Published in Nat Cell Biol on May 01, 2003
The E2F family: specific functions and overlapping interests. EMBO J (2004) 3.33
BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol (2007) 3.10
An E2F1-dependent gene expression program that determines the balance between proliferation and cell death. Cancer Cell (2008) 3.07
p53 and E2f: partners in life and death. Nat Rev Cancer (2009) 3.06
Life and death decisions by the E2F transcription factors. Curr Opin Cell Biol (2007) 2.66
Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation. PLoS Pathog (2009) 2.21
Control of cell cycle transcription during G1 and S phases. Nat Rev Mol Cell Biol (2013) 2.17
Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes. Mol Cell Biol (2006) 2.11
p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2. Genes Dev (2004) 2.07
Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response. DNA Repair (Amst) (2009) 1.89
TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival. Genes Dev (2004) 1.84
Transcriptional and nontranscriptional functions of E2F1 in response to DNA damage. Cancer Res (2011) 1.64
APC/C(Cdc20) targets E2F1 for degradation in prometaphase. Cell Cycle (2010) 1.62
DNA-damage response control of E2F7 and E2F8. EMBO Rep (2008) 1.60
Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress. Mol Biol Cell (2005) 1.60
Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2. Mol Cell Biol (2004) 1.57
Atypical E2Fs: new players in the E2F transcription factor family. Trends Cell Biol (2009) 1.56
Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J (2007) 1.52
Arginine methylation controls growth regulation by E2F-1. EMBO J (2012) 1.44
A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. J Biol Chem (2004) 1.44
Opposing roles of E2Fs in cell proliferation and death. Cancer Biol Ther (2004) 1.33
Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response. J Biol Chem (2009) 1.31
Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair. Genes Dev (2008) 1.27
Polo-like kinase 1 depletion induces DNA damage in early S prior to caspase activation. Mol Cell Biol (2009) 1.25
Inhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathway. PLoS One (2007) 1.23
The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1. EMBO J (2007) 1.23
Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage. Mol Cell Biol (2006) 1.22
Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiation. EMBO J (2011) 1.21
The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis. Mol Biol Cell (2008) 1.21
CHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancer. PLoS One (2008) 1.20
Senescence evasion by MCF-7 human breast tumor-initiating cells. Breast Cancer Res (2010) 1.19
The DNA replication checkpoint directly regulates MBF-dependent G1/S transcription. Mol Cell Biol (2008) 1.18
Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Cancer Discov (2013) 1.17
Jab1 is a specificity factor for E2F1-induced apoptosis. Genes Dev (2006) 1.17
E2F1 promotes the recruitment of DNA repair factors to sites of DNA double-strand breaks. Cell Cycle (2011) 1.15
DNA-damage-responsive acetylation of pRb regulates binding to E2F-1. EMBO Rep (2006) 1.14
Nucleolar stress with and without p53. Nucleus (2014) 1.13
Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1. Mol Cell (2013) 1.12
ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage. Mol Cell Biol (2004) 1.12
The specific role of pRb in p16 (INK4A) -mediated arrest of normal and malignant human breast cells. Cell Cycle (2012) 1.10
CHK2 kinase expression is down-regulated due to promoter methylation in non-small cell lung cancer. Mol Cancer (2004) 1.08
Phosphorylation of p53 on Ser15 during cell cycle caused by Topo I and Topo II inhibitors in relation to ATM and Chk2 activation. Cell Cycle (2008) 1.08
DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues. Mol Cell Biol (2006) 1.07
hSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage. Mol Cell Biol (2009) 1.06
JWA regulates XRCC1 and functions as a novel base excision repair protein in oxidative-stress-induced DNA single-strand breaks. Nucleic Acids Res (2009) 1.05
CHK2 kinase in the DNA damage response and beyond. J Mol Cell Biol (2014) 1.05
E2F3 is a mediator of DNA damage-induced apoptosis. Mol Cell Biol (2009) 1.04
Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response. J Biol Chem (2012) 1.04
DNA damage signals through differentially modified E2F1 molecules to induce apoptosis. Mol Cell Biol (2011) 1.03
