Published in Nat Rev Cancer on December 01, 2003
Efficient tumour formation by single human melanoma cells. Nature (2008) 16.35
Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci U S A (2007) 11.94
Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell (2008) 9.92
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene (2010) 9.66
Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One (2008) 8.97
Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res (2008) 7.65
Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA. Nature (2008) 7.64
Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer. J Clin Invest (2005) 5.90
Molecular genetics of prostate cancer: new prospects for old challenges. Genes Dev (2010) 5.83
WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells. Proc Natl Acad Sci U S A (2007) 4.97
AACR centennial series: the biology of cancer metastasis: historical perspective. Cancer Res (2010) 4.89
Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer. Mol Cancer Res (2009) 4.36
Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment. Proc Natl Acad Sci U S A (2009) 4.19
Tumour-initiating cells: challenges and opportunities for anticancer drug discovery. Nat Rev Drug Discov (2009) 4.12
Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology (2009) 3.92
PML targeting eradicates quiescent leukaemia-initiating cells. Nature (2008) 3.75
Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. Cancer Res (2008) 3.45
GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell (2008) 3.44
Identification of the cell lineage at the origin of basal cell carcinoma. Nat Cell Biol (2010) 2.97
ID genes mediate tumor reinitiation during breast cancer lung metastasis. Proc Natl Acad Sci U S A (2007) 2.85
Sca-1 expression identifies stem cells in the proximal region of prostatic ducts with high capacity to reconstitute prostatic tissue. Proc Natl Acad Sci U S A (2005) 2.77
Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase. Head Neck (2010) 2.76
Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev (2004) 2.75
Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity. Nat Cell Biol (2011) 2.65
Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells. Cancer Res (2012) 2.45
Leukemia stem cells in a genetically defined murine model of blast-crisis CML. Blood (2007) 2.34
Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin. J Cell Biol (2006) 2.32
Cancer stem cells: implications for the progression and treatment of metastatic disease. J Cell Mol Med (2007) 2.29
Liver stem cells and hepatocellular carcinoma. Hepatology (2009) 2.27
Defined factors induce reprogramming of gastrointestinal cancer cells. Proc Natl Acad Sci U S A (2009) 2.11
Nonlinear modelling of cancer: bridging the gap between cells and tumours. Nonlinearity (2010) 2.08
IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L. Immunity (2014) 2.08
Denervation suppresses gastric tumorigenesis. Sci Transl Med (2014) 1.96
Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer. Br J Cancer (2010) 1.96
CD133 expression is correlated with lymph node metastasis and vascular endothelial growth factor-C expression in pancreatic cancer. Br J Cancer (2008) 1.93
Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins. Nat Rev Cancer (2010) 1.93
Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed? Lancet Oncol (2007) 1.89
Defining embryonic stem cell identity using differentiation-related microRNAs and their potential targets. Mamm Genome (2007) 1.88
Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia. Nat Genet (2009) 1.86
Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract. Gastroenterology (2010) 1.86
Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle. Genes Dev (2004) 1.84
Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2. Immunity (2013) 1.77
The adult Drosophila malpighian tubules are maintained by multipotent stem cells. Cell Stem Cell (2007) 1.70
Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer. Br J Cancer (2011) 1.69
High aldehyde dehydrogenase activity: a novel functional marker of murine prostate stem/progenitor cells. Stem Cells (2009) 1.67
Arsenic-transformed malignant prostate epithelia can convert noncontiguous normal stem cells into an oncogenic phenotype. Environ Health Perspect (2012) 1.66
Human embryonic and neuronal stem cell markers in retinoblastoma. Mol Vis (2007) 1.66
Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells. Mol Cell (2012) 1.63
Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions. Genome Biol (2008) 1.62
Dual role of DNA methylation inside and outside of CTCF-binding regions in the transcriptional regulation of the telomerase hTERT gene. Nucleic Acids Res (2007) 1.59
SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells. Oncogenesis (2013) 1.57
Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis. Genes Dev (2005) 1.56
The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell (2008) 1.54
Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression. Cell Tissue Res (2011) 1.53
Cancer stem cells and the ontogeny of lung cancer. J Clin Oncol (2008) 1.51
Salinomycin as a drug for targeting human cancer stem cells. J Biomed Biotechnol (2012) 1.50
The lymphovascular embolus of inflammatory breast cancer expresses a stem cell-like phenotype. Am J Pathol (2008) 1.49
Right on target: eradicating leukemic stem cells. Trends Mol Med (2007) 1.49
Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells. Oncogene (2012) 1.49
Migration rules: tumours are conglomerates of self-metastases. Br J Cancer (2009) 1.48
Metabolic alterations in highly tumorigenic glioblastoma cells: preference for hypoxia and high dependency on glycolysis. J Biol Chem (2011) 1.48
Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma. Cancer Res (2009) 1.46
Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines. BMC Gastroenterol (2011) 1.43
Arsenic exposure transforms human epithelial stem/progenitor cells into a cancer stem-like phenotype. Environ Health Perspect (2010) 1.42
The association between CD166 detection rate and clinicopathologic parameters of patients with colorectal cancer. Caspian J Intern Med (2013) 1.41
Cancer stem cells: the lessons from pre-cancerous stem cells. J Cell Mol Med (2007) 1.38
An embryonic stem cell-like signature identifies poorly differentiated lung adenocarcinoma but not squamous cell carcinoma. Clin Cancer Res (2009) 1.38
Noncanonical TGF-β signaling during mammary tumorigenesis. J Mammary Gland Biol Neoplasia (2011) 1.38
TGF-{beta} maintains dormancy of prostatic stem cells in the proximal region of ducts. J Cell Biol (2005) 1.35
Reciprocal repression between P53 and TCTP. Nat Med (2011) 1.35
Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling. Genes Dev (2008) 1.34
Characterization of side populations in HNSCC: highly invasive, chemoresistant and abnormal Wnt signaling. PLoS One (2010) 1.33
Use of preclinical models to improve treatment of retinoblastoma. PLoS Med (2005) 1.31
Mage-b vaccine delivered by recombinant Listeria monocytogenes is highly effective against breast cancer metastases. Br J Cancer (2008) 1.29
Molecular characterization of spontaneous mesenchymal stem cell transformation. PLoS One (2008) 1.26
The biology of head and neck cancer stem cells. Oral Oncol (2011) 1.25
Pancreatic cancer: pathobiology, treatment options, and drug delivery. AAPS J (2010) 1.25
Cooperation between EZH2, NSPc1-mediated histone H2A ubiquitination and Dnmt1 in HOX gene silencing. Nucleic Acids Res (2008) 1.24
Arsenic-specific stem cell selection during malignant transformation. J Natl Cancer Inst (2010) 1.24
Erythroid progenitor renewal versus differentiation: genetic evidence for cell autonomous, essential functions of EpoR, Stat5 and the GR. Oncogene (2006) 1.22
Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway. Cell Death Differ (2013) 1.22
Gliomas display a microRNA expression profile reminiscent of neural precursor cells. Neuro Oncol (2010) 1.22
Which are the cells of origin in merkel cell carcinoma? J Skin Cancer (2012) 1.21
Glioblastoma Multiforme Oncogenomics and Signaling Pathways. Clin Med Oncol (2009) 1.21
A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell. Curr Opin Genet Dev (2009) 1.20
Simultaneous detection of mRNA and protein stem cell markers in live cells. BMC Biotechnol (2009) 1.20
Senescence evasion by MCF-7 human breast tumor-initiating cells. Breast Cancer Res (2010) 1.19
Hypoxic tumor microenvironment and cancer cell differentiation. Curr Mol Med (2009) 1.19
Loss of the human polycomb group protein BMI1 promotes cancer-specific cell death. Oncogene (2006) 1.19
Identification of a potential ovarian cancer stem cell gene expression profile from advanced stage papillary serous ovarian cancer. PLoS One (2012) 1.18
Genetic variations in the sonic hedgehog pathway affect clinical outcomes in non-muscle-invasive bladder cancer. Cancer Prev Res (Phila) (2010) 1.18
The molecular portrait of in vitro growth by meta-analysis of gene-expression profiles. Genome Biol (2005) 1.17
Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin. Proc Natl Acad Sci U S A (2009) 1.17
The expressions of stem cell markers: Oct4, Nanog, Sox2, nucleostemin, Bmi, Zfx, Tcl1, Tbx3, Dppa4, and Esrrb in bladder, colon, and prostate cancer, and certain cancer cell lines. Anat Cell Biol (2014) 1.15
Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis. Gastroenterology (2009) 1.15
Candidate pathways for promoting differentiation or quiescence of oligodendrocyte progenitor-like cells in glioma. Cancer Res (2012) 1.15
Reciprocal intraepithelial interactions between TP63 and hedgehog signaling regulate quiescence and activation of progenitor elaboration by mammary stem cells. Stem Cells (2008) 1.15
Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance. Autophagy (2013) 1.15
Patient-derived xenografts of non small cell lung cancer: resurgence of an old model for investigation of modern concepts of tailored therapy and cancer stem cells. J Biomed Biotechnol (2012) 1.14
FoxO tumor suppressors and BCR-ABL-induced leukemia: a matter of evasion of apoptosis. Biochim Biophys Acta (2007) 1.13
Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell (2005) 24.00
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev (2003) 20.77
Identification of pancreatic cancer stem cells. Cancer Res (2007) 18.36
Efficient tumour formation by single human melanoma cells. Nature (2008) 16.35
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature (2003) 14.35
Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A (2007) 13.58
The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med (2007) 13.39
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature (2006) 11.86
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature (2003) 11.23
Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature (2009) 10.31
CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer. N Engl J Med (2016) 8.53
Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell (2009) 8.33
Cancer stem cells: models and concepts. Annu Rev Med (2007) 8.06
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature (2006) 8.06
Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotechnol (2011) 7.84
Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell (2009) 7.09
Endothelial and perivascular cells maintain haematopoietic stem cells. Nature (2012) 6.60
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature (2003) 6.35
The biology of cancer stem cells. Annu Rev Cell Dev Biol (2007) 6.23
Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev (2005) 5.78
Tumour heterogeneity and cancer cell plasticity. Nature (2013) 5.47
Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell (2012) 5.44
Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression. Cell (2008) 5.07
Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU. Nature (2007) 4.62
Self-renewal and solid tumor stem cells. Oncogene (2004) 4.60
Stem cells in normal breast development and breast cancer. Cell Prolif (2003) 4.47
Uncertainty in the niches that maintain haematopoietic stem cells. Nat Rev Immunol (2008) 4.42
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A (2012) 4.20
Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell (2007) 4.18
Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature (2013) 4.11
Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PLoS One (2008) 3.97
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature (2010) 3.93
Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness. Neuron (2002) 3.92
Bmi1, stem cells, and senescence regulation. J Clin Invest (2004) 3.80
Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized. Cancer Cell (2010) 3.70
Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors. Stem Cells (2007) 3.60
DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency. Cell Stem Cell (2009) 3.48
Diverse mechanisms regulate stem cell self-renewal. Curr Opin Cell Biol (2004) 3.34
SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity. Blood (2005) 3.22
Therapeutic implications of cancer stem cells. Curr Opin Genet Dev (2004) 3.04
Mechanisms of stem cell self-renewal. Annu Rev Cell Dev Biol (2009) 3.00
Hirschsprung disease is linked to defects in neural crest stem cell function. Science (2003) 2.98
Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance. Cell Stem Cell (2007) 2.96
Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc Natl Acad Sci U S A (2010) 2.89
Cell-intrinsic differences between stem cells from different regions of the peripheral nervous system regulate the generation of neural diversity. Neuron (2002) 2.85
Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors. Nature (2008) 2.82
Dysregulated gene expression networks in human acute myelogenous leukemia stem cells. Proc Natl Acad Sci U S A (2009) 2.76
Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors. Blood (2006) 2.67
HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells. Cell Host Microbe (2011) 2.59
SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors. Cell Stem Cell (2013) 2.47
Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. Proc Natl Acad Sci U S A (2007) 2.41
Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation. Nat Med (2006) 2.23
Recent advances in cancer stem cells. Curr Opin Genet Dev (2008) 2.17
Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. Cell Stem Cell (2012) 2.15
Cancer stem cells and radiotherapy: new insights into tumor radioresistance. J Natl Cancer Inst (2006) 2.10
Neural crest stem cells undergo multilineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells. Development (2004) 1.98
Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer. J Clin Invest (2012) 1.92
Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut. J Clin Invest (2011) 1.88
mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion. Cell Stem Cell (2010) 1.82
FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood (2010) 1.78
Mechanisms that regulate stem cell aging and life span. Cell Stem Cell (2013) 1.73
Maintaining hematopoietic stem cells in the vascular niche. Immunity (2006) 1.72
Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress. Nat Cell Biol (2010) 1.71
Differential gene expression profiling of adult murine hematopoietic stem cells. Blood (2002) 1.69
CD144 (VE-cadherin) is transiently expressed by fetal liver hematopoietic stem cells. Blood (2005) 1.64
CD150- cells are transiently reconstituting multipotent progenitors with little or no stem cell activity. Blood (2008) 1.57
Bmi-1-green fluorescent protein-knock-in mice reveal the dynamic regulation of bmi-1 expression in normal and leukemic hematopoietic cells. Stem Cells (2007) 1.57
The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell (2008) 1.54
Therapeutic implications of the cancer stem cell hypothesis. Semin Radiat Oncol (2009) 1.53
Cancer stem cells and tumor metastasis: first steps into uncharted territory. Cell Stem Cell (2007) 1.48
Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems. Development (2007) 1.47
Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Blood (2008) 1.45
MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11. Nat Commun (2013) 1.43
Hematopoietic stem cell self-renewal. Curr Opin Genet Dev (2006) 1.42
A genetic determinant that specifically regulates the frequency of hematopoietic stem cells. J Immunol (2002) 1.41
Integrating physiological regulation with stem cell and tissue homeostasis. Neuron (2011) 1.41
Temporally distinct requirements for endothelin receptor B in the generation and migration of gut neural crest stem cells. Neuron (2003) 1.41
Hematopoietic stem cells do not depend on N-cadherin to regulate their maintenance. Cell Stem Cell (2009) 1.39
Persistence of leukemia-initiating cells in a conditional knockin model of an imatinib-responsive myeloproliferative disorder. Cancer Cell (2009) 1.36
Sox17 expression confers self-renewal potential and fetal stem cell characteristics upon adult hematopoietic progenitors. Genes Dev (2011) 1.36
Toward an understanding of the physiological function of Mammalian stem cells. Dev Cell (2005) 1.35
Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice. Gastroenterology (2012) 1.32
Spatial differences in hematopoiesis but not in stem cells indicate a lack of regional patterning in definitive hematopoietic stem cells. Dev Biol (2005) 1.22
Effects of time since fire on birds: how informative are generalized fire response curves for conservation management? Ecol Appl (2012) 1.22
Human melanoma metastasis in NSG mice correlates with clinical outcome in patients. Sci Transl Med (2012) 1.18
Inhibition of AMPK catabolic action by GSK3. Mol Cell (2013) 1.18
Temporal specification of blood progenitors from mouse embryonic stem cells and induced pluripotent stem cells. Development (2010) 1.17
Lack of population diversity in commonly used human embryonic stem-cell lines. N Engl J Med (2009) 1.17
Automated microfluidic chromatin immunoprecipitation from 2,000 cells. Lab Chip (2009) 1.17
Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature (2013) 1.13
An in vivo model to study and manipulate the hematopoietic stem cell niche. Blood (2010) 1.11
Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo. Dev Biol (2009) 1.10
MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion. Breast Cancer Res Treat (2012) 1.07
Developmental changes in Notch1 and numb expression mediated by local cell-cell interactions underlie progressively increasing delta sensitivity in neural crest stem cells. Dev Biol (2002) 1.03
Huntingtin Interacting Protein 1 mutations lead to abnormal hematopoiesis, spinal defects and cataracts. Hum Mol Genet (2004) 1.01