Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27598965)

Published in Transl Psychiatry on September 06, 2016

Authors

L Zhou1, S L Ma2, P K K Yeung1,3, Y H Wong4,5, K W K Tsim5,6, K F So1,7,8,9, L C W Lam2, S K Chung1,3,7

Author Affiliations

1: School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
2: Department of Psychiatry, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
3: State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
4: Division of Life Science and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China.
5: State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China.
6: Division of Life Science and Center for Chinese Medicine, Hong Kong University of Science and Technology, Clear Water Bay, Clear Water Bay, Hong Kong SAR, China.
7: Research Center of Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
8: State Key Laboratory of Brain and Cognitive Science, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
9: Department of Ophthalmology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.

Articles cited by this

Emotion circuits in the brain. Annu Rev Neurosci (2000) 24.39

A new clinical scale for the staging of dementia. Br J Psychiatry (1982) 21.77

A new rating scale for Alzheimer's disease. Am J Psychiatry (1984) 15.16

Annotation of functional variation in personal genomes using RegulomeDB. Genome Res (2012) 11.47

Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci (2000) 9.12

A neurotrophic model for stress-related mood disorders. Biol Psychiatry (2006) 8.97

The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Eur J Pharmacol (2003) 6.40

The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. Neurology (1997) 6.33

Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus. Nature (2004) 6.15

A family of cAMP-binding proteins that directly activate Rap1. Science (1998) 6.12

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature (2011) 6.08

Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. Proc Natl Acad Sci U S A (2006) 5.83

Transient expression of doublecortin during adult neurogenesis. J Comp Neurol (2003) 5.61

A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. Neuron (2007) 5.31

Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type. Int Psychogeriatr (1997) 4.87

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature (1998) 4.62

cAMP-dependent signaling as a core component of the mammalian circadian pacemaker. Science (2008) 4.02

Neurogenesis may relate to some but not all types of hippocampal-dependent learning. Hippocampus (2002) 3.91

Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Arch Gen Psychiatry (2004) 3.64

Fluoxetine targets early progenitor cells in the adult brain. Proc Natl Acad Sci U S A (2006) 3.39

Effects of chronic fluoxetine in animal models of anxiety and depression. Neuropsychopharmacology (2004) 3.17

Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy. Arch Gen Psychiatry (2007) 3.15

Short-term and long-term survival of new neurons in the rat dentate gyrus. J Comp Neurol (2003) 3.01

Adult brain neurogenesis and psychiatry: a novel theory of depression. Mol Psychiatry (2000) 2.87

Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology (2003) 2.75

Forced swimming test in mice: a review of antidepressant activity. Psychopharmacology (Berl) (2004) 2.74

Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. Proc Natl Acad Sci U S A (2007) 2.59

Unique processing during a period of high excitation/inhibition balance in adult-born neurons. Science (2012) 2.45

Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease. J Neurochem (2002) 2.45

Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nat Rev Drug Discov (2012) 2.44

Adult hippocampal neurogenesis is involved in anxiety-related behaviors. Mol Psychiatry (2009) 2.17

Structure and regulation of the cAMP-binding domains of Epac2. Nat Struct Biol (2003) 2.11

Circadian clock proteins control adaptation to novel environment and memory formation. Aging (Albany NY) (2010) 1.95

Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation. BMC Neurosci (2006) 1.84

Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone. Neuropsychopharmacology (2004) 1.77

Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation. Mol Cell Biol (2006) 1.75

Acute corticosterone treatment is sufficient to induce anxiety and amygdaloid dendritic hypertrophy. Proc Natl Acad Sci U S A (2008) 1.75

Direct modulation of synaptic vesicle priming by GABA(B) receptor activation at a glutamatergic synapse. Nature (2003) 1.71

Gene enrichment profiles reveal T-cell development, differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor. Blood (2010) 1.69

Modulation of hippocampal cell proliferation, memory, and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress. Neuroscience (2004) 1.66

History of depression, depressive symptoms, and medial temporal lobe atrophy and the risk of Alzheimer disease. Neurology (2008) 1.64

Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines. Nat Neurosci (2009) 1.58

Regulation of adult neurogenesis by antidepressant treatment. Neuropsychopharmacology (2001) 1.54

Increased generation of granule cells in adult Bcl-2-overexpressing mice: a role for cell death during continued hippocampal neurogenesis. Eur J Neurosci (2005) 1.53

Signaling pathways regulating gene expression, neuroplasticity, and neurotrophic mechanisms in the action of antidepressants: a critical overview. Pharmacol Rev (2006) 1.51

High-throughput SNP genotyping by single-tube PCR with Tm-shift primers. Biotechniques (2005) 1.48

Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha. Nat Cell Biol (2003) 1.46

A novel cyclic AMP-dependent Epac-Rit signaling pathway contributes to PACAP38-mediated neuronal differentiation. Mol Cell Biol (2006) 1.45

Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants. J Neurosci (2012) 1.45

Localization of phosphorylated cAMP response element-binding protein in immature neurons of adult hippocampus. J Neurosci (2002) 1.44

Acute hippocampal brain-derived neurotrophic factor restores motivational and forced swim performance after corticosterone. Biol Psychiatry (2008) 1.37

A guideline for analyzing circadian wheel-running behavior in rodents under different lighting conditions. Biol Proced Online (2005) 1.34

