Published in Aging (Albany NY) on May 01, 2010
The circadian clock and pathology of the ageing brain. Nat Rev Neurosci (2012) 1.90
Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J Clin Invest (2013) 1.57
Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice. Aging (Albany NY) (2010) 1.19
The circadian clock: a framework linking metabolism, epigenetics and neuronal function. Nat Rev Neurosci (2012) 1.08
When brain clocks lose track of time: cause or consequence of neuropsychiatric disorders. Curr Opin Neurobiol (2011) 0.97
Fatty-acid binding proteins modulate sleep and enhance long-term memory consolidation in Drosophila. PLoS One (2011) 0.93
Genetic disruption of the core circadian clock impairs hippocampus-dependent memory. Learn Mem (2014) 0.93
Behavioral changes and dopaminergic dysregulation in mice lacking the nuclear receptor Rev-erbα. Mol Endocrinol (2014) 0.92
Aging signaling pathways and circadian clock-dependent metabolic derangements. Trends Endocrinol Metab (2013) 0.90
Time of day regulates subcellular trafficking, tripartite synaptic localization, and polyadenylation of the astrocytic Fabp7 mRNA. J Neurosci (2012) 0.90
Ketamine influences CLOCK:BMAL1 function leading to altered circadian gene expression. PLoS One (2011) 0.87
Transcriptional control of antioxidant defense by the circadian clock. Antioxid Redox Signal (2014) 0.86
Modulation of ATR-mediated DNA damage checkpoint response by cryptochrome 1. Nucleic Acids Res (2014) 0.85
Cognitive dysfunction, elevated anxiety, and reduced cocaine response in circadian clock-deficient cryptochrome knockout mice. Front Behav Neurosci (2013) 0.83
The circadian clock, reward, and memory. Front Mol Neurosci (2011) 0.83
Rhythmic oscillations of the microRNA miR-96-5p play a neuroprotective role by indirectly regulating glutathione levels. Nat Commun (2014) 0.83
BMAL1 controls the diurnal rhythm and set point for electrical seizure threshold in mice. Front Syst Neurosci (2014) 0.83
Influence of aging on Bmal1 and Per2 expression in extra-SCN oscillators in hamster brain. Brain Res (2012) 0.82
Synchrony and desynchrony in circadian clocks: impacts on learning and memory. Learn Mem (2015) 0.80
Pharmacological modulators of the circadian clock as potential therapeutic drugs: focus on genotoxic/anticancer therapy. Handb Exp Pharmacol (2013) 0.80
Neither the SCN nor the adrenals are required for circadian time-place learning in mice. Chronobiol Int (2014) 0.79
Premature aging of the hippocampal neurogenic niche in adult Bmal1-deficient mice. Aging (Albany NY) (2015) 0.78
Mice with altered brain lipoprotein metabolism display maladaptive responses to environmental challenges that may predispose to weight gain. Metab Syndr Relat Disord (2014) 0.78
Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex. Proc Natl Acad Sci U S A (2015) 0.78
Circadian Mechanisms Underlying Reward-Related Neurophysiology and Synaptic Plasticity. Front Psychiatry (2016) 0.78
Aging brains and waning clocks on the process of habituation. Aging (Albany NY) (2010) 0.77
Neuronal correlates of depression. Cell Mol Life Sci (2015) 0.77
The aging clock: to 'BMAL'icious toward learning and memory. Aging (Albany NY) (2010) 0.77
Circadian Clock Genes Are Essential for Normal Adult Neurogenesis, Differentiation, and Fate Determination. PLoS One (2015) 0.77
Diurnal Variation Has Effect on Differential Gene Expression Analysis in the Hippocampus of the Pilocarpine-Induced Model of Mesial Temporal Lobe Epilepsy. PLoS One (2015) 0.76
Circadian Regulation of Synaptic Plasticity. Biology (Basel) (2016) 0.76
Time-place learning over a lifetime: absence of memory loss in trained old mice. Learn Mem (2015) 0.76
Ageing or NOT, clock genes are important for memory processes: an interesting hypothesis raising many questions. Aging (Albany NY) (2010) 0.76
Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer's disease. Sleep Med Rev (2016) 0.75
Aging of Attentiveness in Border Collies and Other Pet Dog Breeds: The Protective Benefits of Lifelong Training. Front Aging Neurosci (2017) 0.75
Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac. Transl Psychiatry (2016) 0.75
Exposure to light at night accelerates aging and spontaneous uterine carcinogenesis in female 129/Sv mice. Cell Cycle (2013) 0.75
Epigenetic alterations in the suprachiasmatic nucleus and hippocampus contribute to age-related cognitive decline. Oncotarget (2015) 0.75
