Published in Genes Dev on May 15, 2010
Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. PLoS One (2011) 1.48
Temporal Dissection of Rate Limiting Transcriptional Events Using Pol II ChIP and RNA Analysis of Adrenergic Stress Gene Activation. PLoS One (2015) 1.40
The p53 circuit board. Biochim Biophys Acta (2012) 1.24
The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3. Cell Cycle (2012) 1.24
Mammalian cells acquire epigenetic hallmarks of human cancer during immortalization. Nucleic Acids Res (2012) 1.05
Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids. Nat Med (2012) 1.00
Chloroquine promotes apoptosis in melanoma cells by inhibiting BH3 domain-mediated PUMA degradation. J Invest Dermatol (2013) 0.97
Mechanisms of cohesin-mediated gene regulation and lessons learned from cohesinopathies. Biochim Biophys Acta (2013) 0.97
Developmentally programmed 3' CpG island methylation confers tissue- and cell-type-specific transcriptional activation. Mol Cell Biol (2013) 0.96
Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex. Elife (2012) 0.95
Genome-wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I. Proc Natl Acad Sci U S A (2015) 0.92
Gain of DNA methylation is enhanced in the absence of CTCF at the human retinoblastoma gene promoter. BMC Cancer (2011) 0.92
Effects of RNA interference-mediated gene silencing of JMJD2A on human breast cancer cell line MDA-MB-231 in vitro. J Exp Clin Cancer Res (2011) 0.92
The SMC1-SMC3 cohesin heterodimer structures DNA through supercoiling-dependent loop formation. Nucleic Acids Res (2013) 0.92
Interactions of chromatin context, binding site sequence content, and sequence evolution in stress-induced p53 occupancy and transactivation. PLoS Genet (2015) 0.91
An insulator embedded in the chicken α-globin locus regulates chromatin domain configuration and differential gene expression. Nucleic Acids Res (2010) 0.90
DNA topoisomerase II modulates insulator function in Drosophila. PLoS One (2011) 0.89
Disparate chromatin landscapes and kinetics of inactivation impact differential regulation of p53 target genes. Cell Cycle (2010) 0.89
A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX. EMBO J (2012) 0.89
Human papillomaviruses activate and recruit SMC1 cohesin proteins for the differentiation-dependent life cycle through association with CTCF insulators. PLoS Pathog (2015) 0.87
A cell cycle role for the epigenetic factor CTCF-L/BORIS. PLoS One (2012) 0.87
Harnessing the p53-PUMA axis to overcome DNA damage resistance in renal cell carcinoma. Neoplasia (2014) 0.86
Epigenetic repression of RARRES1 is mediated by methylation of a proximal promoter and a loss of CTCF binding. PLoS One (2012) 0.86
Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code. Nucleic Acids Res (2013) 0.84
SUMO-activating SAE1 transcription is positively regulated by Myc. Am J Cancer Res (2012) 0.84
Cohesin: a critical chromatin organizer in mammalian gene regulation. Biochem Cell Biol (2011) 0.84
Phosphorylation of Tip60 by p38α regulates p53-mediated PUMA induction and apoptosis in response to DNA damage. Oncotarget (2014) 0.83
Effects of siRNA-mediated knockdown of jumonji domain containing 2A on proliferation, migration and invasion of the human breast cancer cell line MCF-7. Exp Ther Med (2012) 0.83
Effects of low doses of ionizing radiation exposures on stress-responsive gene expression in human embryonic stem cells. Int J Mol Sci (2014) 0.82
De-SUMOylation of CCCTC binding factor (CTCF) in hypoxic stress-induced human corneal epithelial cells. J Biol Chem (2012) 0.81
Rhein Elicits In Vitro Cytotoxicity in Primary Human Liver HL-7702 Cells by Inducing Apoptosis through Mitochondria-Mediated Pathway. Evid Based Complement Alternat Med (2015) 0.80
Whole-genome cartography of p53 response elements ranked on transactivation potential. BMC Genomics (2015) 0.80
Transcription of angiogenin and ribonuclease 4 is regulated by RNA polymerase III elements and a CCCTC binding factor (CTCF)-dependent intragenic chromatin loop. J Biol Chem (2014) 0.79
A Chromatin-Focused siRNA Screen for Regulators of p53-Dependent Transcription. G3 (Bethesda) (2016) 0.79
EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis. Oncotarget (2016) 0.79
A chromatin code for alternative splicing involving a putative association between CTCF and HP1α proteins. BMC Biol (2015) 0.79
Disruption of CTCF/cohesin-mediated high-order chromatin structures by DNA methylation downregulates PTGS2 expression. Oncogene (2015) 0.78
Epigenetic silencing of miR-181c by DNA methylation in glioblastoma cell lines. BMC Cancer (2016) 0.76
