Published in Annu Rev Genet on January 01, 1986
Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. Proc Natl Acad Sci U S A (1997) 8.35
Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes. Nat Genet (2008) 5.50
Introns increase transcriptional efficiency in transgenic mice. Proc Natl Acad Sci U S A (1988) 5.18
Site-specific recombination of a transgene in fertilized eggs by transient expression of Cre recombinase. Proc Natl Acad Sci U S A (1995) 4.28
The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells. J Exp Med (1988) 3.80
A large-scale insertional mutagenesis screen in zebrafish. Genes Dev (1999) 3.57
Heterologous introns can enhance expression of transgenes in mice. Proc Natl Acad Sci U S A (1991) 3.34
A beta-galactosidase hybrid protein targeted to nuclei as a marker for developmental studies. Proc Natl Acad Sci U S A (1987) 3.23
The variability in activity of the universally expressed human cytomegalovirus immediate early gene 1 enhancer/promoter in transgenic mice. Nucleic Acids Res (1991) 2.93
Single-copy transgenic mice with chosen-site integration. Proc Natl Acad Sci U S A (1996) 2.84
Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (1995) 2.79
Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo. Proc Natl Acad Sci U S A (1989) 2.54
High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene. Mol Cell Biol (1989) 2.45
High-level erythroid expression of human alpha-globin genes in transgenic mice. Proc Natl Acad Sci U S A (1989) 2.26
Muscle creatine kinase sequence elements regulating skeletal and cardiac muscle expression in transgenic mice. Mol Cell Biol (1989) 2.24
Forward and reverse genetic approaches to behavior in the mouse. Science (1994) 2.20
Reduced life span of anergic self-reactive B cells in a double-transgenic model. J Exp Med (1994) 2.15
Transgenic mice containing intestinal fatty acid-binding protein-human growth hormone fusion genes exhibit correct regional and cell-specific expression of the reporter gene in their small intestine. Proc Natl Acad Sci U S A (1988) 2.12
The rat elastase I regulatory element is an enhancer that directs correct cell specificity and developmental onset of expression in transgenic mice. Mol Cell Biol (1987) 2.12
The structure of the human CD2 gene and its expression in transgenic mice. EMBO J (1988) 2.00
20 years studying p53 functions in genetically engineered mice. Nat Rev Cancer (2009) 2.00
Podocyte-specific overexpression of the antioxidant metallothionein reduces diabetic nephropathy. J Am Soc Nephrol (2008) 1.94
Influence of flanking sequences on variability in expression levels of an introduced gene in transgenic tobacco plants. Nucleic Acids Res (1988) 1.89
Human erythropoietin gene expression in transgenic mice: multiple transcription initiation sites and cis-acting regulatory elements. Mol Cell Biol (1990) 1.88
Transgenic mice produced by retroviral transduction of male germ-line stem cells. Proc Natl Acad Sci U S A (2001) 1.83
Recent advances in gene mutagenesis by site-directed recombination. J Clin Invest (1996) 1.82
Distinct positive and negative elements control the limited hepatocyte and choroid plexus expression of transthyretin in transgenic mice. EMBO J (1990) 1.78
The mouse mammary tumor virus long terminal repeat directs expression in epithelial and lymphoid cells of different tissues in transgenic mice. J Virol (1987) 1.75
Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice. Mol Cell Biol (1993) 1.75
High-frequency germ-line transmission of plasmid DNA sequences injected into fertilized zebrafish eggs. Proc Natl Acad Sci U S A (1991) 1.73
Bilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoter. J Cell Biol (1992) 1.70
Replication and gene expression of hepatitis B virus in a transgenic mouse that contains the complete viral genome. J Virol (1988) 1.68
Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cells. J Exp Med (1989) 1.67
Instability of long inverted repeats within mouse transgenes. EMBO J (1996) 1.67
Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice. Mol Cell Biol (1992) 1.65
Human poliovirus receptor gene expression and poliovirus tissue tropism in transgenic mice. J Virol (1992) 1.65
Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice. Mol Cell Biol (1992) 1.62
Experimental models of hepatocellular carcinoma. J Hepatol (2008) 1.61
Progressive glomerulosclerosis develops in transgenic mice chronically expressing growth hormone and growth hormone releasing factor but not in those expressing insulinlike growth factor-1. Am J Pathol (1988) 1.55
The human growth hormone gene is regulated by a multicomponent locus control region. Mol Cell Biol (1995) 1.54
E-box sites and a proximal regulatory region of the muscle creatine kinase gene differentially regulate expression in diverse skeletal muscles and cardiac muscle of transgenic mice. Mol Cell Biol (1996) 1.54