E2F4 regulates a stable G2 arrest response to genotoxic stress in prostate carcinoma. Oncogene (2006) 1.03
Regulation of the retinoblastoma proteins by the human herpesviruses. Cell Div (2009) 1.02
Functional and molecular interactions between ERK and CHK2 in diffuse large B-cell lymphoma. Nat Commun (2011) 1.02
The MDM2 ubiquitination signal in the DNA-binding domain of p53 forms a docking site for calcium calmodulin kinase superfamily members. Mol Cell Biol (2007) 1.01
Yox1 links MBF-dependent transcription to completion of DNA synthesis. EMBO Rep (2010) 1.01
Atypical E2F activity coordinates PHR1 photolyase gene transcription with endoreduplication onset. EMBO J (2010) 1.00
Tumour suppressor genes in chemotherapeutic drug response. Biosci Rep (2012) 0.99
Regulation of transcription and chromatin structure by pRB: here, there and everywhere. Cell Cycle (2012) 0.99
The p38 MAPK-MK2 axis regulates E2F1 and FOXM1 expression after epirubicin treatment. Mol Cancer Res (2012) 0.98
Impaired DNA damage checkpoint response in MIF-deficient mice. EMBO J (2007) 0.98
Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379. Mol Cell Biol (2008) 0.98
E2F1 death pathways as targets for cancer therapy. J Cell Mol Med (2007) 0.97
Phosphatases in the cellular response to DNA damage. Cell Commun Signal (2010) 0.97
The role of the apoptotic machinery in tumor suppression. Cold Spring Harb Perspect Biol (2012) 0.97
Impaired DNA damage response--an Achilles' heel sensitizing cancer to chemotherapy and radiotherapy. Eur J Pharmacol (2009) 0.97
Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B. J Biol Chem (2009) 0.94
The rb pathway and cancer therapeutics. Curr Drug Targets (2009) 0.93
Regulation of E2F1 by APC/C Cdh1 via K11 linkage-specific ubiquitin chain formation. Cell Cycle (2012) 0.93
DNA-damage response pathways triggered by viral replication. Expert Rev Mol Med (2006) 0.93
DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosis. Crit Rev Clin Lab Sci (2012) 0.92
MSH3 mismatch repair protein regulates sensitivity to cytotoxic drugs and a histone deacetylase inhibitor in human colon carcinoma cells. PLoS One (2013) 0.91
Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated protein. J Virol (2007) 0.90
ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes. Blood (2011) 0.90
Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription. Curr Biol (2013) 0.90
NEDDylation regulates E2F-1-dependent transcription. EMBO Rep (2012) 0.89
E2F1 mediated apoptosis induced by the DNA damage response is blocked by EBV nuclear antigen 3C in lymphoblastoid cells. PLoS Pathog (2012) 0.89
14-3-3 proteins integrate E2F activity with the DNA damage response. EMBO J (2006) 0.87
The role of the retinoblastoma/E2F1 tumor suppressor pathway in the lesion recognition step of nucleotide excision repair. DNA Repair (Amst) (2009) 0.87
Proto-oncogene activity of melanoma antigen-A11 (MAGE-A11) regulates retinoblastoma-related p107 and E2F1 proteins. J Biol Chem (2013) 0.86
Analysis of individual molecular events of DNA damage response by flow- and image-assisted cytometry. Methods Cell Biol (2011) 0.86
pRB-E2F1 complexes are resistant to adenovirus E1A-mediated disruption. J Virol (2008) 0.86
Phosphorylation and stabilization of topoisomerase IIα protein by p38γ mitogen-activated protein kinase sensitize breast cancer cells to its poisons. J Biol Chem (2011) 0.85
DNA-PK suppresses a p53-independent apoptotic response to DNA damage. EMBO Rep (2008) 0.85
DNA damage response induced by tobacco smoke in normal human bronchial epithelial and A549 pulmonary adenocarcinoma cells assessed by laser scanning cytometry. Cytometry A (2009) 0.85
The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor. Mol Biol Cell (2013) 0.85
Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells. J Biomed Res (2010) 0.84
Transcription addiction: can we garner the Yin and Yang functions of E2F1 for cancer therapy? Cell Death Dis (2014) 0.84
Spliceosomal protein E regulates neoplastic cell growth by modulating expression of cyclin E/CDK2 and G2/M checkpoint proteins. J Cell Mol Med (2008) 0.84
E2F1 regulates the base excision repair gene XRCC1 and promotes DNA repair. J Biol Chem (2008) 0.84
Chk2 mediates RITA-induced apoptosis. Cell Death Differ (2011) 0.84
Intestine-specific homeobox (ISX) upregulates E2F1 expression and related oncogenic activities in HCC. Oncotarget (2016) 0.82
