Src Family Kinases Modulate the Loss of Endothelial Barrier Function in Response to TNF-α: Crosstalk with p38 Signaling.

Regulation of endothelial barrier function by p120-catenin·VE-Cadherin interaction. Mol Biol Cell (2016) 0.75

Impaired activity of adherens junctions contributes to endothelial dilator dysfunction in aging rat arteries. J Physiol (2017) 0.75

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell (1991) 14.89

Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol (1997) 11.36

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol Cell Biol (1996) 6.91

The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood (2003) 5.22

Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J (1999) 5.05

VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin. Nat Cell Biol (2006) 5.00

Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol Cell (1999) 4.55

Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells. J Cell Sci (1998) 3.80

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell (1992) 3.70

The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proc Natl Acad Sci U S A (2011) 3.40

Src kinase regulation by phosphorylation and dephosphorylation. Biochem Biophys Res Commun (2005) 3.31

Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice. Cell (1993) 3.08

Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. J Cell Biol (1996) 2.96

Cytokine serum level during severe sepsis in human IL-6 as a marker of severity. Ann Surg (1992) 2.96

Regulation of endothelial permeability via paracellular and transcellular transport pathways. Annu Rev Physiol (2010) 2.86

Constitutive activation of Src family kinases in mouse embryos that lack Csk. Cell (1993) 2.75

Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity. Mediators Inflamm (2005) 2.63

Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction. J Clin Invest (2004) 2.48

Tumour necrosis factor in bronchopulmonary secretions of patients with adult respiratory distress syndrome. Lancet (1989) 2.43

Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice. Genes Dev (1994) 2.28

Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase/heat shock protein 27 pathway in vascular endothelial cells. Circ Res (1997) 2.27

Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke. Nat Med (2001) 2.16

Role of GTPases in control of microvascular permeability. Cardiovasc Res (2010) 2.12

Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin. Nat Immunol (2014) 2.10

Roles of Rho/ROCK and MLCK in TNF-alpha-induced changes in endothelial morphology and permeability. J Cell Physiol (2007) 2.03

Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells. J Cell Sci (1997) 2.01

Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta) in dengue-infected patients. Am J Trop Med Hyg (1993) 1.90

Histamine induces tyrosine phosphorylation of endothelial cell-to-cell adherens junctions. Arterioscler Thromb Vasc Biol (1999) 1.81

alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. Immunity (1996) 1.79

Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo. Nat Commun (2012) 1.78

Divergent roles of endothelial NF-kappaB in multiple organ injury and bacterial clearance in mouse models of sepsis. J Exp Med (2008) 1.70

TNF-α signals through PKCζ/NF-κB to alter the tight junction complex and increase retinal endothelial cell permeability. Diabetes (2010) 1.60

TLR4 signaling is coupled to SRC family kinase activation, tyrosine phosphorylation of zonula adherens proteins, and opening of the paracellular pathway in human lung microvascular endothelia. J Biol Chem (2008) 1.55

Csk controls antigen receptor-mediated development and selection of T-lineage cells. Nature (1998) 1.54

Adherens junctions connect stress fibres between adjacent endothelial cells. BMC Biol (2010) 1.52

TNF-alpha increases tyrosine phosphorylation of vascular endothelial cadherin and opens the paracellular pathway through fyn activation in human lung endothelia. Am J Physiol Lung Cell Mol Physiol (2006) 1.49

Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis. Blood (1996) 1.37

Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF. J Biol Chem (2006) 1.36

Regulation of the SRC family kinases by Csk. Int J Biol Sci (2012) 1.36

Src-induced tyrosine phosphorylation of VE-cadherin is not sufficient to decrease barrier function of endothelial monolayers. J Biol Chem (2010) 1.35

The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin. J Exp Med (2009) 1.21

A permissive role for tumor necrosis factor in vascular endothelial growth factor-induced vascular permeability. Blood (2001) 1.19

