Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells.

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🔗 View Article (PMID 27828943)

Published in Nature on November 09, 2016

Authors

Olivier De Henau1, Matthew Rausch2, David Winkler2, Luis Felipe Campesato1, Cailian Liu1, Daniel Hirschhorn Cymerman1, Sadna Budhu1, Arnab Ghosh1, Melissa Pink2, Jeremy Tchaicha2, Mark Douglas2, Thomas Tibbitts2, Sujata Sharma2, Jennifer Proctor2, Nicole Kosmider2, Kerry White2, Howard Stern2, John Soglia2, Julian Adams2, Vito J Palombella2, Karen McGovern2, Jeffery L Kutok2, Jedd D Wolchok1,3, Taha Merghoub1

Author Affiliations

1: Memorial Sloan Kettering Cancer Center, Parker Institute for Cancer Immunotherapy and Swim Across America/Ludwig Collaborative Laboratory, New York, New York 10065, USA.
2: Infinity Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, USA.
3: Weill Cornell Medical and Graduate Schools, New York, New York 10065, USA.

Associated clinical trials:

A Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IPI-549 | NCT02637531

Quantifying Systemic Immunosuppression to Personalize Cancer Therapy (SERPENTINE) | NCT04941365

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