Global analysis of phosphorylation networks in humans. Biochim Biophys Acta (2013) 0.82
Irofulven induces replication-dependent CHK2 activation related to p53 status. Biochem Pharmacol (2006) 0.81
The role of the E2F transcription factor family in UV-induced apoptosis. Int J Mol Sci (2011) 0.81
Chromatin relaxation-mediated induction of p19INK4d increases the ability of cells to repair damaged DNA. PLoS One (2013) 0.80
Exogenous expression of marine lectins DlFBL and SpRBL induces cancer cell apoptosis possibly through PRMT5-E2F-1 pathway. Sci Rep (2014) 0.80
E2F1 plays a direct role in Rb stabilization and p53-independent tumor suppression. Cell Cycle (2008) 0.80
Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors. Br J Pharmacol (2010) 0.80
The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation. PLoS One (2013) 0.79
To live or let die - complexity within the E2F1 pathway. Mol Cell Oncol (2015) 0.78
Regulation of E2 Promoter Binding Factor 1 (E2F1) Transcriptional Activity through a Deubiquitinating Enzyme, UCH37. J Biol Chem (2015) 0.78
Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease. Gastroenterology (2008) 4.05
Arginine methylation regulates the p53 response. Nat Cell Biol (2008) 2.94
HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications. Immunol Cell Biol (2011) 2.28
Assessment of contributions to patient safety knowledge by the Agency for Healthcare Research and Quality-funded patient safety projects. Health Serv Res (2009) 1.88
Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101. Mol Cancer Ther (2003) 1.87
E2F and cell cycle control: a double-edged sword. Arch Biochem Biophys (2003) 1.73
The emerging role of E2F-1 in the DNA damage response and checkpoint control. DNA Repair (Amst) (2004) 1.72
Atypical E2F activity restrains APC/CCCS52A2 function obligatory for endocycle onset. Proc Natl Acad Sci U S A (2008) 1.70
E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7. Oncogene (2005) 1.69
HDAC inhibitor-based therapies: can we interpret the code? Mol Oncol (2012) 1.67
DNA-damage response control of E2F7 and E2F8. EMBO Rep (2008) 1.60
Genotype-phenotype analysis in childhood-onset Crohn's disease: NOD2/CARD15 variants consistently predict phenotypic characteristics of severe disease. Inflamm Bowel Dis (2005) 1.55
Chromatin control and cancer-drug discovery: realizing the promise. Drug Discov Today (2006) 1.51
Prevalence of Plasmodium falciparum in active conflict areas of eastern Burma: a summary of cross-sectional data. Confl Health (2007) 1.48
E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains. Oncogene (2004) 1.44
The yin and yang of E2F-1: balancing life and death. Nat Cell Biol (2003) 1.40
Drug Insight: histone deacetylase inhibitor-based therapies for cutaneous T-cell lymphomas. Nat Clin Pract Oncol (2008) 1.38
Mdm2 targets the p53 transcription cofactor JMY for degradation. EMBO Rep (2006) 1.33
Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitor-induced apoptosis. Cancer Cell (2009) 1.33
Histone deacetylase inhibitors: gathering pace. Curr Opin Pharmacol (2006) 1.31
Biomarkers for predicting clinical responses to HDAC inhibitors. Cancer Lett (2009) 1.31
Histone deacetylase inhibitors open new doors in cancer therapy. Biochem Pharmacol (2004) 1.29
Longitudinal analysis of early semantic networks: preferential attachment or preferential acquisition? Psychol Sci (2009) 1.27
HR23B is a biomarker for tumor sensitivity to HDAC inhibitor-based therapy. Proc Natl Acad Sci U S A (2010) 1.26
Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein. EMBO J (2010) 1.25
The p53 response: emerging levels of co-factor complexity. Biochem Biophys Res Commun (2005) 1.22
The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease. Gastroenterology (2005) 1.21
Small worlds and semantic network growth in typical and late talkers. PLoS One (2011) 1.18
A new effector pathway links ATM kinase with the DNA damage response. Nat Cell Biol (2004) 1.17
Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis. Nat Genet (2013) 1.15
DNA-damage-responsive acetylation of pRb regulates binding to E2F-1. EMBO Rep (2006) 1.14
Cross-border malaria control for internally displaced persons: observational results from a pilot programme in eastern Burma/Myanmar. Trop Med Int Health (2009) 1.14
Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1. Mol Cell (2013) 1.12
A transcription co-factor integrates cell adhesion and motility with the p53 response. Proc Natl Acad Sci U S A (2009) 1.11
