Murine Double Minute-2 Inhibition Attenuates Cardiac Dysfunction and Fibrosis by Modulating NF-κB Pathway After Experimental Myocardial Infarction.

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc Natl Acad Sci U S A (2006) 4.68

CCL2/Monocyte Chemoattractant Protein-1 regulates inflammatory responses critical to healing myocardial infarcts. Circ Res (2005) 4.14

A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse. Circ Res (2010) 3.00

Of mice and dogs: species-specific differences in the inflammatory response following myocardial infarction. Am J Pathol (2004) 2.61

Anakinra, a recombinant human interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction. Circulation (2008) 2.23

TNFalpha in atherosclerosis, myocardial ischemia/reperfusion and heart failure. Pharmacol Ther (2010) 2.01

The inflammatory response in myocardial injury, repair, and remodelling. Nat Rev Cardiol (2014) 1.99

Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling. Am J Pathol (2008) 1.97

p53- and Mdm2-independent repression of NF-kappa B transactivation by the ARF tumor suppressor. Mol Cell (2003) 1.92

Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study). Am J Cardiol (2010) 1.82

Anti-monocyte chemoattractant protein-1 gene therapy attenuates left ventricular remodeling and failure after experimental myocardial infarction. Circulation (2003) 1.79

Targeted deletion of CC chemokine receptor 2 attenuates left ventricular remodeling after experimental myocardial infarction. Am J Pathol (2004) 1.79

MDM2 (murine double minute-2) links inflammation and tubular cell healing during acute kidney injury in mice. Kidney Int (2012) 1.74

Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization. J Exp Med (2006) 1.56

Developmental changes in the delayed rectifier K+ channels in mouse heart. Circ Res (1996) 1.55

Downregulation of adiponectin induced by tumor necrosis factor α is involved in the aggravation of posttraumatic myocardial ischemia/reperfusion injury. Crit Care Med (2011) 1.50

p53 Attenuates lipopolysaccharide-induced NF-kappaB activation and acute lung injury. J Immunol (2009) 1.27

Induction of monocyte chemoattractant protein-1 in the small veins of the ischemic and reperfused canine myocardium. Circulation (1997) 1.25

MDM2 induces NF-kappaB/p65 expression transcriptionally through Sp1-binding sites: a novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia. Blood (2002) 1.23

Overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth. J Biol Chem (2006) 1.12

Co-expression of p53 and MDM2 in human atherosclerosis: implications for the regulation of cellularity of atherosclerotic lesions. J Pathol (1998) 1.04

p53-independent roles of MDM2 in NF-κB signaling: implications for cancer therapy, wound healing, and autoimmune diseases. Neoplasia (2012) 1.01

Mdm2 promotes systemic lupus erythematosus and lupus nephritis. J Am Soc Nephrol (2011) 0.99

Podocyte loss involves MDM2-driven mitotic catastrophe. J Pathol (2013) 0.91

A novel mechanism of crosstalk between the p53 and NFκB pathways: MDM2 binds and inhibits p65RelA. Cell Cycle (2013) 0.88

Inflammation as a therapeutic target in myocardial infarction: learning from past failures to meet future challenges. Transl Res (2015) 0.87

Inhibition of MDM2 attenuates neointimal hyperplasia via suppression of vascular proliferation and inflammation. Cardiovasc Res (2011) 0.85

Interleukin-1β blockade improves cardiac remodelling after myocardial infarction without interrupting the inflammasome in the mouse. Exp Physiol (2012) 0.85

Concepts in MDM2 Signaling: Allosteric Regulation and Feedback Loops. Genes Cancer (2012) 0.83

Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development. J Pathol (2012) 0.82

A single intravenous sTNFR-Fc administration at the time of reperfusion limits infarct size--implications in reperfusion strategies in man. Cardiovasc Drugs Ther (2008) 0.82

MDM2 beyond cancer: podoptosis, development, inflammation, and tissue regeneration. Histol Histopathol (2015) 0.78

The potential role of natriuretic peptides and other biomarkers in heart failure diagnosis, prognosis and management. Expert Rev Cardiovasc Ther (2015) 0.77