Promising Druggable Target in Head and Neck Squamous Cell Carcinoma: Wnt Signaling.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27570510)

Published in Front Pharmacol on August 12, 2016

Authors

Amnani Aminuddin1, Pei Yuen Ng1

Author Affiliations

1: Drug Discovery and Development Research Group, Faculty of Pharmacy, Universiti Kebangsaan Malaysia Kuala Lumpur, Malaysia.

Articles cited by this

Cancer statistics, 2010. CA Cancer J Clin (2010) 103.28

Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17

Stem cells, cancer, and cancer stem cells. Nature (2001) 50.27

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med (1997) 32.63

The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol (2004) 24.63

Identification of a cancer stem cell in human brain tumors. Cancer Res (2003) 24.02

Wnt signaling and cancer. Genes Dev (2000) 18.53

Identification of pancreatic cancer stem cells. Cancer Res (2007) 18.36

Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell (2009) 18.31

Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res (2005) 13.89

A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature (2003) 12.81

Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci U S A (2007) 11.94

Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol (2014) 10.04

Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science (1991) 9.89

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature (2009) 9.15

Applying the principles of stem-cell biology to cancer. Nat Rev Cancer (2003) 8.95

Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ (2007) 8.08

Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res (2008) 7.91

Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta (2003) 7.85

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol (2010) 7.73

WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer (2013) 6.64

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr Biol (2001) 5.95

c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev (2004) 5.83

Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov (2006) 5.29

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet (2000) 5.26

Recent advances in head and neck cancer. N Engl J Med (2008) 5.05

WNT signaling pathway and stem cell signaling network. Clin Cancer Res (2007) 4.24

Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol (2010) 4.22

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell (1991) 3.95

The cell-cell adhesion molecule E-cadherin. Cell Mol Life Sci (2008) 3.77

Normal stem cells and cancer stem cells: the niche matters. Cancer Res (2006) 3.60

The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J Biol Chem (2007) 3.24

Niche-mediated control of human embryonic stem cell self-renewal and differentiation. EMBO J (2007) 2.91

GSK3: a multifaceted kinase in Wnt signaling. Trends Biochem Sci (2009) 2.87

Stem cells: a new lease on life. Cell (2000) 2.83

Targeting Wnt signaling: can we safely eradicate cancer stem cells? Clin Cancer Res (2010) 2.67

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proc Natl Acad Sci U S A (2013) 2.49

An updated overview on Wnt signaling pathways: a prelude for more. Circ Res (2010) 2.40

Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors. Genes Dev (2010) 2.28

Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays. Oncogene (2000) 2.11

Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance. Drug Resist Updat (2010) 1.98

Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res (2012) 1.89

Evidence for epithelial-mesenchymal transition in cancer stem cells of head and neck squamous cell carcinoma. PLoS One (2011) 1.87

Understanding and targeting cancer stem cells: therapeutic implications and challenges. Acta Pharmacol Sin (2013) 1.83

Disruption of E-cadherin by matrix metalloproteinase directly mediates epithelial-mesenchymal transition downstream of transforming growth factor-beta1 in renal tubular epithelial cells. Am J Pathol (2009) 1.75

Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis. Cancer Res (2000) 1.71

Drug discovery approaches to target Wnt signaling in cancer stem cells. Oncotarget (2010) 1.71

Epithelial to mesenchymal transition in head and neck squamous cell carcinoma. Oral Oncol (2012) 1.60

Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells. Blood (2015) 1.50

A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. Cell (2014) 1.44

Wnt signaling and the regulation of stem cell function. Curr Opin Cell Biol (2004) 1.42

The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/beta-catenin pathway. Oncogene (2009) 1.37

Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas. Oncogene (2002) 1.37

The first five years of the Wnt targetome. Cell Signal (2007) 1.36

Wnt signalling and the mechanistic basis of tumour development. J Pathol (2005) 1.36

A role for cancer stem cells in therapy resistance: cellular and molecular mechanisms. Semin Cancer Biol (2014) 1.33

Characterization of side populations in HNSCC: highly invasive, chemoresistant and abnormal Wnt signaling. PLoS One (2010) 1.33

Side population in oral squamous cell carcinoma possesses tumor stem cell phenotypes. Cancer Lett (2009) 1.27

Expression of matrix metalloproteinase 1, matrix metalloproteinase 2, and matrix metalloproteinase 9 in carcinoma of the head and neck. Cancer (2002) 1.25

Cancer stem cell traits in squamospheres derived from primary head and neck squamous cell carcinomas. Oral Oncol (2010) 1.22

