A Highly Polymorphic Copy Number Variant in the NSF Gene is Associated with Cocaine Dependence.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27498889)

Published in Sci Rep on August 08, 2016

Authors

Judit Cabana-Domínguez1,2,3,4, Carlos Roncero5,6,7,8, Lara Grau-López5,6,7,8, Laia Rodríguez-Cintas6,7, Carmen Barral5,6,7,8, Alfonso C Abad5,6, Galina Erikson9, Nathan E Wineinger9, Bàrbara Torrico1,2,3,4, Concepció Arenas1, Miquel Casas5,7,8, Marta Ribasés5,8,10, Bru Cormand1,2,3,4, Noèlia Fernàndez-Castillo1,2,3,4

Author Affiliations

1: Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Catalonia, Spain.
2: Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Spain.
3: Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Catalonia, Spain.
4: Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, Esplugues, Barcelona, Catalonia, Spain.
5: Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Catalonia, Spain.
6: Addiction and Dual Diagnosis Unit Clinic Vall Hebron, Psychiatric Services, Hospital Universitari Vall d'Hebron-ASPB, Barcelona, Catalonia, Spain.
7: Psychiatric Department and Legal Medicine. Universitat Autònoma de Barcelona, Catalonia, Spain.
8: Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain.
9: Scripps Translational Science Institute, La Jolla, CA, United States of America.
10: Psychiatric Genetics Unit, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.

Articles cited by this

Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27

A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res (1988) 77.80

Finding the missing heritability of complex diseases. Nature (2009) 67.95

A common inversion under selection in Europeans. Nat Genet (2005) 13.66

Diversity of human copy number variation and multicopy genes. Science (2010) 8.97

Diet and the evolution of human amylase gene copy number variation. Nat Genet (2007) 8.64

Structural variation in the human genome and its role in disease. Annu Rev Med (2010) 7.85

Genomic disorders: molecular mechanisms for rearrangements and conveyed phenotypes. PLoS Genet (2005) 7.60

CNVs: harbingers of a rare variant revolution in psychiatric genetics. Cell (2012) 4.81

Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases. Hum Mol Genet (2007) 4.07

Interaction of the N-ethylmaleimide-sensitive factor with AMPA receptors. Neuron (1998) 3.90

Drug addiction as a pathology of staged neuroplasticity. Neuropsychopharmacology (2007) 3.73

From first drug use to drug dependence; developmental periods of risk for dependence upon marijuana, cocaine, and alcohol. Neuropsychopharmacology (2002) 3.56

Illicit psychoactive substance use, heavy use, abuse, and dependence in a US population-based sample of male twins. Arch Gen Psychiatry (2000) 3.33

Evaluating the comparability of gene expression in blood and brain. Am J Med Genet B Neuropsychiatr Genet (2006) 3.19

Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction. J Neurosci (2000) 3.19

The dopamine hypothesis of the reinforcing properties of cocaine. Trends Neurosci (1991) 3.07

Glutamatergic substrates of drug addiction and alcoholism. Biochem Pharmacol (2007) 3.06

NSF binding to GluR2 regulates synaptic transmission. Neuron (1998) 2.92

Neuroplasticity in the mesolimbic dopamine system and cocaine addiction. Br J Pharmacol (2008) 2.83

Copy number variants, diseases and gene expression. Hum Mol Genet (2009) 2.66

A cannabinoid mechanism in relapse to cocaine seeking. Nat Med (2001) 2.65

Reward deficiency syndrome: genetic aspects of behavioral disorders. Prog Brain Res (2000) 2.58

Role of dopamine, the frontal cortex and memory circuits in drug addiction: insight from imaging studies. Neurobiol Learn Mem (2002) 2.50

The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs. Neuron (1998) 2.25

NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex. Neuron (2002) 1.83

Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. J Psychopharmacol (1999) 1.78

Membrane fusion: SNAREs and regulation. Cell Mol Life Sci (2008) 1.74

Cocaine use, abuse and dependence in a population-based sample of female twins. Br J Psychiatry (1998) 1.66

The subcellular distribution of GABARAP and its ability to interact with NSF suggest a role for this protein in the intracellular transport of GABA(A) receptors. Mol Cell Neurosci (2001) 1.60

Neurobiology of cocaine addiction: implications for new pharmacotherapy. Am J Addict (2007) 1.59

