Spatiotemporal regulation of enhancers during cardiogenesis.

Model-based analysis of ChIP-Seq (MACS). Genome Biol (2008) 51.63

ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature (2009) 18.38

A user's guide to the encyclopedia of DNA elements (ENCODE). PLoS Biol (2011) 16.53

In vivo enhancer analysis of human conserved non-coding sequences. Nature (2006) 10.60

ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. Genome Res (2012) 9.13

A map of the cis-regulatory sequences in the mouse genome. Nature (2012) 8.74

Germ-line transformation of mice. Annu Rev Genet (1986) 8.67

Building the mammalian heart from two sources of myocardial cells. Nat Rev Genet (2005) 5.51

De novo mutations in histone-modifying genes in congenital heart disease. Nature (2013) 5.15

Transcription factors: from enhancer binding to developmental control. Nat Rev Genet (2012) 5.00

The developmental genetics of congenital heart disease. Nature (2008) 4.61

ChIP-Seq identification of weakly conserved heart enhancers. Nat Genet (2010) 4.32

Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. Cell (2012) 4.22

Ultraconservation identifies a small subset of extremely constrained developmental enhancers. Nat Genet (2008) 3.55

Sequencing depth and coverage: key considerations in genomic analyses. Nat Rev Genet (2014) 3.52

Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart. Proc Natl Acad Sci U S A (2011) 3.18

Emerging properties of animal gene regulatory networks. Nature (2010) 2.89

Cardiovascular disease in Europe 2014: epidemiological update. Eur Heart J (2014) 2.87

Large-scale discovery of enhancers from human heart tissue. Nat Genet (2011) 2.70

Return to the fetal gene program protects the stressed heart: a strong hypothesis. Heart Fail Rev (2007) 2.67

Cardiac chamber formation: development, genes, and evolution. Physiol Rev (2003) 2.40

Roles of cardiac transcription factors in cardiac hypertrophy. Circ Res (2003) 2.31

Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state. Nat Biotechnol (2015) 2.03

Sequentially acting Sox transcription factors in neural lineage development. Genes Dev (2011) 1.97

Genetics of congenital heart disease: the glass half empty. Circ Res (2013) 1.90

Genome-wide detection of DNase I hypersensitive sites in single cells and FFPE tissue samples. Nature (2015) 1.86

Rapid and pervasive changes in genome-wide enhancer usage during mammalian development. Cell (2013) 1.79

Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium. Proc Natl Acad Sci U S A (2012) 1.73

Long noncoding RNAs and microRNAs in cardiovascular pathophysiology. Circ Res (2015) 1.55

Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function. J Clin Invest (2011) 1.46

Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer. J Clin Invest (2012) 1.43

Transcription factor pathways and congenital heart disease. Curr Top Dev Biol (2012) 1.41

Regulatory variation in a TBX5 enhancer leads to isolated congenital heart disease. Hum Mol Genet (2012) 1.34

Application of microRNAs in diagnosis and treatment of cardiovascular disease. Acta Physiol (Oxf) (2014) 1.27

In pursuit of design principles of regulatory sequences. Nat Rev Genet (2014) 1.22

Clonal analysis reveals common lineage relationships between head muscles and second heart field derivatives in the mouse embryo. Development (2010) 1.21

Hoxa2 selectively enhances Meis binding to change a branchial arch ground state. Dev Cell (2015) 1.19

A common genetic variant within SCN10A modulates cardiac SCN5A expression. J Clin Invest (2014) 1.17

Direct cardiac reprogramming: progress and challenges in basic biology and clinical applications. Circ Res (2015) 1.16

Of mice and men: molecular genetics of congenital heart disease. Cell Mol Life Sci (2013) 1.10

HEART DEVELOPMENT. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts. Science (2015) 1.09

Pitx2, an atrial fibrillation predisposition gene, directly regulates ion transport and intercalated disc genes. Circ Cardiovasc Genet (2014) 1.07

Atrial identity is determined by a COUP-TFII regulatory network. Dev Cell (2013) 1.01

Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility. Epigenetics Chromatin (2015) 0.97

NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets. Elife (2015) 0.96

Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease. Nat Commun (2014) 0.96

Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure. Eur Heart J (2016) 0.91

Single molecule and single cell epigenomics. Methods (2014) 0.89

Investigating the transcriptional control of cardiovascular development. Circ Res (2015) 0.87

Organogenesis of the vertebrate heart. Wiley Interdiscip Rev Dev Biol (2012) 0.87

Distal enhancers: new insights into heart development and disease. Trends Cell Biol (2013) 0.86

Histone H3 globular domain acetylation identifies a new class of enhancers. Nat Genet (2016) 0.84

Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis. Cell (2016) 0.84

Foxd3: A Repressor, an Activator, or Both? Cell Stem Cell (2016) 0.82

A common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node. Development (2015) 0.81

Transcription factor ISL1 is essential for pacemaker development and function. J Clin Invest (2015) 0.81

Mechanisms of epigenetic and cell-type specific regulation of Hey target genes in ES cells and cardiomyocytes. J Mol Cell Cardiol (2014) 0.79

Recent advances in direct cardiac reprogramming. Curr Opin Genet Dev (2015) 0.78

Sequential Binding of MEIS1 and NKX2-5 on the Popdc2 Gene: A Mechanism for Spatiotemporal Regulation of Enhancers during Cardiogenesis. Cell Rep (2015) 0.78

OccuPeak: ChIP-Seq peak calling based on internal background modelling. PLoS One (2014) 0.78

Recounting Cardiac Cellular Composition. Circ Res (2016) 0.78

Identification of a regulatory domain controlling the Nppa-Nppb gene cluster during heart development and stress. Development (2016) 0.76