Homozygous mdm2 SNP309 cancer cells with compromised transcriptional elongation at p53 target genes are sensitive to induction of p53-independent cell death. Oncotarget (2015) 0.75
How p53 wields the scales of fate: arrest or death? Transcription (2012) 0.75
Human pregnane X receptor compromises the function of p53 and promotes malignant transformation. Cell Death Discov (2016) 0.75
Get your fingers out of p53's way! EMBO Rep (2012) 0.75
We bonded--now make a decision. Nat Rev Cancer (2010) 0.75
High-Resolution 4C Reveals Rapid p53-Dependent Chromatin Reorganization of the CDKN1A Locus in Response to Stress. PLoS One (2016) 0.75
Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2. Biol Psychiatry (2017) 0.75
A Scalable Epitope Tagging Approach for High Throughput ChIP-Seq Analysis. ACS Synth Biol (2017) 0.75
High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell (1993) 33.20
A chromatin landmark and transcription initiation at most promoters in human cells. Cell (2007) 23.41
Blinded by the Light: The Growing Complexity of p53. Cell (2009) 17.75
Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. Science (2005) 16.82
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell (2007) 16.66
Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters. Science (2008) 16.48
High-resolution mapping and characterization of open chromatin across the genome. Cell (2008) 15.93
CTCF: master weaver of the genome. Cell (2009) 15.09
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell (1995) 14.90
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell (1997) 12.83
Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev (2001) 12.46
Cohesin mediates transcriptional insulation by CCCTC-binding factor. Nature (2008) 12.01
PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell (2001) 11.04
The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell (1999) 9.74
Genome-wide transcription and the implications for genomic organization. Nat Rev Genet (2007) 9.45
The RNA polymerase II core promoter. Annu Rev Biochem (2003) 9.37
Elongation by RNA polymerase II: the short and long of it. Genes Dev (2004) 9.17
Deciphering the transcriptional histone acetylation code for a human gene. Cell (2002) 8.96
PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell (2001) 7.95
Cohesins functionally associate with CTCF on mammalian chromosome arms. Cell (2008) 7.80
Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains. Genome Res (2008) 7.41
Interchromosomal interactions and olfactory receptor choice. Cell (2006) 6.93
NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. Cell (1999) 6.34
Transcription of eukaryotic protein-coding genes. Annu Rev Genet (2000) 6.12
Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell (2006) 5.64
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell (2000) 5.64
Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell (2006) 5.40
Chimeric transcript discovery by paired-end transcriptome sequencing. Proc Natl Acad Sci U S A (2009) 5.30
Biochemistry and structural biology of transcription factor IID (TFIID). Annu Rev Biochem (1996) 5.19
Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev (2000) 5.04
Phosphorylation of serine 2 within the RNA polymerase II C-terminal domain couples transcription and 3' end processing. Mol Cell (2004) 5.01
CTCF physically links cohesin to chromatin. Proc Natl Acad Sci U S A (2008) 4.89
PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc Natl Acad Sci U S A (2003) 4.46
ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell (2001) 4.38
Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation. Curr Opin Cell Biol (2008) 4.25
Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Genes Dev (2006) 4.06
Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. Mol Cell (2001) 3.74
NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly. Genes Dev (2008) 3.69
hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes. Cell (2007) 3.56
Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ (2006) 3.53
p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage. Mol Cell (2003) 3.05
Cell type specificity of chromatin organization mediated by CTCF and cohesin. Proc Natl Acad Sci U S A (2010) 3.03
p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. J Exp Med (1998) 2.91
CDK8 is a stimulus-specific positive coregulator of p53 target genes. Mol Cell (2007) 2.88
Relationship between histone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment. Mol Cell Biol (2005) 2.86
Control of elongation by RNA polymerase II. Trends Biochem Sci (2000) 2.79