Stress impairs GABAergic network function in the hippocampus by activating nongenomic glucocorticoid receptors and affecting the integrity of the parvalbumin-expressing neuronal network. Neuropsychopharmacology (2010) 1.27

EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation. Neuron (2012) 1.27

Bidirectional modulation of long-term potentiation by novelty-exploration in rat dentate gyrus. Neurosci Lett (2003) 1.25

Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein-mediated neurogenesis in the hippocampus. Neuropsychopharmacology (2009) 1.21

Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions. Pharmacol Rev (2013) 1.21

Novel environments enhance the induction and maintenance of long-term potentiation in the dentate gyrus. J Neurosci (2004) 1.13

Epac signaling is required for hippocampus-dependent memory retrieval. Proc Natl Acad Sci U S A (2008) 1.11

Behavioral, neuroendocrine and serotonergic consequences of single social defeat and repeated fluoxetine pretreatment in the Lewis rat strain. Neuroscience (1999) 1.06

Behavioural trait of reactivity to novelty is related to hippocampal neurogenesis. Eur J Neurosci (1999) 1.05

Circadian rhythms and depression: effects of exercise in an animal model. Am J Physiol (1999) 1.02

Social, communication, and cortical structural impairments in Epac2-deficient mice. J Neurosci (2012) 1.02

Differential roles of Epac in regulating cell death in neuronal and myocardial cells. J Biol Chem (2010) 1.02

Cyclic nucleotide signalling: a molecular approach to drug discovery for Alzheimer's disease. Biochem Soc Trans (2005) 1.00

Developmental etiology for neuroanatomical and cognitive deficits in mice overexpressing Galphas, a G-protein subunit genetically linked to schizophrenia. Mol Psychiatry (2008) 0.99

Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function. J Cell Physiol (2009) 0.99

Validation study of the Chinese version of the neuropsychiatric inventory (CNPI). Int J Geriatr Psychiatry (2001) 0.97

The reliability and validity of the Alzheimer's Disease Assessment Scale Cognitive Subscale (ADAS-Cog) among the elderly Chinese in Hong Kong. Ann Acad Med Singapore (2000) 0.97

ACTH inhibits bTREK-1 K+ channels through multiple cAMP-dependent signaling pathways. J Gen Physiol (2008) 0.96

Hippocampal GABAergic dysfunction in a rat chronic mild stress model of depression. Hippocampus (2011) 0.95

Critical maturational period of new neurons in adult dentate gyrus for their involvement in memory formation. Eur J Neurosci (2011) 0.95

Differential and brain region-specific regulation of Rap-1 and Epac in depressed suicide victims. Arch Gen Psychiatry (2006) 0.94

A remote and highly conserved enhancer supports amygdala specific expression of the gene encoding the anxiogenic neuropeptide substance-P. Mol Psychiatry (2006) 0.92

Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop β-cell dysfunction and metabolic syndrome. FASEB J (2013) 0.91

Neuronal and glial alterations, increased anxiety, and cognitive impairment before hippocampal amyloid deposition in PDAPP mice, model of Alzheimer's disease. Hippocampus (2013) 0.90

Anxiety is related to Alzheimer cerebrospinal fluid markers in subjects with mild cognitive impairment. Psychol Med (2012) 0.90

Chronic stress enhances synaptic plasticity due to disinhibition in the anterior cingulate cortex and induces hyper-locomotion in mice. Neuropharmacology (2009) 0.89

Transgenic mice over-expressing endothelial endothelin-1 show cognitive deficit with blood-brain barrier breakdown after transient ischemia with long-term reperfusion. Neurobiol Learn Mem (2013) 0.89

Effects of fluoxetine administration on mood response to tryptophan depletion in healthy subjects. Biol Psychiatry (1997) 0.89

Effect of chronic antidepressant treatment on transcription factor binding activity in rat hippocampus and frontal cortex. Prog Neuropsychopharmacol Biol Psychiatry (1998) 0.88

Exchange protein activated by cyclic AMP 2 (Epac2) plays a specific and time-limited role in memory retrieval. Hippocampus (2010) 0.87

Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac. FEBS Lett (2005) 0.87

The establishment of a sensitive method in determining different neurotransmitters simultaneously in rat brains by using liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2011) 0.86

GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors. Development (2013) 0.86

Cortical migration defects in mice expressing A-RAF from the B-RAF locus. Mol Cell Biol (2006) 0.84

Animal models of anxiety. Handb Exp Pharmacol (2005) 0.83

MR diffusion tensor imaging detects rapid microstructural changes in amygdala and hippocampus following fear conditioning in mice. PLoS One (2013) 0.82

Chronic allopregnanolone treatment accelerates Alzheimer's disease development in AβPP(Swe)PSEN1(ΔE9) mice. J Alzheimers Dis (2012) 0.81

An inhibitor of cAMP-dependent protein kinase induces behavioural and neurological antidepressant-like effects in rats. Neurosci Lett (2011) 0.79

An association between Epac-1 gene variants and anxiety and depression in two independent samples. Am J Med Genet B Neuropsychiatr Genet (2010) 0.77

Evaluation of an algorithm of tagging SNPs selection by linkage disequilibrium. Clin Biochem (2006) 0.77