Towards the Analysis of High Molecular Weight Proteins and Protein complexes using TIMS-MS.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27818614)

Published in Int J Ion Mobil Spectrom on June 07, 2016

Authors

Paolo Benigni1, Rebecca Marin1, Juan Camilo Molano-Arevalo1, Alyssa Garabedian1, Jeremy J Wolff2, Mark E Ridgeway2, Melvin A Park2, Francisco Fernandez-Lima3

Author Affiliations

1: Department of Chemistry & Biochemistry, Florida International University, Miami, FL 33199, USA.
2: Bruker Daltonics, Inc., Billerica, Massachusetts 01821, USA.
3: Department of Chemistry & Biochemistry, Florida International University, Miami, FL 33199, USA; Biomolecular Science Institute, Florida International University, Miami, FL 33199, USA.

Articles cited by this

(truncated to the top 100)

Intrinsically unstructured proteins and their functions. Nat Rev Mol Cell Biol (2005) 17.63

Structure of ubiquitin refined at 1.8 A resolution. J Mol Biol (1987) 9.19

Intrinsic disorder and protein function. Biochemistry (2002) 8.54

Evolution of function in protein superfamilies, from a structural perspective. J Mol Biol (2001) 6.63

The cell as a collection of protein machines: preparing the next generation of molecular biologists. Cell (1998) 5.91

Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell (2002) 5.19

Structure and energetics of ligand binding to proteins: Escherichia coli dihydrofolate reductase-trimethoprim, a drug-receptor system. Proteins (1988) 4.82

Structure of a protein determined by solid-state magic-angle-spinning NMR spectroscopy. Nature (2002) 4.29

Studying noncovalent protein complexes by electrospray ionization mass spectrometry. Mass Spectrom Rev (1998) 3.90

High-resolution three-dimensional structure of horse heart cytochrome c. J Mol Biol (1990) 3.83

A tandem mass spectrometer for improved transmission and analysis of large macromolecular assemblies. Anal Chem (2002) 3.83

Progress and challenges in protein structure prediction. Curr Opin Struct Biol (2008) 3.48

The relationship between protein structure and function: a comprehensive survey with application to the yeast genome. J Mol Biol (1999) 3.46

Structure determination of membrane proteins by NMR spectroscopy. Chem Rev (2004) 3.25

The molecular sociology of the cell. Nature (2007) 3.23

Prediction of protein function from protein sequence and structure. Q Rev Biophys (2003) 3.03

Ion mobility-mass spectrometry. J Mass Spectrom (2008) 2.91

Detection of transient protein folding populations by mass spectrometry. Science (1993) 2.85

Implications of protein flexibility for drug discovery. Nat Rev Drug Discov (2003) 2.83

From words to literature in structural proteomics. Nature (2003) 2.80

The unfoldomics decade: an update on intrinsically disordered proteins. BMC Genomics (2008) 2.72

An IMS-IMS analogue of MS-MS. Anal Chem (2006) 2.68

Collision cross sections of proteins and their complexes: a calibration framework and database for gas-phase structural biology. Anal Chem (2010) 2.62

Stepwise evolution of protein native structure with electrospray into the gas phase, 10(-12) to 10(2) s. Proc Natl Acad Sci U S A (2008) 1.91

A large protein complex containing the yeast Sin3p and Rpd3p transcriptional regulators. Mol Cell Biol (1997) 1.83

Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action. Trends Pharmacol Sci (2009) 1.79

Ion mobility mass spectrometry of proteins and protein assemblies. Chem Soc Rev (2009) 1.77

Electrospray ionization high-resolution ion mobility spectrometry-mass spectrometry. Anal Chem (1998) 1.70

Ion mobility-mass spectrometry of a rotary ATPase reveals ATP-induced reduction in conformational flexibility. Nat Chem (2014) 1.63

The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription. EMBO Rep (2006) 1.59

High-resolution ion cyclotron mobility spectrometry. Anal Chem (2009) 1.56

Electrospray ionization mass spectrometry and ion mobility analysis of the 20S proteasome complex. J Am Soc Mass Spectrom (2005) 1.53

Biosimilar, biobetter, and next generation antibody characterization by mass spectrometry. Anal Chem (2012) 1.49

Interrogating viral capsid assembly with ion mobility-mass spectrometry. Nat Chem (2010) 1.47

Ion mobility-mass spectrometry reveals long-lived, unfolded intermediates in the dissociation of protein complexes. Angew Chem Int Ed Engl (2007) 1.47

