Published in J Mol Biol on October 06, 2016
Piecing it together: Unraveling the elusive structure-function relationship in single-pass membrane receptors. Biochim Biophys Acta (2017) 0.76
Death Receptor 5 Activation Is Energetically Coupled to Opening of the Transmembrane Domain Dimer. Biophys J (2017) 0.75
Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. Biopolymers (1983) 99.69
Functional rafts in cell membranes. Nature (1997) 38.89
Lipid rafts and signal transduction. Nat Rev Mol Cell Biol (2000) 25.87
Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations. J Comput Chem (2004) 17.97
Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Biol (1998) 14.83
Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity (1995) 10.59
Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med (1999) 9.78
Experimentally determined hydrophobicity scale for proteins at membrane interfaces. Nat Struct Biol (1996) 8.57
A transmembrane helix dimer: structure and implications. Science (1997) 6.46
A unified model for apical caspase activation. Mol Cell (2003) 6.12
An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science (1997) 6.10
Optimization of the additive CHARMM all-atom protein force field targeting improved sampling of the backbone φ, ψ and side-chain χ(1) and χ(2) dihedral angles. J Chem Theory Comput (2012) 5.57
Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. Cell (1993) 5.37
The preference of tryptophan for membrane interfaces. Biochemistry (1998) 5.10
The GxxxG motif: a framework for transmembrane helix-helix association. J Mol Biol (2000) 5.09
Generalized born model with a simple smoothing function. J Comput Chem (2003) 4.36
An induced proximity model for caspase-8 activation. J Biol Chem (1998) 4.18
Structure of fully hydrated fluid phase DMPC and DLPC lipid bilayers using X-ray scattering from oriented multilamellar arrays and from unilamellar vesicles. Biophys J (2005) 3.76
The nature of the hydrophobic binding of small peptides at the bilayer interface: implications for the insertion of transbilayer helices. Biochemistry (1989) 3.71
Death receptor-induced cell killing. Cell Signal (2004) 3.67
A series of PDB related databases for everyday needs. Nucleic Acids Res (2010) 3.60
Resistance of cell membranes to different detergents. Proc Natl Acad Sci U S A (2003) 3.57
The molecular architecture of the TNF superfamily. Trends Biochem Sci (2002) 3.39
An implicit membrane generalized born theory for the study of structure, stability, and interactions of membrane proteins. Biophys J (2003) 2.91
Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity. Nat Med (2001) 2.87
Hydrophobic interactions of peptides with membrane interfaces. Biochim Biophys Acta (1998) 2.79
Non-random distribution of amino acids in the transmembrane segments of human type I single span membrane proteins. J Mol Biol (1993) 2.70
Ligand-based targeting of apoptosis in cancer: the potential of recombinant human apoptosis ligand 2/Tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL). J Clin Oncol (2008) 2.57
Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death. Nat Immunol (2004) 2.55
Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5. Mol Cell (1999) 2.42
Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation. Immunity (2003) 2.41
The Fas-FADD death domain complex structure unravels signalling by receptor clustering. Nature (2008) 2.11
Insights into the regulatory mechanism for caspase-8 activation. Mol Cell (2003) 2.01
Detergent resistance as a tool in membrane research. Nat Protoc (2007) 1.86
Getting TRAIL back on track for cancer therapy. Cell Death Differ (2014) 1.86
Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers. Proc Natl Acad Sci U S A (2003) 1.82
On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics. Oncogene (2012) 1.75
Proapoptotic DR4 and DR5 signaling in cancer cells: toward clinical translation. Curr Opin Cell Biol (2010) 1.75
SPOTS: signaling protein oligomeric transduction structures are early mediators of death receptor-induced apoptosis at the plasma membrane. J Cell Biol (2004) 1.75
Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5. Cell Death Differ (2008) 1.61
The atomic-resolution structure of human caspase-8, a key activator of apoptosis. Structure (1999) 1.54
Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. Mol Cell Biol (2006) 1.52
Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts. Blood (2006) 1.49
Targeted induction of apoptosis in cancer management: the emerging role of tumor necrosis factor-related apoptosis-inducing ligand receptor activating agents. J Clin Oncol (2005) 1.44
