Telomere Transcripts Target Telomerase in Human Cancer Cells.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27537914)

Published in Genes (Basel) on August 16, 2016

Authors

Theresa Kreilmeier1,2, Doris Mejri3, Marlene Hauck4, Miriam Kleiter5, Klaus Holzmann6

Author Affiliations

1: Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, Vienna 1090, Austria. theresa.kreilmeier@gmx.at.
2: Department for Companion Animals and Horses, University of Veterinary Medicine Vienna, Veterinärplatz 1, Vienna 1210, Austria. theresa.kreilmeier@gmx.at.
3: Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, Vienna 1090, Austria. doris.mejri@meduniwien.ac.at.
4: Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA. marlene_hauck@ncsu.edu.
5: Department for Companion Animals and Horses, University of Veterinary Medicine Vienna, Veterinärplatz 1, Vienna 1210, Austria. miriam.kleiter@vetmeduni.ac.at.
6: Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, Vienna 1090, Austria. klaus.holzmann@meduniwien.ac.at.

Articles cited by this

Hallmarks of cancer: the next generation. Cell (2011) 140.01

Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science (2007) 6.33

Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II. Nat Cell Biol (2007) 4.84

The telomere syndromes. Nat Rev Genet (2012) 4.01

Telomerase maintains telomere structure in normal human cells. Cell (2003) 3.29

G-quadruplex structures: in vivo evidence and function. Trends Cell Biol (2009) 3.25

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev (1999) 3.04

Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia. N Engl J Med (2015) 3.00

Cell culture of human colon adenomas and carcinomas. Cancer Res (1987) 2.68

Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway. PLoS Genet (2012) 2.63

Hayflick, his limit, and cellular ageing. Nat Rev Mol Cell Biol (2000) 2.15

A Pilot Study of the Telomerase Inhibitor Imetelstat for Myelofibrosis. N Engl J Med (2015) 2.08

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase. Nucleic Acids Res (2010) 2.05

A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay. Proc Natl Acad Sci U S A (2004) 1.97

Telomeric noncoding RNA TERRA is induced by telomere shortening to nucleate telomerase molecules at short telomeres. Mol Cell (2013) 1.89

Molecular dissection of telomeric repeat-containing RNA biogenesis unveils the presence of distinct and multiple regulatory pathways. Mol Cell Biol (2010) 1.89

Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances. Genes Dev (2014) 1.85

TRF1 promotes parallel pairing of telomeric tracts in vitro. J Mol Biol (1998) 1.73

CpG-island promoters drive transcription of human telomeres. RNA (2009) 1.66

SYBR Green real-time telomeric repeat amplification protocol for the rapid quantification of telomerase activity. Nucleic Acids Res (2003) 1.59

Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine. Cancer Discov (2014) 1.59

Telomeres: structure and synthesis. J Biol Chem (1990) 1.58

Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription. Nucleic Acids Res (2009) 1.55

Telomerase: central regulator of all of the hallmarks of cancer. Trends Biochem Sci (2013) 1.46

TERRA biogenesis, turnover and implications for function. FEBS Lett (2010) 1.31

Cells obtained from colorectal microadenomas mirror early premalignant growth patterns in vitro. Eur J Cancer (2002) 1.18

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells. Nat Commun (2014) 1.07

A randomized phase II study of the telomerase inhibitor imetelstat as maintenance therapy for advanced non-small-cell lung cancer. Ann Oncol (2014) 1.06

Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin. Nucleic Acids Res (2014) 1.05

Telomere lengths and telomerase activity in dog tissues: a potential model system to study human telomere and telomerase biology. Neoplasia (2001) 1.05

Role of Telomeres and Telomerase in Aging and Cancer. Cancer Discov (2016) 1.03

Differential effects of polymorphic alleles of FGF receptor 4 on colon cancer growth and metastasis. Cancer Res (2012) 1.03

Chromatin regulation and non-coding RNAs at mammalian telomeres. Semin Cell Dev Biol (2009) 1.02

Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase. Proc Natl Acad Sci U S A (2014) 0.98

A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A. Biochem Biophys Res Commun (2000) 0.92

TERRA and the state of the telomere. Nat Struct Mol Biol (2015) 0.91

Understanding TERT Promoter Mutations: A Common Path to Immortality. Mol Cancer Res (2016) 0.90

Analysis of cellular senescence in culture in vivo: the senescence-associated beta-galactosidase assay. Curr Protoc Cell Biol (2005) 0.89

Isolation and expression of the reverse transcriptase component of the Canis familiaris telomerase ribonucleoprotein (dogTERT). Gene (2004) 0.89

Expression of telomeres in astrocytoma WHO grade 2 to 4: TERRA level correlates with telomere length, telomerase activity, and advanced clinical grade. Transl Oncol (2012) 0.89

Telomeric repeat-containing RNA/G-quadruplex-forming sequences cause genome-wide alteration of gene expression in human cancer cells in vivo. Nucleic Acids Res (2015) 0.88

Cancer stem cells and telomerase as potential biomarkers in veterinary oncology. Vet J (2010) 0.87

Telomerase: a potential diagnostic and therapeutic tool in canine oncology. Vet Pathol (2003) 0.85

Breaking new ground: digging into TERRA function. Biochim Biophys Acta (2014) 0.84

LINE-1 induces hTERT and ensures telomere maintenance in tumour cell lines. Oncogene (2015) 0.82

Transcriptional regulation of telomeric non-coding RNA: implications on telomere biology, replicative senescence and cancer. RNA Biol (2010) 0.82

Transient expression of wild-type or biologically inactive telomerase allows the formation of artificial telomeres in mortal human cells. Exp Cell Res (2001) 0.81

Inhibition of cell growth and telomerase activity in osteosarcoma cells by DN-hTERT. J Huazhong Univ Sci Technolog Med Sci (2006) 0.81

Telomeres and disease: enter TERRA. RNA Biol (2012) 0.80

Knockdown of hTERT and Treatment with BIBR1532 Inhibit Cell Proliferation and Invasion in Endometrial Cancer Cells. J Cancer (2015) 0.80

The combined use of known antiviral reverse transcriptase inhibitors AZT and DDI induce anticancer effects at low concentrations. Neoplasia (2012) 0.79

Canine and human sarcomas exhibit predominant FGFR1 expression and impaired viability after inhibition of signaling. Mol Carcinog (2014) 0.79

Loss of the malignant phenotype of human neuroblastoma cells by a catalytically inactive dominant-negative hTERT mutant. Mol Cancer Ther (2012) 0.79

Monitoring viral decontamination procedures with green fluorescent protein-expressing adenovirus. Anal Biochem (2006) 0.78

Resistance to telomerase inhibition by human squamous cell carcinoma cell lines. Int J Oncol (2011) 0.77

TERRA -a calling card for telomerase. Mol Cell (2013) 0.76

Correlation of telomerase activity and telomere length to chemosensitivity. Methods Mol Med (2005) 0.76

Articles by these authors

Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas. Genes (Basel) (2017) 0.75