Published in Science on September 22, 1989
A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1. Proc Natl Acad Sci U S A (1992) 2.79
A regulatory system for use in gene transfer. Proc Natl Acad Sci U S A (1994) 2.22
Regulation of Cre recombinase activity by the synthetic steroid RU 486. Nucleic Acids Res (1996) 1.91
Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor. EMBO J (1990) 1.90
Uterine DCs are crucial for decidua formation during embryo implantation in mice. J Clin Invest (2008) 1.82
Regulatable gene expression systems for gene therapy applications: progress and future challenges. Mol Ther (2005) 1.61
RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation. EMBO J (1995) 1.58
The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells. Mol Cell Biol (1994) 1.48
Synergistic action of interleukin-6 and glucocorticoids is mediated by the interleukin-6 response element of the rat alpha 2 macroglobulin gene. Mol Cell Biol (1992) 1.46
RU 486. Am J Public Health (1992) 1.39
The search for meaning: RU 486 and the law of abortion. Am J Public Health (1992) 1.26
Progress in neuroprotective strategies for preventing epilepsy. Prog Neurobiol (2007) 1.24
Two types of antiprogestins identified by their differential action in transcriptionally active extracts from T47D cells. Nucleic Acids Res (1991) 1.20
Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers. Proc Natl Acad Sci U S A (1991) 1.14
Intra- and inter-molecular recombination of mitochondrial DNA after in vivo induction of multiple double-strand breaks. Nucleic Acids Res (2009) 1.13
The regulation of embryo implantation and endometrial decidualization by progesterone receptor signaling. Mol Cell Endocrinol (2011) 1.07
Sparfloxacin, ethambutol, and cortisol receptor inhibitor RU-40 555 treatment for disseminated Mycobacterium avium complex infection of normal C57BL/6 mice. Antimicrob Agents Chemother (1992) 1.07
Progesterone enhances target gene transcription by receptor free of heat shock proteins hsp90, hsp56, and hsp70. Mol Cell Biol (1991) 1.00
Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles. J Clin Endocrinol Metab (2011) 0.95
Progesterone and RU486: opposing effects on human sperm. Proc Natl Acad Sci U S A (1994) 0.94
Regulatable gene expression systems for gene therapy. Curr Gene Ther (2006) 0.92
Progesterone receptor B recruits a repressor complex to a half-PRE site of the estrogen receptor alpha gene promoter. Mol Endocrinol (2009) 0.92
Mifepristone (RU486) protects Purkinje cells from cell death in organotypic slice cultures of postnatal rat and mouse cerebellum. Proc Natl Acad Sci U S A (2003) 0.91
The glucocorticoid receptor hormone binding domain mediates transcriptional activation in vitro in the absence of ligand. Nucleic Acids Res (1993) 0.90
Repression of the alpha-fetoprotein gene promoter by progesterone and chimeric receptors in the presence of hormones and antihormones. Mol Cell Biol (1990) 0.86
E1A-mediated repression of progesterone receptor-dependent transactivation involves inhibition of the assembly of a multisubunit coactivation complex. Mol Cell Biol (2000) 0.85
A complex role for the progesterone receptor in the response to vascular injury. J Clin Invest (2001) 0.85
In vivo evidence against the existence of antiprogestins disrupting receptor binding to DNA. Proc Natl Acad Sci U S A (1993) 0.83
Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone. Cell Calcium (2011) 0.83
Novel type of Gq/11 protein-coupled neurosteroid receptor sensitive to endocrine disrupting chemicals in mast cell line (RBL-2H3). Br J Pharmacol (2005) 0.82
Nuclear progesterone receptor is mainly heat shock protein 90-free in vivo. Proc Natl Acad Sci U S A (1993) 0.82
Sex-specific modification of progesterone receptor expression by 17β-oestradiol in human cardiac tissues. Biol Sex Differ (2010) 0.81
Progesterone is not the same as 17α-hydroxyprogesterone caproate: implications for obstetrical practice. Am J Obstet Gynecol (2013) 0.80
Mifepristone (RU486), a pure antiprogesterone drug, in combination with vinblastine for the treatment of progesterone receptor-positive desmoid tumor. Tech Coloproctol (2010) 0.79
Disruption of endogenous regulator homeostasis underlies the mechanism of rat CYP1A1 mRNA induction by metyrapone. Biochem J (1998) 0.79
Sustained decreases in weight and serum insulin, glucose, triacylglycerol and cholesterol in JCR:LA-corpulent rats treated with D-fenfluramine. Br J Pharmacol (1992) 0.78
Different dosages of mifepristone versus enantone to treat uterine fibroids: A multicenter randomized controlled trial. Medicine (Baltimore) (2017) 0.78
The chemopreventive effect of mifepristone on mammary tumorigenesis is associated with an anti-invasive and anti-inflammatory gene signature. Cancer Prev Res (Phila) (2012) 0.77
Modeling hormonal and inflammatory contributions to preterm and term labor using uterine temporal transcriptomics. BMC Med (2016) 0.77
Effect of antiprogesterone RU486 on VEGF expression and blood vessel remodeling on ovarian follicles before ovulation. PLoS One (2014) 0.76
The Role of Mifepristone in Meningiomas Management: A Systematic Review of the Literature. Biomed Res Int (2015) 0.75
Double-Blind Phase III Randomized Trial of the Antiprogestin Agent Mifepristone in the Treatment of Unresectable Meningioma: SWOG S9005. J Clin Oncol (2015) 0.75
Inhibition of the tocolytic activity of atrial natriuretic factor by progesterone and potentiation by progesterone receptor antagonist RU486 in rats. Br J Pharmacol (1991) 0.75
Ginsenoside Rg1 protects against neuronal degeneration induced by chronic dexamethasone treatment by inhibiting NLRP-1 inflammasomes in mice. Int J Mol Med (2017) 0.75