CRISPR-Cas9 genome editing of a single regulatory element nearly abolishes target gene expression in mice--brief report. Arterioscler Thromb Vasc Biol (2014) 1.53
Inducible and tissue-specific expression of human C-reactive protein in transgenic mice. EMBO J (1987) 1.51
A milk protein gene promoter directs the expression of human tissue plasminogen activator cDNA to the mammary gland in transgenic mice. Proc Natl Acad Sci U S A (1988) 1.49
High blood pressure in transgenic mice carrying the rat angiotensinogen gene. EMBO J (1992) 1.48
Myosin light chain enhancer activates muscle-specific, developmentally regulated gene expression in transgenic mice. Proc Natl Acad Sci U S A (1989) 1.46
Expression of the human beta-globin gene after retroviral transfer into murine erythroleukemia cells and human BFU-E cells. Mol Cell Biol (1988) 1.45
NMR detection of creatine kinase expressed in liver of transgenic mice: determination of free ADP levels. Proc Natl Acad Sci U S A (1990) 1.45
Retroviral gene transfer into primary hepatocytes: implications for genetic therapy of liver-specific functions. Proc Natl Acad Sci U S A (1987) 1.44
Expression in transgenic mice of class I histocompatibility antigens controlled by the metallothionein promoter. Proc Natl Acad Sci U S A (1989) 1.44
The marks, mechanisms and memory of epigenetic states in mammals. Biochem J (2001) 1.43
High expression of human beta S- and alpha-globins in transgenic mice: hemoglobin composition and hematological consequences. Proc Natl Acad Sci U S A (1992) 1.42
Requirement for the simian virus 40 small tumor antigen in tumorigenesis in transgenic mice. Mol Cell Biol (1988) 1.40
An upstream regulatory region mediates high-level, tissue-specific expression of the human alpha 1(I) collagen gene in transgenic mice. Mol Cell Biol (1991) 1.36
Expression of the human beta-globin gene following retroviral-mediated transfer into multipotential hematopoietic progenitors of mice. Proc Natl Acad Sci U S A (1988) 1.36
Tissue-specific and insulin-dependent expression of a pancreatic amylase gene in transgenic mice. Mol Cell Biol (1987) 1.35
Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins. Mol Cell Biol (1988) 1.35
Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4). J Clin Invest (1995) 1.35
LCR/MEL: a versatile system for high-level expression of heterologous proteins in erythroid cells. Nucleic Acids Res (1992) 1.34
Coordinate expression of the endogenous p53 gene in beta cells of transgenic mice expressing hybrid insulin-SV40 T antigen genes. EMBO J (1987) 1.32
Heart and bone tumors in transgenic mice. Proc Natl Acad Sci U S A (1988) 1.31
An upstream region of the mouse ZP3 gene directs expression of firefly luciferase specifically to growing oocytes in transgenic mice. Proc Natl Acad Sci U S A (1990) 1.30
A cell-specific enhancer far upstream of the mouse tyrosinase gene confers high level and copy number-related expression in transgenic mice. EMBO J (1994) 1.27
Human cytomegalovirus (HCMV) immediate-early enhancer/promoter specificity during embryogenesis defines target tissues of congenital HCMV infection. J Virol (1995) 1.27
Analysis of muscle creatine kinase gene regulatory elements in skeletal and cardiac muscles of transgenic mice. Mol Cell Biol (1996) 1.27
Position-independent transgene expression mediated by boundary elements from the apolipoprotein B chromatin domain. Mol Cell Biol (1995) 1.26
Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen. Mol Cell Biol (1994) 1.26
An ovine transgenic Huntington's disease model. Hum Mol Genet (2010) 1.24
Shared role for differentially methylated domains of imprinted genes. Mol Cell Biol (2002) 1.24
Transgenic mice generated by pronuclear injection of a yeast artificial chromosome. Nucleic Acids Res (1992) 1.24
The cytoplasmic domains of immunoglobulin (Ig) alpha and Ig beta can independently induce the precursor B cell transition and allelic exclusion. J Exp Med (1995) 1.23
Unexpected thymic hyperplasia in transgenic mice harboring a neuronal promoter fused with simian virus 40 large T antigen. Mol Cell Biol (1987) 1.23
Refined human artificial chromosome vectors for gene therapy and animal transgenesis. Gene Ther (2010) 1.23
Transgenic mice express the human phenylethanolamine N-methyltransferase gene in adrenal medulla and retina. Proc Natl Acad Sci U S A (1988) 1.22
Transgenic mouse model of AA amyloidosis. Am J Pathol (1999) 1.21
The chicken skeletal muscle alpha-actin promoter is tissue specific in transgenic mice. Mol Cell Biol (1989) 1.21
Analysis of the integrant in MyK-103 transgenic mice in which males fail to transmit the integrant. Mol Cell Biol (1987) 1.21
Delayed thymocyte development induced by augmented expression of p56lck. J Exp Med (1991) 1.20
Genetic ablation in transgenic mice with an attenuated diphtheria toxin A gene. Mol Cell Biol (1990) 1.20