Macromolecular structural elucidation with solid-state NMR-derived orientational constraints. J Biomol NMR (1996) 1.46

High-resolution study of the three-dimensional structure of horse heart metmyoglobin. J Mol Biol (1990) 1.43

Chaperonin complexes monitored by ion mobility mass spectrometry. J Am Chem Soc (2009) 1.33

Overtone mobility spectrometry: part 1. Experimental observations. J Am Soc Mass Spectrom (2008) 1.32

Charge-state dependent compaction and dissociation of protein complexes: insights from ion mobility and molecular dynamics. J Am Chem Soc (2012) 1.30

Gas-phase unfolding and disassembly reveals stability differences in ligand-bound multiprotein complexes. Chem Biol (2009) 1.27

Silicon cluster ions: Evidence for a structural transition. Phys Rev Lett (1991) 1.26

Experimental evaluation and optimization of structures for lossless ion manipulations for ion mobility spectrometry with time-of-flight mass spectrometry. Anal Chem (2014) 1.24

Note: Integration of trapped ion mobility spectrometry with mass spectrometry. Rev Sci Instrum (2011) 1.23

Integrating ion mobility mass spectrometry with molecular modelling to determine the architecture of multiprotein complexes. PLoS One (2010) 1.22

Monitoring copopulated conformational states during protein folding events using electrospray ionization-ion mobility spectrometry-mass spectrometry. J Am Soc Mass Spectrom (2007) 1.22

Collision induced unfolding of protein ions in the gas phase studied by ion mobility-mass spectrometry: the effect of ligand binding on conformational stability. J Am Soc Mass Spectrom (2009) 1.21

Travelling wave ion mobility mass spectrometry studies of protein structure: biological significance and comparison with X-ray crystallography and nuclear magnetic resonance spectroscopy measurements. Rapid Commun Mass Spectrom (2008) 1.18

Number of solution states of bradykinin from ion mobility and mass spectrometry measurements. J Am Chem Soc (2011) 1.18

Drug binding in human P-glycoprotein causes conformational changes in both nucleotide-binding domains. J Biol Chem (2002) 1.18

Characterizing oligosaccharides using injected-ion mobility/mass spectrometry. Anal Chem (1997) 1.15

The potential of differential mobility analysis coupled to MS for the study of very large singly and multiply charged proteins and protein complexes in the gas phase. Biotechnol J (2006) 1.07

Ion mobility mass spectrometry of two tetrameric membrane protein complexes reveals compact structures and differences in stability and packing. J Am Chem Soc (2010) 1.07

A scanning frequency mode for ion cyclotron mobility spectrometry. Anal Chem (2010) 1.07

Conformation types of ubiquitin [M+8H]8+ Ions from water:methanol solutions: evidence for the N and A States in aqueous solution. J Phys Chem B (2012) 1.06

Characterizing intermediates along the transition from polyproline I to polyproline II using ion mobility spectrometry-mass spectrometry. J Am Chem Soc (2014) 1.06

Ion mobility analysis of molecular dynamics. Annu Rev Phys Chem (2013) 1.05

Ion mobility spectrometer with radial collisional focusing. Anal Chem (2005) 1.04

A review of current applications of mass spectrometry for biomarker/molecular tracer elucidation. Mass Spectrom Rev (2005) 1.03

Ion dynamics in a trapped ion mobility spectrometer. Analyst (2014) 1.02

Traveling-wave ion mobility mass spectrometry of protein complexes: accurate calibrated collision cross-sections of human insulin oligomers. Rapid Commun Mass Spectrom (2012) 1.01

Ion mobilities in diatomic gases: measurement versus prediction with non-specular scattering models. J Phys Chem A (2013) 1.01

Mass spectrometry in systems biology: an overview. Mass Spectrom Rev (2008) 1.00

Conformational changes in oxidatively stressed monoclonal antibodies studied by hydrogen exchange mass spectrometry. Protein Sci (2010) 0.99

Intrinsically disordered p53 and its complexes populate compact conformations in the gas phase. Angew Chem Int Ed Engl (2012) 0.98

Isomerization kinetics of AT hook decapeptide solution structures. Anal Chem (2014) 0.97

Assembly of multiprotein complexes that control genome function. J Cell Biol (2009) 0.96

Energetics of binding the mammalian high mobility group protein HMGA2 to poly(dA-dT)2 and poly(dA)-poly(dT). J Mol Biol (2005) 0.95

Structural details, pathways, and energetics of unfolding apomyoglobin. J Mol Biol (2003) 0.94

