Published in Mol Biol Cell on September 28, 2016
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature (2009) 8.44
Emerging roles of caspase-3 in apoptosis. Cell Death Differ (1999) 8.05
Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clin Exp Immunol (1998) 5.77
Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem (1997) 5.14
Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science (2001) 4.82
Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature (2007) 4.68
COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases. Cell (2003) 4.25
Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice. Nat Med (1996) 4.09
Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. J Immunol (2003) 4.00
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J Clin Invest (2004) 3.90
Nedd8 on cullin: building an expressway to protein destruction. Oncogene (2004) 3.29
Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia. J Exp Med (2001) 3.02
Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology (2008) 2.99
MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma. Blood (2010) 2.49
The search for effective therapy for sepsis: back to the drawing board? JAMA (2011) 2.46
Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways. Immunity (2010) 2.39
The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice. J Cell Biol (2001) 2.26
Commensal bacteria modulate cullin-dependent signaling via generation of reactive oxygen species. EMBO J (2007) 1.86
A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. Nat Struct Mol Biol (2004) 1.72
DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1. J Biol Chem (2003) 1.72
Regulation of cullin-RING E3 ubiquitin-ligases by neddylation and dimerization. Cell Mol Life Sci (2009) 1.67
NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins. J Biol Chem (2003) 1.64
Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins. Genome Biol (2001) 1.61
Regulation of NF-κB by ubiquitination and degradation of the IκBs. Immunol Rev (2012) 1.51
Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation. J Clin Invest (2007) 1.47
Activation of hypoxia-inducible factor attenuates renal injury in rat remnant kidney. Nephrol Dial Transplant (2009) 1.37
Control of IFN-alphaA by CD73: implications for mucosal inflammation. J Immunol (2008) 1.34
NF-kappaB and the intestine: friend or foe? Inflamm Bowel Dis (2008) 1.33
Regulation of cullin-based ubiquitin ligases by the Nedd8/RUB ubiquitin-like proteins. Semin Cell Dev Biol (2004) 1.29
Cleavage of the C-terminus of NEDD8 by UCH-L3. Biochem Biophys Res Commun (1998) 1.16
Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes. Biochem J (2012) 1.15
The NEDD8 pathway is essential for SCF(beta -TrCP)-mediated ubiquitination and processing of the NF-kappa B precursor p105. J Biol Chem (2002) 1.11
The life and death of epithelia during inflammation: lessons learned from the gut. Annu Rev Pathol (2011) 0.99
Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response. J Immunol (2012) 0.98
NFκB and HIF display synergistic behaviour during hypoxic inflammation. Cell Mol Life Sci (2011) 0.94
Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling. Proc Natl Acad Sci U S A (2012) 0.92
Glutamine treatment attenuates endoplasmic reticulum stress and apoptosis in TNBS-induced colitis. PLoS One (2012) 0.92
Cord blood interleukin-6 as a predictor of early-onset neonatal sepsis. Acta Paediatr (2012) 0.87
Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway. Cell Rep (2015) 0.86
Implications of protein post-translational modifications in IBD. Inflamm Bowel Dis (2012) 0.86
Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responses. FASEB J (2014) 0.83
Targeting neddylation effectively antagonizes nuclear factor-κB in chronic lymphocytic leukemia B-cells. Leuk Lymphoma (2015) 0.78
The discovery of a reciprocal relationship between tyrosine-kinase signaling and cullin neddylation. PLoS One (2013) 0.77