MAP kinases in lung endothelial permeability induced by microtubule disassembly. Am J Physiol Lung Cell Mol Physiol (2005) 1.18

p38 MAPK activation by TGF-beta1 increases MLC phosphorylation and endothelial monolayer permeability. Am J Physiol Lung Cell Mol Physiol (2002) 1.12

Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin. Am J Physiol Lung Cell Mol Physiol (2002) 1.12

Plasma levels of tumor necrosis factor in the adult respiratory distress syndrome. Am Rev Respir Dis (1991) 1.06

Three-dimensional reconstruction of endothelial cell gaps in psoriatic vessels and their morphologic identity with gaps produced by the intradermal injection of histamine. J Invest Dermatol (1986) 1.05

Intravital video-capillaroscopy for the study of the microcirculation in psoriasis. Br J Dermatol (1992) 1.05

The Dual Role of TNF in Pulmonary Edema. J Cardiovasc Dis Res (2010) 0.99

C-terminal Src kinase controls development and maintenance of mouse squamous epithelia. EMBO J (2007) 0.99

Adenovirus-mediated overexpression of C-terminal Src kinase (Csk) in type I astrocytes interferes with cell spreading and attachment to fibronectin. Correlation with tyrosine phosphorylations of paxillin and FAK. J Biol Chem (1999) 0.99

Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk). J Exp Med (2001) 0.97

A critical role for Lyn kinase in strengthening endothelial integrity and barrier function. Blood (2013) 0.95

TNF-induced endothelial barrier disruption: beyond actin and Rho. Thromb Haemost (2014) 0.95

Transforming growth factor-beta1 effects on endothelial monolayer permeability involve focal adhesion kinase/Src. Am J Respir Cell Mol Biol (2007) 0.94

Barrier dysfunction of the corneal endothelium in response to TNF-alpha: role of p38 MAP kinase. Invest Ophthalmol Vis Sci (2009) 0.88

Phosphatases and kinases as regulators of the endothelial barrier function. Cell Tissue Res (2014) 0.88

A disintegrin and metalloproteinase 15 contributes to atherosclerosis by mediating endothelial barrier dysfunction via Src family kinase activity. Arterioscler Thromb Vasc Biol (2012) 0.87

The role of actin-binding proteins in the control of endothelial barrier integrity. Thromb Haemost (2014) 0.87

Plasma concentrations of tumour necrosis factor-alpha, tumour necrosis factor-related apoptosis-inducing ligand, and FasLigand/CD95L in patients with Chagas cardiomyopathy correlate with left ventricular dysfunction. Eur J Heart Fail (2009) 0.85

Endothelial barrier protection by local anesthetics: ropivacaine and lidocaine block tumor necrosis factor-α-induced endothelial cell Src activation. Anesthesiology (2014) 0.85

Epidermal hyperplasia and papillomatosis in mice with a keratinocyte-restricted deletion of csk. Carcinogenesis (2007) 0.84

Mechanical control of the endothelial barrier. Cell Tissue Res (2014) 0.84

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases. PLoS One (2015) 0.84

Ropivacaine attenuates endotoxin plus hyperinflation-mediated acute lung injury via inhibition of early-onset Src-dependent signaling. BMC Anesthesiol (2014) 0.83

Ablation of Csk in neural crest lineages causes corneal anomaly by deregulating collagen fibril organization and cell motility. Dev Biol (2008) 0.83

VE-cadherin Y685F knock-in mouse is sensitive to vascular permeability in recurrent angiogenic organs. Am J Physiol Heart Circ Physiol (2014) 0.81

New insights in the control of vascular permeability: vascular endothelial-cadherin and other players. Curr Opin Hematol (2015) 0.78

Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation. Mediators Inflamm (2015) 0.78

Dynamic phosphorylation of VE-cadherin Y685 throughout mouse estrous cycle in ovary and uterus. Am J Physiol Heart Circ Physiol (2014) 0.76