The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase.

PubWeight™: 2.05‹?› | Rank: Top 2%

🔗 View Article (PMC 2943627)

Published in Nucleic Acids Res on May 11, 2010

Authors

Sophie Redon1, Patrick Reichenbach, Joachim Lingner

Author Affiliations

1: Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Frontiers in Genetics National Center of Competence in Research, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

Articles citing this

Molecular mechanisms of long noncoding RNAs. Mol Cell (2011) 11.44

The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol (2012) 5.60

Long noncoding RNAs and the genetics of cancer. Br J Cancer (2013) 2.98

TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. Nature (2011) 2.17

Molecular dissection of telomeric repeat-containing RNA biogenesis unveils the presence of distinct and multiple regulatory pathways. Mol Cell Biol (2010) 1.89

Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α. Nat Struct Mol Biol (2012) 1.52

Long non-coding RNAs: versatile master regulators of gene expression and crucial players in cancer. Am J Transl Res (2012) 1.33

A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. Genome Biol (2011) 1.32

Long noncoding RNAs in development and cancer: potential biomarkers and therapeutic targets. Mol Cell Ther (2015) 1.32

Long noncoding RNA involvement in cancer. BMB Rep (2012) 1.28

Human telomerase: biogenesis, trafficking, recruitment, and activation. Genes Dev (2015) 1.14

TERRA promotes telomere shortening through exonuclease 1-mediated resection of chromosome ends. PLoS Genet (2012) 1.13

Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast. EMBO Rep (2011) 1.13

The telomeric transcriptome of Schizosaccharomyces pombe. Nucleic Acids Res (2011) 1.10

TERRA RNA Antagonizes ATRX and Protects Telomeres. Cell (2017) 1.09

Long noncoding RNAs in cancer: mechanisms of action and technological advancements. Mol Cancer (2016) 1.08

The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening. EMBO J (2013) 1.07

Selective RNA versus DNA G-quadruplex targeting by in situ click chemistry. Angew Chem Int Ed Engl (2012) 1.07

Non-coding RNAs: multi-tasking molecules in the cell. Int J Mol Sci (2013) 1.07

Telomerase efficiently elongates highly transcribing telomeres in human cancer cells. PLoS One (2012) 1.06

Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin. Nucleic Acids Res (2014) 1.05

Shelterin complex and associated factors at human telomeres. Nucleus (2011) 1.04

Noncoding RNA in oncogenesis: a new era of identifying key players. Int J Mol Sci (2013) 1.03

Deregulated telomere transcription causes replication-dependent telomere shortening and promotes cellular senescence. Nucleic Acids Res (2012) 1.03

Epigenetics in hepatocellular carcinoma: an update and future therapy perspectives. World J Gastroenterol (2014) 1.00

Molecular mechanisms and function prediction of long noncoding RNA. ScientificWorldJournal (2012) 0.98

TERRA Expression Levels Do Not Correlate with Telomere Length and Radiation Sensitivity in Human Cancer Cell Lines. Front Oncol (2013) 0.98

Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase. Proc Natl Acad Sci U S A (2014) 0.98

Telomerase regulation. Mutat Res (2011) 0.98

Promoting transcription of chromosome ends. Transcription (2010) 0.97

Non-coding telomeric and subtelomeric transcripts are differentially regulated by telomeric and heterochromatin assembly factors in fission yeast. Nucleic Acids Res (2011) 0.95

The bright side of dark matter: lncRNAs in cancer. J Clin Invest (2016) 0.94

Bioinformatics tools and novel challenges in long non-coding RNAs (lncRNAs) functional analysis. Int J Mol Sci (2011) 0.92

A three-state model for the regulation of telomerase by TERRA and hnRNPA1. Nucleic Acids Res (2013) 0.92

Long noncoding RNAs(lncRNAs) and the molecular hallmarks of aging. Aging (Albany NY) (2014) 0.92

Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators. Genome Res (2013) 0.91

Identification of TERRA locus unveils a telomere protection role through association to nearly all chromosomes. Nat Commun (2014) 0.90

Transcription regulates telomere dynamics in human cancer cells. RNA (2012) 0.90

DNA repair at telomeres: keeping the ends intact. Cold Spring Harb Perspect Biol (2013) 0.89

