Metal-coupled folding as the driving force for the extreme stability of Rad50 zinc hook dimer assembly.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27808280)

Published in Sci Rep on November 03, 2016

Authors

Tomasz Kochańczyk1, Michał Nowakowski2, Dominika Wojewska1, Anna Kocyła1, Andrzej Ejchart3, Wiktor Koźmiński2, Artur Krężel1

Author Affiliations

1: Department of Chemical Biology, Faculty of Biotechnology, University of Wrocław, Joliot-Curie 14a, 50-383 Wrocław, Poland.
2: Biological and Chemical Research Center, Faculty of Chemistry, University of Warsaw, Żwirki i Wigury 101, 02-089 Warsaw, Poland.
3: Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a, 02-106, Warsaw, Poland.

Articles cited by this

Inference of macromolecular assemblies from crystalline state. J Mol Biol (2007) 44.95

Principles of protein-protein interactions. Proc Natl Acad Sci U S A (1996) 14.51

Primary structure effects on peptide group hydrogen exchange. Proteins (1993) 10.79

Folding dynamics and mechanism of beta-hairpin formation. Nature (1997) 7.30

The MRE11 complex: starting from the ends. Nat Rev Mol Cell Biol (2011) 3.83

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair. Nature (2002) 3.48

Diversity of protein-protein interactions. EMBO J (2003) 3.35

Zinc-buffering capacity of a eukaryotic cell at physiological pZn. J Biol Inorg Chem (2006) 2.03

Coordination dynamics of zinc in proteins. Chem Rev (2009) 1.95

Enthalpy and heat capacity changes for the proton dissociation of various buffer components in 0.1 M potassium chloride. Proteins (1998) 1.84

The x-ray crystal structure of lysine-2,3-aminomutase from Clostridium subterminale. Proc Natl Acad Sci U S A (2005) 1.72

Zn2+-binding and molecular determinants of tetramerization in voltage-gated K+ channels. Nat Struct Biol (1999) 1.57

Isokinetic relationship, isoequilibrium relationship, and enthalpy-entropy compensation. Chem Rev (2001) 1.49

Understanding the key factors that control the rate of beta-hairpin folding. Proc Natl Acad Sci U S A (2004) 1.40

Dual nanomolar and picomolar Zn(II) binding properties of metallothionein. J Am Chem Soc (2007) 1.38

Crystallographic evidence for dual coordination around zinc in the T3R3 human insulin hexamer. Biochemistry (1994) 1.27

Toward assessing the position-dependent contributions of backbone hydrogen bonding to beta-sheet folding thermodynamics employing amide-to-ester perturbations. J Am Chem Soc (2004) 1.26

Transient protein-protein interactions. Protein Eng Des Sel (2011) 1.22

A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science (2003) 1.21

Controlled formation of model homo- and heterodimer coiled coil polypeptides. Biochemistry (1993) 1.20

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions. Nat Struct Mol Biol (2011) 1.16

The glutaredoxin -C-P-Y-C- motif: influence of peripheral residues. Structure (2004) 1.11

Interaction of circadian clock proteins CRY1 and PER2 is modulated by zinc binding and disulfide bond formation. Cell (2014) 1.07

Relationship between the architecture of zinc coordination and zinc binding affinity in proteins--insights into zinc regulation. Metallomics (2015) 1.06

Reactivity of zinc finger cores: analysis of protein packing and electrostatic screening. J Am Chem Soc (2001) 1.01

Coordination properties of tris(2-carboxyethyl)phosphine, a newly introduced thiol reductant, and its oxide. Inorg Chem (2003) 1.01

Properties of the Sp1 zinc finger 3 peptide: coordination chemistry, redox reactions, and metal binding competition with metallothionein. Chem Res Toxicol (1995) 0.97

Femtomolar Zn(II) affinity in a peptide-based ligand designed to model thiolate-rich metalloprotein active sites. Inorg Chem (2006) 0.96

Metal-coupled folding of Cys2His2 zinc-finger. J Am Chem Soc (2007) 0.95

Biochemical characterization of bacteriophage T4 Mre11-Rad50 complex. J Biol Chem (2010) 0.95

Thermodynamics of Zn2+ binding to Cys2His2 and Cys2HisCys zinc fingers and a Cys4 transcription factor site. J Am Chem Soc (2012) 0.93

Metals in protein-protein interfaces. Annu Rev Biophys (2014) 0.92

Factors governing the protonation state of cysteines in proteins: an Ab initio/CDM study. J Am Chem Soc (2002) 0.89

Determination of the pK(a) of the four Zn2+-coordinating residues of the distal finger motif of the HIV-1 nucleocapsid protein: consequences on the binding of Zn2+. J Mol Biol (2001) 0.88

Deducing the energetic cost of protein folding in zinc finger proteins using designed metallopeptides. J Am Chem Soc (2007) 0.88

Role of protons in the thermodynamic contribution of a Zn(II)-Cys4 site toward metalloprotein stability. Biochemistry (2007) 0.87

Interdependence of the rad50 hook and globular domain functions. Mol Cell (2015) 0.86

The Rad50 hook domain regulates DNA damage signaling and tumorigenesis. Genes Dev (2014) 0.83

Femtomolar Zn(II) affinity of minimal zinc hook peptides--a promising small tag for protein engineering. Chem Commun (Camb) (2013) 0.82

The biological inorganic chemistry of zinc ions. Arch Biochem Biophys (2016) 0.81

Cooperative metal binding and helical folding in model peptides of treble-clef zinc fingers. Chemistry (2009) 0.81

The concerted action of a positive charge and hydrogen bonds dynamically regulates the pKa of the nucleophilic cysteine in the NrdH-redoxin family. Protein Sci (2013) 0.81

Functional Analysis of the Bacteriophage T4 Rad50 Homolog (gp46) Coiled-coil Domain. J Biol Chem (2015) 0.80

Homodimerization and heterodimerization of minimal zinc(II)-binding-domain peptides of T-cell proteins CD4, CD8alpha, and Lck. J Am Chem Soc (2009) 0.80

Probing the role of backbone hydrogen bonds in protein-peptide interactions by amide-to-ester mutations. J Am Chem Soc (2013) 0.79

Metal binding properties of the zinc finger metallome--insights into variations in stability. Metallomics (2014) 0.79

Coordination properties of dithiobutylamine (DTBA), a newly introduced protein disulfide reducing agent. Inorg Chem (2014) 0.79

Isothermal Titration Calorimetry Measurements of Metal Ions Binding to Proteins. Methods Enzymol (2016) 0.78

Femtomolar Zn2+ affinity of LIM domain of PDLIM1 protein uncovers crucial contribution of protein-protein interactions to protein stability. J Inorg Biochem (2012) 0.78

NMR measurements of proton exchange between solvent and peptides and proteins. Acta Biochim Pol (1999) 0.76

Thermodynamics of formation of the insulin hexamer: metal-stabilized proton-coupled assembly of quaternary structure. Biochemistry (2014) 0.76

Dissecting ITC data of metal ions binding to ligands and proteins. Biochim Biophys Acta (2015) 0.76

Zn(II) binding and DNA binding properties of ligand-substituted CXHH-type zinc finger proteins. Biochemistry (2012) 0.76