Published in Basic Res Cardiol on September 28, 2016
A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell (2008) 6.16
The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res (2003) 4.13
Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res (2004) 4.11
CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy. J Clin Invest (2006) 3.53
Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II. Biochem J (2002) 3.29
Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart. Cardiovasc Res (2006) 2.30
Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature (2013) 2.08
Stoichiometric phosphorylation of cardiac ryanodine receptor on serine 2809 by calmodulin-dependent kinase II and protein kinase A. J Biol Chem (2003) 2.04
Intracoronary adenovirus encoding adenylyl cyclase VI increases left ventricular function in heart failure. Circulation (2004) 2.01
Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure. Cardiovasc Res (2004) 2.00
Design of a phase 2b trial of intracoronary administration of AAV1/SERCA2a in patients with advanced heart failure: the CUPID 2 trial (calcium up-regulation by percutaneous administration of gene therapy in cardiac disease phase 2b). JACC Heart Fail (2014) 1.76
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nat Med (2011) 1.74
NO-dependent CaMKII activation during β-adrenergic stimulation of cardiac muscle. Cardiovasc Res (2013) 1.72
A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circ Res (2011) 1.61
Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy. Nat Med (2015) 1.46
Arrhythmia causes lipid accumulation and reduced glucose uptake. Basic Res Cardiol (2015) 1.45
CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes. Circ Res (2009) 1.33
Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation. Circulation (2013) 1.29
CaMKII inhibitors: from research tools to therapeutic agents. Front Pharmacol (2014) 1.12
CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis. Nat Med (2016) 1.09
Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes. Circ Res (2011) 1.02
S100A1: a multifaceted therapeutic target in cardiovascular disease. J Cardiovasc Transl Res (2010) 0.96
CaMKIIdelta subtypes: localization and function. Front Pharmacol (2014) 0.91
Functional interplay between dual site phospholambam phosphorylation: insights from genetically altered mouse models. Basic Res Cardiol (2002) 0.91
Gene therapy for cardiovascular disease: advances in vector development, targeting, and delivery for clinical translation. Cardiovasc Res (2015) 0.89
CaMKIIδB mediates aberrant NCX1 expression and the imbalance of NCX1/SERCA in transverse aortic constriction-induced failing heart. PLoS One (2011) 0.87
CaMKII phosphorylates a threonine residue in the C-terminal tail of Cav1.2 Ca(2+) channel and modulates the interaction of the channel with calmodulin. J Physiol Sci (2009) 0.87
S-Nitrosylation Induces Both Autonomous Activation and Inhibition of Calcium/Calmodulin-dependent Protein Kinase II δ. J Biol Chem (2015) 0.85
Role of CaMKII in cardiac arrhythmias. Trends Cardiovasc Med (2014) 0.83
Intratracheal Gene Delivery of SERCA2a Ameliorates Chronic Post-Capillary Pulmonary Hypertension: A Large Animal Model. J Am Coll Cardiol (2016) 0.83
Identification of a calmodulin-dependent protein kinase in the cardiac cytosol, which phosphorylates phospholamban in the sarcoplasmic reticulum. J Biochem (1985) 0.83
Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart. Int J Cardiol (2014) 0.82
Regulation of CaMKII signaling in cardiovascular disease. Front Pharmacol (2015) 0.82
Ca2+-independent activation of Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain of CaV2.1 calcium channels. J Biol Chem (2012) 0.81
Oxidant stress promotes disease by activating CaMKII. J Mol Cell Cardiol (2015) 0.80
The promise of CaMKII inhibition for heart disease: preventing heart failure and arrhythmias. Expert Opin Ther Targets (2013) 0.79
Atrial remodelling in atrial fibrillation: CaMKII as a nodal proarrhythmic signal. Cardiovasc Res (2016) 0.79
KN-93 inhibits IKr in mammalian cardiomyocytes. J Mol Cell Cardiol (2015) 0.78
Heart failure-specific changes in protein kinase signalling. Pflugers Arch (2014) 0.78
Irregular rhythm and atrial metabolism are key for the evolution of proarrhythmic atrial remodeling in atrial fibrillation. Basic Res Cardiol (2015) 0.77
Cardiac calcium handling on trial: targeting the failing cardiomyocyte signalosome. Circ Res (2014) 0.77
Calm down when the heart is stressed: Inhibiting calmodulin-dependent protein kinase II for antiarrhythmias. Trends Cardiovasc Med (2015) 0.77
CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. J Mol Cell Cardiol (2016) 0.77
Cardiomyocytes, endothelial cells and cardiac fibroblasts: S100A1's triple action in cardiovascular pathophysiology. Future Cardiol (2015) 0.77
Inducible cardiomyocyte-specific deletion of CaM kinase II protects from pressure overload-induced heart failure. Basic Res Cardiol (2016) 0.76