Expression of telomeres in astrocytoma WHO grade 2 to 4: TERRA level correlates with telomere length, telomerase activity, and advanced clinical grade. Transl Oncol (2012) 0.89

Emerging role of non-coding RNA in neural plasticity, cognitive function, and neuropsychiatric disorders. Front Genet (2012) 0.89

Basic biology and therapeutic implications of lncRNA. Adv Drug Deliv Rev (2015) 0.88

Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma. J Cell Sci (2012) 0.88

Telomeric repeat-containing RNA/G-quadruplex-forming sequences cause genome-wide alteration of gene expression in human cancer cells in vivo. Nucleic Acids Res (2015) 0.88

Screening of lymph nodes metastasis associated lncRNAs in colorectal cancer patients. World J Gastroenterol (2014) 0.88

Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity. Front Genet (2015) 0.88

Reactivation of telomerase in cancer. Cell Mol Life Sci (2016) 0.87

Compromised telomere maintenance in hypomethylated Arabidopsis thaliana plants. Nucleic Acids Res (2013) 0.85

In situ visualization of telomere elongation patterns in human cells. Nucleic Acids Res (2013) 0.85

The crosstalk of telomere dysfunction and inflammation through cell-free TERRA containing exosomes. RNA Biol (2016) 0.85

Transcription of tandemly repetitive DNA: functional roles. Chromosome Res (2015) 0.84

Role of TERRA in the regulation of telomere length. Int J Biol Sci (2015) 0.83

TERRA promotes telomerase-mediated telomere elongation in Schizosaccharomyces pombe. EMBO Rep (2016) 0.83

Chromatin structure in telomere dynamics. Front Oncol (2013) 0.82

Telomere and Telomerase Therapeutics in Cancer. Genes (Basel) (2016) 0.81

How homologous recombination maintains telomere integrity. Chromosoma (2014) 0.81

Subtelomeric p53 binding prevents accumulation of DNA damage at human telomeres. EMBO J (2015) 0.81

Recognition of chelerythrine to human telomeric DNA and RNA G-quadruplexes. Sci Rep (2014) 0.80

Telomeres and viruses: common themes of genome maintenance. Front Oncol (2012) 0.80

Fission yeast Cactin restricts telomere transcription and elongation by controlling Rap1 levels. EMBO J (2014) 0.79

Noncoding RNA control of cellular senescence. Wiley Interdiscip Rev RNA (2015) 0.79

Telomeres, a busy platform for cell signaling. Front Oncol (2013) 0.78

Non-coding RNA LINC00857 is predictive of poor patient survival and promotes tumor progression via cell cycle regulation in lung cancer. Oncotarget (2016) 0.78

Structure of noncoding RNA is a determinant of function of RNA binding proteins in transcriptional regulation. Cell Biosci (2012) 0.78

Global identification and analysis of long non-coding RNAs in diploid strawberry Fragaria vesca during flower and fruit development. BMC Genomics (2015) 0.78

The differential processing of telomeres in response to increased telomeric transcription and RNA-DNA hybrid accumulation. RNA Biol (2014) 0.78

Targeting noncoding RNAs in disease. J Clin Invest (2017) 0.78

KLF4 downregulates hTERT expression and telomerase activity to inhibit lung carcinoma growth. Oncotarget (2016) 0.77

Telomerase Regulation from Beginning to the End. Genes (Basel) (2016) 0.77

TeloPIN: a database of telomeric proteins interaction network in mammalian cells. Database (Oxford) (2015) 0.77

More on the Lack of Correlation between Terra Expression and Telomere Length. Front Oncol (2013) 0.76

G-quadruplex RNA binding and recognition by the lysine-specific histone demethylase-1 enzyme. RNA (2016) 0.76

Preparation of 6/8/11-Amino/Chloro-Oxoisoaporphine and Group-10 Metal Complexes and Evaluation of Their in Vitro and in Vivo Antitumor Activity. Sci Rep (2016) 0.76

Telomeric RNAs are essential to maintain telomeres. Nat Commun (2016) 0.75

Telomere homeostasis in mammalian germ cells: a review. Chromosoma (2015) 0.75

TERRA Incognita at chromosome ends. EMBO Rep (2016) 0.75

The Rb1 tumour suppressor gene modifies telomeric chromatin architecture by regulating TERRA expression. Sci Rep (2017) 0.75

