Published in J Biol Chem on August 08, 2016
A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell (1995) 11.62
A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell (1995) 10.18
The calpain system. Physiol Rev (2003) 9.95
HERG, a human inward rectifier in the voltage-gated potassium channel family. Science (1995) 7.26
hERG potassium channels and cardiac arrhythmia. Nature (2006) 6.63
MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell (1999) 5.49
Molecular and cellular mechanisms of cardiac arrhythmias. Cell (2001) 5.41
Targeting proteases: successes, failures and future prospects. Nat Rev Drug Discov (2006) 4.39
Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments. J Biol Chem (1995) 3.52
QT interval prolongation as predictor of sudden death in patients with myocardial infarction. Circulation (1978) 3.32
Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism. Circulation (2006) 3.23
Alterations of K+ currents in isolated human ventricular myocytes from patients with terminal heart failure. Circ Res (1993) 2.94
HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defects. J Biol Chem (1998) 2.52
Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins. J Biol Chem (2002) 2.31
Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG. Circ Res (2003) 2.27
Regulation of the epithelial sodium channel by serine proteases in human airways. J Biol Chem (2001) 2.22
Molecular determinants of dofetilide block of HERG K+ channels. Circ Res (1998) 2.13
A minK-HERG complex regulates the cardiac potassium current I(Kr). Nature (1997) 2.03
Matrix metalloproteinase-2 contributes to ischemia-reperfusion injury in the heart. Circulation (2000) 2.01
Peripheral blood levels of matrix metalloproteases-2 and -9 are elevated in patients with acute coronary syndromes. J Am Coll Cardiol (1998) 1.91
Protein kinase Ciota promotes nicotine-induced migration and invasion of cancer cells via phosphorylation of micro- and m-calpains. J Biol Chem (2005) 1.44
Effect of coronary angioplasty on electrocardiographic changes in patients with unstable angina secondary to left anterior descending coronary artery disease. J Am Coll Cardiol (1990) 1.44
Role of glycosylation in cell surface expression and stability of HERG potassium channels. Am J Physiol Heart Circ Physiol (2002) 1.38
Extracellular K+ concentration controls cell surface density of IKr in rabbit hearts and of the HERG channel in human cell lines. J Clin Invest (2009) 1.37
Prolongation of the QTc interval is seen uniformly during early transmural ischemia. J Am Coll Cardiol (2007) 1.29
PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites. PLoS One (2012) 1.28
Identification of IKr and its trafficking disruption induced by probucol in cultured neonatal rat cardiomyocytes. J Pharmacol Exp Ther (2007) 1.27
Isolation and characterization of single canine cardiac purkinje cells. Circ Res (1983) 1.24
Preparation of beating heart cells from adult rats. Science (1970) 1.13
Sudden death in coronary artery disease: acute ischemia versus myocardial substrate. Circulation (1997) 1.11
Pharmacological removal of human ether-à-go-go-related gene potassium channel inactivation by 3-nitro-N-(4-phenoxyphenyl) benzamide (ICA-105574). Mol Pharmacol (2009) 1.10
Rescue of aberrant gating by a genetically encoded PAS (Per-Arnt-Sim) domain in several long QT syndrome mutant human ether-á-go-go-related gene potassium channels. J Biol Chem (2011) 1.10
Structure of the HERG K+ channel S5P extracellular linker: role of an amphipathic alpha-helix in C-type inactivation. J Biol Chem (2003) 1.08
Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis. J Biol Chem (2010) 1.08
Dynamic conformational changes of extracellular S5-P linkers in the hERG channel. J Physiol (2005) 1.07
Method for isolation of human ventricular myocytes from single endocardial and epicardial biopsies. Am J Physiol (1995) 1.00
Extracellular K+ is a prerequisite for the function and plasma membrane stability of HERG channels. Circ Res (2010) 1.00
Probing the outer mouth structure of the HERG channel with peptide toxin footprinting and molecular modeling. Biophys J (2007) 0.99
BeKm-1 is a HERG-specific toxin that shares the structure with ChTx but the mechanism of action with ErgTx1. Biophys J (2003) 0.97
The role of calpains in myocardial remodelling and heart failure. Cardiovasc Res (2012) 0.96
MMP-7 cleaves the NR1 NMDA receptor subunit and modifies NMDA receptor function. FASEB J (2008) 0.95
Repolarizing K+ currents in nonfailing human hearts. Similarities between right septal subendocardial and left subepicardial ventricular myocytes. Circulation (1995) 0.95
Specific serine proteases selectively damage KCNH2 (hERG1) potassium channels and I(Kr). Am J Physiol Heart Circ Physiol (2005) 0.93
Matriptase-2 (TMPRSS6) is directly up-regulated by hypoxia inducible factor-1: identification of a hypoxia-responsive element in the TMPRSS6 promoter region. Biol Chem (2012) 0.86
New binding site on common molecular scaffold provides HERG channel specificity of scorpion toxin BeKm-1. J Biol Chem (2002) 0.85
Calpains contribute to vascular repair in rapidly progressive form of glomerulonephritis: potential role of their externalization. Arterioscler Thromb Vasc Biol (2011) 0.83
Repolarizing currents in ventricular myocytes from young patients with tetralogy of Fallot. Cardiovasc Res (1999) 0.82
An antiarrhythmic effect of a chymase inhibitor after myocardial infarction. J Pharmacol Exp Ther (2004) 0.82
Extracellular and intracellular proteases in cardiac dysfunction due to ischemia-reperfusion injury. Int J Cardiol (2012) 0.81
L-arginine administration recovers sarcoplasmic reticulum function in ischemic reperfused hearts by preventing calpain activation. Cardiovasc Res (2005) 0.81
Reduction of myocardial infarction by postischemic administration of the calpain inhibitor A-705253 in comparison to the Na(+)/H(+) exchange inhibitor Cariporide in isolated perfused rabbit hearts. Biol Chem (2008) 0.80
Rab11-dependent Recycling of the Human Ether-a-go-go-related Gene (hERG) Channel. J Biol Chem (2015) 0.77
Regulation of the human ether-a-go-go-related gene (hERG) potassium channel by Nedd4 family interacting proteins (Ndfips). Biochem J (2015) 0.77
Febrile temperature facilitates hERG/IKr degradation through an altered K(+) dependence. Heart Rhythm (2016) 0.76
Calpains Released by T Lymphocytes Cleave TLR2 To Control IL-17 Expression. J Immunol (2015) 0.76
Proteolytic cleavage in the S1-S2 linker of the Kv1.5 channel does not affect channel function. Biochim Biophys Acta (2016) 0.76
Prognostic value of corrected QT-interval prolongation in patients with unstable angina pectoris. Am J Cardiol (2003) 0.76
Rab11-dependent Recycling of the Human Ether-a-go-go-related Gene (hERG) Channel. J Biol Chem (2015) 0.77