Patient survival and tumor characteristics associated with CHEK2:p.I157T - findings from the Breast Cancer Association Consortium.

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Published in Breast Cancer Res on October 03, 2016

Authors

Taru A Muranen1, Carl Blomqvist2, Thilo Dörk3, Anna Jakubowska4, Päivi Heikkilä5, Rainer Fagerholm1, Dario Greco6, Kristiina Aittomäki7, Stig E Bojesen8,9,10, Mitul Shah11, Alison M Dunning11, Valerie Rhenius11, Per Hall12, Kamila Czene12, Judith S Brand12, Hatef Darabi12, Jenny Chang-Claude13,14, Anja Rudolph13, Børge G Nordestgaard8,10, Fergus J Couch15, Steven N Hart16, Jonine Figueroa17, Montserrat García-Closas17,18, Peter A Fasching19,20, Matthias W Beckmann19, Jingmei Li12, Jianjun Liu21, Irene L Andrulis22,23, Robert Winqvist24,25, Katri Pylkäs24,25, Arto Mannermaa26,27,28, Vesa Kataja26,29, Annika Lindblom12, Sara Margolin30, Jan Lubinski4, Natalia Dubrowinskaja3, Manjeet K Bolla31, Joe Dennis31, Kyriaki Michailidou31,32, Qin Wang31, Douglas F Easton11,31, Paul D P Pharoah11,31, Marjanka K Schmidt33, Heli Nevanlinna34

Author Affiliations

1: Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, P.O. Box 700, 00029, HUS, Helsinki, Finland.
2: Department of Oncology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
3: Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
4: Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
5: Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
6: Unit of Systems Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland.
7: Department of Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
8: Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
9: Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark.
10: Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark.
11: Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
12: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
13: Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
14: University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
15: Department of Laboratory Medicine and Pathology Mayo Clinic, Rochester, MN, USA.
16: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
17: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
18: Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
19: Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
20: Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
21: Human Genetics Division, Genome Institute of Singapore, Singapore, Singapore.
22: Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada.
23: Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
24: Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland.
25: Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit and Biocenter Oulu, University of Oulu, Oulu, Finland.
26: Cancer Center, Kuopio University Hospital, Kuopio, Finland.
27: Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.
28: Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.
29: Central Finland Hospital District, Jyväskylä Central Hospital, Jyväskylä, Finland.
30: Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden.
31: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
32: Department of Electron Microscopy/Molecular Pathology, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
33: Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
34: Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, P.O. Box 700, 00029, HUS, Helsinki, Finland. Heli.Nevanlinna@hus.fi.

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