Structure and target interaction of a G-quadruplex RNA-aptamer. RNA Biol (2016) 0.75

Telomere Transcripts Target Telomerase in Human Cancer Cells. Genes (Basel) (2016) 0.75

Chimeric bifunctional oligonucleotides as a novel tool to invade telomerase assembly. Nucleic Acids Res (2014) 0.75

Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas. Genes (Basel) (2017) 0.75

Mechanistic Insight into Long Noncoding RNAs and the Placenta. Int J Mol Sci (2017) 0.75

Articles cited by this

Specific association of human telomerase activity with immortal cells and cancer. Science (1994) 28.20

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell (1985) 24.17

Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science (2007) 6.33

Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II. Nat Cell Biol (2007) 4.84

How telomeres solve the end-protection problem. Science (2009) 4.54

The epigenetic regulation of mammalian telomeres. Nat Rev Genet (2007) 3.82

Protein composition of catalytically active human telomerase from immortal cells. Science (2007) 3.53

Beginning to understand the end of the chromosome. Cell (2004) 3.46

Telomere length homeostasis requires that telomerase levels are limiting. EMBO J (2006) 2.81

Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase. Nat Genet (1998) 2.53

The Rat1p 5' to 3' exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae. Mol Cell (2008) 2.36

A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed. Curr Biol (2003) 2.14

Functional conservation of the telomerase protein Est1p in humans. Curr Biol (2003) 2.00

Human telomerase contains two cooperating telomerase RNA molecules. EMBO J (2001) 1.99

Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro. Mol Cell Biol (2005) 1.94

The anchor site of telomerase from Euplotes aediculatus revealed by photo-cross-linking to single- and double-stranded DNA primers. Mol Cell Biol (1997) 1.94

TERRA: telomeric repeat-containing RNA. EMBO J (2009) 1.94

Functional multimerization of the human telomerase reverse transcriptase. Mol Cell Biol (2001) 1.90

A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J (2001) 1.79

Functional organization of repeat addition processivity and DNA synthesis determinants in the human telomerase multimer. Mol Cell Biol (2004) 1.63

Telomeric position effect: from the yeast paradigm to human pathologies? Biochimie (2007) 1.57

Transcription of a yeast telomere alleviates telomere position effect without affecting chromosome stability. Proc Natl Acad Sci U S A (1994) 1.51

Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate. J Biol Chem (2002) 1.40

A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulation. Oncogene (2002) 1.34

Telomeres: the silence is broken. Cell Cycle (2008) 1.32

hnRNP A1 may interact simultaneously with telomeric DNA and the human telomerase RNA in vitro. Nucleic Acids Res (2001) 1.31

Mutation in TERT separates processivity from anchor-site function. Nat Struct Mol Biol (2008) 1.24

Characterization of physical and functional anchor site interactions in human telomerase. Mol Cell Biol (2007) 1.24

A physical and functional constituent of telomerase anchor site. J Biol Chem (2005) 1.21

Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase. Nucleic Acids Res (2007) 1.13

Two independent regions of human telomerase reverse transcriptase are important for its oligomerization and telomerase activity. J Biol Chem (2001) 1.07

Low- to high-throughput analysis of telomerase modulators with Telospot. Nat Methods (2007) 1.02

Articles by these authors

Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science (2007) 6.33

Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states. Cell (2004) 4.79

Telomere length homeostasis requires that telomerase levels are limiting. EMBO J (2006) 2.81

TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo. Mol Cell Biol (2010) 2.39

The Rat1p 5' to 3' exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae. Mol Cell (2008) 2.36

The human RNA surveillance factor UPF1 is required for S phase progression and genome stability. Curr Biol (2006) 2.16

A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed. Curr Biol (2003) 2.14

Telomere length homeostasis. Chromosoma (2006) 2.12

Telomerase: biochemical considerations for enzyme and substrate. Trends Biochem Sci (2002) 2.07

Human telomerase RNA accumulation in Cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation. Mol Cell (2007) 2.03

Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro. Mol Cell Biol (2005) 1.94

TERRA: telomeric repeat-containing RNA. EMBO J (2009) 1.94

Molecular dissection of telomeric repeat-containing RNA biogenesis unveils the presence of distinct and multiple regulatory pathways. Mol Cell Biol (2010) 1.89

