Published in Diabetes on August 01, 2006
GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells. J Biol Chem (2009) 1.36
The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice. Metabolism (2009) 1.31
Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion. J Biol Chem (2010) 1.27
The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes. Diabetologia (2011) 1.26
Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice. Endocrinology (2010) 1.17
β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency. Diabetes (2010) 1.10
Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets. Diabetes (2009) 1.02
Quercetin potentiates insulin secretion and protects INS-1 pancreatic β-cells against oxidative damage via the ERK1/2 pathway. Br J Pharmacol (2010) 1.02
Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis. J Biol Chem (2007) 0.96
Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathways. Endocrinology (2010) 0.93
Soluble adenylyl cyclase mediates bicarbonate-dependent corneal endothelial cell protection. Am J Physiol Cell Physiol (2010) 0.85
Evidence that Ca2+ within the microdomain of the L-type voltage gated Ca2+ channel activates ERK in MIN6 cells in response to glucagon-like peptide-1. PLoS One (2012) 0.85
Macrophage migration inhibitory factor deficiency protects pancreatic islets from cytokine-induced apoptosis in vitro. Clin Exp Immunol (2012) 0.84
Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination. EMBO Mol Med (2013) 0.84
R-spondin-1 is a novel beta-cell growth factor and insulin secretagogue. J Biol Chem (2010) 0.83
Molecular mechanisms of muscarinic acetylcholine receptor-stimulated increase in cytosolic free Ca(2+) concentration and ERK1/2 activation in the MIN6 pancreatic β-cell line. Acta Diabetol (2011) 0.82
Pro-oxidant/antioxidant balance controls pancreatic β-cell differentiation through the ERK1/2 pathway. Cell Death Dis (2014) 0.81
High glucose predisposes gene expression and ERK phosphorylation to apoptosis and impaired glucose-stimulated insulin secretion via the cytoskeleton. PLoS One (2012) 0.80
The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules. J Biol Chem (2015) 0.80
Neuroprotective effect of arctigenin via upregulation of P-CREB in mouse primary neurons and human SH-SY5Y neuroblastoma cells. Int J Mol Sci (2013) 0.79
Molecular and cellular key players in human islet transplantation. J Cell Mol Med (2007) 0.77
Inhibition of the MAP3 kinase Tpl2 protects rodent and human β-cells from apoptosis and dysfunction induced by cytokines and enhances anti-inflammatory actions of exendin-4. Cell Death Dis (2016) 0.75
Exendin-4 Promotes Survival of Mouse Pancreatic β-Cell Line in Lipotoxic Conditions, through the Extracellular Signal-Related Kinase 1/2 Pathway. J Diabetes Res (2016) 0.75
A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma. Nature (2011) 3.53
Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens. Proc Natl Acad Sci U S A (2002) 2.95
International Union of Pharmacology. XXXV. The glucagon receptor family. Pharmacol Rev (2003) 2.25
Time required for a complete skin examination with and without dermoscopy: a prospective, randomized multicenter study. Arch Dermatol (2008) 1.53
Distinctive features of melanoma and its management in elderly patients: a population-based study in France. JAMA Dermatol (2013) 1.49
Variations in management of stage I to stage III cutaneous melanoma: a population-based study of clinical practices in France. Arch Dermatol (2008) 1.45
The CDK4-pRB-E2F1 pathway controls insulin secretion. Nat Cell Biol (2009) 1.45
Apoptotic induction by anti-CD20 antibodies in chronic lymphocytic leukemia: comparison of rituximab and obinutuzumab. Leuk Lymphoma (2013) 1.43
Molecular characterization of a purified 5-HT4 receptor: a structural basis for drug efficacy. J Biol Chem (2005) 1.41
GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells. J Biol Chem (2009) 1.36
The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic beta-cell line. EMBO Rep (2009) 1.34
Role of p/q-Ca2+ channels in metabotropic glutamate receptor 2/3-dependent presynaptic long-term depression at nucleus accumbens synapses. J Neurosci (2002) 1.29
Extranuclear estrogen receptor-alpha stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis. Proc Natl Acad Sci U S A (2010) 1.28
Co-assembly of two GluR6 kainate receptor splice variants within a functional protein complex. Neuron (2005) 1.24