Modafinil and cocaine: a double-blind, placebo-controlled drug interaction study. Drug Alcohol Depend (2003) 1.50

Cannabinoid CB1 receptors control conditioned drug seeking. Trends Pharmacol Sci (2005) 1.45

Relating CNVs to transcriptome data at fine resolution: assessment of the effect of variant size, type, and overlap with functional regions. Genome Res (2011) 1.42

Lack of CB1 cannabinoid receptor impairs cocaine self-administration. Neuropsychopharmacology (2005) 1.41

GABAA receptor-associated protein traffics GABAA receptors to the plasma membrane in neurons. J Neurosci (2004) 1.28

Relationship between psychostimulant-induced "high" and dopamine transporter occupancy. Proc Natl Acad Sci U S A (1996) 1.27

Binding of the beta2 adrenergic receptor to N-ethylmaleimide-sensitive factor regulates receptor recycling. J Biol Chem (2001) 1.23

SNARE-complex disassembly by NSF follows synaptic-vesicle fusion. Proc Natl Acad Sci U S A (2001) 1.19

Nucleus accumbens dopamine release modulation by mesolimbic GABAA receptors-an in vivo electrochemical study. Brain Res (1998) 1.18

Neurobiology of cocaine abuse. Trends Pharmacol Sci (1992) 1.17

Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. Nat Neurosci (2010) 1.13

Human genes involved in copy number variation: mechanisms of origin, functional effects and implications for disease. Cytogenet Genome Res (2009) 1.13

Regulation of neurotransmitter release kinetics by NSF. Science (1998) 1.13

GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats. PLoS One (2012) 1.12

Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking. J Biol Chem (2004) 1.09

GABAergic attenuation of cocaine-induced dopamine release and locomotor activity. Synapse (1997) 1.05

Glutamate: the new frontier in pharmacotherapy for cocaine addiction. CNS Neurol Disord Drug Targets (2008) 1.04

A novel site of action for alpha-SNAP in the SNARE conformational cycle controlling membrane fusion. Mol Biol Cell (2007) 1.04

Tiagabine increases cocaine-free urines in cocaine-dependent methadone-treated patients: results of a randomized pilot study. Addiction (2003) 1.00

GABAA receptor trafficking is regulated by protein kinase C(epsilon) and the N-ethylmaleimide-sensitive factor. J Neurosci (2010) 0.99

Effects of pharmacologic increases in brain GABA levels on cocaine-induced changes in extracellular dopamine. Synapse (1998) 0.91

Coordinated action of NSF and PKC regulates GABAB receptor signaling efficacy. EMBO J (2006) 0.91

Distinct in vitro interaction pattern of dopamine receptor subtypes with adaptor proteins involved in post-endocytotic receptor targeting. FEBS Lett (2004) 0.87

Effect of homozygous deletions at 22q13.1 on alcohol dependence severity and cue-elicited BOLD response in the precuneus. Addict Biol (2011) 0.86

Association study of 37 genes related to serotonin and dopamine neurotransmission and neurotrophic factors in cocaine dependence. Genes Brain Behav (2013) 0.82

N-ethylmaleimide-sensitive factor interacts with the serotonin transporter and modulates its trafficking: implications for pathophysiology in autism. Mol Autism (2014) 0.82

The genetic effect of copy number variations on the risk of alcoholism in a Korean population. Alcohol Clin Exp Res (2011) 0.79

A Method to Assess Linkage Disequilibrium between CNVs and SNPs Inside Copy Number Variable Regions. Front Genet (2011) 0.79

Association of genetic copy number variations at 11 q14.2 with brain regional volume differences in an alcohol use disorder population. Alcohol (2012) 0.79

The N-ethylmaleimide-sensitive factor and dysbindin interact to modulate synaptic plasticity. J Neurosci (2015) 0.79

Interactions between N-ethylmaleimide-sensitive factor and GluR2 in the nucleus accumbens contribute to the expression of locomotor sensitization to cocaine. J Neurosci (2014) 0.78

Candidate pathway association study in cocaine dependence: the control of neurotransmitter release. World J Biol Psychiatry (2011) 0.78

Genome-wide association study of copy number variations (CNVs) with opioid dependence. Neuropsychopharmacology (2014) 0.77

Genomic copy number variants: evidence for association with antibody response to anthrax vaccine adsorbed. PLoS One (2013) 0.76