The human CST complex is a terminator of telomerase activity. Nature (2012) 1.81

Telomerase repeat addition processivity is increased at critically short telomeres in a Tel1-dependent manner in Saccharomyces cerevisiae. Genes Dev (2007) 1.67

Regulation of the human telomerase reverse transcriptase gene. Oncogene (2002) 1.47

Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate. J Biol Chem (2002) 1.40

Intracellular trafficking of yeast telomerase components. EMBO Rep (2002) 1.34

Telomeres: the silence is broken. Cell Cycle (2008) 1.32

TERRA biogenesis, turnover and implications for function. FEBS Lett (2010) 1.31

Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action. Proc Natl Acad Sci U S A (2007) 1.29

Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast. EMBO Rep (2007) 1.26

Structure of active dimeric human telomerase. Nat Struct Mol Biol (2013) 1.23

Telomerase limits the extent of base pairing between template RNA and telomeric DNA. EMBO Rep (2005) 1.20

Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay. Nucleic Acids Res (2007) 1.18

The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast. Nat Cell Biol (2011) 1.17

TERRA promotes telomere shortening through exonuclease 1-mediated resection of chromosome ends. PLoS Genet (2012) 1.13

Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase. Nucleic Acids Res (2007) 1.13

Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast. EMBO Rep (2011) 1.13

The double life of UPF1 in RNA and DNA stability pathways. Cell Cycle (2006) 1.08

The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening. EMBO J (2013) 1.07

A quantitative telomeric chromatin isolation protocol identifies different telomeric states. Nat Commun (2013) 1.04

Replication of telomeres and the regulation of telomerase. Cold Spring Harb Perspect Biol (2013) 1.03

Low- to high-throughput analysis of telomerase modulators with Telospot. Nat Methods (2007) 1.02

Detection of promoter activity by flow cytometric analysis of GFP reporter expression. Nucleic Acids Res (2002) 1.01

The finger subdomain of yeast telomerase cooperates with Pif1p to limit telomere elongation. Nat Struct Mol Biol (2006) 0.97

CST for the grand finale of telomere replication. Nucleus (2013) 0.94

Yeast telomerase is specialized for C/A-rich RNA templates. Nucleic Acids Res (2003) 0.93

A three-state model for the regulation of telomerase by TERRA and hnRNPA1. Nucleic Acids Res (2013) 0.92

Molecular basis of telomere syndrome caused by CTC1 mutations. Genes Dev (2013) 0.92

Telomerase is essential to alleviate pif1-induced replication stress at telomeres. Genetics (2009) 0.90

Telomere length homeostasis responds to changes in intracellular dNTP pools. Genetics (2013) 0.84

Telomerase unplugged. ACS Chem Biol (2007) 0.82

Cell biology. Telomere wedding ends in divorce. Science (2004) 0.82

A chromosome 3-encoded repressor of the human telomerase reverse transcriptase (hTERT) gene controls the state of hTERT chromatin. Cancer Res (2003) 0.81

Cell signaling. Tel2 finally tells one story. Science (2008) 0.80

Molecular biology: damage control. Nature (2007) 0.79

Specific binding of telomeric G-quadruplexes by hydrosoluble perylene derivatives inhibits repeat addition processivity of human telomerase. Biochimie (2011) 0.78

An affinity oligonucleotide displacement strategy to purify ribonucleoprotein complexes applied to human telomerase. Methods Mol Biol (2008) 0.77

Methods for the ex vivo characterization of human CD8+ T subsets based on gene expression and replicative history analysis. Methods Mol Med (2005) 0.77

Induction of interleukin-2 receptor alpha (IL-2Ralpha) expression by interleukin-2: important role of the interleukin-2 receptor beta chain region between the two Stat5 docking sites. Eur Cytokine Netw (2002) 0.76

AUF1/HnRNP D RNA binding protein functions in telomere maintenance. Mol Cell (2012) 0.76

Related mechanisms for end processing at telomeres and DNA double-strand breaks. Mol Cell (2009) 0.76

Telomerase inhibitors from cyanobacteria: isolation and synthesis of sulfoquinovosyl diacylglycerols from Microcystis aeruguinosa PCC 7806. Chemistry (2013) 0.76

Fingering the ends: how to make new telomeres. Cell (2003) 0.75