Extracellularly regulated kinases 1/2 (p44/42 mitogen-activated protein kinases) phosphorylate synapsin I and regulate insulin secretion in the MIN6 beta-cell line and islets of Langerhans. Endocrinology (2004) 1.20
Effects of ectopic decorin in modulating intracranial glioma progression in vivo, in a rat syngeneic model. Cancer Gene Ther (2004) 1.14
Vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med (2011) 1.14
Chicoric acid, a new compound able to enhance insulin release and glucose uptake. Biochem Biophys Res Commun (2008) 1.08
Characteristics of the coexistence of melanoma and renal cell carcinoma. Cancer (2010) 1.08
Glucagon promotes cAMP-response element-binding protein phosphorylation via activation of ERK1/2 in MIN6 cell line and isolated islets of Langerhans. J Biol Chem (2004) 1.05
Melanoma prone families with CDK4 germline mutation: phenotypic profile and associations with MC1R variants. J Med Genet (2013) 1.04
Identification and functional roles of metabotropic glutamate receptor-interacting proteins. Semin Cell Dev Biol (2004) 1.03
Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets. Diabetes (2009) 1.02
Clinical and sociodemographic characteristics associated with thick melanomas. A population-based, case-case study in France. Arch Dermatol (2012) 0.98
Expression of purinergic P2Y receptor subtypes by INS-1 insulinoma beta-cells: a molecular and binding characterization. Eur J Pharmacol (2007) 0.93
Cell-permeable peptide-based disruption of endogenous PKA-AKAP complexes: a tool for studying the molecular roles of AKAP-mediated PKA subcellular anchoring. Am J Physiol Cell Physiol (2008) 0.92
P2 purinergic signalling in the pancreatic beta-cell: control of insulin secretion and pharmacology. Eur J Pharm Sci (2009) 0.92
Peripheral T-cell lymphoma with eosinophilia presenting as monoarthritis: a case study. Leuk Lymphoma (2002) 0.92
Knock-in mice lacking the PDZ-ligand motif of mGluR7a show impaired PKC-dependent autoinhibition of glutamate release, spatial working memory deficits, and increased susceptibility to pentylenetetrazol. J Neurosci (2008) 0.91
Emerging roles for β-arrestin-1 in the control of the pancreatic β-cell function and mass: new therapeutic strategies and consequences for drug screening. Cell Signal (2010) 0.91
Targeted therapies in metastatic melanoma: toward a clinical breakthrough? Anticancer Agents Med Chem (2010) 0.90
β-Arrestin2 plays a key role in the modulation of the pancreatic beta cell mass in mice. Diabetologia (2013) 0.89
Dermoscopy provides useful information for the management of melanonychia striata. Dermatol Ther (2007) 0.89
Benign dermoscopic parallel ridge pattern variants. Arch Dermatol (2011) 0.89
Elastosis perforans serpiginosa associated with pseudo-pseudoxanthoma elasticum during treatment of Wilson's disease with penicillamine. Dermatology (2005) 0.89
SL65.0155, a novel 5-hydroxytryptamine(4) receptor partial agonist with potent cognition-enhancing properties. J Pharmacol Exp Ther (2002) 0.88
Acrodermatitis continua of Hallopeau treated successfully with ustekinumab and acitretin after failure of tumour necrosis factor blockade and anakinra. Dermatology (2014) 0.88
beta-Arrestin 1 is required for PAC1 receptor-mediated potentiation of long-lasting ERK1/2 activation by glucose in pancreatic beta-cells. J Biol Chem (2008) 0.88
New founder germline mutations of CDKN2A in melanoma-prone families and multiple primary melanoma development in a patient receiving levodopa treatment. Genes Chromosomes Cancer (2007) 0.88
5-HT receptor-associated protein networks: new targets for drug discovery in psychiatric disorders? Curr Drug Targets (2012) 0.87
Cooperative effects between protein kinase A and p44/p42 mitogen-activated protein kinase to promote cAMP-responsive element binding protein activation after beta cell stimulation by glucose and its alteration due to glucotoxicity. Ann N Y Acad Sci (2004) 0.87
VRX-03011, a novel 5-HT4 agonist, enhances memory and hippocampal acetylcholine efflux. Neuropharmacology (2007) 0.86
Multiple adult xanthogranuloma: case report and literature review. Dermatology (2006) 0.86
Successful treatment of necrobiosis lipoidica with antimalarial agents. Arch Dermatol (2008) 0.85
Dermoscopy of lymphomatoid papulosis. Arch Dermatol (2009) 0.85
GLP-1-based strategies: a physiological analysis of differential mode of action. Physiology (Bethesda) (2014) 0.85
Pharmacological and physiological characterization of d[Leu4, Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology (2007) 0.84
Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain. Mol Ther (2010) 0.84
Allogeneic stem cell transplantation for advanced cutaneous T-cell lymphomas: a study from the French Society of Bone Marrow Transplantation and French Study Group on Cutaneous Lymphomas. Haematologica (2013) 0.83
Special locations dermoscopy: facial, acral, and nail. Dermatol Clin (2013) 0.83
Understanding and circumventing resistance to anticancer monoclonal antibodies. MAbs (2009) 0.83
Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production. Eur J Med Chem (2004) 0.82
Effect of epiregulin on pancreatic beta cell growth and insulin secretion. Growth Factors (2005) 0.82
Antihyperglycemic effect of a natural chicoric acid extract of chicory (Cichorium intybus L.): a comparative in vitro study with the effects of caffeic and ferulic acids. J Ethnopharmacol (2013) 0.82
Miniglucagon (MG)-generating endopeptidase, which processes glucagon into MG, is composed of N-arginine dibasic convertase and aminopeptidase B. Endocrinology (2004) 0.82
Familial melanoma: clinical factors associated with germline CDKN2A mutations according to the number of patients affected by melanoma in a family. J Am Acad Dermatol (2012) 0.82
The contribution of large genomic deletions at the CDKN2A locus to the burden of familial melanoma. Br J Cancer (2008) 0.81
Effects of oral monosodium (L)-glutamate on insulin secretion and glucose tolerance in healthy volunteers. Br J Clin Pharmacol (2002) 0.81
Pituitary adenylate cyclase-activating polypeptide receptors mediating insulin secretion in rodent pancreatic islets are coupled to adenylate cyclase but not to PLC. Endocrinology (2002) 0.81
New therapeutical strategies in the treatment of metastatic disease. Dermatol Ther (2012) 0.81
M19 modulates skeletal muscle differentiation and insulin secretion in pancreatic β-cells through modulation of respiratory chain activity. PLoS One (2012) 0.80
Permissive effect of voltage on mGlu 7 receptor subtype signaling in neurons. J Biol Chem (2001) 0.80
Ungueotropic T-cell lymphoma. Arch Dermatol (2006) 0.80
Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma. J Clin Invest (2016) 0.80
Deregulation of hepatic insulin sensitivity induced by central lipid infusion in rats is mediated by nitric oxide. PLoS One (2009) 0.79
Scleromyxedema: successful treatment with thalidomide in two patients. Dermatology (2007) 0.79
Characterization of two novel forms of the rat sulphonylurea receptor SUR1A2 and SUR1BDelta31. Br J Pharmacol (2002) 0.79
The promnesic effect of G-protein-coupled 5-HT4 receptors activation is mediated by a potentiation of learning-induced spine growth in the mouse hippocampus. Neuropsychopharmacology (2007) 0.79
Miniglucagon (glucagon 19-29): a novel regulator of the pancreatic islet physiology. Diabetes (2002) 0.79
The role of circumstances of diagnosis and access to dermatological care in early diagnosis of cutaneous melanoma: a population-based study in France. Arch Dermatol (2010) 0.78
Endurance training increases lactate transport in male Zucker fa/fa rats. Biochem Biophys Res Commun (2005) 0.77
Improvement of survival in patients with primary cutaneous diffuse large B-cell lymphoma, leg type, in France. JAMA Dermatol (2014) 0.77
Counteracting neuronal nitric oxide synthase proteasomal degradation improves glucose transport in insulin-resistant skeletal muscle from Zucker fa/fa rats. Diabetologia (2013) 0.77
Identification of a novel e8/a4 BCR/ABL fusion transcript in a case of a transformed Sézary syndrome. Haematologica (2007) 0.77
Vemurafenib-induced panniculitis. Eur J Dermatol (2013) 0.76
Effects of exposure to a 128-mT static magnetic field on glucose and lipid metabolism in serum and skeletal muscle of rats. Arch Med Res (2010) 0.76
The glucagon-miniglucagon interplay: a new level in the metabolic regulation. Ann N Y Acad Sci (2006) 0.76
An alpha40 subunit of a GTP-binding protein immunologically related to G0 mediates a dopamine-induced decrease of Ca2+ current in snail neurons.. Neuron (2008) 0.75
Block of Ca(2+)-channels by alpha-endosulphine inhibits insulin release. Br J Pharmacol (2002) 0.75
Corrigendum: A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma. Nature (2015) 0.75
Fast-growing cutaneous squamous cell carcinoma in a patient treated with vismodegib. Dermatology (2015) 0.75
Sentinel Node Status and Immunosuppression: Recurrence Factors in Localized Merkel Cell Carcinoma. Acta Derm Venereol (2015) 0.75