Clock Genes in Glia Cells: A Rhythmic History. ASN Neuro (2016) 0.75
Modulation of learning and memory by the targeted deletion of the circadian clock gene Bmal1 in forebrain circuits. Behav Brain Res (2016) 0.75
Signatures of selection in mammalian clock genes with coding trinucleotide repeats: Implications for studying the genomics of high-pace adaptation. Ecol Evol (2017) 0.75
GSK3 activity regulates rhythms in hippocampal clock gene expression and synaptic plasticity. Hippocampus (2017) 0.75
Mop3 is an essential component of the master circadian pacemaker in mammals. Cell (2000) 8.72
Functional identification of the mouse circadian Clock gene by transgenic BAC rescue. Cell (1997) 5.51
Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. Genes Dev (2006) 4.90
Translational control of long-lasting synaptic plasticity and memory. Neuron (2009) 4.77
Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Science (1999) 4.70
Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2. Proc Natl Acad Sci U S A (1999) 4.62
Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A (2007) 3.92
Neural mechanisms of ageing and cognitive decline. Nature (2010) 3.59
Habituation revisited: an updated and revised description of the behavioral characteristics of habituation. Neurobiol Learn Mem (2008) 3.23
Circadian oscillation of hippocampal MAPK activity and cAmp: implications for memory persistence. Nat Neurosci (2008) 3.03
Measuring normal and pathological anxiety-like behaviour in mice: a review. Behav Brain Res (2001) 2.98
Regulation of dopaminergic transmission and cocaine reward by the Clock gene. Proc Natl Acad Sci U S A (2005) 2.95
Cocaine sensitization and reward are under the influence of circadian genes and rhythm. Proc Natl Acad Sci U S A (2002) 2.40
Impaired cued and contextual memory in NPAS2-deficient mice. Science (2000) 2.14
Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood. Curr Biol (2008) 1.97
Healthy clocks, healthy body, healthy mind. Trends Cell Biol (2009) 1.95
Posttranscriptional and posttranslational regulation of clock genes. J Biol Rhythms (2004) 1.94
Circadian modulation of learning and memory in fear-conditioned mice. Behav Brain Res (2002) 1.84
Dual role of the CLOCK/BMAL1 circadian complex in transcriptional regulation. FASEB J (2006) 1.76
Living by the clock: the circadian pacemaker in older people. Ageing Res Rev (2005) 1.73
Reactive oxygen species and synaptic plasticity in the aging hippocampus. Ageing Res Rev (2004) 1.72
Circadian clock genes and sleep homeostasis. Eur J Neurosci (2009) 1.62
Habituation in rodents: a review of behavior, neurobiology, and genetics. Neurosci Biobehav Rev (2006) 1.59
What is remembered? Role of attention on the encoding and retrieval of hippocampal representations. J Physiol (2009) 1.53
Rearing on hind legs, environmental novelty, and the hippocampal formation. Rev Neurosci (2006) 1.40
Cycling behavior and memory formation. J Neurosci (2009) 1.37
Mitogen-activated protein kinase pathways in redox signaling. Front Biosci (2003) 1.33
Neurobiology of a simple memory. J Neurophysiol (2008) 1.28
Expression of the circadian clock gene Period2 in the hippocampus: possible implications for synaptic plasticity and learned behaviour. ASN Neuro (2009) 1.26
Temporal dynamics of mouse hippocampal clock gene expression support memory processing. Hippocampus (2010) 1.24
The role of mammalian circadian proteins in normal physiology and genotoxic stress responses. Curr Top Dev Biol (2007) 1.23
Functional magnetic resonance imaging-assessed brain responses during an executive task depend on interaction of sleep homeostasis, circadian phase, and PER3 genotype. J Neurosci (2009) 1.20
Genetic dissection of mouse exploratory behaviour. Behav Brain Res (2001) 1.19
Hippocampus, theta, and spatial memory. Curr Opin Neurobiol (1993) 1.17
Reversible impairment of long-term potentiation in transgenic Cu/Zn-SOD mice. Eur J Neurosci (1998) 1.14
The circadian Clock mutation increases exploratory activity and escape-seeking behavior. Genes Brain Behav (2003) 1.13
Circadian time-place learning in mice depends on Cry genes. Curr Biol (2008) 1.07
Circadian modulation of short-term memory in Drosophila. Learn Mem (2008) 1.05
Chronic cocaine or ethanol exposure during adolescence alters novelty-related behaviors in adulthood. Pharmacol Biochem Behav (2007) 0.98
Locomotory patterns, spatiotemporal organization of exploration and spatial memory in serotonin transporter knockout mice. Brain Res (2007) 0.93
