Published in Cell Death Discov on April 18, 2016
The hallmarks of cancer. Cell (2000) 113.05
WAF1, a potential mediator of p53 tumor suppression. Cell (1993) 38.72
Surfing the p53 network. Nature (2000) 35.36
A global map of p53 transcription-factor binding sites in the human genome. Cell (2006) 20.65
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell (1992) 19.87
Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science (1998) 17.91
The DNA-damage response in human biology and disease. Nature (2009) 17.86
Participation of p53 protein in the cellular response to DNA damage. Cancer Res (1991) 16.00
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science (1994) 13.51
p53: puzzle and paradigm. Genes Dev (1996) 13.16
p53 in health and disease. Nat Rev Mol Cell Biol (2007) 11.33
Suppression of human colorectal carcinoma cell growth by wild-type p53. Science (1990) 11.18
Transcriptional control of human p53-regulated genes. Nat Rev Mol Cell Biol (2008) 11.05
WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res (1994) 9.00
The p53 pathway. J Pathol (1999) 6.79
p53 functions as a cell cycle control protein in osteosarcomas. Mol Cell Biol (1990) 5.20
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest (1998) 4.76
SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev (1998) 4.19
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med (2001) 3.45
Unravelling mechanisms of p53-mediated tumour suppression. Nat Rev Cancer (2014) 3.37
Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci U S A (1998) 3.24
p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa. Cell Rep (2013) 2.00
Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding. Genes Dev (2010) 1.76
PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators. Toxicol Appl Pharmacol (2004) 1.37
Human pregnane X receptor and resistance to chemotherapy in prostate cancer. Cancer Res (2007) 1.35
Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice. J Clin Invest (2011) 1.27
The antiapoptotic role of pregnane X receptor in human colon cancer cells. Mol Endocrinol (2007) 1.26
Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer. Clin Cancer Res (2008) 1.18
PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line. Cancer Chemother Pharmacol (2009) 1.16
Down-regulation of pregnane X receptor contributes to cell growth inhibition and apoptosis by anticancer agents in endometrial cancer cells. Mol Pharmacol (2007) 1.11
Pregnane X receptor suppresses proliferation and tumourigenicity of colon cancer cells. Br J Cancer (2010) 1.07
Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells. BMC Cancer (2011) 0.97
Identification of the novel splicing variants for the hPXR in human livers. Biochem Biophys Res Commun (2002) 0.91
Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity. Mol Pharmacol (2013) 0.89
Identification and characterization of phosphorylation sites within the pregnane X receptor protein. Biochem Pharmacol (2013) 0.89
NuMA is required for the selective induction of p53 target genes. Mol Cell Biol (2013) 0.88
Human pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alpha. BMC Cancer (2008) 0.87
Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2. Biochem J (2014) 0.85
Clinical significance of steroid and xenobiotic receptor and its targeted gene CYP3A4 in human prostate cancer. Cancer Sci (2011) 0.84
Formation of stress-specific p53 binding patterns is influenced by chromatin but not by modulation of p53 binding affinity to response elements. Nucleic Acids Res (2010) 0.84