Direct observation of differences of carotenoid polyene chain cis/trans isomers resulting from structural topology. Anal Chem (2014) 0.91

Proteomics meets cell biology: the establishment of subcellular proteomes. Electrophoresis (2000) 0.91

Calmodulin-cardiac troponin C chimeras. Effects of domain exchange on calcium binding and enzyme activation. J Biol Chem (1993) 0.90

Ion Mobility-Mass Spectrometry Reveals the Energetics of Intermediates that Guide Polyproline Folding. J Am Soc Mass Spectrom (2015) 0.89

Probing a cell-embedded megadalton protein complex by DNP-supported solid-state NMR. Nat Methods (2015) 0.89

An assessment of computational methods for obtaining structural information of moderately flexible biomolecules from ion mobility spectrometry. J Am Soc Mass Spectrom (2012) 0.88

Molecular dynamics and ion mobility spectrometry study of model β-hairpin peptide, trpzip1. J Phys Chem A (2011) 0.88

Solution dependence of the collisional activation of ubiquitin [M + 7H](7+) ions. J Am Soc Mass Spectrom (2014) 0.87

A glimpse of structural biology through X-ray crystallography. Cell (2014) 0.87

Linking molecular models with ion mobility experiments. Illustration with a rigid nucleic acid structure. J Mass Spectrom (2015) 0.87

Intrinsic disorder in proteins: a challenge for (un)structural biology met by ion mobility-mass spectrometry. Biochem Soc Trans (2012) 0.87

Targeted high-resolution ion mobility separation coupled to ultrahigh-resolution mass spectrometry of endocrine disruptors in complex mixtures. Anal Chem (2015) 0.86

Ion mobility measurements of nondenatured 12-150 kDa proteins and protein multimers by tandem differential mobility analysis-mass spectrometry (DMA-MS). J Am Soc Mass Spectrom (2011) 0.85

Collisional and Coulombic unfolding of gas-phase proteins: high correlation to their domain structures in solution. Angew Chem Int Ed Engl (2014) 0.85

Flavin adenine dinucleotide structural motifs: from solution to gas phase. Anal Chem (2014) 0.85

Native mass spectrometry and ion mobility characterization of trastuzumab emtansine, a lysine-linked antibody drug conjugate. Protein Sci (2015) 0.84

A mass-selective variable-temperature drift tube ion mobility-mass spectrometer for temperature dependent ion mobility studies. J Am Soc Mass Spectrom (2011) 0.84

Ion Mobility Spectrometry-Mass Spectrometry of Intrinsically Unfolded Proteins: Trying to Put Order into Disorder. Curr Anal Chem (2013) 0.83

Supercharging with m-nitrobenzyl alcohol and propylene carbonate: forming highly charged ions with extended, near-linear conformations. Anal Chem (2015) 0.83

"Wet" Versus "Dry" Folding of Polyproline. J Am Soc Mass Spectrom (2016) 0.83

Mass spectrometry as a readout of protein structure and function. Mass Spectrom Rev (1998) 0.82

Collisional unfolding of multiprotein complexes reveals cooperative stabilization upon ligand binding. Protein Sci (2015) 0.82

Ion mobility-mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5. Proteomics (2015) 0.80

Kinetic intermediates of holo- and apo-myoglobin studied Using HDX-TIMS-MS and molecular dynamic simulations. J Am Soc Mass Spectrom (2015) 0.80

Microheterogeneity within conformational states of ubiquitin revealed by high resolution trapped ion mobility spectrometry. Analyst (2015) 0.80

The collision cross sections of iodide salt cluster ions in air via differential mobility analysis-mass spectrometry. J Am Soc Mass Spectrom (2013) 0.80

On the structural denaturation of biological analytes in trapped ion mobility spectrometry - mass spectrometry. Analyst (2016) 0.79

Gas molecule scattering & ion mobility measurements for organic macro-ions in He versus N2 environments. Phys Chem Chem Phys (2015) 0.79

A 1 MDa protein complex containing critical components of the Escherichia coli divisome. Sci Rep (2015) 0.79

Advances in ion mobility-mass spectrometry instrumentation and techniques for characterizing structural heterogeneity. Analyst (2015) 0.79

Fast Screening of Polycyclic Aromatic Hydrocarbons using Trapped Ion Mobility Spectrometry - Mass Spectrometry. Anal Methods (2014) 0.79

Articles by these authors

Isomer Separation of Polybrominated Diphenyl Ether Metabolites using nanoESI-TIMS-MS. Int J Ion Mobil Spectrom (2016) 0.76