Diversified transcription initiation complexes expand promoter selectivity and tissue-specific gene expression. Genes Dev (2003) 2.73
CDK8 is a positive regulator of transcriptional elongation within the serum response network. Nat Struct Mol Biol (2010) 2.70
Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary. Mol Cell (2009) 2.21
Outcomes of p53 activation--spoilt for choice. J Cell Sci (2006) 1.88
The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator. Mol Cell Biol (2008) 1.88
Kinetics of p53 binding to promoter sites in vivo. Mol Cell Biol (2001) 1.87
The LPS-induced transcriptional upregulation of the chicken lysozyme locus involves CTCF eviction and noncoding RNA transcription. Mol Cell (2008) 1.81
Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site. Oncogene (2000) 1.79
Mediator complexes and eukaryotic transcription regulation: an overview. Biochimie (2007) 1.60
Massive transcriptional start site analysis of human genes in hypoxia cells. Nucleic Acids Res (2009) 1.60
Mechanisms of regulatory diversity within the p53 transcriptional network. Oncogene (2008) 1.57
TFIIB and the regulation of transcription by RNA polymerase II. Chromosoma (2007) 1.53
Regulation of the p53 transcriptional response by structurally diverse core promoters. Genes Dev (2009) 1.52
DNA damage-induced protein 14-3-3 sigma inhibits protein kinase B/Akt activation and suppresses Akt-activated cancer. Cancer Res (2006) 1.27
Chromatin structure is implicated in "late" elongation checkpoints on the U2 snRNA and beta-actin genes. Mol Cell Biol (2009) 1.23
PUMA promotes Bax translocation by both directly interacting with Bax and by competitive binding to Bcl-X L during UV-induced apoptosis. Mol Biol Cell (2009) 1.16
The plasticity of the mammalian transcriptome. Genomics (2009) 1.07
Contribution of membrane localization to the apoptotic activity of PUMA. Apoptosis (2008) 1.02
Apoptosis. p53 and PUMA: a deadly duo. Science (2005) 0.98
A block of transcription elongation by RNA polymerase II at synthetic sites in vitro. J Biol Chem (1989) 0.96
Induction of PUMA-alpha and down-regulation of PUMA-beta expression is associated with benzo(a)pyrene-induced apoptosis in MCF-7 cells. Toxicol Lett (2009) 0.81
CDK8 is a positive regulator of transcriptional elongation within the serum response network. Nat Struct Mol Biol (2010) 2.70
HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia. Cell (2013) 1.58
CDK8: a positive regulator of transcription. Transcription (2012) 1.53
Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. EMBO J (2008) 1.44
ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. Nat Chem Biol (2012) 1.26
The p53 circuit board. Biochim Biophys Acta (2012) 1.24
BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death. Cell Cycle (2008) 1.11
Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation. Cell Cycle (2008) 1.11
CBX3 regulates efficient RNA processing genome-wide. Genome Res (2012) 1.10
A genetic screen identifies TCF3/E2A and TRIAP1 as pathway-specific regulators of the cellular response to p53 activation. Cell Rep (2013) 1.07
ΔNp63α represses anti-proliferative genes via H2A.Z deposition. Genes Dev (2012) 1.02
Schizosaccharomyces pombe mst2+ encodes a MYST family histone acetyltransferase that negatively regulates telomere silencing. Mol Cell Biol (2005) 1.01
Inhibition of telomerase recruitment and cancer cell death. J Biol Chem (2013) 0.94
Lessons on transcriptional control from the serum response network. Curr Opin Genet Dev (2011) 0.92
Differential regulation of p53 target genes: it's (core promoter) elementary. Genes Dev (2010) 0.92
Disparate chromatin landscapes and kinetics of inactivation impact differential regulation of p53 target genes. Cell Cycle (2010) 0.89
A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX. EMBO J (2012) 0.89
Trypanosoma cruzi TcSRPK, the first protozoan member of the SRPK family, is biochemically and functionally conserved with metazoan SR protein-specific kinases. Mol Biochem Parasitol (2003) 0.82
An early ancestor in the evolution of splicing: a Trypanosoma cruzi serine-arginine-rich protein (TcSR) is functional in cis-splicing. Mol Biochem Parasitol (2003) 0.80
Tumor suppression by p53: is apoptosis important or not? Cell Rep (2013) 0.79
ATM regulates cell fate choice upon p53 activation by modulating mitochondrial turnover and ROS levels. Cell Cycle (2015) 0.79
ΔNp63α utilizes multiple mechanisms to repress transcription in squamous cell carcinoma cells. Cell Cycle (2013) 0.76
Human ACAP2 is a homolog of C. elegans CNT-1 that promotes apoptosis in cancer cells. Cell Cycle (2015) 0.75
How does ΔNp63α drive cancer? Epigenomics (2013) 0.75