Serum albumin is strongly associated with erythropoietin sensitivity in hemodialysis patients. Clin J Am Soc Nephrol (2007) 1.06
Categorical structure among shared features in networks of early-learned nouns. Cognition (2009) 1.03
p53 ubiquitination by Mdm2: a never ending tail? DNA Repair (Amst) (2009) 0.99
p14(ARF) regulates E2F activity. Oncogene (2002) 0.99
A transcription cofactor required for the heat-shock response. EMBO Rep (2008) 0.99
ATM and Chk2 kinase target the p53 cofactor Strap. EMBO Rep (2008) 0.95
Attenuation of capillary leakage by hydroxyethyl starch (130/0.42) in a porcine model of septic shock. Crit Care Med (2006) 0.93
A framework of operating models for interdisciplinary research programs in clinical service organizations. Eval Program Plann (2008) 0.90
p53 methylation--the Arg-ument is clear. Cell Cycle (2009) 0.90
NEDDylation regulates E2F-1-dependent transcription. EMBO Rep (2012) 0.89
Effect of testosterone on T cell-mediated immunity in two species of Mediterranean lacertid lizards. J Exp Zool A Comp Exp Biol (2004) 0.88
A new role for E2F-1 in checkpoint control. Cell Cycle (2003) 0.88
Actin nucleators in the nucleus: an emerging theme. J Cell Sci (2012) 0.87
14-3-3 proteins integrate E2F activity with the DNA damage response. EMBO J (2006) 0.87
Investigation of NOD1/CARD4 variation in inflammatory bowel disease using a haplotype-tagging strategy. Hum Mol Genet (2007) 0.86
Resuscitation from septic shock with capillary leakage: hydroxyethyl starch (130 kd), but not Ringer's solution maintains plasma volume and systemic oxygenation. Shock (2004) 0.85
Priming overgeneralizations in two- and four-year-old children. J Child Lang (2006) 0.84
The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure. Proc Natl Acad Sci U S A (2012) 0.83
An evaluation of pulsed shortwave on knee osteoarthritis using radioleucoscintigraphy: a randomised, double blind, controlled trial. Joint Bone Spine (2005) 0.83
Mdm2 widens its repertoire. Cell Cycle (2007) 0.83
Detailed haplotype-tagging study of germline variation of MUC19 in inflammatory bowel disease. Inflamm Bowel Dis (2010) 0.82
The cell cycle, chromatin and cancer: mechanism-based therapeutics come of age. Drug Discov Today (2003) 0.81
Actin nucleation by a transcription co-factor that links cytoskeletal events with the p53 response. Cell Cycle (2010) 0.80
Vaccination with a modified-live bovine viral diarrhea virus (BVDV) type 1a vaccine completely protected calves against challenge with BVDV type 1b strains. Vaccine (2010) 0.80
Guidelines for the management of head injuries in remote and rural Alaska. Alaska Med (2005) 0.79
Arsenic and selenium in human hair: a comparison of five countries with and without arsenicosis. Biol Trace Elem Res (2005) 0.79
Randomized controlled trial: lisinopril reduces proteinuria, ammonia, and renal polypeptide tubular catabolism in patients with chronic allograft nephropathy. Transplantation (2010) 0.79
Mapping the themes of Maori talk about health. N Z Med J (2003) 0.78
Lysine methylation and the regulation of p53. Essays Biochem (2012) 0.78
Signalling DNA damage by regulating p53 co-factor activity. Cell Cycle (2005) 0.78
E2F-7 couples DNA damage-dependent transcription with the DNA repair process. Cell Cycle (2013) 0.78
Cell cycle control by a methylation-phosphorylation switch. Cell Cycle (2011) 0.78
Histone deacetylase inhibitors in psoriasis therapy. Curr Drug Targets Inflamm Allergy (2004) 0.77
Strap: a versatile transcription co-factor. Cell Cycle (2008) 0.77
Drug discovery and the p53 family. Prog Cell Cycle Res (2003) 0.77
Acute Stridor and Respiratory Failure due to Retrosternal Subglottic Stenosis of Unknown Origin. Case Rep Emerg Med (2013) 0.75
Fetal protection against bovine viral diarrhea virus types 1 and 2 after the use of a modified-live virus vaccine. Can J Vet Res (2009) 0.75
Physician as Healer, Leader and Partner: Tackling the Nursing Shortage. Perm J (2004) 0.75
A mismatched role for Bcl-2. Nat Cell Biol (2005) 0.75
T-ARG-eting E2F-1 growth control. Cell Cycle (2012) 0.75
New IT system to support TB and brucellosis testing. Vet Rec (2004) 0.75
Intervention Project for Nurses: substance abuse in nurses. Fla Nurse (2013) 0.75
E2F proteins. Curr Biol (2002) 0.75
Nurses recovering from substance use disorders: a review of policies and position statements. J Nurs Adm (2011) 0.75
No ladies allowed. Hosp Health Netw (2004) 0.75