets of the vitamin D3 receptor-mediating cell cycle arrest and differentiation. J Nutr (1999) 1.02

Associations of circulating 25-hydroxyvitamin D with prostate cancer diagnosis, stage and grade. Int J Cancer (2011) 1.01

Vitamin D, PTH, and calcium and the risk of prostate cancer: a prospective nested case-control study. Cancer Causes Control (2012) 1.01

Serum 25-hydroxyvitamin D concentrations and risk of prostate cancer: results from the Prostate Cancer Prevention Trial. Cancer Epidemiol Biomarkers Prev (2014) 1.00

25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and postoperative outcome in cardiac surgery. J Clin Endocrinol Metab (2015) 0.98

Vitamin D, season, and risk of prostate cancer: a nested case-control study within Norwegian health studies. Am J Clin Nutr (2012) 0.98

25-hydroxyvitamin D and breast cancer, colorectal cancer, and colorectal adenomas: case-control versus nested case-control studies. Anticancer Res (2015) 0.98

Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma. Ann N Y Acad Sci (2014) 0.97

Prospective association of 25-hydroxyvitamin d3 and d2 with childhood lung function, asthma, wheezing, and flexural dermatitis. Epidemiology (2013) 0.95

Positive association between circulating 25-hydroxyvitamin D levels and prostate cancer risk: new findings from an updated meta-analysis. J Cancer Res Clin Oncol (2014) 0.95

Early-life supplementation of vitamins A and D, in water-soluble form or in peanut oil, and allergic diseases during childhood. J Allergy Clin Immunol (2006) 0.95

Neyman's bias re-visited. J Clin Epidemiol (2003) 0.93

Post-hoc comparison of vitamin D status at three timepoints during pregnancy demonstrates lower risk of preterm birth with higher vitamin D closer to delivery. J Steroid Biochem Mol Biol (2014) 0.93

Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters. Asian J Androl (2012) 0.91

What is the role of vitamin D in autism? Dermatoendocrinol (2013) 0.89

Developing vitamin D dietary guidelines and the lack of 25-hydroxyvitamin D assay standardization: The ever-present past. J Steroid Biochem Mol Biol (2015) 0.88

Update on the Vitamin D and OmegA-3 trial (VITAL). J Steroid Biochem Mol Biol (2015) 0.85

Circulating 25-Hydroxyvitamin D and Prostate Cancer Survival. Cancer Epidemiol Biomarkers Prev (2016) 0.84

Articles by these authors

The risks and benefits of sun exposure 2016. Dermatoendocrinol (2016) 0.81