Exendin-4 Promotes Survival of Mouse Pancreatic β-Cell Line in Lipotoxic Conditions, through the Extracellular Signal-Related Kinase 1/2 Pathway.

AKT/PKB signaling: navigating downstream. Cell (2007) 31.26

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell (1995) 21.15

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes (2003) 16.62

The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet (2006) 15.76

Biology of incretins: GLP-1 and GIP. Gastroenterology (2007) 10.45

Islet beta cell failure in type 2 diabetes. J Clin Invest (2006) 7.67

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science (1999) 7.37

What if Minkowski had been ageusic? An alternative angle on diabetes. Science (1992) 6.07

Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr Rev (2007) 4.91

ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence. FEBS J (2009) 4.05

Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology (2003) 3.93

Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM. Diabetes (1988) 3.67

GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress. Cell Metab (2006) 3.28

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. Endocrinology (2003) 2.76

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. Diabetes (2003) 2.62

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes (2002) 2.58

Fatty acid signaling in the beta-cell and insulin secretion. Diabetes (2006) 2.22

MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells. J Cell Biochem (2000) 2.19

The ghrelin gene products and exendin-4 promote survival of human pancreatic islet endothelial cells in hyperglycaemic conditions, through phosphoinositide 3-kinase/Akt, extracellular signal-related kinase (ERK)1/2 and cAMP/protein kinase A (PKA) signalling pathways. Diabetologia (2012) 2.19

Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets. Diabetologia (1993) 2.11

Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice. Diabetologia (2002) 1.77

Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. J Biol Chem (2003) 1.76

Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). J Biol Chem (2002) 1.76

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets. Diabetes (2004) 1.72

Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression. J Biol Chem (2005) 1.62

Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis. Diabetes (2008) 1.61

Glucagon-like peptide-1 prevents beta cell glucolipotoxicity. Diabetologia (2004) 1.59

Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction. Trends Cell Biol (2011) 1.54

beta-cell apoptosis: stimuli and signaling. Diabetes (2001) 1.49

Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes. Biochem Soc Trans (2008) 1.45

Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B. Diabetologia (2005) 1.44

Pancreatic beta cell lines and their applications in diabetes mellitus research. ALTEX (2010) 1.32

Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells. Diabetologia (2004) 1.32

Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1. Endocrinology (2003) 1.32

Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway. Diabetes (2008) 1.27

Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release. Endocrinology (1993) 1.25

Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells. Diabetes (2003) 1.22

ERK1/2 control phosphorylation and protein level of cAMP-responsive element-binding protein: a key role in glucose-mediated pancreatic beta-cell survival. Diabetes (2006) 1.13

Emerging role of protein kinase B/Akt signaling in pancreatic beta-cell mass and function. Int J Biochem Cell Biol (2005) 1.12

Mitochondria mediated cell death in diabetes. Apoptosis (2009) 0.99

Palmitate potentiation of glucose-induced insulin release: a study using 2-bromopalmitate. Metabolism (2003) 0.96

The incretin approach for diabetes treatment: modulation of islet hormone release by GLP-1 agonism. Diabetes (2004) 0.94

Exendin-4 protects against sulfonylurea-induced β-cell apoptosis. J Pharmacol Sci (2011) 0.84