Published in Thromb J on October 04, 2016
The ins and outs of endocytic trafficking in platelet functions. Curr Opin Hematol (2017) 0.75
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol (2013) 11.58
Thrombin signalling and protease-activated receptors. Nature (2000) 9.27
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal (2010) 8.61
Platelets. Lancet (2000) 3.53
Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood (2011) 3.37
Role of thrombin signalling in platelets in haemostasis and thrombosis. Nature (2001) 3.15
Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Proc Natl Acad Sci U S A (2003) 2.89
Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor. EMBO J (2002) 2.53
Signaling during platelet adhesion and activation. Arterioscler Thromb Vasc Biol (2010) 2.43
Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton. Traffic (2002) 2.37
Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2. Traffic (2001) 2.31
A single common portal for clathrin-mediated endocytosis of distinct cargo governed by cargo-selective adaptors. Mol Biol Cell (2006) 1.75
Protection against thrombosis in mice lacking PAR3. Blood (2002) 1.74
The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway. EMBO J (2001) 1.72
The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2. J Biol Chem (2002) 1.68
Regulation of the Wnt signaling pathway by disabled-2 (Dab2). EMBO J (2003) 1.57
Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product. J Biol Chem (1995) 1.52
Molecular cloning of differentially expressed genes in human epithelial ovarian cancer. Gynecol Oncol (1994) 1.48
Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. J Cell Biol (2009) 1.32
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2. Oncogene (1998) 1.30
DOC-2/DAB2 is the binding partner of myosin VI. Biochem Biophys Res Commun (2002) 1.23
Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction. Curr Opin Cell Biol (2012) 1.21
Regulation of rat DOC-2 gene during castration-induced rat ventral prostate degeneration and its growth inhibitory function in human prostatic carcinoma cells. Endocrinology (1998) 1.20
Endocytosis of megalin by visceral endoderm cells requires the Dab2 adaptor protein. J Cell Sci (2005) 1.19
Applications of lentiviral vectors for shRNA delivery and transgenesis. Curr Gene Ther (2008) 1.14
The inhibitory role of DOC-2/DAB2 in growth factor receptor-mediated signal cascade. DOC-2/DAB2-mediated inhibition of ERK phosphorylation via binding to Grb2. J Biol Chem (2001) 1.14
Disabled-2 small interfering RNA modulates cellular adhesive function and MAPK activity during megakaryocytic differentiation of K562 cells. FEBS Lett (2003) 1.13
Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer. J Biol Chem (2002) 1.12
Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference. Nucleic Acids Res (2015) 1.10
Type II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2. Mol Biol Cell (2010) 1.06
Megalin and nonmuscle myosin heavy chain IIA interact with the adaptor protein Disabled-2 in proximal tubule cells. Kidney Int (2009) 0.99
Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin. EMBO J (2012) 0.99
The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. An underlying mechanism of its tumor-suppressive function in prostate cancer. J Biol Chem (1999) 0.98
Tissue factor and thrombin mediate myocardial ischemia-reperfusion injury. Ann Thorac Surg (2003) 0.94
Dab2 links CIN85 with clathrin-mediated receptor internalization. FEBS Lett (2003) 0.93
Oral antiplatelet therapy for atherothrombotic disease: current evidence and new directions. Am Heart J (2011) 0.92
Disabled-2 is a negative regulator of integrin alpha(IIb)beta(3)-mediated fibrinogen adhesion and cell signaling. J Biol Chem (2004) 0.92
Disabled-2 is a novel alphaIIb-integrin-binding protein that negatively regulates platelet-fibrinogen interactions and platelet aggregation. J Cell Sci (2006) 0.90
Induction of disabled-2 gene during megakaryocyte differentiation of k562 cells. Biochem Biophys Res Commun (2001) 0.89
Cell cycle-dependent phosphorylation of Disabled-2 by cdc2. Oncogene (2003) 0.87
p67 isoform of mouse disabled 2 protein acts as a transcriptional activator during the differentiation of F9 cells. Biochem J (2000) 0.85
Cutting edge: Dab2 is a FOXP3 target gene required for regulatory T cell function. J Immunol (2009) 0.85
Evaluation of the role of Disabled-2 in nerve growth factor-mediated neurite outgrowth and cellular signalling. Cell Signal (2007) 0.84
PKB/Akt partners with Dab2 in albumin endocytosis. Am J Physiol Renal Physiol (2012) 0.84
Disabled-2 is required for mesoderm differentiation of murine embryonic stem cells. J Cell Physiol (2010) 0.83
The dimeric platelet collagen receptor GPVI-Fc reduces platelet adhesion to activated endothelium and preserves myocardial function after transient ischemia in mice. Am J Physiol Cell Physiol (2012) 0.82
Sulfatides partition disabled-2 in response to platelet activation. PLoS One (2009) 0.81
Structure, sulfatide binding properties, and inhibition of platelet aggregation by a disabled-2 protein-derived peptide. J Biol Chem (2012) 0.80
The endocytic adaptor protein Disabled-2 is required for cellular uptake of fibrinogen. Biochim Biophys Acta (2012) 0.80
Networks in signal transduction: the role of adaptor proteins in platelet activation. Platelets (2000) 0.80
Disabled-2 modulates homotypic and heterotypic platelet interactions by binding to sulfatides. Br J Haematol (2011) 0.79
Autocrine signaling of platelet-derived growth factor regulates disabled-2 expression during megakaryocytic differentiation of K562 cells. FEBS Lett (2005) 0.78
Disabled-2 is required for efficient hemostasis and platelet activation by thrombin in mice. Arterioscler Thromb Vasc Biol (2014) 0.78
Akt recruits Dab2 to albumin endocytosis in the proximal tubule. Am J Physiol Renal Physiol (2014) 0.78
Animal models: mastering RNAi in mice. Nat Rev Genet (2011) 0.76