A role for reactive oxygen/nitrogen species and iron on neuronal synaptic plasticity. Antioxid Redox Signal (2007) 0.92
Behavioral habituation to spatial novelty: interference and noninterference studies. Neurosci Biobehav Rev (1994) 0.92
Rhythms of memory. Nat Neurosci (2008) 0.86
Coordinated transcription of key pathways in the mouse by the circadian clock. Cell (2002) 14.07
Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. Genes Dev (2006) 4.90
Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation. Proc Natl Acad Sci U S A (2007) 3.06
Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature (2012) 2.59
BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system. Genes Dev (2003) 2.37
The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude. Proc Natl Acad Sci U S A (2006) 2.36
Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice. Oncogene (2004) 2.34
Rapamycin extends maximal lifespan in cancer-prone mice. Am J Pathol (2010) 2.22
Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex. Proc Natl Acad Sci U S A (2005) 1.91
The circadian clock and pathology of the ageing brain. Nat Rev Neurosci (2012) 1.90
Circadian clock protein BMAL1 regulates cellular senescence in vivo. Cell Cycle (2011) 1.87
Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice. Aging (Albany NY) (2012) 1.79
Dual role of the CLOCK/BMAL1 circadian complex in transcriptional regulation. FASEB J (2006) 1.76
The orphan receptor Rev-erbalpha gene is a target of the circadian clock pacemaker. J Mol Endocrinol (2004) 1.50
BMAL1-dependent regulation of the mTOR signaling pathway delays aging. Aging (Albany NY) (2014) 1.48
New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis. Aging (Albany NY) (2012) 1.47
Post-translational regulation of circadian transcriptional CLOCK(NPAS2)/BMAL1 complex by CRYPTOCHROMES. Cell Cycle (2006) 1.43
Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis. Cell Cycle (2008) 1.35
Circadian proteins in the regulation of cell cycle and genotoxic stress responses. Trends Cell Biol (2007) 1.30
Core circadian protein CLOCK is a positive regulator of NF-κB-mediated transcription. Proc Natl Acad Sci U S A (2012) 1.28
A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation. Cell Cycle (2009) 1.27
Circadian regulation of cell cycle: Molecular connections between aging and the circadian clock. Ann Med (2010) 1.25
The role of mammalian circadian proteins in normal physiology and genotoxic stress responses. Curr Top Dev Biol (2007) 1.23
Circadian clock genes as modulators of sensitivity to genotoxic stress. Cell Cycle (2005) 1.20
Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice. Aging (Albany NY) (2010) 1.19
Antioxidant N-acetyl-L-cysteine ameliorates symptoms of premature aging associated with the deficiency of the circadian protein BMAL1. Aging (Albany NY) (2009) 1.14
A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice. Cell Cycle (2010) 1.01
Dominant negative form of signal-regulatory protein-alpha (SIRPalpha /SHPS-1) inhibits tumor necrosis factor-mediated apoptosis by activation of NF-kappa B. J Biol Chem (2002) 1.00
Circadian proteins and genotoxic stress response. Circ Res (2010) 0.99
Poliovirus protein 3A binds and inactivates LIS1, causing block of membrane protein trafficking and deregulation of cell division. Cell Cycle (2005) 0.89
An extraribosomal function of ribosomal protein L13a in macrophages resolves inflammation. J Immunol (2013) 0.88
Evidence for circadian regulation of activating transcription factor 5 but not tyrosine hydroxylase by the chromaffin cell clock. Endocrinology (2007) 0.88
Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1. Oncotarget (2011) 0.87
Transcriptional control of antioxidant defense by the circadian clock. Antioxid Redox Signal (2014) 0.86
The ability of protein tyrosine phosphatase SHP-1 to suppress NFkappaB can be inhibited by dominant negative mutant of SIRPalpha. DNA Cell Biol (2004) 0.85
Selection-subtraction approach (SSA): a universal genetic screening technique that enables negative selection. Proc Natl Acad Sci U S A (2004) 0.84
Pharmacological modulators of the circadian clock as potential therapeutic drugs: focus on genotoxic/anticancer therapy. Handb Exp Pharmacol (2013) 0.80
Daily rhythms are retained both in spontaneously developed sarcomas and in xenografts grown in immunocompromised SCID mice. Chronobiol Int (2014) 0.75