Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants.

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Published in Nat Genet on October 10, 2016

Authors

Ying Jin1,2, Genevieve Andersen1, Daniel Yorgov3, Tracey M Ferrara1, Songtao Ben1, Kelly M Brownson1, Paulene J Holland1, Stanca A Birlea1,4, Janet Siebert5, Anke Hartmann6, Anne Lienert6, Nanja van Geel7, Jo Lambert7, Rosalie M Luiten8, Albert Wolkerstorfer8, J P Wietze van der Veen8,9, Dorothy C Bennett10, Alain Taïeb11, Khaled Ezzedine11, E Helen Kemp12, David J Gawkrodger12, Anthony P Weetman12, Sulev Kõks13, Ele Prans13, Külli Kingo14, Maire Karelson14, Margaret R Wallace15, Wayne T McCormack16, Andreas Overbeck17, Silvia Moretti18, Roberta Colucci18, Mauro Picardo19, Nanette B Silverberg20,21, Mats Olsson22, Yan Valle23, Igor Korobko23,24, Markus Böhm25, Henry W Lim26, Iltefat Hamzavi26, Li Zhou26, Qing-Sheng Mi26, Pamela R Fain1,2, Stephanie A Santorico1,3,27, Richard A Spritz1,2

Author Affiliations

1: Human Medical Genetics and Genomics Program, University of Colorado School of Medicine, Aurora, Colorado, USA.
2: Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
3: Department of Mathematical and Statistical Sciences, University of Colorado Denver, Denver, Colorado, USA.
4: Department of Dermatology, University of Colorado School of Medicine, Aurora, Colorado, USA.
5: CytoAnalytics, Denver, Colorado, USA.
6: Department of Dermatology, University Hospital Erlangen, Erlangen, Germany.
7: Department of Dermatology, Ghent University Hospital, Ghent, Belgium.
8: Netherlands Institute for Pigment Disorders, Department of Dermatology, Academic Medical Centre University of Amsterdam, Amsterdam, the Netherlands.
9: Department of Dermatology, Medical Centre Haaglanden, The Hague, the Netherlands.
10: Molecular and Clinical Sciences Research Institute, St. George's, University of London, London, UK.
11: Centre de Référence des Maladies Rares de la Peau, Department of Dermatology, Hôpital St.-André, Bordeaux, France.
12: Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
13: Department of Pathophysiology, University of Tartu, Tartu, Estonia.
14: Department of Dermatology, University of Tartu, Tartu, Estonia.
15: Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA.
16: Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.
17: Lumiderm, Madrid, Spain.
18: Section of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.
19: Laboratorio Fisiopatologia Cutanea, Istituto Dermatologico San Gallicano, Rome, Italy.
20: Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, New York, USA.
21: Pediatric and Adolescent Dermatology, St. Luke's-Roosevelt Hospital Center, New York, New York, USA.
22: International Vitiligo Center, Uppsala, Sweden.
23: Vitiligo Research Foundation, New York, New York, USA.
24: Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
25: Department of Dermatology, University of Münster, Münster, Germany.
26: Department of Dermatology, Henry Ford Hospital, Detroit, Michigan, USA.
27: Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado, Aurora, Colorado, USA.

Associated clinical trials:

Study of the Role of Innate Lymphoid Cells and Natural Killer Cells in Immune Activation of Vitiligo - INNATE Vitiligo (INNATEvitiligo) | NCT03859518

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