The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis. Structure (1999) 1.39
Theoretical insights into the mechanism for thiol/disulfide exchange. Chemistry (2004) 1.38
Lipid rafts and nonrafts mediate tumor necrosis factor related apoptosis-inducing ligand induced apoptotic and nonapoptotic signals in non small cell lung carcinoma cells. Cancer Res (2007) 1.31
The effect of cholesterol on short- and long-chain monounsaturated lipid bilayers as determined by molecular dynamics simulations and X-ray scattering. Biophys J (2008) 1.30
TNF-alpha-mediated apoptosis is initiated in caveolae-like domains. J Immunol (1999) 1.28
Three is better than one: pre-ligand receptor assembly in the regulation of TNF receptor signaling. Cytokine (2007) 1.28
Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells. Oncogene (2004) 1.19
The death-inducing signalling complex is recruited to lipid rafts in Fas-induced apoptosis. Biochem Biophys Res Commun (2002) 1.15
Death receptor 5 internalization is required for lysosomal permeabilization by TRAIL in malignant liver cell lines. Gastroenterology (2009) 1.14
A novel humanized anti-human death receptor 5 antibody CS-1008 induces apoptosis in tumor cells without toxicity in hepatocytes. Ann Oncol (2008) 1.13
Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nat Chem Biol (2012) 1.13
The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability. J Cell Biol (2005) 1.10
Enhanced apoptosis and tumor regression induced by a direct agonist antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2. Clin Cancer Res (2005) 1.09
Lexatumumab (TRAIL-receptor 2 mAb) induces expression of DR5 and promotes apoptosis in primary and metastatic renal cell carcinoma in a mouse orthotopic model. Cancer Lett (2006) 1.05
Regulation of the extrinsic apoptotic pathway by the extracellular matrix glycoprotein EMILIN2. Mol Cell Biol (2007) 1.05
Effect of pathogenic cysteine mutations on FGFR3 transmembrane domain dimerization in detergents and lipid bilayers. Biochemistry (2007) 1.05
Apoptosis induced by death receptors. Pharm Acta Helv (2000) 1.04
Restricted localization of the TNF receptor CD120a to lipid rafts: a novel role for the death domain. J Immunol (2002) 1.02
TNFR1 signaling is associated with backbone conformational changes of receptor dimers consistent with overactivation in the R92Q TRAPS mutant. Biochemistry (2012) 0.99
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces death receptor 5 networks that are highly organized. J Biol Chem (2012) 0.93
Quantitative single-molecule localization microscopy combined with rule-based modeling reveals ligand-induced TNF-R1 reorganization toward higher-order oligomers. Histochem Cell Biol (2014) 0.93
Dual function of cysteine rich domain (CRD) 1 of TNF receptor type 1: conformational stabilization of CRD2 and control of receptor responsiveness. Cell Signal (2010) 0.92
Cholesterol homeostasis in T cells. Methyl-beta-cyclodextrin treatment results in equal loss of cholesterol from Triton X-100 soluble and insoluble fractions. Biochim Biophys Acta (2008) 0.92
The tumor necrosis factor receptor stalk regions define responsiveness to soluble versus membrane-bound ligand. Mol Cell Biol (2012) 0.88
Therapeutic targeting of CD95 and the TRAIL death receptors. Recent Pat Anticancer Drug Discov (2011) 0.86
Oxidative stress promotes ligand-independent and enhanced ligand-dependent tumor necrosis factor receptor signaling. J Biol Chem (2008) 0.86
Thiol modification of diacylglycerol kinase: dependence upon site membrane disposition and reagent hydrophobicity. FEBS Lett (2000) 0.85
Conatumumab, a fully human mAb against death receptor 5 for the treatment of cancer. Curr Opin Investig Drugs (2010) 0.84
Effect of cholesterol on the bilayer thickness in unilamellar extruded DLPC and DOPC liposomes: SANS contrast variation study. Gen Physiol Biophys (2004) 0.84
Death receptor 5-recruited raft components contributes to the sensitivity of Jurkat leukemia cell lines to TRAIL-induced cell death. IUBMB Life (2009) 0.83
Antagonistic TNF receptor one-specific antibody (ATROSAB): receptor binding and in vitro bioactivity. PLoS One (2013) 0.79
Open and closed conformations of the isolated transmembrane domain of death receptor 5 support a new model of activation. Biophys J (2014) 0.78
The effect of hydrophilic substitutions and anionic lipids upon the transverse positioning of the transmembrane helix of the ErbB2 (neu) protein incorporated into model membrane vesicles. J Mol Biol (2009) 0.78
Imaging of Fas-FasL membrane microdomains during apoptosis in a reconstituted cell-cell junction. Biochem Biophys Res Commun (2012) 0.76