Wnt pathway activity in breast cancer sub-types and stem-like cells. PLoS One (2013) 1.21

Inhibition of Wnt signaling pathway decreases chemotherapy-resistant side-population colon cancer cells. Anticancer Res (2010) 1.20

Involvement of the Wnt-β-catenin pathway in invasion and migration of oral squamous carcinoma cells. Int J Oncol (2010) 1.17

Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening. Proteins (2006) 1.15

Wnt addiction of genetically defined cancers reversed by PORCN inhibition. Oncogene (2015) 1.11

Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells. Invest New Drugs (2010) 1.11

Isolation and characterization of cancer stem-like side population cells in human oral cancer cells. Oral Oncol (2011) 1.10

Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene (2006) 1.10

Reduction of beta-catenin/T-cell transcription factor signaling by aspirin and indomethacin is caused by an increased stabilization of phosphorylated beta-catenin. Mol Cancer Ther (2003) 1.06

Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Manag Res (2009) 1.05

NLK positively regulates Wnt/β-catenin signalling by phosphorylating LEF1 in neural progenitor cells. EMBO J (2012) 1.05

New avenues to target Wnt/β-catenin signaling. Drug Discov Today (2010) 1.03

Promoter demethylation of WIF-1 by epigallocatechin-3-gallate in lung cancer cells. Anticancer Res (2009) 1.02

Targeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28. Pharmacol Ther (2014) 1.00

Emodin represses TWIST1-induced epithelial-mesenchymal transitions in head and neck squamous cell carcinoma cells by inhibiting the β-catenin and Akt pathways. Eur J Cancer (2013) 0.99

All-trans-retinoic acid inhibits growth of head and neck cancer stem cells by suppression of Wnt/β-catenin pathway. Eur J Cancer (2012) 0.98

Cancer stem cells hypothesis and stem cells in head and neck cancers. Cancer Treat Rev (2011) 0.97

Cancer stem cell-like cells from a single cell of oral squamous carcinoma cell lines. Biochem Biophys Res Commun (2011) 0.94

Wnt/β-catenin signalling maintains self-renewal and tumourigenicity of head and neck squamous cell carcinoma stem-like cells by activating Oct4. J Pathol (2014) 0.93

Cancer stem-like cells from head and neck cancers are chemosensitized by the Wnt antagonist, sFRP4, by inducing apoptosis, decreasing stemness, drug resistance and epithelial to mesenchymal transition. Cancer Gene Ther (2014) 0.92

Honokiol Eliminates Human Oral Cancer Stem-Like Cells Accompanied with Suppression of Wnt/ β -Catenin Signaling and Apoptosis Induction. Evid Based Complement Alternat Med (2013) 0.90

Both canonical and non-canonical Wnt signaling independently promote stem cell growth in mammospheres. PLoS One (2014) 0.88

A basal-cell-like compartment in head and neck squamous cell carcinomas represents the invasive front of the tumor and is expressing MMP-9. Oral Oncol (2009) 0.87

Expression of the cancer stem cell markers CD44v6 and ABCG2 in tongue cancer: effect of neoadjuvant chemotherapy on local recurrence. Int J Oncol (2014) 0.87

Updating the Wnt pathways. Biosci Rep (2014) 0.86

Mechanisms that mediate stem cell self-renewal and differentiation. J Cell Biochem (2008) 0.86

Wnt signaling regulates the stemness of lung cancer stem cells and its inhibitors exert anticancer effect on lung cancer SPC-A1 cells. Med Oncol (2015) 0.85

Cancer stem cells accountability in progression of head and neck squamous cell carcinoma: the most recent trends! Mol Biol Int (2014) 0.84

Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms. Am J Physiol Cell Physiol (2015) 0.84

The role of canonical WNT signaling pathway in oral carcinogenesis: a comprehensive review. Anticancer Res (2012) 0.83

Cancer stem cells in head and neck squamous cell carcinoma. Otolaryngol Pol (2013) 0.83

Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment. Oncotarget (2015) 0.82

Functionalized curcumin analogs as potent modulators of the Wnt/β-catenin signaling pathway. Eur J Med Chem (2013) 0.81

Cancer stem cells and stemness markers in oral squamous cell carcinomas. Asian Pac J Cancer Prev (2014) 0.80

Stem cell researchers find their niche. Development (2008) 0.77

What are stem cells and how are they controlled? J Pathol (1989) 0.76

A stem cell molecular signature: are there hallmark properties that are shared by all stem cells? Chembiochem (2003) 0.76