A Mup promoter-thymidine kinase reporter gene shows relaxed tissue-specific expression and confers male sterility upon transgenic mice. Mol Cell Biol (1988) 1.18
Prenatal lethality in a transgenic mouse line is the result of a chromosomal translocation. Proc Natl Acad Sci U S A (1988) 1.17
Tissue-specific expression of the rat beta-casein gene in transgenic mice. Nucleic Acids Res (1988) 1.16
Large-scale identification of sequence variants influencing human transcription factor occupancy in vivo. Nat Genet (2015) 1.16
Gene transactivation mediated by the TAT gene of human immunodeficiency virus in transgenic mice. Nucleic Acids Res (1988) 1.15
Tissue-specific and cell surface expression of human major histocompatibility complex class I heavy (HLA-B7) and light (beta 2-microglobulin) chain genes in transgenic mice. Proc Natl Acad Sci U S A (1988) 1.15
The developmental regulation of the human zeta-globin gene in transgenic mice employing beta-galactosidase as a reporter gene. Nucleic Acids Res (1992) 1.14
Lost in transgenesis: a user's guide for genetically manipulating the mouse in cardiac research. Circ Res (2012) 1.14
Appropriate in vivo expression of a muscle-specific promoter by using avian retroviral vectors for gene transfer [corrected]. J Virol (1992) 1.13
The LCR-like alpha-globin positive regulatory element functions as an enhancer in transiently transfected cells during erythroid differentiation. Nucleic Acids Res (1992) 1.13
Transcriptional promiscuity of the human alpha-globin gene. Mol Cell Biol (1989) 1.12
Transcriptional insulation of the human keratin 18 gene in transgenic mice. Mol Cell Biol (1993) 1.11
Alu sequence involvement in transcriptional insulation of the keratin 18 gene in transgenic mice. Mol Cell Biol (1993) 1.11
A bcr-v-abl oncogene induces lymphomas in transgenic mice. Mol Cell Biol (1989) 1.10
Dissecting a locus control region: facilitation of enhancer function by extended enhancer-flanking sequences. Mol Cell Biol (1995) 1.08
Transgenic mice overexpressing the complement inhibitor crry as a soluble protein are protected from antibody-induced glomerular injury. J Exp Med (1998) 1.08
A 500-bp region, approximately 40 kb upstream of the human CYP19 (aromatase) gene, mediates placenta-specific expression in transgenic mice. Proc Natl Acad Sci U S A (1999) 1.08
Genomic analysis using a yeast artificial chromosome library with mouse DNA inserts. Proc Natl Acad Sci U S A (1992) 1.07
T antigen transgenic mouse models. Semin Cancer Biol (2009) 1.06
Differential regulation of rat beta-casein-chloramphenicol acetyltransferase fusion gene expression in transgenic mice. Mol Cell Biol (1989) 1.06
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature (1986) 14.56
Magnesium precipitation of ribonucleoprotein complexes. Expedient techniques for the isolation of undergraded polysomes and messenger ribonucleic acid. Biochemistry (1974) 11.67
Transcriptional regulation of the ovalbumin and conalbumin genes by steroid hormones in chick oviduct. J Biol Chem (1979) 9.48
Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs. Proc Natl Acad Sci U S A (1985) 7.32
Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature (2001) 6.36
Erythroid-specific expression of human beta-globin genes in transgenic mice. EMBO J (1985) 5.84
Introns increase transcriptional efficiency in transgenic mice. Proc Natl Acad Sci U S A (1988) 5.18
Regulation of metallothionein--thymidine kinase fusion plasmids injected into mouse eggs. Nature (1982) 5.14
A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene. Proc Natl Acad Sci U S A (1984) 5.08
Structure of mouse metallothionein-I gene and its mRNA. Nature (1981) 5.06
Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport. Nat Cell Biol (1999) 4.76
A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice. Genes Dev (1989) 4.60
Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring. Cell (1982) 4.60
The mouse metallothionein-I gene is transcriptionally regulated by cadmium following transfection into human or mouse cells. Cell (1982) 4.55
An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice. Genes Dev (1987) 4.48
Ovalbumin: a secreted protein without a transient hydrophobic leader sequence. Proc Natl Acad Sci U S A (1978) 4.46
Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature (1982) 4.30
Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell (1981) 4.23
Transcriptional regulation of the mouse metallothionein-I gene by heavy metals. J Biol Chem (1981) 4.20
Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell (1990) 4.05
Human gamma- to beta-globin gene switching in transgenic mice. Genes Dev (1990) 4.04
Metallothionein-human GH fusion genes stimulate growth of mice. Science (1983) 4.03
Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene. Cell (1987) 4.02
Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature (1996) 3.99
Two 3' sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice. Proc Natl Acad Sci U S A (1987) 3.81
The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells. J Exp Med (1988) 3.80
DNA methylation controls the inducibility of the mouse metallothionein-I gene lymphoid cells. Cell (1981) 3.67
Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell (1989) 3.60
Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell (1984) 3.56
Diversity of alpha-fetoprotein gene expression in mice is generated by a combination of separate enhancer elements. Science (1987) 3.44
Building a metal-responsive promoter with synthetic regulatory elements. Mol Cell Biol (1985) 3.39
Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet (1999) 3.37
Heterologous introns can enhance expression of transgenes in mice. Proc Natl Acad Sci U S A (1991) 3.34
Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene. Cell (1991) 3.31
A practical approach for quantitating specific mRNAs by solution hybridization. Anal Biochem (1983) 3.30
Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science (1996) 3.28
Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice. Science (1990) 3.26
Regulation, linkage, and sequence of mouse metallothionein I and II genes. Mol Cell Biol (1984) 3.25
Replacement of diseased mouse liver by hepatic cell transplantation. Science (1994) 3.18
Isolation and characterization of the mouse metallothionein-I gene. Proc Natl Acad Sci U S A (1980) 3.17
The effect of cells transferred into the mouse blastocyst on subsequent development. J Exp Med (1974) 3.17
Ovalbumin messenger ribonucleic acid translation. Comparable rates of polypeptide initiation and elongation on ovalbumin and globin messenger ribonucleic acid in a rabbit reticulocyte lysate. J Biol Chem (1973) 3.13
Amplification of the metallothionein-I gene in cadmium-resistant mouse cells. Proc Natl Acad Sci U S A (1981) 3.11
Transplantation of testis germinal cells into mouse seminiferous tubules. Int J Dev Biol (1997) 3.10
Identification and isolation of ovalbumin-synthesizing polysomes. I. Specific binding of 125 I-anti-ovalbumin to polysomes. J Biol Chem (1972) 2.96
Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice. J Virol (1986) 2.94
beta1- and alpha6-integrin are surface markers on mouse spermatogonial stem cells. Proc Natl Acad Sci U S A (1999) 2.91
Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell (1995) 2.89
Correlation of procollagen mRNA levels in normal and transformed chick embryo fibroblasts with different rates of procollagen synthesis. Biochemistry (1978) 2.85
Noradrenaline is essential for mouse fetal development. Nature (1995) 2.84
Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice. Nature (1985) 2.77
Regulation of protein synthesis in chick oviduct. I. Independent regulation of ovalbumin, conalbumin, ovomucoid, and lysozyme induction. J Biol Chem (1972) 2.76
Quantitation of parameters that determine the rate of ovalbumin synthesis. Cell (1975) 2.74
Modulation of ovalbumin synthesis by estradiol-17 beta and actinomycin D as studied in explants of chick oviduct in culture. J Biol Chem (1971) 2.73
Tissue-specific expression of the rat pancreatic elastase I gene in transgenic mice. Cell (1984) 2.59
Identification of multiple metal regulatory elements in mouse metallothionein-I promoter by assaying synthetic sequences. Nature (1985) 2.58
Transcriptional regulation of mouse liver metallothionein-I gene by glucocorticoids. Nature (1981) 2.58
Ethanol consumption and resistance are inversely related to neuropeptide Y levels. Nature (1998) 2.57
Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene. Proc Natl Acad Sci U S A (1999) 2.50
Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline. Nature (1997) 2.47
A transgenic mouse model of the chronic hepatitis B surface antigen carrier state. Science (1985) 2.47
Genetically haploid spermatids are phenotypically diploid. Nature (1989) 2.45
Prevention of NH2-terminal acetylation of proteins synthesized in cell-free systems. J Biol Chem (1977) 2.38
Transplantation of male germ line stem cells restores fertility in infertile mice. Nat Med (2000) 2.37
Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature (1995) 2.37
The dopamine beta-hydroxylase gene promoter directs expression of E. coli lacZ to sympathetic and other neurons in adult transgenic mice. Neuron (1991) 2.37
Spermatid-specific expression of protamine 1 in transgenic mice. Proc Natl Acad Sci U S A (1987) 2.36
Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells. Cell (1988) 2.36
Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice. Science (1987) 2.35
Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc Natl Acad Sci U S A (1994) 2.34
Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice. Cell (1987) 2.32